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The map label for this gene is cpgS

Identifier: 20093943

GI number: 20093943

Start: 466623

End: 467993

Strand: Direct

Name: cpgS

Synonym: MK0505

Alternate gene names: 20093943

Gene position: 466623-467993 (Clockwise)

Preceding gene: 20093942

Following gene: 20093945

Centisome position: 27.53

GC content: 62.36

Gene sequence:

>1371_bases
CTGACCGCCGTGAAGAGGATACTGGCGTTGGTGGACGGTGAGCACTACATCCCCGTAACTCGGGAGGCGTTAGAGACTGT
GGAGGAATTGGACCTCGGAGAGCTCGTAGGAGCCGTGTTCATCGGAGGGACTGAGAAGATCAGCGAGCCCGAGGCCGTCA
AGCGGGAGCTGGGTGTACGGGTCTGGCTATCGGAGTCGGAAGACGAGATACCGGTGGACATGATCGTCAAGGTGATCGAG
GAAGAGGACGTCGACGTGGTGCTGGACCTGAGCGACGAGCCCGTGGTTAGCCCCGACAACAGGTTCGAGATAGCCTCAGC
GGTACTCTCCGCGGGAGCGGAGTACTGGTGCCCGGACCTCCGACTGAAGCCGGTGGAGTTCCACGACGTCCTCGAGAAAC
CATCGCTTCGGATCATAGGGACCGGGAAGAGGGTGGGCAAGACCGCCGTCTCCGCCTACACCTGTCGTGTGCTCAACGCA
CGGGGCTACAACCCGTGCGTAGTGGTGATGGGTCGTGGAGGTCCGAGGGAGCCCGAAATAGTACGTGGGGACGAGATCGA
GCTGACTCCCGAGTACCTACTGAAAGAGGCCGAGAAGGGTAAGCACGCGGCGAGCGATCACTGGGAGGACGCGCTCCTCA
GCAGGATCCCGACTGTCGGATGTCGGCGGTGCGCGGGTGGACTGGCGGGACGTACCTTCACCACGAACATCGTGCGCGGT
GCCAAGATAGCTAACGAGTTGCCGGCCGACTTCGTCGTGGTCGAAGGTAGTGGCGCGGCCGTACCACCGATCAAGACGGA
CGCGGGTATCGTGATCGTCGGAGCCAACCAGCCGTTAGAGCACATCGGCGGGTACTTAGGACCTTATAGGATCCGGATGT
GCGACCTGGCGATCATCACGATGTGCGAGGAACCGATGGCGGACGACGCGAAAATCAGGAAAGTCGAGCGCACCGTCCGG
GAAGCCGGCGACGGCATCGAGGTAGTACTCTCGGTGTTCCGACCTAAACCCACCGAGGACGTGGAGGGTAAGCGGGCGAT
GTTCGTGACGACGGCACCCGAGGAGGTCGTCTCGAGGCTCGTCGAGCACCTGGAAGAGGAATACGGGTGTGAGATCGTCG
GGACGTCGCCGCACCTCAGCAACCGTCCGAAGCTCCGCAAAGACCTGGAGAAGTACATCGACGATGCGGACATACTGCTC
ACGGAGCTGAAGGCGGCCGCCGTCGACGTGGCCACTCGGGAGGCCCTGAAGGCCGGACTGGGCGTGGTGTACGTGGACAA
CGTCCCCATCGCCGTCGGAGGTGATTACGACCACGTGGGTGACGCCGTGGAGAACGTAGCCGAGCTGGCGATCGATCGGT
TCGAGGGTTAA

Upstream 100 bases:

>100_bases
ACTGCGTGGCGTCGCTTGAGGAGGAATCCCACCGGTTCGCTTTGAAGCACATGGAAAAGCTCGGGGCGGAGGTAGTCGAT
TCGGAGGAGATACTGGGGGA

Downstream 100 bases:

>100_bases
TCACTGTCGATCCCGAACACCACCTCGGCGAAAGCGCGCTCGACATCTACCCGCTCTACGAACCGGCTGCCCCGTGACGC
CGCGATCTCTCCGGCCCGTT

Product: cyclic 2,3-diphosphoglycerate-synthetase

Products: NA

Alternate protein names: cDPGS

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTAVKRILALVDGEHYIPVTREALETVEELDLGELVGAVFIGGTEKISEPEAVKRELGVRVWLSESEDEIPVDMIVKVIE
EEDVDVVLDLSDEPVVSPDNRFEIASAVLSAGAEYWCPDLRLKPVEFHDVLEKPSLRIIGTGKRVGKTAVSAYTCRVLNA
RGYNPCVVVMGRGGPREPEIVRGDEIELTPEYLLKEAEKGKHAASDHWEDALLSRIPTVGCRRCAGGLAGRTFTTNIVRG
AKIANELPADFVVVEGSGAAVPPIKTDAGIVIVGANQPLEHIGGYLGPYRIRMCDLAIITMCEEPMADDAKIRKVERTVR
EAGDGIEVVLSVFRPKPTEDVEGKRAMFVTTAPEEVVSRLVEHLEEEYGCEIVGTSPHLSNRPKLRKDLEKYIDDADILL
TELKAAAVDVATREALKAGLGVVYVDNVPIAVGGDYDHVGDAVENVAELAIDRFEG

Sequences:

