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The map label for this gene is argH

Identifier: 197120002

GI number: 197120002

Start: 4165311

End: 4166687

Strand: Direct

Name: argH

Synonym: Gbem_3641

Alternate gene names: 197120002

Gene position: 4165311-4166687 (Clockwise)

Preceding gene: 197120001

Following gene: 308535380

Centisome position: 90.25

GC content: 62.53

Gene sequence:

>1377_bases
ATGTCCAAAGACAAGCTGTGGGGCGGGCGTTTCACCCAACCCACCGACAAGTTCGTAGAAGAATTCACCGCCTCCATCAA
CTTCGATAAGCGCCTGTACCACCAGGACATCCGCGGCTCCATCGCCCACGCCACCATGCTGGGCAAGCAGGGGATCATCC
CGGTTGCCGACGTCGAAAGCATCGTCTCGGGGCTGAAGACTATCCTGGAGCAGATCGAGGCGGGCGAGTTCGACTTCTCG
GTCTCTTTGGAAGATATCCACATGAACATCGAGGCGCGGCTCTCCGAGAAGATCGGCGACGCCGGCAAGAGGCTCCACAC
CGGCCGCTCCAGAAACGACCAGGTGGCGCTCGACATCAGGCTCTACCTGCGGGACGAACTGGTGGAGGTCTCGGCGTACA
TCGACCTCCTGATCGACGCCATCATCCACCAGGCGGAGGAGAACCTCGGCGTGATCATGCCGGGCTTCACCCACCTGCAG
ACCGCCCAGCCGATCCTCTTCTCGCACCACATGATGGCCTACCACGAGATGCTCAAGCGGGACAAGGCGCGTATGGAGGA
CTGCCTGAAAAGGACCAACGTGCTTCCCCTGGGCGCAGGCGCCCTGGCCGGGACCACCTTCCCCATCGACCGCGAGTATG
TGGCGGAACTCCTCGACTTCGACGGTGTCACCCGCAACTCGCTCGACTCGGTCTCCGACCGCGACTTCGCCATGGAGTTC
TGCGCCGCCTCGTCGATCCTGATGGTGCACCTCTCCCGCTTCTCGGAGGAGCTGATCCTCTGGTCCACCAGCGAGTTCAA
GTTCGTGGAGCTCTCCGACTCCTTCTGCACCGGCTCCTCCATCATGCCGCAGAAGAAGAACCCGGACGTCCCGGAGCTGG
TGCGCGGCAAGACCGGCCGCGTCAACGGCAACCTGGTGGCCCTCTTGACCCTGATGAAATCGCTCCCGCTCGCCTACAAC
AAGGACATGCAGGAAGACAAGGAGCCGTTATTCGACACCATCGACACCGTGAAAGGGTGCCTCAAGGTCTTCGCCGACAT
GGTGCGCGAAATGAAGATCAACCCGGAGCGGATGAAGACCGCCGCGGCAGCGGGTTTCTCCACCGCGACCGATGTGGCCG
ACTACCTGGTGCGTAAGGGAATCCCCTTCCGCGACGCCCACGAGATCGTTGGTAAGACGGTGCGCTACTGCATCGAGAAC
GAGATGGACATCCCCGAGCTTTCGCTTGCCGAGTGGCAGCTTTTCTCCGGGCGCATCGAGGAGGACATCTTCGAATCGAT
CACCCTGCAGGCCTCGGTCAACGCCCGTCGCGCGACCGGCGGCACCGCGCTGGAGCGGGTGCGCGCGGAGATCGCCCGGG
CCAAGGAAGGTAGGTAA

Upstream 100 bases:

>100_bases
GGGGGTAGGCGCAACGACAGCGCTTATTGCAGCTCCACCCACCCCCCGGCCCCCTCCCGTCCAGGGAGGGAGGGGCGAAA
ACCAGCAGCAGGAGACAAAC

Downstream 100 bases:

>100_bases
CCGGTGGCGGTCTTGAGGGGAATTTGCTGCGGCTTCATCCTGGCGGCGACGCTGGCGCTTCTTTCCGGCTGCGGCAAGAA
AGGACCGCTGGTGCCGCCGG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSKDKLWGGRFTQPTDKFVEEFTASINFDKRLYHQDIRGSIAHATMLGKQGIIPVADVESIVSGLKTILEQIEAGEFDFS
VSLEDIHMNIEARLSEKIGDAGKRLHTGRSRNDQVALDIRLYLRDELVEVSAYIDLLIDAIIHQAEENLGVIMPGFTHLQ
TAQPILFSHHMMAYHEMLKRDKARMEDCLKRTNVLPLGAGALAGTTFPIDREYVAELLDFDGVTRNSLDSVSDRDFAMEF
CAASSILMVHLSRFSEELILWSTSEFKFVELSDSFCTGSSIMPQKKNPDVPELVRGKTGRVNGNLVALLTLMKSLPLAYN
KDMQEDKEPLFDTIDTVKGCLKVFADMVREMKINPERMKTAAAAGFSTATDVADYLVRKGIPFRDAHEIVGKTVRYCIEN
EMDIPELSLAEWQLFSGRIEEDIFESITLQASVNARRATGGTALERVRAEIARAKEGR

Sequences:

>Translated_458_residues
MSKDKLWGGRFTQPTDKFVEEFTASINFDKRLYHQDIRGSIAHATMLGKQGIIPVADVESIVSGLKTILEQIEAGEFDFS
VSLEDIHMNIEARLSEKIGDAGKRLHTGRSRNDQVALDIRLYLRDELVEVSAYIDLLIDAIIHQAEENLGVIMPGFTHLQ
TAQPILFSHHMMAYHEMLKRDKARMEDCLKRTNVLPLGAGALAGTTFPIDREYVAELLDFDGVTRNSLDSVSDRDFAMEF
CAASSILMVHLSRFSEELILWSTSEFKFVELSDSFCTGSSIMPQKKNPDVPELVRGKTGRVNGNLVALLTLMKSLPLAYN
KDMQEDKEPLFDTIDTVKGCLKVFADMVREMKINPERMKTAAAAGFSTATDVADYLVRKGIPFRDAHEIVGKTVRYCIEN
EMDIPELSLAEWQLFSGRIEEDIFESITLQASVNARRATGGTALERVRAEIARAKEGR
>Mature_457_residues
SKDKLWGGRFTQPTDKFVEEFTASINFDKRLYHQDIRGSIAHATMLGKQGIIPVADVESIVSGLKTILEQIEAGEFDFSV
SLEDIHMNIEARLSEKIGDAGKRLHTGRSRNDQVALDIRLYLRDELVEVSAYIDLLIDAIIHQAEENLGVIMPGFTHLQT
AQPILFSHHMMAYHEMLKRDKARMEDCLKRTNVLPLGAGALAGTTFPIDREYVAELLDFDGVTRNSLDSVSDRDFAMEFC
AASSILMVHLSRFSEELILWSTSEFKFVELSDSFCTGSSIMPQKKNPDVPELVRGKTGRVNGNLVALLTLMKSLPLAYNK
DMQEDKEPLFDTIDTVKGCLKVFADMVREMKINPERMKTAAAAGFSTATDVADYLVRKGIPFRDAHEIVGKTVRYCIENE
MDIPELSLAEWQLFSGRIEEDIFESITLQASVNARRATGGTALERVRAEIARAKEGR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=44.1241685144124, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=44.1241685144124, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=41.9068736141907, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=41.4634146341463, Blast_Score=343, Evalue=1e-94,
Organism=Escherichia coli, GI1790398, Length=451, Percent_Identity=48.3370288248337, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321806, Length=455, Percent_Identity=43.956043956044, Blast_Score=375, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=439, Percent_Identity=41.2300683371298, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI78706858, Length=439, Percent_Identity=41.2300683371298, Blast_Score=348, Evalue=4e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_GEOBB (B5ED16)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002140429.1
- ProteinModelPortal:   B5ED16
- SMR:   B5ED16
- GeneID:   6780505
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_3641
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51348; Mature: 51217

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDKLWGGRFTQPTDKFVEEFTASINFDKRLYHQDIRGSIAHATMLGKQGIIPVADVES
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IVSGLKTILEQIEAGEFDFSVSLEDIHMNIEARLSEKIGDAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LYLRDELVEVSAYIDLLIDAIIHQAEENLGVIMPGFTHLQTAQPILFSHHMMAYHEMLKR
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCHHHHHHHHHHHHHHHHH
DKARMEDCLKRTNVLPLGAGALAGTTFPIDREYVAELLDFDGVTRNSLDSVSDRDFAMEF
HHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCCHHHHHHH
CAASSILMVHLSRFSEELILWSTSEFKFVELSDSFCTGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
VNGNLVALLTLMKSLPLAYNKDMQEDKEPLFDTIDTVKGCLKVFADMVREMKINPERMKT
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAAAGFSTATDVADYLVRKGIPFRDAHEIVGKTVRYCIENEMDIPELSLAEWQLFSGRIE
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHH
EDIFESITLQASVNARRATGGTALERVRAEIARAKEGR
HHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKDKLWGGRFTQPTDKFVEEFTASINFDKRLYHQDIRGSIAHATMLGKQGIIPVADVES
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IVSGLKTILEQIEAGEFDFSVSLEDIHMNIEARLSEKIGDAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LYLRDELVEVSAYIDLLIDAIIHQAEENLGVIMPGFTHLQTAQPILFSHHMMAYHEMLKR
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCHHHHHHHHHHHHHHHHH
DKARMEDCLKRTNVLPLGAGALAGTTFPIDREYVAELLDFDGVTRNSLDSVSDRDFAMEF
HHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCCHHHHHHH
CAASSILMVHLSRFSEELILWSTSEFKFVELSDSFCTGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
VNGNLVALLTLMKSLPLAYNKDMQEDKEPLFDTIDTVKGCLKVFADMVREMKINPERMKT
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAAAGFSTATDVADYLVRKGIPFRDAHEIVGKTVRYCIENEMDIPELSLAEWQLFSGRIE
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHH
EDIFESITLQASVNARRATGGTALERVRAEIARAKEGR
HHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA