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The map label for this gene is degQ [H]

Identifier: 197119758

GI number: 197119758

Start: 3909120

End: 3910550

Strand: Direct

Name: degQ [H]

Synonym: Gbem_3394

Alternate gene names: 197119758

Gene position: 3909120-3910550 (Clockwise)

Preceding gene: 197119752

Following gene: 197119759

Centisome position: 84.7

GC content: 60.73

Gene sequence:

>1431_bases
ATGAAAAGCATCAGACTCCTCGCTGTCTGCCTTATTGTCTGCACGTTAATGATAGCCTGCAAGAAAAAGGAGCAGGCATC
CTTCTACGAATCCGAGCGAAAGGAGAGCGTCCCGGCCCCGGTCCAGGAGGTCCCCAAGGACATCCTGGTGACGCAACAGG
CCTTCACCACGCTGGTCAAGACCGTGACCCCCTCCGTCGTCAACATCTCCACCATCGGCAAGAAAAAGCTGGTCCGCCCC
TTCTTCGAGTCGTCACCTTTCTTCGACGAGTTCTTCGGCGAAAACGCACGCCCGCAGTATCGAAGGGAACATAGCTTAGG
CTCCGGCTTCATCCTGAACAAGGAAGGGTATATCGTCACCAACGACCACGTGGTGCGGGACGCCGAGACCATACAGGTGA
AGCTTTCCAACGAAAGCGTCTACAAGGGGAAGGTGATCGGCTCGGACCCGAAGACGGACATCGCGGTGATAAAGATCGAC
GCCAAAGAGCCGCTGCCTGCAGCGGTCCTCGGGGATTCCAACAAGCTGCAGGTCGGGCAGTGGGCCGTCGCCATCGGGAA
CCCCTTTGGCCTGGACCGCACCGTCACCGTCGGCGTTGTCTCGGCAACCGGCAGGTCGAACATGGGGATCGAGACCTACG
AGGATTTCATACAGACCGACGCCTCCATCAACCCCGGAAACTCCGGCGGACCGCTGCTTAACATCTACGGCGAGGTGATC
GGAATCAACACAGCCATCGTCGCCGCCGGACAGGGAATCGGCTTCGCCATCCCGGTAAACATGGCAAAGCAGGTGGTGAC
GCAGTTGATCAGCAAGGGGAACGTAAGCCGCGGCTGGCTCGGCGTCTCGATCCAGTCGGTGACCGAAGAGATGGCAAACT
CCTTCGGGCTTCCCAAAGCGTACGGCGCGCTGGTGAACGACGTCGTTCCAGGGGGGCCGGCTGCGAAGGCCGGCGTCATG
CAGGGGGACGTAATCACGAGCTTTGCCGGGACGGCCGTAAAGGACGTGCGCCAGTTGCAGCGCCTGGTCGGCGAAACACC
CATCGGCAAGAAAGTTCCGGTGGAGCTCTATCGCGACGGCAAGAAGATCAACGTCCAGATAACCACTGCACCTGCCGACA
GCGCCCAGGCACAGACACAAAGACCTGCCGAGCGGGAAGCGGGAGCCCTGGGGCTCTCGGTCGAGGAACTGGGAGCGGAG
ATGCGTTCCCGCGGCGTCACCGGCGTGGTGGTGAGCGACCTCGAACCGGGCGGGATCGCGGAAGAAAGCGGCATCCAGCG
CGGCGACATCATCGTATCCGTGAACCAGAAGAAAGTGAGAAATCTGGCCGAGTACCAGAAGGCAATGGCGGACGCCGGCA
AACGCGGCGCCGTCGCGCTCCTAGTCCGGAGAGGCTCGGCCAGCATCTACTTCGCCCTAAAATTAAGATAG

Upstream 100 bases:

>100_bases
CTCCCCAGTAGCCACCCAAACGGCGGAAGGGGTTGACATCAATCCTTTTTTTGGCTAGCCTTTACACTTCCTGCCCGAGC
ATCACCCCAAGGAGCGACAA

Downstream 100 bases:

>100_bases
AATCTTGCGAAAAAACTGCGTATAGTGCGTTGCTGACATTCAGCACCGGGGAGCGATCCAATGAGTCTCATTGAAAATCC
AGACCAGGCTAAACGACTCG

Product: protease lipoprotein DegQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKSIRLLAVCLIVCTLMIACKKKEQASFYESERKESVPAPVQEVPKDILVTQQAFTTLVKTVTPSVVNISTIGKKKLVRP
FFESSPFFDEFFGENARPQYRREHSLGSGFILNKEGYIVTNDHVVRDAETIQVKLSNESVYKGKVIGSDPKTDIAVIKID
AKEPLPAAVLGDSNKLQVGQWAVAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNIYGEVI
GINTAIVAAGQGIGFAIPVNMAKQVVTQLISKGNVSRGWLGVSIQSVTEEMANSFGLPKAYGALVNDVVPGGPAAKAGVM
QGDVITSFAGTAVKDVRQLQRLVGETPIGKKVPVELYRDGKKINVQITTAPADSAQAQTQRPAEREAGALGLSVEELGAE
MRSRGVTGVVVSDLEPGGIAEESGIQRGDIIVSVNQKKVRNLAEYQKAMADAGKRGAVALLVRRGSASIYFALKLR

Sequences:

