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The map label for this gene is argJ

Identifier: 20094301

GI number: 20094301

Start: 818237

End: 819400

Strand: Direct

Name: argJ

Synonym: MK0865

Alternate gene names: 20094301

Gene position: 818237-819400 (Clockwise)

Preceding gene: 20094300

Following gene: 20094302

Centisome position: 48.27

GC content: 58.42

Gene sequence:

>1164_bases
TTGCGGGCACCTGAAGGCTTCCTTCTAGGTGGCATCAAACGCGAAGGTATAGGAGTCGGGTTGATCTTCTCGGAGCGTCG
ATGTGCCGTGGCGGGCACTTTCACCGAGAACACCCTCCGCGCCGCTCCGGTGGAGCACTCCGAGGAAGTGTGCGATCGAG
GTGTCGCCCGCGGAGTGATAGTGAACAGTGGTCACGCCAACGCGATGACGGGTGAGGAGGGGTATCAGGACGTACTGCGC
ACGGCGGAAGCGATCGCTGAGCTAATGGGGGCTCCGGAGGACGAGATAGTGGTGTGTTCTACGGGCGTGATCGGTGAGCG
TCCTCCTGTCGACAAGATCGTGAGGTACGCGCGCGAAGTTTGGGAGGATATAGGACCCACCGAACGGCACGTTCGGGAGT
TTAGTCGGGCTATCATGACCACCGATACCGAGGAGAAAATAGCTTTGTACGAAGGCGATGGCTGGTCACTTCTCGGAATC
GCGAAGGGTGCGGGTATGATACATCCGAACATGTCCACTATGCTCGCGTTCTTGCTCACCGATGTAGGAGCGAAACCGAA
AGAGCTTCAGATGTGGCTACGCGATGTCGTGAACGACACGTTCAACATGATAACGGTAGATGGGGATGAAAGCACTAACG
ATTCCGTGGTGCTGCTGGCGAACGGCAGCTCGAACCTCAAAGTCGGCAGCGATGTTACCATCACGGAGTTCCAGCGCGCC
CTGGAAGAGGTCTGTACGGAGCTCGCTGAGAAGATCGTACGAGACGGTGAAGGAGCGACGAAGCTCATGATAGTGTGTGT
ACACGGTGCGAGTAATGAAGTAGAAGCTCGGCGTGCGGCCCGTGCGATAGCGTCCTCAAACCTGGTGAAGGCGGCGCTGT
TCGGCGAGAATCCGAACTGGGGCCGGATCGGAGCCGCTGTCGGGGCCGCACGCGTCGATGTTGATCCGGACGAGTTACGG
ATAGCTTTCCGCAGCTCAGAGGGCGAGATAGTGACCTACGAAGGAGGTCCAGTGGACTTCGACGAAGAGAAGGCTAAGCG
CGTTCTCTCCGCGAGTGAAGTCGAGATTGTGGTGGACTTAGGCGTAGGTGACGCGTCCGCCCGCGCGTGGGGGTGCGACT
TAACGTACGAGTACGTACGGATCAACGCGGAGTACAGGACTTGA

Upstream 100 bases:

>100_bases
CGAGGAGTACCGTGAGAAGGCGCGTGAGCGCTGGTTCGATTCCGGATCCTCTCGGTCATAGTTTTTAAACTCGGGTCAGG
GGCCCCTCCAGGGAACCGCG

Downstream 100 bases:

>100_bases
CCCTCCCCGCCTTAAAGGATGATTCGGGGCGTCGGCCCTCTGTTCAGTCACATCTTTCACTGGGCGGGCAGTCGAGCCGT
TCAGAATGCATTTCGGGAGC

Product: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

Products: NA

Alternate protein names: Glutamate N-acetyltransferase; Ornithine acetyltransferase; OATase; Ornithine transacetylase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MRAPEGFLLGGIKREGIGVGLIFSERRCAVAGTFTENTLRAAPVEHSEEVCDRGVARGVIVNSGHANAMTGEEGYQDVLR
TAEAIAELMGAPEDEIVVCSTGVIGERPPVDKIVRYAREVWEDIGPTERHVREFSRAIMTTDTEEKIALYEGDGWSLLGI
AKGAGMIHPNMSTMLAFLLTDVGAKPKELQMWLRDVVNDTFNMITVDGDESTNDSVVLLANGSSNLKVGSDVTITEFQRA
LEEVCTELAEKIVRDGEGATKLMIVCVHGASNEVEARRAARAIASSNLVKAALFGENPNWGRIGAAVGAARVDVDPDELR
IAFRSSEGEIVTYEGGPVDFDEEKAKRVLSASEVEIVVDLGVGDASARAWGCDLTYEYVRINAEYRT

Sequences:

