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The map label for this gene is 20094263

Identifier: 20094263

GI number: 20094263

Start: 785439

End: 785981

Strand: Direct

Name: 20094263

Synonym: MK0827

Alternate gene names: NA

Gene position: 785439-785981 (Clockwise)

Preceding gene: 20094262

Following gene: 20094264

Centisome position: 46.34

GC content: 59.48

Gene sequence:

>543_bases
CTGCCTCATAACGTCGTTCTTACCGGTCGTCCCGGTATCGGTAAGACCACAGTTTGTCTCAAAGTTCGTAACGTTCTAGA
GGAGGAGGGCTACACCGTCGGCGGAATCTATTGCCCCGAGATCAGGGAGGGTGGTCGACGGATAGGCTTCGAGATCGTCG
ACCTCACCGAGGGTGACCGGTACCTACTGGCAAGGGAAGGAGCTTCGGGGCCCAGAGTCGGTCGTTACGGGGTTTTCGTC
GATAACCTCGAGCGGGCCGCCGAATCCATCGAACGTGCCGTGAAAAGGACCGACGTCGTGATCGTCGACGAGGTCGGCCC
CATGGAGCTCAAGTCGAACGCGTTCGTAGACGCCGTGAGACGGGCGGCCGACGCGCACACACCCGCGATCTTCGTAGTGC
ACGAGCGATCGCGACATCCAGTCGTAGTGGATCTTAGGGAGGAACGCCCCGACGTCGTGCGTTTCCGGGTCACACTTTCC
AATAGGGATGAGTTGTCCGACAGAATCCTCGAGCACGTGCTTGAGTGGTTGGAGGAGAGGTGA

Upstream 100 bases:

>100_bases
GAGGAGGAAGAGGCGGAGGAAGAAGAGGAAGAGGAGGAAGAAGAGGCGGCGGCAGGTCTCGGAGCTCTATTCGGTTAACC
GACCACGGGGGCCCTATTCC

Downstream 100 bases:

>100_bases
TCGTTTTGGAGCATCTGGAATGTGACGTGCTCGTGATCGGAGGTGGTGGTGCGGCCGCCCGTGCGGCGATCGAGGCCGCT
AGGAGGAATCTGAACGTGGT

Product: putative NTPase

Products: NA

Alternate protein names: NTPase THEP1; Nucleoside triphosphate phosphohydrolase

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MPHNVVLTGRPGIGKTTVCLKVRNVLEEEGYTVGGIYCPEIREGGRRIGFEIVDLTEGDRYLLAREGASGPRVGRYGVFV
DNLERAAESIERAVKRTDVVIVDEVGPMELKSNAFVDAVRRAADAHTPAIFVVHERSRHPVVVDLREERPDVVRFRVTLS
NRDELSDRILEHVLEWLEER

Sequences:

>Translated_180_residues
MPHNVVLTGRPGIGKTTVCLKVRNVLEEEGYTVGGIYCPEIREGGRRIGFEIVDLTEGDRYLLAREGASGPRVGRYGVFV
DNLERAAESIERAVKRTDVVIVDEVGPMELKSNAFVDAVRRAADAHTPAIFVVHERSRHPVVVDLREERPDVVRFRVTLS
NRDELSDRILEHVLEWLEER
>Mature_179_residues
PHNVVLTGRPGIGKTTVCLKVRNVLEEEGYTVGGIYCPEIREGGRRIGFEIVDLTEGDRYLLAREGASGPRVGRYGVFVD
NLERAAESIERAVKRTDVVIVDEVGPMELKSNAFVDAVRRAADAHTPAIFVVHERSRHPVVVDLREERPDVVRFRVTLSN
RDELSDRILEHVLEWLEER

Specific function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency

COG id: COG1618

COG function: function code F; Predicted nucleotide kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the THEP1 NTPase family

Homologues:

Organism=Homo sapiens, GI14150100, Length=188, Percent_Identity=36.7021276595745, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI85726488, Length=183, Percent_Identity=32.7868852459016, Blast_Score=90, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPTH_METKA (Q8TX49)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614110.1
- ProteinModelPortal:   Q8TX49
- GeneID:   1476928
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0827
- NMPDR:   fig|190192.1.peg.823
- HOGENOM:   HBG574935
- OMA:   MEFKSNE
- ProtClustDB:   PRK13695
- BioCyc:   MKAN190192:MK0827-MONOMER
- HAMAP:   MF_00796
- InterPro:   IPR003593
- InterPro:   IPR004948
- SMART:   SM00382

Pfam domain/function: PF03266 DUF265

EC number: =3.6.1.15

Molecular weight: Translated: 20326; Mature: 20195

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHNVVLTGRPGIGKTTVCLKVRNVLEEEGYTVGGIYCPEIREGGRRIGFEIVDLTEGDR
CCCCEEEECCCCCCCHHHHHHHHHHHHHCCCEECCEECCHHHCCCEEECEEEEEECCCCE
YLLAREGASGPRVGRYGVFVDNLERAAESIERAVKRTDVVIVDEVGPMELKSNAFVDAVR
EEEEECCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEECCHHHHHHHH
RAADAHTPAIFVVHERSRHPVVVDLREERPDVVRFRVTLSNRDELSDRILEHVLEWLEER
HHHCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PHNVVLTGRPGIGKTTVCLKVRNVLEEEGYTVGGIYCPEIREGGRRIGFEIVDLTEGDR
CCCEEEECCCCCCCHHHHHHHHHHHHHCCCEECCEECCHHHCCCEEECEEEEEECCCCE
YLLAREGASGPRVGRYGVFVDNLERAAESIERAVKRTDVVIVDEVGPMELKSNAFVDAVR
EEEEECCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEECCHHHHHHHH
RAADAHTPAIFVVHERSRHPVVVDLREERPDVVRFRVTLSNRDELSDRILEHVLEWLEER
HHHCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014