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The map label for this gene is MhpD [C]

Identifier: 20094438

GI number: 20094438

Start: 962187

End: 962981

Strand: Direct

Name: MhpD [C]

Synonym: MK1002

Alternate gene names: 20094438

Gene position: 962187-962981 (Clockwise)

Preceding gene: 20094437

Following gene: 20094440

Centisome position: 56.77

GC content: 58.24

Gene sequence:

>795_bases
TTGCGGGTAGGGACCTACCTGGTGGATGGCACCCCTCGTCCCGCCGTGTTTCTCGACGACGAGGTCCACGTCTACGACCT
TCCCGTGCTCGAATTCATCGAAGTCGTCCACAGTGACGGGTTGGGTGATCTGGACTACTCTGTGTATCCGCTATCGGAGC
TCAGAATAGGTCCCCCAGTTCCGCGGCCTCCTAAGATAATCTGCTTCGGACTCAACTACCGTGAGCACGTCGAGGAGTTA
CGCGAAATGGGAATGGACGTCCCCAGTGAGCCCGTCATGACCATGAAGGCGCCCACCGCGGTAATCGGCCACCTGGATAC
CGTTAAGTTACCGAGGGAGGCACGCAGGGTCGATCACGAGCTCGAGCTGGCCGTGGTGATCGGAGAGCGATGTCGTAAAG
TGTCTCCTGAGGAGGCTCGAGACGCCGTTCTCGGGTTCACTATCATCAACGACGTGACGGCTCGTGACATAGAGAAAAGA
GAGGGCCAATGGGTCCGAGCGAAGAGCTACGACACGTTCGCGCCTTTAGGACCGTGGATCGAAACCGAACTAGAGCCCGA
CGGACTCGAAATGGAGCTCCGTGTTAACGGCGAGGTGCGCCAGCGTGCTACCACCGACGACATGGTTCGGGATCCGTACG
AGCTGGTATCTTTCACGTCTAGGGTGATGACGCTCGAGCCCGGTGATATCATCGCTACGGGAACCCCGCCCGGTGTGGGT
CCGATGGAACCGGACGATAAGATCGAGTTGGAAATCGAACGCATTGGCAGGCTCGTACATTACGTAGGACAGTGA

Upstream 100 bases:

>100_bases
TGTCCCGTCGACGCCATCTCAATCAACGTCTCCTATGAGCGCTCCGGTGAGATGGAGTGAGTTTTTTCACCCACCCCACC
CGCTCCGCCCGGGGCGAACG

Downstream 100 bases:

>100_bases
ATACCATAGAGACCGCGTGACACCGTTTAGCGTCCCCACACAGTTTCTTTACGAACAGAAGAAGCTCCGGGGAGAACTCT
CAAAGGTAGCCGCGAGGATC

Product: 2-keto-4-pentenoate hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRVGTYLVDGTPRPAVFLDDEVHVYDLPVLEFIEVVHSDGLGDLDYSVYPLSELRIGPPVPRPPKIICFGLNYREHVEEL
REMGMDVPSEPVMTMKAPTAVIGHLDTVKLPREARRVDHELELAVVIGERCRKVSPEEARDAVLGFTIINDVTARDIEKR
EGQWVRAKSYDTFAPLGPWIETELEPDGLEMELRVNGEVRQRATTDDMVRDPYELVSFTSRVMTLEPGDIIATGTPPGVG
PMEPDDKIELEIERIGRLVHYVGQ

Sequences:

>Translated_264_residues
MRVGTYLVDGTPRPAVFLDDEVHVYDLPVLEFIEVVHSDGLGDLDYSVYPLSELRIGPPVPRPPKIICFGLNYREHVEEL
REMGMDVPSEPVMTMKAPTAVIGHLDTVKLPREARRVDHELELAVVIGERCRKVSPEEARDAVLGFTIINDVTARDIEKR
EGQWVRAKSYDTFAPLGPWIETELEPDGLEMELRVNGEVRQRATTDDMVRDPYELVSFTSRVMTLEPGDIIATGTPPGVG
PMEPDDKIELEIERIGRLVHYVGQ
>Mature_264_residues
MRVGTYLVDGTPRPAVFLDDEVHVYDLPVLEFIEVVHSDGLGDLDYSVYPLSELRIGPPVPRPPKIICFGLNYREHVEEL
REMGMDVPSEPVMTMKAPTAVIGHLDTVKLPREARRVDHELELAVVIGERCRKVSPEEARDAVLGFTIINDVTARDIEKR
EGQWVRAKSYDTFAPLGPWIETELEPDGLEMELRVNGEVRQRATTDDMVRDPYELVSFTSRVMTLEPGDIIATGTPPGVG
PMEPDDKIELEIERIGRLVHYVGQ

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=227, Percent_Identity=39.647577092511, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI40786394, Length=227, Percent_Identity=39.647577092511, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI66348062, Length=195, Percent_Identity=41.5384615384615, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI13654274, Length=195, Percent_Identity=41.5384615384615, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI215422413, Length=195, Percent_Identity=41.5384615384615, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1787428, Length=196, Percent_Identity=37.7551020408163, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17557057, Length=192, Percent_Identity=34.8958333333333, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324161, Length=226, Percent_Identity=30.5309734513274, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24663695, Length=220, Percent_Identity=38.1818181818182, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28572127, Length=217, Percent_Identity=36.8663594470046, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28571789, Length=204, Percent_Identity=31.3725490196078, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 29725; Mature: 29725

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGTYLVDGTPRPAVFLDDEVHVYDLPVLEFIEVVHSDGLGDLDYSVYPLSELRIGPPV
CCCCEEEECCCCCCEEEECCCEEEEECCHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCC
PRPPKIICFGLNYREHVEELREMGMDVPSEPVMTMKAPTAVIGHLDTVKLPREARRVDHE
CCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHCCCCCCCCCHHHHHCCCH
LELAVVIGERCRKVSPEEARDAVLGFTIINDVTARDIEKREGQWVRAKSYDTFAPLGPWI
HEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
ETELEPDGLEMELRVNGEVRQRATTDDMVRDPYELVSFTSRVMTLEPGDIIATGTPPGVG
ECCCCCCCCEEEEEECCHHHHHCCHHHHHHCHHHHHHHHHHEEEECCCCEEECCCCCCCC
PMEPDDKIELEIERIGRLVHYVGQ
CCCCCCCEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MRVGTYLVDGTPRPAVFLDDEVHVYDLPVLEFIEVVHSDGLGDLDYSVYPLSELRIGPPV
CCCCEEEECCCCCCEEEECCCEEEEECCHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCC
PRPPKIICFGLNYREHVEELREMGMDVPSEPVMTMKAPTAVIGHLDTVKLPREARRVDHE
CCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHCCCCCCCCCHHHHHCCCH
LELAVVIGERCRKVSPEEARDAVLGFTIINDVTARDIEKREGQWVRAKSYDTFAPLGPWI
HEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
ETELEPDGLEMELRVNGEVRQRATTDDMVRDPYELVSFTSRVMTLEPGDIIATGTPPGVG
ECCCCCCCCEEEEEECCHHHHHCCHHHHHHCHHHHHHHHHHEEEECCCCEEECCCCCCCC
PMEPDDKIELEIERIGRLVHYVGQ
CCCCCCCEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]