>Translated_476_residues
MKSIRLLAVCLIVCTLMIACKKKEQASFYESERKESVPAPVQEVPKDILVTQQAFTTLVKTVTPSVVNISTIGKKKLVRP
FFESSPFFDEFFGENARPQYRREHSLGSGFILNKEGYIVTNDHVVRDAETIQVKLSNESVYKGKVIGSDPKTDIAVIKID
AKEPLPAAVLGDSNKLQVGQWAVAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNIYGEVI
GINTAIVAAGQGIGFAIPVNMAKQVVTQLISKGNVSRGWLGVSIQSVTEEMANSFGLPKAYGALVNDVVPGGPAAKAGVM
QGDVITSFAGTAVKDVRQLQRLVGETPIGKKVPVELYRDGKKINVQITTAPADSAQAQTQRPAEREAGALGLSVEELGAE
MRSRGVTGVVVSDLEPGGIAEESGIQRGDIIVSVNQKKVRNLAEYQKAMADAGKRGAVALLVRRGSASIYFALKLR
>Mature_476_residues
MKSIRLLAVCLIVCTLMIACKKKEQASFYESERKESVPAPVQEVPKDILVTQQAFTTLVKTVTPSVVNISTIGKKKLVRP
FFESSPFFDEFFGENARPQYRREHSLGSGFILNKEGYIVTNDHVVRDAETIQVKLSNESVYKGKVIGSDPKTDIAVIKID
AKEPLPAAVLGDSNKLQVGQWAVAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNIYGEVI
GINTAIVAAGQGIGFAIPVNMAKQVVTQLISKGNVSRGWLGVSIQSVTEEMANSFGLPKAYGALVNDVVPGGPAAKAGVM
QGDVITSFAGTAVKDVRQLQRLVGETPIGKKVPVELYRDGKKINVQITTAPADSAQAQTQRPAEREAGALGLSVEELGAE
MRSRGVTGVVVSDLEPGGIAEESGIQRGDIIVSVNQKKVRNLAEYQKAMADAGKRGAVALLVRRGSASIYFALKLR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=308, Percent_Identity=37.987012987013, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI22129776, Length=309, Percent_Identity=35.9223300970874, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI24308541, Length=290, Percent_Identity=35.8620689655172, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI7019477, Length=246, Percent_Identity=38.6178861788618, Blast_Score=146, Evalue=5e-35,
Organism=Escherichia coli, GI1786356, Length=447, Percent_Identity=39.8210290827741, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1789629, Length=426, Percent_Identity=39.6713615023474, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1789630, Length=375, Percent_Identity=33.3333333333333, Blast_Score=195, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24646839, Length=307, Percent_Identity=32.2475570032573, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50756; Mature: 50756

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIRLLAVCLIVCTLMIACKKKEQASFYESERKESVPAPVQEVPKDILVTQQAFTTLVK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHH
TVTPSVVNISTIGKKKLVRPFFESSPFFDEFFGENARPQYRREHSLGSGFILNKEGYIVT
HHCCCEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHCCCCCCEEECCCCEEEE
NDHVVRDAETIQVKLSNESVYKGKVIGSDPKTDIAVIKIDAKEPLPAAVLGDSNKLQVGQ
CCCEEECCEEEEEEECCCCEEECEEECCCCCCCEEEEEEECCCCCCEEEECCCCCEEECE
WAVAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNIYGEVI
EEEEECCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECHHHH
GINTAIVAAGQGIGFAIPVNMAKQVVTQLISKGNVSRGWLGVSIQSVTEEMANSFGLPKA
CCCEEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCHH
YGALVNDVVPGGPAAKAGVMQGDVITSFAGTAVKDVRQLQRLVGETPIGKKVPVELYRDG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KKINVQITTAPADSAQAQTQRPAEREAGALGLSVEELGAEMRSRGVTGVVVSDLEPGGIA
CEEEEEEEECCCCCCHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
EESGIQRGDIIVSVNQKKVRNLAEYQKAMADAGKRGAVALLVRRGSASIYFALKLR
HHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEEC
>Mature Secondary Structure
MKSIRLLAVCLIVCTLMIACKKKEQASFYESERKESVPAPVQEVPKDILVTQQAFTTLVK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHH
TVTPSVVNISTIGKKKLVRPFFESSPFFDEFFGENARPQYRREHSLGSGFILNKEGYIVT
HHCCCEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHCCCCCCEEECCCCEEEE
NDHVVRDAETIQVKLSNESVYKGKVIGSDPKTDIAVIKIDAKEPLPAAVLGDSNKLQVGQ
CCCEEECCEEEEEEECCCCEEECEEECCCCCCCEEEEEEECCCCCCEEEECCCCCEEECE
WAVAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNIYGEVI
EEEEECCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECHHHH
GINTAIVAAGQGIGFAIPVNMAKQVVTQLISKGNVSRGWLGVSIQSVTEEMANSFGLPKA
CCCEEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCHH
YGALVNDVVPGGPAAKAGVMQGDVITSFAGTAVKDVRQLQRLVGETPIGKKVPVELYRDG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KKINVQITTAPADSAQAQTQRPAEREAGALGLSVEELGAEMRSRGVTGVVVSDLEPGGIA
CEEEEEEEECCCCCCHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
EESGIQRGDIIVSVNQKKVRNLAEYQKAMADAGKRGAVALLVRRGSASIYFALKLR
HHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]