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The map label for this gene is MtlD

Identifier: 20806859

GI number: 20806859

Start: 363110

End: 364270

Strand: Direct

Name: MtlD

Synonym: TTE0342

Alternate gene names: 20806859

Gene position: 363110-364270 (Clockwise)

Preceding gene: 20806858

Following gene: 20806860

Centisome position: 13.5

GC content: 34.02

Gene sequence:

>1161_bases
ATGCTGAAGGCGCTTCACTTTGGAGCAGGCAATATAGGGAGAGGATTTATTGGATATTTACTTAATAAATCCGGATATGA
AGTTACCTTTGTAGATATTTCGAAAGAAATTGTGGATAATATTAATAAGTACAAAAAGTACAATGTCATTATTTTAAAAG
AGCCTGTGGAAAAAGAGGAAGTAAAAGAGGTCAAGGCTTTGCATCTAGAGGAAGAGGATAAAGTGCTTGATGCTTTTTTA
GAGGCGGATATGGTTACAACTTCTGTAGGTGTTTCAAACCTTTCTTCCATTGGTGGAAGATTAAAGAAATACTTAAAGGC
AAGAAAAGAAAAAAATGAAAAACCTCTTGACATAATGGCTTGCGAAAATGCGCTTTTTGCTACTGACGTTTTAAGAGAAA
GGGTAGTAAAAGAAGAGGACGATGATTTTATTACTTACCTCAATTTAAAAGTTGGTTTTCCCAATACAGCAGTTGATAGG
ATTGTTCCAGCAGTTAAAATTGATAAAAAACTTCCTGTGGATGTGGCAGTAGAAGAGTTTTTTGAGTGGGATATTGAGAA
AAATAAAATTAAAGGGAACCTCCAAATAGAAGGGGTAGAATTAGTAGATGATTTAAAACCTTATATAGAGAGGAAATTAT
TTTTGCTAAATGGAGCCCACGCTACAACAGCCTATTTGGGCTATTTAAGAGGTTATACGTATATTCATCAAGCGATAAAA
GATGACAATATAAGGGCTATAGTGAAAGGAATGCAGGAAGAAATATCTACTGCTCTTTCTAAAAAATATGATGTAGATAA
AGAATCTCTTATGGCCTATGCAGAAAAAGTGATTAAGAGGTTTGAAAATCCATATTTACAAGATGAGGTTACAAGAGTTG
GAAGGGAACCTTTGAGAAAGCTTTCATCAGAAGATAGATTAATTGCACCTTTAAAGCTTTGCAGTGAAGTTGGAATTACG
CCAAACTTTATCCTCTATGGAATTGCTGCTGGGCTTTTATTTGACTACAAAGAAGATGCACAGGCCGTTAAAATGAGAGA
ATATGTAGAACAATTTGGCATAAAAAAGGCTGTAAATGTTATTACAGGACTTGAAGAGGAAAGTGATTTAGTAGAAGAGA
TAGAGAAAAGGTACTTTGAGCTAAAAGGAAAATTAATATAA

Upstream 100 bases:

>100_bases
ATAGCTTTGACATGCCAGTACGAAGAGAATGTAGAAAAGCTCAAAAAAGCAAAGACTCCACAGGAGATAATAGAAATCCT
GGAGAAAGGTGATGAGTAAA

Downstream 100 bases:

>100_bases
AAAGGGCGTTTTGTGATAAGGCACAAAATGCCCTTAAAAATGTTTACAAGAGAGAGAAAACGTATAAAATTGGGAGAAAA
TAAGAGCAAAGGCCAAAAAG

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MLKALHFGAGNIGRGFIGYLLNKSGYEVTFVDISKEIVDNINKYKKYNVIILKEPVEKEEVKEVKALHLEEEDKVLDAFL
EADMVTTSVGVSNLSSIGGRLKKYLKARKEKNEKPLDIMACENALFATDVLRERVVKEEDDDFITYLNLKVGFPNTAVDR
IVPAVKIDKKLPVDVAVEEFFEWDIEKNKIKGNLQIEGVELVDDLKPYIERKLFLLNGAHATTAYLGYLRGYTYIHQAIK
DDNIRAIVKGMQEEISTALSKKYDVDKESLMAYAEKVIKRFENPYLQDEVTRVGREPLRKLSSEDRLIAPLKLCSEVGIT
PNFILYGIAAGLLFDYKEDAQAVKMREYVEQFGIKKAVNVITGLEEESDLVEEIEKRYFELKGKLI

Sequences:

