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The map label for this gene is IleS

Identifier: 20094335

GI number: 20094335

Start: 848389

End: 851631

Strand: Direct

Name: IleS

Synonym: MK0899

Alternate gene names: 20094335

Gene position: 848389-851631 (Clockwise)

Preceding gene: 20094330

Following gene: 20094336

Centisome position: 50.05

GC content: 64.2

Gene sequence:

>3243_bases
GTGGGGGCTGGGGAGATGGCCGAGGCTCTCGGCGAGGAACTGGAGCGCGAAATTCAGCGGAGATGGGAAGAGATGGACCT
ACTTTCGAAGGTCCTAGAGAAGAACCGCGACGGACCTCTCTTCTACTTCCTCGACGGTCCACCTTACGCGAGCGGCTCGA
TTCACCTCGGTACAGCCTGGAACAAGATCATCAAGGACGCCGTGAACCGGTACAAGCTGATGCGCGGATACCGGGTCCGA
CTGCAGCCCGGTTGGGACTGCCACGGTCTCCCGATCGAGGTGAAGGTCGAGCAGGAGGTCCTCTCGGACGAGATCGAGTG
CAAGAAGGACATCGAGGAGAAGGTCGGCGTCGACAAGTTCGTGGAAAAGTGCAAGGAATTCGCCCTGAAGCACGTAGAGA
TCATGACGGAGCAGTTCAAGCGTCTGGGCGTCCTGATGGACTGGGACAACCCGTACATGACCCTGGACAACGAGTACATC
GAGGGAGCCTGGTACACGCTCAAGCGCGCCCACGAGCGCGGTCTCCTCGACCGGGACGTGAGGATCGTCAACTGGTGCCC
GCGGTGTGAGACCGCCCTGGCGGACCACGAGGTCGAGTACAAGGAGGTCGAGGACCCCTCGATCTTCGTGATCTTTCCGA
TCGAGGACGATTCCGACGCCGAGGTCGACTTACCCGAGAACTCAGCCCTGCTGATCTGGACGACCACCCCGTGGACGTTG
CCCGCCAACCTAGCCGTCGCCGTGCACCCAGAGGAGGAGTACGTCCTCGCGCGCGCCGAGGTGGACGGCGAGGAGTGGCA
CCTGATCGTCGCTGACAAGCTCAAGGTCGTGCTGTCCGTCGTGACGGACTCGTACGAGATCGTGGACTCGTTTCCGGGAG
AGGCGCTGGAGGGTCTCCGGTACCGCCCGCCGCTGTGGGAGGAGGTGCCCAAGCTGCGCGAGCTGCACGAGGAGGACGAC
CGTGTCCACCGCGTGTACACCGCCGAGTGGGTCACGATGGAGGAGGGTACCGGGTGCGTCCACTCGGCGCCCGGTCACGG
TGAGGAGGACTTCGAGCTCGGCCGAGAGGTCGGCCTGCCTCCGCACTGCCCGGTGGCCGAGGACGGTACGTTCACAGAAG
ACGGCGGTAAGTACGAGGGACTCTATGTGCGCGACGCCAACGAGAAGATCGTCGAGGACCTACGTGAGAAGGGACTCCTC
GCGCACGAGGACACCGTGGAGCACCGGTACGGTCACTGTTGGCGCTGTAAGACCCCGATCATCTACCGGGCTACCGAGCA
GTGGTTCCTCAAAGTCACTGAGGTGAAGGACGAGATGCTCGAGTGGATAGAGCGGGTGGAGTGGATCCCGGAATGGGCGG
GTCACTCCCGGTTCAAAAGCTGGGTCGAGAACGCCCGGGACTGGTGTATCTCGCGTCAGCGGTACTGGGGTATCCCGCTT