>Translated_387_residues
MRAPEGFLLGGIKREGIGVGLIFSERRCAVAGTFTENTLRAAPVEHSEEVCDRGVARGVIVNSGHANAMTGEEGYQDVLR
TAEAIAELMGAPEDEIVVCSTGVIGERPPVDKIVRYAREVWEDIGPTERHVREFSRAIMTTDTEEKIALYEGDGWSLLGI
AKGAGMIHPNMSTMLAFLLTDVGAKPKELQMWLRDVVNDTFNMITVDGDESTNDSVVLLANGSSNLKVGSDVTITEFQRA
LEEVCTELAEKIVRDGEGATKLMIVCVHGASNEVEARRAARAIASSNLVKAALFGENPNWGRIGAAVGAARVDVDPDELR
IAFRSSEGEIVTYEGGPVDFDEEKAKRVLSASEVEIVVDLGVGDASARAWGCDLTYEYVRINAEYRT
>Mature_387_residues
MRAPEGFLLGGIKREGIGVGLIFSERRCAVAGTFTENTLRAAPVEHSEEVCDRGVARGVIVNSGHANAMTGEEGYQDVLR
TAEAIAELMGAPEDEIVVCSTGVIGERPPVDKIVRYAREVWEDIGPTERHVREFSRAIMTTDTEEKIALYEGDGWSLLGI
AKGAGMIHPNMSTMLAFLLTDVGAKPKELQMWLRDVVNDTFNMITVDGDESTNDSVVLLANGSSNLKVGSDVTITEFQRA
LEEVCTELAEKIVRDGEGATKLMIVCVHGASNEVEARRAARAIASSNLVKAALFGENPNWGRIGAAVGAARVDVDPDELR
IAFRSSEGEIVTYEGGPVDFDEEKAKRVLSASEVEIVVDLGVGDASARAWGCDLTYEYVRINAEYRT

Specific function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

COG id: COG1364

COG function: function code E; N-acetylglutamate synthase (N-acetylornithine aminotransferase)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgJ family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323707, Length=416, Percent_Identity=36.5384615384615, Blast_Score=244, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGJ_METKA (Q8TX15)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614148.1
- ProteinModelPortal:   Q8TX15
- SMR:   Q8TX15
- MEROPS:   T05.001
- GeneID:   1476966
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0865
- NMPDR:   fig|190192.1.peg.861
- HOGENOM:   HBG284202
- OMA:   QNRFCAA
- ProtClustDB:   PRK05388
- BioCyc:   MKAN190192:MK0865-MONOMER
- BRENDA:   2.3.1.1
- BRENDA:   2.3.1.35
- GO:   GO:0005737
- HAMAP:   MF_01106
- InterPro:   IPR002813
- InterPro:   IPR016117
- PANTHER:   PTHR23100
- TIGRFAMs:   TIGR00120

Pfam domain/function: PF01960 ArgJ; SSF56266 Pept_S58_DmpA/Arg_biosyn_ArgJ

EC number: =2.3.1.35; =2.3.1.1

Molecular weight: Translated: 41841; Mature: 41841

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPEGFLLGGIKREGIGVGLIFSERRCAVAGTFTENTLRAAPVEHSEEVCDRGVARGVI
CCCCCCCEEECEEECCCEEEEEEECCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCEE
VNSGHANAMTGEEGYQDVLRTAEAIAELMGAPEDEIVVCSTGVIGERPPVDKIVRYAREV
EECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
WEDIGPTERHVREFSRAIMTTDTEEKIALYEGDGWSLLGIAKGAGMIHPNMSTMLAFLLT
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCEECCCHHHHHHHHHH
DVGAKPKELQMWLRDVVNDTFNMITVDGDESTNDSVVLLANGSSNLKVGSDVTITEFQRA
HCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHH
LEEVCTELAEKIVRDGEGATKLMIVCVHGASNEVEARRAARAIASSNLVKAALFGENPNW
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
GRIGAAVGAARVDVDPDELRIAFRSSEGEIVTYEGGPVDFDEEKAKRVLSASEVEIVVDL
CHHHHHHCCEEECCCHHHEEEEEECCCCCEEEECCCCCCCCHHHHHHHHCCCCEEEEEEE
GVGDASARAWGCDLTYEYVRINAEYRT
CCCCCCCCEECCCCEEEEEEEEEEECC
>Mature Secondary Structure
MRAPEGFLLGGIKREGIGVGLIFSERRCAVAGTFTENTLRAAPVEHSEEVCDRGVARGVI
CCCCCCCEEECEEECCCEEEEEEECCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCEE
VNSGHANAMTGEEGYQDVLRTAEAIAELMGAPEDEIVVCSTGVIGERPPVDKIVRYAREV
EECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
WEDIGPTERHVREFSRAIMTTDTEEKIALYEGDGWSLLGIAKGAGMIHPNMSTMLAFLLT
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCEECCCHHHHHHHHHH
DVGAKPKELQMWLRDVVNDTFNMITVDGDESTNDSVVLLANGSSNLKVGSDVTITEFQRA
HCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHH
LEEVCTELAEKIVRDGEGATKLMIVCVHGASNEVEARRAARAIASSNLVKAALFGENPNW
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
GRIGAAVGAARVDVDPDELRIAFRSSEGEIVTYEGGPVDFDEEKAKRVLSASEVEIVVDL
CHHHHHHCCEEECCCHHHEEEEEECCCCCEEEECCCCCCCCHHHHHHHHCCCCEEEEEEE
GVGDASARAWGCDLTYEYVRINAEYRT
CCCCCCCCEECCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014