>Translated_456_residues
MTAVKRILALVDGEHYIPVTREALETVEELDLGELVGAVFIGGTEKISEPEAVKRELGVRVWLSESEDEIPVDMIVKVIE
EEDVDVVLDLSDEPVVSPDNRFEIASAVLSAGAEYWCPDLRLKPVEFHDVLEKPSLRIIGTGKRVGKTAVSAYTCRVLNA
RGYNPCVVVMGRGGPREPEIVRGDEIELTPEYLLKEAEKGKHAASDHWEDALLSRIPTVGCRRCAGGLAGRTFTTNIVRG
AKIANELPADFVVVEGSGAAVPPIKTDAGIVIVGANQPLEHIGGYLGPYRIRMCDLAIITMCEEPMADDAKIRKVERTVR
EAGDGIEVVLSVFRPKPTEDVEGKRAMFVTTAPEEVVSRLVEHLEEEYGCEIVGTSPHLSNRPKLRKDLEKYIDDADILL
TELKAAAVDVATREALKAGLGVVYVDNVPIAVGGDYDHVGDAVENVAELAIDRFEG
>Mature_455_residues
TAVKRILALVDGEHYIPVTREALETVEELDLGELVGAVFIGGTEKISEPEAVKRELGVRVWLSESEDEIPVDMIVKVIEE
EDVDVVLDLSDEPVVSPDNRFEIASAVLSAGAEYWCPDLRLKPVEFHDVLEKPSLRIIGTGKRVGKTAVSAYTCRVLNAR
GYNPCVVVMGRGGPREPEIVRGDEIELTPEYLLKEAEKGKHAASDHWEDALLSRIPTVGCRRCAGGLAGRTFTTNIVRGA
KIANELPADFVVVEGSGAAVPPIKTDAGIVIVGANQPLEHIGGYLGPYRIRMCDLAIITMCEEPMADDAKIRKVERTVRE
AGDGIEVVLSVFRPKPTEDVEGKRAMFVTTAPEEVVSRLVEHLEEEYGCEIVGTSPHLSNRPKLRKDLEKYIDDADILLT
ELKAAAVDVATREALKAGLGVVYVDNVPIAVGGDYDHVGDAVENVAELAIDRFEG

Specific function: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP

COG id: COG2403

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CPGS_METKA (Q8TY02)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613790.1
- ProteinModelPortal:   Q8TY02
- GeneID:   1476606
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0505
- NMPDR:   fig|190192.1.peg.503
- HOGENOM:   HBG539597
- OMA:   LIDGEHY
- ProtClustDB:   CLSK785466
- BioCyc:   MKAN190192:MK0505-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01908
- InterPro:   IPR016557
- PIRSF:   PIRSF009445

Pfam domain/function: NA

EC number: 4.6.1.-

Molecular weight: Translated: 49620; Mature: 49489

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVKRILALVDGEHYIPVTREALETVEELDLGELVGAVFIGGTEKISEPEAVKRELGVR
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCEE
VWLSESEDEIPVDMIVKVIEEEDVDVVLDLSDEPVVSPDNRFEIASAVLSAGAEYWCPDL
EEECCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
RLKPVEFHDVLEKPSLRIIGTGKRVGKTAVSAYTCRVLNARGYNPCVVVMGRGGPREPEI
EECCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHEEEECCCCCCCEEEEECCCCCCCCCE
VRGDEIELTPEYLLKEAEKGKHAASDHWEDALLSRIPTVGCRRCAGGLAGRTFTTNIVRG
ECCCCEEECHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHH
AKIANELPADFVVVEGSGAAVPPIKTDAGIVIVGANQPLEHIGGYLGPYRIRMCDLAIIT
HHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHHHH
MCEEPMADDAKIRKVERTVREAGDGIEVVLSVFRPKPTEDVEGKRAMFVTTAPEEVVSRL
HHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHH
VEHLEEEYGCEIVGTSPHLSNRPKLRKDLEKYIDDADILLTELKAAAVDVATREALKAGL
HHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
GVVYVDNVPIAVGGDYDHVGDAVENVAELAIDRFEG
CEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAVKRILALVDGEHYIPVTREALETVEELDLGELVGAVFIGGTEKISEPEAVKRELGVR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCEE
VWLSESEDEIPVDMIVKVIEEEDVDVVLDLSDEPVVSPDNRFEIASAVLSAGAEYWCPDL
EEECCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
RLKPVEFHDVLEKPSLRIIGTGKRVGKTAVSAYTCRVLNARGYNPCVVVMGRGGPREPEI
EECCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHEEEECCCCCCCEEEEECCCCCCCCCE
VRGDEIELTPEYLLKEAEKGKHAASDHWEDALLSRIPTVGCRRCAGGLAGRTFTTNIVRG
ECCCCEEECHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHH
AKIANELPADFVVVEGSGAAVPPIKTDAGIVIVGANQPLEHIGGYLGPYRIRMCDLAIIT
HHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHHHH
MCEEPMADDAKIRKVERTVREAGDGIEVVLSVFRPKPTEDVEGKRAMFVTTAPEEVVSRL
HHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHH
VEHLEEEYGCEIVGTSPHLSNRPKLRKDLEKYIDDADILLTELKAAAVDVATREALKAGL
HHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
GVVYVDNVPIAVGGDYDHVGDAVENVAELAIDRFEG
CEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014