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The map label for this gene is TrpD

Identifier: 20094116

GI number: 20094116

Start: 634980

End: 635999

Strand: Direct

Name: TrpD

Synonym: MK0678

Alternate gene names: 20094116

Gene position: 634980-635999 (Clockwise)

Preceding gene: 20094114

Following gene: 20094134

Centisome position: 37.46

GC content: 63.33

Gene sequence:

>1020_bases
TTGAGCGTCCTCGAGAGGATCATCCGCGGATCGGATCTGGATCGGGAAGAGGCCCGCGATTTGATGTGTCGAATCGTCGG
CGGTGAGCTTTCCGACGTTGAAGTAGCCGGTATCTTGGTGGCGCTACGCTGTAAGGGGTACACCTCGGAGGAACTCGTAG
GTTTCGTCGACGGGATGATGGAGCACGCGGTGAAGGTGGATCCGGACGTCGAGAGACTCGTGGATACGGCCGGCACCGGT
GGGGACGAACTGGACACCTTCAACGCCAGCACGCTGGCGGGGCTCACCGCGGCGGCGGCCGGCGTGCCCGTCGCGAAGCA
CGGGAACCGCAGCGTCACCAGCGAGTGCGGTAGTGCCGACATCCTGGAGGCCCTCGGTGTGAACATCGAGGCGGATCCAG
ACACGGTTAAGCGCTGCATCGAAGAGGTTGGATTCGGATTCATGTTCGCGCCGAAGTTCCATCCCGCCATGAAGAACGTC
ATGCCGGTACGCCGTAAGCTGGGGATCCGAACTGTCTTCAACGTCCTCGGACCACTCACCAACCCCGCCCGGGAGCGCGT
TACCGGGCAGGTCATCGGTGTGTACTCGGAAAACCTGCTGGACCTCGTGGCCGGTGCCCTCGCGGAACTCGGGGTTCGGA
GGGGACTCGTGGTTTACGGTTTAGACGGTGTTGACGAGCTGAGCGTCACCTGCGAGAACGAGGTGGTGTACGTGGACGAC
GGGGAGGTGACGGATAGGGACACGGTGGCCCCCGAAGACGTCGGACTGGATCGAGCCGATCCGAAGGACGTCGCGGGTGC
GGATCCGGAGACCTCGGCCGAGGAAGCTCGGAAGATCCTGGGCGGTGAGCTGCCCGTCGACCACCCGAAGGTCCAGATGA
CGGCGTTCAACGCGGGTGCCGCTCTCTACGTCGGGGAAGCCGTCGATTCGTTGGAGAAGGGAATTCAGCGCGCACTGGAC
GTCCTGGAGGAGGGACGGGCTCTGGAAGTCCTGGAGAAGGTAGTCGACCTCTCCTCCTAA

Upstream 100 bases:

>100_bases
TTCACCATCCGGTATCACCCCCTACGTCGCCGTACCGGCCCACAACGCCGTAGGTAAGGTAAAAAGAAAACCGCCGCGGC
TCGTGGTGGGGCGGCGCGGT

Downstream 100 bases:

>100_bases
CACCTCGTACCCCGGACGATACGTTTCGGACTCTATAACGATTGGTGCGGGCGGGGGCGTTTACCCGCCGTAGTCCTCGA
TGTAGTCCTCCGGCTTCGGG

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSVLERIIRGSDLDREEARDLMCRIVGGELSDVEVAGILVALRCKGYTSEELVGFVDGMMEHAVKVDPDVERLVDTAGTG
GDELDTFNASTLAGLTAAAAGVPVAKHGNRSVTSECGSADILEALGVNIEADPDTVKRCIEEVGFGFMFAPKFHPAMKNV
MPVRRKLGIRTVFNVLGPLTNPARERVTGQVIGVYSENLLDLVAGALAELGVRRGLVVYGLDGVDELSVTCENEVVYVDD
GEVTDRDTVAPEDVGLDRADPKDVAGADPETSAEEARKILGGELPVDHPKVQMTAFNAGAALYVGEAVDSLEKGIQRALD
VLEEGRALEVLEKVVDLSS

Sequences:

>Translated_339_residues
MSVLERIIRGSDLDREEARDLMCRIVGGELSDVEVAGILVALRCKGYTSEELVGFVDGMMEHAVKVDPDVERLVDTAGTG
GDELDTFNASTLAGLTAAAAGVPVAKHGNRSVTSECGSADILEALGVNIEADPDTVKRCIEEVGFGFMFAPKFHPAMKNV
MPVRRKLGIRTVFNVLGPLTNPARERVTGQVIGVYSENLLDLVAGALAELGVRRGLVVYGLDGVDELSVTCENEVVYVDD
GEVTDRDTVAPEDVGLDRADPKDVAGADPETSAEEARKILGGELPVDHPKVQMTAFNAGAALYVGEAVDSLEKGIQRALD
VLEEGRALEVLEKVVDLSS
>Mature_338_residues
SVLERIIRGSDLDREEARDLMCRIVGGELSDVEVAGILVALRCKGYTSEELVGFVDGMMEHAVKVDPDVERLVDTAGTGG
DELDTFNASTLAGLTAAAAGVPVAKHGNRSVTSECGSADILEALGVNIEADPDTVKRCIEEVGFGFMFAPKFHPAMKNVM
PVRRKLGIRTVFNVLGPLTNPARERVTGQVIGVYSENLLDLVAGALAELGVRRGLVVYGLDGVDELSVTCENEVVYVDDG
EVTDRDTVAPEDVGLDRADPKDVAGADPETSAEEARKILGGELPVDHPKVQMTAFNAGAALYVGEAVDSLEKGIQRALDV
LEEGRALEVLEKVVDLSS

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=281, Percent_Identity=37.3665480427046, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1787019, Length=313, Percent_Identity=25.2396166134185, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320561, Length=326, Percent_Identity=28.5276073619632, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_METKA (Q8TXJ5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613963.1
- ProteinModelPortal:   Q8TXJ5
- SMR:   Q8TXJ5
- GeneID:   1476779
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0678
- NMPDR:   fig|190192.1.peg.676
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- BioCyc:   MKAN190192:MK0678-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 36019; Mature: 35888

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLERIIRGSDLDREEARDLMCRIVGGELSDVEVAGILVALRCKGYTSEELVGFVDGMM
CHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHH
EHAVKVDPDVERLVDTAGTGGDELDTFNASTLAGLTAAAAGVPVAKHGNRSVTSECGSAD
HHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCHH
ILEALGVNIEADPDTVKRCIEEVGFGFMFAPKFHPAMKNVMPVRRKLGIRTVFNVLGPLT
HHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
NPARERVTGQVIGVYSENLLDLVAGALAELGVRRGLVVYGLDGVDELSVTCENEVVYVDD
CHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEECCCEEEECC
GEVTDRDTVAPEDVGLDRADPKDVAGADPETSAEEARKILGGELPVDHPKVQMTAFNAGA
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCC
ALYVGEAVDSLEKGIQRALDVLEEGRALEVLEKVVDLSS
CEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SVLERIIRGSDLDREEARDLMCRIVGGELSDVEVAGILVALRCKGYTSEELVGFVDGMM
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHH
EHAVKVDPDVERLVDTAGTGGDELDTFNASTLAGLTAAAAGVPVAKHGNRSVTSECGSAD
HHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCHH
ILEALGVNIEADPDTVKRCIEEVGFGFMFAPKFHPAMKNVMPVRRKLGIRTVFNVLGPLT
HHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
NPARERVTGQVIGVYSENLLDLVAGALAELGVRRGLVVYGLDGVDELSVTCENEVVYVDD
CHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEECCCEEEECC
GEVTDRDTVAPEDVGLDRADPKDVAGADPETSAEEARKILGGELPVDHPKVQMTAFNAGA
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCC
ALYVGEAVDSLEKGIQRALDVLEEGRALEVLEKVVDLSS
CEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014