CCGGTCTGGGAGTGCGAGGAGTGCGGTCATCTCGAGGTGATCGGCTCGCTGAGCGAGCTCGAGGCGAAGGCGGTCAGTCT
CCCGCCCGGTGAACCCGACCTGCACAGGCCCTGGGTCGACGAGGTAGTCCTGAAGTGCCCGGAGTGCGGCTCCTACATGA
GGCGCGTGCCGGACGTGCTCGACGTCTGGGTAGACTCGGGAGTCGCCGCGTGGGCCTCGCTCGGGTACCCACGTCGCGAG
GACGAGTTCGAGCGGTGGTTCCTCAAGGAGGGACGCTGTGACCCCGACGATCCGGAGGCGGGCGCGGACTTCATCACCGA
GGGTCACGACCAGACCCGCGGATGGTTCTACTCGCAGCTAGGTTGTGGCGTCGTCACCTTCGATACGTGCCCGTACAGGA
CCGTGCTCATGCACGGGTTCACGCTCGACGAGGAAGGTCGGAAGATGAGCAAGTCCCTGGGTAACGTCGTCGACCCGATG
GACGTCGTTGAGAAGTACGGTGCCGATACCCTACGCTGGTACGTCCTGCGCTCCAACGCACCCTGGCGGGATATGCACTT
CAGCTGGCAGGACGTGCGCGACACCCACCGGGCGCTCAACGTCCTGTGGAACGCGTACCGGTTCACGAAGATGTACTCGG
AACTGGACGAGTTCGACCCCGAGGAACACCCGCTGGAGGATCTGGAGGAGCACCTCAAGCCAGAGGATCGGTGGCTGCTC
TCCCGGATCAACTCGCTGGTGGAGGAGGTCACCGACGCGTTCGAGCGGTACCACGTCCATGAGGCGGCCCGCGCGCTGTA
CCGCTTCGTCACGGAGGACCTCAGCCGGTGGTACATCCGGCTGGTCAGGGAGCGCGTATGGCTGGAGGGTGACGATCCCG
AGAAACTCGCGGTCTACGCGGTGCTGCACTACACGTTCGATCGGCTGGTCAGACTTCTGGCGCCGATCGTGCCACACGTC
GCCGAGCGGATATACCTGGATTACGTCCGCGCGGGCGACGATCCAGAGAGCGTTCACCTCACGGACTGGCCCGAAGTAGA
CGACCGATGGGTCGACGAGGGACTGGAAAAGGCCATGGAGCTCGTCCGGAAGGCCGCGGAGGCCGCCCTCTCGGTCCGGC
AGCGTGCCGGGGTCAAGACACGCTGGCCACTACGTCGCCTGTTCGTGGAGGTCGAGGATCCGAAGCGGCTAGAGGACCTC
AAGGACGTGCTGGCCCGCGTCGCGAACGTCAAGGAGGTCGAGCTCGGGGAGGAGTTCCCGGAGAAGGTACCCGTGGCCGA
GCCGAGGCCCGATAAGATCGGTCCCGAGTTCCGATCGCTGGCGGGCCGCGTGATCGAGCACGTCAAGGACCGCGCGGAGG
AGGTGGCGCGGTCGATCCTGAAGGACGGGGAGTACAGGACCGAGCTGGACGGCGAGGATGTCGTCCTGACGGAGGAGCAC
GTTAAGGTGACCGAGGACCTGCCCGAGGGCTGGGAGGCCGAGGAGTTCGAGGGCGGCCGGGTGTACGTCTTCGTCGAGCT
GGACGAGGAGTTGAAGTCCGAGGCGTGGGCCAGGGAGGTCGTTCGTCGCGTCCAGGAGATGAGGAAAGAGCTGGACTTGA
ACCTGGAGGAGAGGATCAGGGTGTGGATCGAAACGGACGAAGAGATCGCGGAGGCCGTGGAAGAGCACTCGGAATACGTA
CGTGGTGAGACGCGGGCGGACGAGCTCCACGTGAACGAGGGTTGGCCCGAAGAAGTCGATCTGGAGCGCGAGTGGGAGGT
GGAGGACAGGACGATCCGCATCGCCGTGGTCGTTTCGGGGTGA

Upstream 100 bases:

>100_bases
CAAACGTCCGCCCCGGTCGCTTCGGTCACCCGCGGGGTTTAATCCTGAGCGCGTCGGGACAGACGTAATCAAGGGGTACG
CGGCGGGCCCCTCGGAGGTC

Downstream 100 bases:

>100_bases
AGTGGATGAAGGTCGACCCCTCGGAGTTCGAGCTGGAGTTCTTCGAGGAGATCGGGTTCGAGCGTAAGCGCTGTCCCGAG
TGCGGCGAGTACTTCTGGGG

Product: isoleucyl-tRNA synthetase

Products: NA

Alternate protein names: Isoleucine--tRNA ligase; IleRS

Number of amino acids: Translated: 1080; Mature: 1079

Protein sequence:

>1080_residues
MGAGEMAEALGEELEREIQRRWEEMDLLSKVLEKNRDGPLFYFLDGPPYASGSIHLGTAWNKIIKDAVNRYKLMRGYRVR
LQPGWDCHGLPIEVKVEQEVLSDEIECKKDIEEKVGVDKFVEKCKEFALKHVEIMTEQFKRLGVLMDWDNPYMTLDNEYI
EGAWYTLKRAHERGLLDRDVRIVNWCPRCETALADHEVEYKEVEDPSIFVIFPIEDDSDAEVDLPENSALLIWTTTPWTL
PANLAVAVHPEEEYVLARAEVDGEEWHLIVADKLKVVLSVVTDSYEIVDSFPGEALEGLRYRPPLWEEVPKLRELHEEDD
RVHRVYTAEWVTMEEGTGCVHSAPGHGEEDFELGREVGLPPHCPVAEDGTFTEDGGKYEGLYVRDANEKIVEDLREKGLL
AHEDTVEHRYGHCWRCKTPIIYRATEQWFLKVTEVKDEMLEWIERVEWIPEWAGHSRFKSWVENARDWCISRQRYWGIPL
PVWECEECGHLEVIGSLSELEAKAVSLPPGEPDLHRPWVDEVVLKCPECGSYMRRVPDVLDVWVDSGVAAWASLGYPRRE
DEFERWFLKEGRCDPDDPEAGADFITEGHDQTRGWFYSQLGCGVVTFDTCPYRTVLMHGFTLDEEGRKMSKSLGNVVDPM
DVVEKYGADTLRWYVLRSNAPWRDMHFSWQDVRDTHRALNVLWNAYRFTKMYSELDEFDPEEHPLEDLEEHLKPEDRWLL
SRINSLVEEVTDAFERYHVHEAARALYRFVTEDLSRWYIRLVRERVWLEGDDPEKLAVYAVLHYTFDRLVRLLAPIVPHV
AERIYLDYVRAGDDPESVHLTDWPEVDDRWVDEGLEKAMELVRKAAEAALSVRQRAGVKTRWPLRRLFVEVEDPKRLEDL
KDVLARVANVKEVELGEEFPEKVPVAEPRPDKIGPEFRSLAGRVIEHVKDRAEEVARSILKDGEYRTELDGEDVVLTEEH
VKVTEDLPEGWEAEEFEGGRVYVFVELDEELKSEAWAREVVRRVQEMRKELDLNLEERIRVWIETDEEIAEAVEEHSEYV
RGETRADELHVNEGWPEEVDLEREWEVEDRTIRIAVVVSG

Sequences:

>Translated_1080_residues
MGAGEMAEALGEELEREIQRRWEEMDLLSKVLEKNRDGPLFYFLDGPPYASGSIHLGTAWNKIIKDAVNRYKLMRGYRVR
LQPGWDCHGLPIEVKVEQEVLSDEIECKKDIEEKVGVDKFVEKCKEFALKHVEIMTEQFKRLGVLMDWDNPYMTLDNEYI
EGAWYTLKRAHERGLLDRDVRIVNWCPRCETALADHEVEYKEVEDPSIFVIFPIEDDSDAEVDLPENSALLIWTTTPWTL
PANLAVAVHPEEEYVLARAEVDGEEWHLIVADKLKVVLSVVTDSYEIVDSFPGEALEGLRYRPPLWEEVPKLRELHEEDD
RVHRVYTAEWVTMEEGTGCVHSAPGHGEEDFELGREVGLPPHCPVAEDGTFTEDGGKYEGLYVRDANEKIVEDLREKGLL
AHEDTVEHRYGHCWRCKTPIIYRATEQWFLKVTEVKDEMLEWIERVEWIPEWAGHSRFKSWVENARDWCISRQRYWGIPL
PVWECEECGHLEVIGSLSELEAKAVSLPPGEPDLHRPWVDEVVLKCPECGSYMRRVPDVLDVWVDSGVAAWASLGYPRRE
DEFERWFLKEGRCDPDDPEAGADFITEGHDQTRGWFYSQLGCGVVTFDTCPYRTVLMHGFTLDEEGRKMSKSLGNVVDPM
DVVEKYGADTLRWYVLRSNAPWRDMHFSWQDVRDTHRALNVLWNAYRFTKMYSELDEFDPEEHPLEDLEEHLKPEDRWLL
SRINSLVEEVTDAFERYHVHEAARALYRFVTEDLSRWYIRLVRERVWLEGDDPEKLAVYAVLHYTFDRLVRLLAPIVPHV
AERIYLDYVRAGDDPESVHLTDWPEVDDRWVDEGLEKAMELVRKAAEAALSVRQRAGVKTRWPLRRLFVEVEDPKRLEDL
KDVLARVANVKEVELGEEFPEKVPVAEPRPDKIGPEFRSLAGRVIEHVKDRAEEVARSILKDGEYRTELDGEDVVLTEEH
VKVTEDLPEGWEAEEFEGGRVYVFVELDEELKSEAWAREVVRRVQEMRKELDLNLEERIRVWIETDEEIAEAVEEHSEYV
RGETRADELHVNEGWPEEVDLEREWEVEDRTIRIAVVVSG
>Mature_1079_residues
GAGEMAEALGEELEREIQRRWEEMDLLSKVLEKNRDGPLFYFLDGPPYASGSIHLGTAWNKIIKDAVNRYKLMRGYRVRL
QPGWDCHGLPIEVKVEQEVLSDEIECKKDIEEKVGVDKFVEKCKEFALKHVEIMTEQFKRLGVLMDWDNPYMTLDNEYIE
GAWYTLKRAHERGLLDRDVRIVNWCPRCETALADHEVEYKEVEDPSIFVIFPIEDDSDAEVDLPENSALLIWTTTPWTLP
ANLAVAVHPEEEYVLARAEVDGEEWHLIVADKLKVVLSVVTDSYEIVDSFPGEALEGLRYRPPLWEEVPKLRELHEEDDR
VHRVYTAEWVTMEEGTGCVHSAPGHGEEDFELGREVGLPPHCPVAEDGTFTEDGGKYEGLYVRDANEKIVEDLREKGLLA
HEDTVEHRYGHCWRCKTPIIYRATEQWFLKVTEVKDEMLEWIERVEWIPEWAGHSRFKSWVENARDWCISRQRYWGIPLP
VWECEECGHLEVIGSLSELEAKAVSLPPGEPDLHRPWVDEVVLKCPECGSYMRRVPDVLDVWVDSGVAAWASLGYPRRED
EFERWFLKEGRCDPDDPEAGADFITEGHDQTRGWFYSQLGCGVVTFDTCPYRTVLMHGFTLDEEGRKMSKSLGNVVDPMD
VVEKYGADTLRWYVLRSNAPWRDMHFSWQDVRDTHRALNVLWNAYRFTKMYSELDEFDPEEHPLEDLEEHLKPEDRWLLS
RINSLVEEVTDAFERYHVHEAARALYRFVTEDLSRWYIRLVRERVWLEGDDPEKLAVYAVLHYTFDRLVRLLAPIVPHVA
ERIYLDYVRAGDDPESVHLTDWPEVDDRWVDEGLEKAMELVRKAAEAALSVRQRAGVKTRWPLRRLFVEVEDPKRLEDLK
DVLARVANVKEVELGEEFPEKVPVAEPRPDKIGPEFRSLAGRVIEHVKDRAEEVARSILKDGEYRTELDGEDVVLTEEHV
KVTEDLPEGWEAEEFEGGRVYVFVELDEELKSEAWAREVVRRVQEMRKELDLNLEERIRVWIETDEEIAEAVEEHSEYVR
GETRADELHVNEGWPEEVDLEREWEVEDRTIRIAVVVSG

Specific function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activi

COG id: COG0060

COG function: function code J; Isoleucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily

Homologues:

