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The map label for this gene is PyrH

Identifier: 20094197

GI number: 20094197

Start: 723901

End: 724572

Strand: Direct

Name: PyrH

Synonym: MK0760

Alternate gene names: 20094197

Gene position: 723901-724572 (Clockwise)

Preceding gene: 20094185

Following gene: 20094198

Centisome position: 42.71

GC content: 59.97

Gene sequence:

>672_bases
ATGTATTCGGTCGTGGCACTGGGTGGCTCGGTCGTAAACGTGGATAAACCCGAACGCATCAAGGAAACCGCCGAAATCTT
GCGAAATGGGCTCGATTCCGGGCTGAAGATATGCGTCGTCGTCGGTGGTGGGCCGACCGCCCGTCGGTACATAAACGTAG
CGCGAAACCTCGGGACACCGGAAACTCTACTCGACGAGATGGGTATCGCCGTTACCCGGCTGAACGCGATGCTTCTAGGG
GCGGCGTTGGGTCTGCACGATCTGCACGTGCCTGAGACCCCAGTAGAAGCCGCGAGAATAGTCCGGCGGAACGGTGTGGC
AGTCTGCGGTGGTACACATCCCGGCCACACAACCGACGCCGTAGCGGCCATGATCGCGGAACTGCTCGAGGGTCCACTCG
TCATAGTTACCAATGTCGACGGGGTGTACGACAAGGACCCCAGTGAACCAGGCGCGCGCAAACTCCGGGAACTGAGGCCC
GAAGAGCTGGAAGAACTGGCAGTCCGCGCTGAGCTTAAGGCGGGGGGAAGCTTCGTAGTGGACCCCCTCGCCGCCAAGAT
GATAAGCAGGGGTCAAATCGTCACGCACGTGGTTTCGTGGGAAGACTTCCGGTCCCGTGGGTTGGAAAACGTGGTTCGAG
GCCGTCATAATGGGACGATAATCGAGGGGTGA

Upstream 100 bases:

>100_bases
TCCGCGCAGGTTTTCCAGTCTCTCTATCATCTTCCTGAACCTATATCTCTCGACCGTAGACGATTCGGCCATCGTGAACA
CCCCCTAGGGGTGAGACAGC

Downstream 100 bases:

>100_bases
AAGGGTTTGACGGAGCGCGTACCTCCCCACTCCCACTGTATCGTTTGTGGGGCCGCAATCCCGGAAGGGGAGCGATTTTG
CAGCGAGAAGTGCCGGATGG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MYSVVALGGSVVNVDKPERIKETAEILRNGLDSGLKICVVVGGGPTARRYINVARNLGTPETLLDEMGIAVTRLNAMLLG
AALGLHDLHVPETPVEAARIVRRNGVAVCGGTHPGHTTDAVAAMIAELLEGPLVIVTNVDGVYDKDPSEPGARKLRELRP
EELEELAVRAELKAGGSFVVDPLAAKMISRGQIVTHVVSWEDFRSRGLENVVRGRHNGTIIEG

Sequences:

>Translated_223_residues
MYSVVALGGSVVNVDKPERIKETAEILRNGLDSGLKICVVVGGGPTARRYINVARNLGTPETLLDEMGIAVTRLNAMLLG
AALGLHDLHVPETPVEAARIVRRNGVAVCGGTHPGHTTDAVAAMIAELLEGPLVIVTNVDGVYDKDPSEPGARKLRELRP
EELEELAVRAELKAGGSFVVDPLAAKMISRGQIVTHVVSWEDFRSRGLENVVRGRHNGTIIEG
>Mature_223_residues
MYSVVALGGSVVNVDKPERIKETAEILRNGLDSGLKICVVVGGGPTARRYINVARNLGTPETLLDEMGIAVTRLNAMLLG
AALGLHDLHVPETPVEAARIVRRNGVAVCGGTHPGHTTDAVAAMIAELLEGPLVIVTNVDGVYDKDPSEPGARKLRELRP
EELEELAVRAELKAGGSFVVDPLAAKMISRGQIVTHVVSWEDFRSRGLENVVRGRHNGTIIEG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_METKA (Q8TXB4)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614044.1
- ProteinModelPortal:   Q8TXB4
- SMR:   Q8TXB4
- GeneID:   1476861
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0760
- NMPDR:   fig|190192.1.peg.757
- HOGENOM:   HBG497552
- OMA:   TARRYIN
- BioCyc:   MKAN190192:MK0760-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 23775; Mature: 23775

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: BINDING 43-43 BINDING 44-44 BINDING 48-48 BINDING 65-65 BINDING 137-137 BINDING 138-138 BINDING 143-143 BINDING 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSVVALGGSVVNVDKPERIKETAEILRNGLDSGLKICVVVGGGPTARRYINVARNLGTP
CCEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCH
ETLLDEMGIAVTRLNAMLLGAALGLHDLHVPETPVEAARIVRRNGVAVCGGTHPGHTTDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHH
VAAMIAELLEGPLVIVTNVDGVYDKDPSEPGARKLRELRPEELEELAVRAELKAGGSFVV
HHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEE
DPLAAKMISRGQIVTHVVSWEDFRSRGLENVVRGRHNGTIIEG
CHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCEECC
>Mature Secondary Structure
MYSVVALGGSVVNVDKPERIKETAEILRNGLDSGLKICVVVGGGPTARRYINVARNLGTP
CCEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCH
ETLLDEMGIAVTRLNAMLLGAALGLHDLHVPETPVEAARIVRRNGVAVCGGTHPGHTTDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHH
VAAMIAELLEGPLVIVTNVDGVYDKDPSEPGARKLRELRPEELEELAVRAELKAGGSFVV
HHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEE
DPLAAKMISRGQIVTHVVSWEDFRSRGLENVVRGRHNGTIIEG
CHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014