>Translated_386_residues
MLKALHFGAGNIGRGFIGYLLNKSGYEVTFVDISKEIVDNINKYKKYNVIILKEPVEKEEVKEVKALHLEEEDKVLDAFL
EADMVTTSVGVSNLSSIGGRLKKYLKARKEKNEKPLDIMACENALFATDVLRERVVKEEDDDFITYLNLKVGFPNTAVDR
IVPAVKIDKKLPVDVAVEEFFEWDIEKNKIKGNLQIEGVELVDDLKPYIERKLFLLNGAHATTAYLGYLRGYTYIHQAIK
DDNIRAIVKGMQEEISTALSKKYDVDKESLMAYAEKVIKRFENPYLQDEVTRVGREPLRKLSSEDRLIAPLKLCSEVGIT
PNFILYGIAAGLLFDYKEDAQAVKMREYVEQFGIKKAVNVITGLEEESDLVEEIEKRYFELKGKLI
>Mature_386_residues
MLKALHFGAGNIGRGFIGYLLNKSGYEVTFVDISKEIVDNINKYKKYNVIILKEPVEKEEVKEVKALHLEEEDKVLDAFL
EADMVTTSVGVSNLSSIGGRLKKYLKARKEKNEKPLDIMACENALFATDVLRERVVKEEDDDFITYLNLKVGFPNTAVDR
IVPAVKIDKKLPVDVAVEEFFEWDIEKNKIKGNLQIEGVELVDDLKPYIERKLFLLNGAHATTAYLGYLRGYTYIHQAIK
DDNIRAIVKGMQEEISTALSKKYDVDKESLMAYAEKVIKRFENPYLQDEVTRVGREPLRKLSSEDRLIAPLKLCSEVGIT
PNFILYGIAAGLLFDYKEDAQAVKMREYVEQFGIKKAVNVITGLEEESDLVEEIEKRYFELKGKLI

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=379, Percent_Identity=43.2717678100264, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1788497, Length=432, Percent_Identity=26.1574074074074, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1787823, Length=355, Percent_Identity=27.6056338028169, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790779, Length=261, Percent_Identity=31.8007662835249, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI48994885, Length=241, Percent_Identity=29.4605809128631, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324401, Length=217, Percent_Identity=33.6405529953917, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320765, Length=217, Percent_Identity=33.6405529953917, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_THETN (Q8RCS0)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622030.1
- ProteinModelPortal:   Q8RCS0
- GeneID:   996309
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0342
- NMPDR:   fig|273068.3.peg.188
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- BioCyc:   TTEN273068:TTE0342-MONOMER
- BRENDA:   1.1.1.17
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 44022; Mature: 44022

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKALHFGAGNIGRGFIGYLLNKSGYEVTFVDISKEIVDNINKYKKYNVIILKEPVEKEE
CCCEEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHEEEEEEECCCCHHH
VKEVKALHLEEEDKVLDAFLEADMVTTSVGVSNLSSIGGRLKKYLKARKEKNEKPLDIMA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CENALFATDVLRERVVKEEDDDFITYLNLKVGFPNTAVDRIVPAVKIDKKLPVDVAVEEF
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHH
FEWDIEKNKIKGNLQIEGVELVDDLKPYIERKLFLLNGAHATTAYLGYLRGYTYIHQAIK
HHCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHC
DDNIRAIVKGMQEEISTALSKKYDVDKESLMAYAEKVIKRFENPYLQDEVTRVGREPLRK
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSSEDRLIAPLKLCSEVGITPNFILYGIAAGLLFDYKEDAQAVKMREYVEQFGIKKAVNV
CCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHH
ITGLEEESDLVEEIEKRYFELKGKLI
HHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKALHFGAGNIGRGFIGYLLNKSGYEVTFVDISKEIVDNINKYKKYNVIILKEPVEKEE
CCCEEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHEEEEEEECCCCHHH
VKEVKALHLEEEDKVLDAFLEADMVTTSVGVSNLSSIGGRLKKYLKARKEKNEKPLDIMA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CENALFATDVLRERVVKEEDDDFITYLNLKVGFPNTAVDRIVPAVKIDKKLPVDVAVEEF
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHH
FEWDIEKNKIKGNLQIEGVELVDDLKPYIERKLFLLNGAHATTAYLGYLRGYTYIHQAIK
HHCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHC
DDNIRAIVKGMQEEISTALSKKYDVDKESLMAYAEKVIKRFENPYLQDEVTRVGREPLRK
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSSEDRLIAPLKLCSEVGITPNFILYGIAAGLLFDYKEDAQAVKMREYVEQFGIKKAVNV
CCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHH
ITGLEEESDLVEEIEKRYFELKGKLI
HHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336