Organism=Homo sapiens, GI94721239, Length=1069, Percent_Identity=32.2731524789523, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI94721241, Length=1069, Percent_Identity=32.2731524789523, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI46852147, Length=831, Percent_Identity=33.453670276775, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI268370297, Length=903, Percent_Identity=25.2491694352159, Blast_Score=229, Evalue=1e-59,
Organism=Homo sapiens, GI268370293, Length=903, Percent_Identity=25.2491694352159, Blast_Score=229, Evalue=1e-59,
Organism=Homo sapiens, GI268370295, Length=894, Percent_Identity=25.2796420581655, Blast_Score=229, Evalue=1e-59,
Organism=Homo sapiens, GI5454158, Length=946, Percent_Identity=24.4186046511628, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI7661872, Length=189, Percent_Identity=28.042328042328, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI2367096, Length=896, Percent_Identity=34.5982142857143, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1790708, Length=954, Percent_Identity=22.8511530398323, Blast_Score=209, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17541896, Length=1050, Percent_Identity=31.6190476190476, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI71980946, Length=815, Percent_Identity=29.8159509202454, Blast_Score=305, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17510661, Length=904, Percent_Identity=23.6725663716814, Blast_Score=248, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI72001587, Length=891, Percent_Identity=24.0179573512907, Blast_Score=210, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71997517, Length=158, Percent_Identity=29.1139240506329, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997510, Length=158, Percent_Identity=29.1139240506329, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319395, Length=1078, Percent_Identity=30.3339517625232, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6325217, Length=815, Percent_Identity=31.5337423312883, Blast_Score=358, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6321531, Length=928, Percent_Identity=23.2758620689655, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323414, Length=191, Percent_Identity=26.1780104712042, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574730, Length=1041, Percent_Identity=31.1239193083574, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24668547, Length=1041, Percent_Identity=31.1239193083574, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24668543, Length=1041, Percent_Identity=31.1239193083574, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI281366294, Length=845, Percent_Identity=31.3609467455621, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17864482, Length=865, Percent_Identity=24.393063583815, Blast_Score=243, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24653289, Length=865, Percent_Identity=24.393063583815, Blast_Score=243, Evalue=5e-64,
Organism=Drosophila melanogaster, GI21355675, Length=926, Percent_Identity=24.8380129589633, Blast_Score=217, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21355409, Length=190, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYI_METKA (Q8TWY2)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614182.1
- ProteinModelPortal:   Q8TWY2
- SMR:   Q8TWY2
- GeneID:   1477000
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0899
- NMPDR:   fig|190192.1.peg.895
- HOGENOM:   HBG577712
- OMA:   WLLSRIN
- BioCyc:   MKAN190192:MK0899-MONOMER
- BRENDA:   6.1.1.5
- GO:   GO:0005737
- HAMAP:   MF_02003
- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002301
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF9
- PRINTS:   PR00984
- TIGRFAMs:   TIGR00392

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1; SSF47323 tRNAsyn_1a_bind; SSF50677 ValRS_IleRS_edit

EC number: =6.1.1.5

Molecular weight: Translated: 126029; Mature: 125897

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 631-631

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGEMAEALGEELEREIQRRWEEMDLLSKVLEKNRDGPLFYFLDGPPYASGSIHLGTAW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEECHHH
NKIIKDAVNRYKLMRGYRVRLQPGWDCHGLPIEVKVEQEVLSDEIECKKDIEEKVGVDKF
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHH
VEKCKEFALKHVEIMTEQFKRLGVLMDWDNPYMTLDNEYIEGAWYTLKRAHERGLLDRDV
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC
RIVNWCPRCETALADHEVEYKEVEDPSIFVIFPIEDDSDAEVDLPENSALLIWTTTPWTL
CEEECCCCHHHHHHCCCCCHHCCCCCEEEEEEEECCCCCCEEECCCCCEEEEEECCCCCC
PANLAVAVHPEEEYVLARAEVDGEEWHLIVADKLKVVLSVVTDSYEIVDSFPGEALEGLR
CCCCEEEECCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCHHHHHCCCCHHHHCCC
YRPPLWEEVPKLRELHEEDDRVHRVYTAEWVTMEEGTGCVHSAPGHGEEDFELGREVGLP
CCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCEECCCCCCCHHHHHHHHCCCC
PHCPVAEDGTFTEDGGKYEGLYVRDANEKIVEDLREKGLLAHEDTVEHRYGHCWRCKTPI
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCE
IYRATEQWFLKVTEVKDEMLEWIERVEWIPEWAGHSRFKSWVENARDWCISRQRYWGIPL
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PVWECEECGHLEVIGSLSELEAKAVSLPPGEPDLHRPWVDEVVLKCPECGSYMRRVPDVL
CCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
DVWVDSGVAAWASLGYPRREDEFERWFLKEGRCDPDDPEAGADFITEGHDQTRGWFYSQL
HHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHCCEEHHHC
GCGVVTFDTCPYRTVLMHGFTLDEEGRKMSKSLGNVVDPMDVVEKYGADTLRWYVLRSNA
CCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEEECCC
PWRDMHFSWQDVRDTHRALNVLWNAYRFTKMYSELDEFDPEEHPLEDLEEHLKPEDRWLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
SRINSLVEEVTDAFERYHVHEAARALYRFVTEDLSRWYIRLVRERVWLEGDDPEKLAVYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VLHYTFDRLVRLLAPIVPHVAERIYLDYVRAGDDPESVHLTDWPEVDDRWVDEGLEKAME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHH
LVRKAAEAALSVRQRAGVKTRWPLRRLFVEVEDPKRLEDLKDVLARVANVKEVELGEEFP
HHHHHHHHHHHHHHHCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHCCCHHHHHCHHHH
EKVPVAEPRPDKIGPEFRSLAGRVIEHVKDRAEEVARSILKDGEYRTELDGEDVVLTEEH
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEHHH
VKVTEDLPEGWEAEEFEGGRVYVFVELDEELKSEAWAREVVRRVQEMRKELDLNLEERIR
HHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEE
VWIETDEEIAEAVEEHSEYVRGETRADELHVNEGWPEEVDLEREWEVEDRTIRIAVVVSG
EEECCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
GAGEMAEALGEELEREIQRRWEEMDLLSKVLEKNRDGPLFYFLDGPPYASGSIHLGTAW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEECHHH
NKIIKDAVNRYKLMRGYRVRLQPGWDCHGLPIEVKVEQEVLSDEIECKKDIEEKVGVDKF
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHH
VEKCKEFALKHVEIMTEQFKRLGVLMDWDNPYMTLDNEYIEGAWYTLKRAHERGLLDRDV
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC
RIVNWCPRCETALADHEVEYKEVEDPSIFVIFPIEDDSDAEVDLPENSALLIWTTTPWTL
CEEECCCCHHHHHHCCCCCHHCCCCCEEEEEEEECCCCCCEEECCCCCEEEEEECCCCCC
PANLAVAVHPEEEYVLARAEVDGEEWHLIVADKLKVVLSVVTDSYEIVDSFPGEALEGLR
CCCCEEEECCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCHHHHHCCCCHHHHCCC
YRPPLWEEVPKLRELHEEDDRVHRVYTAEWVTMEEGTGCVHSAPGHGEEDFELGREVGLP
CCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCEECCCCCCCHHHHHHHHCCCC
PHCPVAEDGTFTEDGGKYEGLYVRDANEKIVEDLREKGLLAHEDTVEHRYGHCWRCKTPI
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCE
IYRATEQWFLKVTEVKDEMLEWIERVEWIPEWAGHSRFKSWVENARDWCISRQRYWGIPL
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PVWECEECGHLEVIGSLSELEAKAVSLPPGEPDLHRPWVDEVVLKCPECGSYMRRVPDVL
CCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
DVWVDSGVAAWASLGYPRREDEFERWFLKEGRCDPDDPEAGADFITEGHDQTRGWFYSQL
HHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHCCEEHHHC
GCGVVTFDTCPYRTVLMHGFTLDEEGRKMSKSLGNVVDPMDVVEKYGADTLRWYVLRSNA
CCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEEECCC
PWRDMHFSWQDVRDTHRALNVLWNAYRFTKMYSELDEFDPEEHPLEDLEEHLKPEDRWLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
SRINSLVEEVTDAFERYHVHEAARALYRFVTEDLSRWYIRLVRERVWLEGDDPEKLAVYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VLHYTFDRLVRLLAPIVPHVAERIYLDYVRAGDDPESVHLTDWPEVDDRWVDEGLEKAME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHH
LVRKAAEAALSVRQRAGVKTRWPLRRLFVEVEDPKRLEDLKDVLARVANVKEVELGEEFP
HHHHHHHHHHHHHHHCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHCCCHHHHHCHHHH
EKVPVAEPRPDKIGPEFRSLAGRVIEHVKDRAEEVARSILKDGEYRTELDGEDVVLTEEH
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEHHH
VKVTEDLPEGWEAEEFEGGRVYVFVELDEELKSEAWAREVVRRVQEMRKELDLNLEERIR
HHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEE
VWIETDEEIAEAVEEHSEYVRGETRADELHVNEGWPEEVDLEREWEVEDRTIRIAVVVSG
EEECCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014