Click here to switch to the map view.

The map label for this gene is Lpd [H]

Identifier: 20094285

GI number: 20094285

Start: 805062

End: 806366

Strand: Direct

Name: Lpd [H]

Synonym: MK0849

Alternate gene names: 20094285

Gene position: 805062-806366 (Clockwise)

Preceding gene: 20094282

Following gene: 20094292

Centisome position: 47.5

GC content: 59.31

Gene sequence:

>1305_bases
GTGGACGTAGTGATCGGTGCGGGACCTGCCGGCCGCACTTACGCAATGATCCTCGCCGAAGCTGGACACGAAGTGCTGCT
ACTTGATAGAAATGGAAAGGAAGGAACCGGTGGCAAATGCCTGAACGAGGCGTGTGTCGTGCTCGGTGCGCTGATCGAGG
CCGCTAGACTCGTCGTGTGGGCGAAGCTCGGTATTCCGGGAGTGGAGCTGGACGTCGGGGACATCAACTTCAGACGTCTA
ACGCGGTCCGTAAGGAAAGTCGTAGAGACCATACGACAACGATTGATCAAAGAGACCGAGAGAGCCGGTGTTGAGATTCT
GCGGGCTGAGGCGGTGAAGGTAGACGAGTCGCTCAACGTCTACACCAAAGATGGTGATGTTCTCGAGGCCGATAGAGTGC
TGATAGCCACCGGTTCCCGACCGGCGATTCCCGAGGTGGAGGGGGTGGATTCGGACGCCGTGTTTACTTTTCGGGAAATT
TTGGAAATGGAAGTGCCCTCAGAGCTCTGCGTCGTCGGTGGAGGTCCGACGGCCCTTGAGTCCGCTTTTGCTTTCGCGGC
TCTCGGGTCCGAAGTAGTTCTGGCGTACAGGTCTAGAATACTACCGAATGCTCCGGAGGAAGTCCGTCGCGAGATCCTTA
AGGATTTGGAGCTCGTGGGTGTCAACGCCGTCCGTGCGGGAGAACTACGGGCGATTCGGGAGACTTCCAGCGGTGTGGAA
TGTAGGTTTGAGCGCGGAGCTACCGTGGCGGACGCAGTTTTACTAGCCACTGGCCTCGAACCTAACTCCGATATTGCCGC
TAACTCCGGACTCCCCTTACGGAAGGACGGGTCCGTCGTGGTGGATGATGGGATGAGAACACCGCGTGATGGAGTTTACG
CTGCAGGCGACGTGACAGGACCTCCCTATCTGACTCCCGTCGCTCGGTACGAGGGAACGGTGGCCGCACTGAACGCGTTG
GGCAAGAACGTCCGACGGGGGAATCCGCCGGCTCCTCGCGTGATCAGACTCTTCCGAGACTTCGGCCGACTGGAACTGAG
GGGGATCGACTGGGAAGGCTCACTCCCTACACCGGTAGGTGGACCCGCGTTCTGGATGCTTCATCATGGTATCAAGGGTA
AGATGGTGTGCAGGAAGCGCGGAGTTACTACCGAGGCGTTCATCGTGGCGCCCAGAATCGCACCGATGCTCCCGTACCCA
CGCTGTGTGGAACCTGACTGGCGGCTGATCGAGGTGCATCCTACCCCGGACCCTGTGATCGGCCTGCTCAAGCAGCTGGG
GCTCCGCAGGACGCTTGGTGAGTGA

Upstream 100 bases:

>100_bases
CAGCCCCACGCCCGCAAGGAGGAGACAGAGCTCTTGAGACAAGGTGTCCACCCCCTAGAACTATCCCTCCGGTTATGTGA
TATTCGAGCGGGGGAGCCAC

Downstream 100 bases:

>100_bases
ATCATCTGATCCGCTCTCCGGGCTCCACTTCCCTCTTACTCTCGTCGATAGTCAACAATGCGGGTTCGTCCCCAACGGCC
AGGATCATCGCTTCCGACCG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDVVIGAGPAGRTYAMILAEAGHEVLLLDRNGKEGTGGKCLNEACVVLGALIEAARLVVWAKLGIPGVELDVGDINFRRL
TRSVRKVVETIRQRLIKETERAGVEILRAEAVKVDESLNVYTKDGDVLEADRVLIATGSRPAIPEVEGVDSDAVFTFREI
LEMEVPSELCVVGGGPTALESAFAFAALGSEVVLAYRSRILPNAPEEVRREILKDLELVGVNAVRAGELRAIRETSSGVE
CRFERGATVADAVLLATGLEPNSDIAANSGLPLRKDGSVVVDDGMRTPRDGVYAAGDVTGPPYLTPVARYEGTVAALNAL
GKNVRRGNPPAPRVIRLFRDFGRLELRGIDWEGSLPTPVGGPAFWMLHHGIKGKMVCRKRGVTTEAFIVAPRIAPMLPYP
RCVEPDWRLIEVHPTPDPVIGLLKQLGLRRTLGE

Sequences:

>Translated_434_residues
MDVVIGAGPAGRTYAMILAEAGHEVLLLDRNGKEGTGGKCLNEACVVLGALIEAARLVVWAKLGIPGVELDVGDINFRRL
TRSVRKVVETIRQRLIKETERAGVEILRAEAVKVDESLNVYTKDGDVLEADRVLIATGSRPAIPEVEGVDSDAVFTFREI
LEMEVPSELCVVGGGPTALESAFAFAALGSEVVLAYRSRILPNAPEEVRREILKDLELVGVNAVRAGELRAIRETSSGVE
CRFERGATVADAVLLATGLEPNSDIAANSGLPLRKDGSVVVDDGMRTPRDGVYAAGDVTGPPYLTPVARYEGTVAALNAL
GKNVRRGNPPAPRVIRLFRDFGRLELRGIDWEGSLPTPVGGPAFWMLHHGIKGKMVCRKRGVTTEAFIVAPRIAPMLPYP
RCVEPDWRLIEVHPTPDPVIGLLKQLGLRRTLGE
>Mature_434_residues
MDVVIGAGPAGRTYAMILAEAGHEVLLLDRNGKEGTGGKCLNEACVVLGALIEAARLVVWAKLGIPGVELDVGDINFRRL
TRSVRKVVETIRQRLIKETERAGVEILRAEAVKVDESLNVYTKDGDVLEADRVLIATGSRPAIPEVEGVDSDAVFTFREI
LEMEVPSELCVVGGGPTALESAFAFAALGSEVVLAYRSRILPNAPEEVRREILKDLELVGVNAVRAGELRAIRETSSGVE
CRFERGATVADAVLLATGLEPNSDIAANSGLPLRKDGSVVVDDGMRTPRDGVYAAGDVTGPPYLTPVARYEGTVAALNAL
GKNVRRGNPPAPRVIRLFRDFGRLELRGIDWEGSLPTPVGGPAFWMLHHGIKGKMVCRKRGVTTEAFIVAPRIAPMLPYP
RCVEPDWRLIEVHPTPDPVIGLLKQLGLRRTLGE

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=296, Percent_Identity=27.027027027027, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI22035672, Length=331, Percent_Identity=25.3776435045317, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87081717, Length=314, Percent_Identity=26.7515923566879, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1786307, Length=341, Percent_Identity=29.0322580645161, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87082354, Length=323, Percent_Identity=28.1733746130031, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789915, Length=287, Percent_Identity=28.2229965156794, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789065, Length=225, Percent_Identity=28, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17557007, Length=339, Percent_Identity=27.4336283185841, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321091, Length=458, Percent_Identity=25.764192139738, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=314, Percent_Identity=23.8853503184713, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737741, Length=349, Percent_Identity=27.2206303724928, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640551, Length=358, Percent_Identity=26.8156424581006, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640549, Length=358, Percent_Identity=26.8156424581006, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640553, Length=357, Percent_Identity=26.3305322128852, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 46791; Mature: 46791

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVVIGAGPAGRTYAMILAEAGHEVLLLDRNGKEGTGGKCLNEACVVLGALIEAARLVVW
CCEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
AKLGIPGVELDVGDINFRRLTRSVRKVVETIRQRLIKETERAGVEILRAEAVKVDESLNV
HCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
YTKDGDVLEADRVLIATGSRPAIPEVEGVDSDAVFTFREILEMEVPSELCVVGGGPTALE
EECCCCEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHH
SAFAFAALGSEVVLAYRSRILPNAPEEVRREILKDLELVGVNAVRAGELRAIRETSSGVE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCE
CRFERGATVADAVLLATGLEPNSDIAANSGLPLRKDGSVVVDDGMRTPRDGVYAAGDVTG
EEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCC
PPYLTPVARYEGTVAALNALGKNVRRGNPPAPRVIRLFRDFGRLELRGIDWEGSLPTPVG
CCCCCCHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
GPAFWMLHHGIKGKMVCRKRGVTTEAFIVAPRIAPMLPYPRCVEPDWRLIEVHPTPDPVI
CCEEEEECCCCCCCEEEHHCCCCCEEEEECCCHHCCCCCCCCCCCCCEEEEECCCCCHHH
GLLKQLGLRRTLGE
HHHHHHHHHHHCCC
>Mature Secondary Structure
MDVVIGAGPAGRTYAMILAEAGHEVLLLDRNGKEGTGGKCLNEACVVLGALIEAARLVVW
CCEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
AKLGIPGVELDVGDINFRRLTRSVRKVVETIRQRLIKETERAGVEILRAEAVKVDESLNV
HCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
YTKDGDVLEADRVLIATGSRPAIPEVEGVDSDAVFTFREILEMEVPSELCVVGGGPTALE
EECCCCEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHH
SAFAFAALGSEVVLAYRSRILPNAPEEVRREILKDLELVGVNAVRAGELRAIRETSSGVE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCE
CRFERGATVADAVLLATGLEPNSDIAANSGLPLRKDGSVVVDDGMRTPRDGVYAAGDVTG
EEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCC
PPYLTPVARYEGTVAALNALGKNVRRGNPPAPRVIRLFRDFGRLELRGIDWEGSLPTPVG
CCCCCCHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
GPAFWMLHHGIKGKMVCRKRGVTTEAFIVAPRIAPMLPYPRCVEPDWRLIEVHPTPDPVI
CCEEEEECCCCCCCEEEHHCCCCCEEEEECCCHHCCCCCCCCCCCCCEEEEECCCCCHHH
GLLKQLGLRRTLGE
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]