Definition Geobacter bemidjiensis Bem chromosome, complete genome.
Accession NC_011146
Length 4,615,150

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The map label for this gene is thiE/thiD [H]

Identifier: 197119824

GI number: 197119824

Start: 3975447

End: 3976901

Strand: Direct

Name: thiE/thiD [H]

Synonym: Gbem_3462

Alternate gene names: 197119824

Gene position: 3975447-3976901 (Clockwise)

Preceding gene: 308535366

Following gene: 197119825

Centisome position: 86.14

GC content: 66.67

Gene sequence:

>1455_bases
GTGCTAAGACTCGTGGTGGATCATAGTGGCAAGGAGCGGCGCATAGGGGGGCTCTACCTCATCACGGATCAAGCTGAGCG
CCTGGTCCACCGCGTGCGCGAGGCGCTCTCCTCGGGAGGGGTCGCCGTCCTGCAGTACCGGGACAAGGTCCGCAGCTACG
AGGAACGCCTGGAACTGGGACAGGAGCTGAAACACCTCTGCACGGAATTCCAGGTGGAATTCATCGTCAACGACGACGTC
GAACTGGCCTTCGCCCTCGACGCCGACGGCGTCCATCTGGGGCAGGACGACGGCGACCCGGCCGCGGCACGCGAGGCGCT
CGGCCCCAAAAAGATGATCGGGATCTCGACCCATTCGCTCACGGAAGCGCTCGAGGCGCAGGAGGCCGGCGCCGACTACG
TCGGCTTCGGAGCCATCTACCCCACCGACAGCAAGGAGGTCGAGCATATCCAGGGGCCGGAGAAGCTCGTGCTTTTGAAG
GAAAAGCTGAGGATACCGGTGGTCGCCATCGGCGGCATCACCAGGGACAACGCCTGCGCGGTGATCGACGCCGGAGCCGA
CGCCATCGCGGTGATCTCGGCGGTGCTGTCGGCCAGATCCCCCGCGCTCGCCGCGACGGAACTGGCGCTCCTCTTCAACA
GGAAGGCGATGCAGCCGCGCGGCGGCGTGCTCACCGTGGCCGGGAGCGACTCGGGAGGGGGCGCCGGCATCCAGGCGGAC
CTGAAGACTGTGACGCTTTTGGGAAGCTACGGCGCCTCTGCCGTCACCGCGCTTACCGCACAGAACACCCGCGGCGTTAC
CGCCATCCATCCGGTCCCGGCCGCCTTCCTCGCGGAACAGATCGACGCGGTCCTTACGGACATCCCGATCGACGTGGTGA
AGGTAGGGATGCTCTCCTCGGCCGAGAACGCCGCCACCCTCGCCGACAGGCTCACCGACCACGGCGTGAGGATGGTGGTG
CTCGACCCGGTGATGAGCGCCAAGGGGGGGGTAGCGCTCATGGAGGACGAGGCGCTAGGCGTCCTGAAACAGAGGCTCAT
CCCGCTTTGCTACCTGCTCACGCCGAACATCCCGGAGGCCGAGGCCCTCACCGGGCTCACCATCACCGATACGGCCGGCA
TGGAACTAGCTGCTCGGGCTCTGCACCTCATGGGGGCAAAGCACGTGCTGGTCAAGGGGGGGCACCTGACCGAGGGGGTA
GTCACCGACATCCTCTTCGACGGCGCCGGCTTCACCCGCTTCACGGCTCCGCGCGTACTCACCCGCAACACCCACGGCAC
CGGCTGCACGCTGGCCTCGGCAATAGCAAGCTATCTAGCCCAGGGGGAACCGCTCCCCGGCGCGGTGCTCCGGGCGAAGC
TCTTCGTCACCCGCGCCATCAAGTACGCCCAACCGCTGGGAAAGGGGCACGGCCCCGTGAACCATTTCATGGCGGCAAGA
GACCAGGCCGAATAA

Upstream 100 bases:

>100_bases
GACTTTGCTTTTAGCTTCTCTCCGGTTCTGTTTATTCTCAGATGTGCTCAGATTTTCTCCTTGTTAGAGGTTTGGTTTCT
CCAGTTTCTCTGAGGTTACC

Downstream 100 bases:

>100_bases
ACCAGGGGCTAGGGGCTGGGAATTTTCATCGACACGACAAGAAGCAAGTTCAATAAAGGAGTAGACATGACTCAGCTCGA
ATACGCCCGCAAGGGGATCA

Product: bifunctional 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate kinase/thiamin monophosphate synthase

Products: NA

Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MLRLVVDHSGKERRIGGLYLITDQAERLVHRVREALSSGGVAVLQYRDKVRSYEERLELGQELKHLCTEFQVEFIVNDDV
ELAFALDADGVHLGQDDGDPAAAREALGPKKMIGISTHSLTEALEAQEAGADYVGFGAIYPTDSKEVEHIQGPEKLVLLK
EKLRIPVVAIGGITRDNACAVIDAGADAIAVISAVLSARSPALAATELALLFNRKAMQPRGGVLTVAGSDSGGGAGIQAD
LKTVTLLGSYGASAVTALTAQNTRGVTAIHPVPAAFLAEQIDAVLTDIPIDVVKVGMLSSAENAATLADRLTDHGVRMVV
LDPVMSAKGGVALMEDEALGVLKQRLIPLCYLLTPNIPEAEALTGLTITDTAGMELAARALHLMGAKHVLVKGGHLTEGV
VTDILFDGAGFTRFTAPRVLTRNTHGTGCTLASAIASYLAQGEPLPGAVLRAKLFVTRAIKYAQPLGKGHGPVNHFMAAR
DQAE

Sequences:

>Translated_484_residues
MLRLVVDHSGKERRIGGLYLITDQAERLVHRVREALSSGGVAVLQYRDKVRSYEERLELGQELKHLCTEFQVEFIVNDDV
ELAFALDADGVHLGQDDGDPAAAREALGPKKMIGISTHSLTEALEAQEAGADYVGFGAIYPTDSKEVEHIQGPEKLVLLK
EKLRIPVVAIGGITRDNACAVIDAGADAIAVISAVLSARSPALAATELALLFNRKAMQPRGGVLTVAGSDSGGGAGIQAD
LKTVTLLGSYGASAVTALTAQNTRGVTAIHPVPAAFLAEQIDAVLTDIPIDVVKVGMLSSAENAATLADRLTDHGVRMVV
LDPVMSAKGGVALMEDEALGVLKQRLIPLCYLLTPNIPEAEALTGLTITDTAGMELAARALHLMGAKHVLVKGGHLTEGV
VTDILFDGAGFTRFTAPRVLTRNTHGTGCTLASAIASYLAQGEPLPGAVLRAKLFVTRAIKYAQPLGKGHGPVNHFMAAR
DQAE
>Mature_484_residues
MLRLVVDHSGKERRIGGLYLITDQAERLVHRVREALSSGGVAVLQYRDKVRSYEERLELGQELKHLCTEFQVEFIVNDDV
ELAFALDADGVHLGQDDGDPAAAREALGPKKMIGISTHSLTEALEAQEAGADYVGFGAIYPTDSKEVEHIQGPEKLVLLK
EKLRIPVVAIGGITRDNACAVIDAGADAIAVISAVLSARSPALAATELALLFNRKAMQPRGGVLTVAGSDSGGGAGIQAD
LKTVTLLGSYGASAVTALTAQNTRGVTAIHPVPAAFLAEQIDAVLTDIPIDVVKVGMLSSAENAATLADRLTDHGVRMVV
LDPVMSAKGGVALMEDEALGVLKQRLIPLCYLLTPNIPEAEALTGLTITDTAGMELAARALHLMGAKHVLVKGGHLTEGV
VTDILFDGAGFTRFTAPRVLTRNTHGTGCTLASAIASYLAQGEPLPGAVLRAKLFVTRAIKYAQPLGKGHGPVNHFMAAR
DQAE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=262, Percent_Identity=45.8015267175573, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1790426, Length=194, Percent_Identity=34.5360824742268, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6325378, Length=273, Percent_Identity=35.1648351648352, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324997, Length=272, Percent_Identity=37.5, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324517, Length=274, Percent_Identity=36.1313868613139, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325042, Length=221, Percent_Identity=30.316742081448, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013749
- InterPro:   IPR004399
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF08543 Phos_pyr_kin; PF02581 TMP-TENI [H]

EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 50909; Mature: 50909

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLVVDHSGKERRIGGLYLITDQAERLVHRVREALSSGGVAVLQYRDKVRSYEERLELG
CEEEEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
QELKHLCTEFQVEFIVNDDVELAFALDADGVHLGQDDGDPAAAREALGPKKMIGISTHSL
HHHHHHHHHEEEEEEECCCCEEEEEECCCCEECCCCCCCHHHHHHHCCCHHEEECCHHHH
TEALEAQEAGADYVGFGAIYPTDSKEVEHIQGPEKLVLLKEKLRIPVVAIGGITRDNACA
HHHHHHHHCCCCEEECCEECCCCCCHHHHHCCCHHEEEEHHHHCCCEEEECCCCCCCCEE
VIDAGADAIAVISAVLSARSPALAATELALLFNRKAMQPRGGVLTVAGSDSGGGAGIQAD
EEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEC
LKTVTLLGSYGASAVTALTAQNTRGVTAIHPVPAAFLAEQIDAVLTDIPIDVVKVGMLSS
CEEEEEEECCCCHHEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHCC
AENAATLADRLTDHGVRMVVLDPVMSAKGGVALMEDEALGVLKQRLIPLCYLLTPNIPEA
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHEEEEECCCCCCH
EALTGLTITDTAGMELAARALHLMGAKHVLVKGGHLTEGVVTDILFDGAGFTRFTAPRVL
HHHCCEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCEECCCCEE
TRNTHGTGCTLASAIASYLAQGEPLPGAVLRAKLFVTRAIKYAQPLGKGHGPVNHFMAAR
ECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHC
DQAE
CCCC
>Mature Secondary Structure
MLRLVVDHSGKERRIGGLYLITDQAERLVHRVREALSSGGVAVLQYRDKVRSYEERLELG
CEEEEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
QELKHLCTEFQVEFIVNDDVELAFALDADGVHLGQDDGDPAAAREALGPKKMIGISTHSL
HHHHHHHHHEEEEEEECCCCEEEEEECCCCEECCCCCCCHHHHHHHCCCHHEEECCHHHH
TEALEAQEAGADYVGFGAIYPTDSKEVEHIQGPEKLVLLKEKLRIPVVAIGGITRDNACA
HHHHHHHHCCCCEEECCEECCCCCCHHHHHCCCHHEEEEHHHHCCCEEEECCCCCCCCEE
VIDAGADAIAVISAVLSARSPALAATELALLFNRKAMQPRGGVLTVAGSDSGGGAGIQAD
EEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEC
LKTVTLLGSYGASAVTALTAQNTRGVTAIHPVPAAFLAEQIDAVLTDIPIDVVKVGMLSS
CEEEEEEECCCCHHEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHCC
AENAATLADRLTDHGVRMVVLDPVMSAKGGVALMEDEALGVLKQRLIPLCYLLTPNIPEA
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHEEEEECCCCCCH
EALTGLTITDTAGMELAARALHLMGAKHVLVKGGHLTEGVVTDILFDGAGFTRFTAPRVL
HHHCCEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCEECCCCEE
TRNTHGTGCTLASAIASYLAQGEPLPGAVLRAKLFVTRAIKYAQPLGKGHGPVNHFMAAR
ECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHC
DQAE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA