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The map label for this gene is dxs-1 [H]

Identifier: 197119726

GI number: 197119726

Start: 3864605

End: 3866512

Strand: Direct

Name: dxs-1 [H]

Synonym: Gbem_3362

Alternate gene names: 197119726

Gene position: 3864605-3866512 (Clockwise)

Preceding gene: 197119725

Following gene: 197119727

Centisome position: 83.74

GC content: 63.57

Gene sequence:

>1908_bases
ATGTACAAACTGCTAAGCAAGATCAACGGTCCCGACGACCTGAAGAAGCTTGATGCCGAGGAACTGACTCCCCTTGCCGA
AGAAGTGCGCGCCTTTCTCCTGGAGACGGTGACAAGGACCGGCGGACACCTCGCCTCCAACCTCGGAGCGGTCGAGCTGA
CCATCGCGCTGCACTACTGCTTCGATTCCCCCAAGGACAAGATCATCTGGGACGTCGGGCACCAGGCCTACACCCACAAG
ATCCTCACCGGTCGCCGCGACAGCTTCCACACCCAGCGCTGCTACAAGGGGATCAGCGGCTTTCCCAAGCGCGCGGAATC
CCCCCACGACGCCTTCGGCGTAGGTCACTCCTCCACCTCCATCTCCGCCGGGCTCGGCATGGCGGTAGCGCAGGGGCTCA
AGGAGGATGCGGCCCGCGTCATCTCCGTCATCGGCGACGGCTCCCTTACCGGCGGCATGGCCTTCGAGGCGTTGAACCAG
GCGGGTCATCTCAAGAAAAACCTGATAGTGGTCTTGAACGACAACGAGATGTCCATCTCCAAAAACGTCGGCGCCCTCTC
CTCCTTCATCTCGCGCAAGATGACCGGCGGCTATTACCGCAGCCTCAAGAAGGAGATGGAGGCGCTCATGGCCAACATCC
CTGCCATCGGCGGCAACATCCTGCACTTCGCGAAGAAGGCGGAGAACTCGCTCAAGGGTTTCCTCACCCCCGGCACCCTC
TTCGAGGGTCTCGGCTTCGAGTACGTCGGCCCCATCGCCGGGCACGACCTCCCCACCCTCCTGGGTGTGCTGGAAAACGT
AAAACGGCTCGAAGGGCCGATCCTTTTGCACGTGATGACCAAGAAGGGAAAGGGCTACCCGCCCGCCGAGACCATGCCGG
ACAAGTTCCACGGTGTGGCGCCCACCAAGCCGGCGAGCGCCTCCCCGGCCAAGCTCCCCCCTCCTTCCTACACCAGCGTC
TTCGGCAACACCATGGTGAAGCTGGGCGAGATAGACCCGAAGATACTGGCGATCACCGCCGCCATGCCCGACGGCACCGG
CTTGACGCCGTTCGCCGAGCGCTTCCCGGACCGTTTCTTCGACGTGGGAATAGCCGAGCAGCACGCGCTCACCTTCGCGG
CGGGGCTCGCCGTAGAAGGGTTCCGCCCGGTCGCCGCCATCTACTCCACCTTTACCCAGCGTGCTTACGACCAGATCTTC
CACGACGTCTGCCTGCAGAAGCTGCCGGTCACCCTCGCGCTCGACCGCGCAGGCCTCGTCGGCGACGACGGCCCGACGCA
CCACGGCAGCTTCGACATCTCGTATCTCCGGCACCTCCCCGAGCTGACCGTAATGGCGCCCAAAGACGAGAACGAACTGC
AGCACATGCTGAAGACCGCCCTTTACTCGGGGCGTCCCATCTCGCTGCGCTACCCGCGCGGCGCCGGTTTCGGCGTCCCC
CTGGACCATGAGCTGCAGGAGCTTCCCATCGGCAAGGGCGAACTCCTTATCGATGGCGGCGATCTCACCATAGTCGCCAT
AGGGTCCACCGTCCATCCGGCACTGGAGGCCGCGGCCCAGCTAAGGCAGAAGGGAATCTTCGCCGCCGTGGTCAACGCGC
GCTTCATAAAGCCGATCGACTCCGAGCTGATCTTGGCCCAGGCCAAAAAGACCGGCTGCCTCGTCACCGTCGAAGAGAAC
GCGCTTTTGGGCGGCTTCGGCAGCGCCGTGCTCGAACTCCTTTCCGACGCGGGATTGAACGCGGTCCGGATCAAGAGGAT
CGGCATACCCGACCGCTTCATTGAGCAGGGGACCCAGGCACAGTTGAGGGCGGACCTTGGTCTCGATGCCGCCGGCATCG
CCGCCACCTGCGAAACATTCCTCAAAGGGGAGAGCGGAACGTCTCCGCAGCTTGCCGTGGTCAAATAG

Upstream 100 bases:

>100_bases
GCAGCAACGGCTACGTAAACCGGTGAAGCAAAAGCCGTAGACGTTGGACATTGAGTTTCTTTTTTTGCATTGATATCGCT
ACGGGTTCTCAAGGAGATCC

Downstream 100 bases:

>100_bases
CTTAAAATCCCCGGGAGTCACCAGATGCGGGACAGGCTGAGCGGAAGATTTTCTCCGGCTTGTCCCGCAACCTTGTTCGT
CCGTAAAATCCAGAGCCATA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 2; DXP synthase 2; DXPS 2 [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MYKLLSKINGPDDLKKLDAEELTPLAEEVRAFLLETVTRTGGHLASNLGAVELTIALHYCFDSPKDKIIWDVGHQAYTHK
ILTGRRDSFHTQRCYKGISGFPKRAESPHDAFGVGHSSTSISAGLGMAVAQGLKEDAARVISVIGDGSLTGGMAFEALNQ
AGHLKKNLIVVLNDNEMSISKNVGALSSFISRKMTGGYYRSLKKEMEALMANIPAIGGNILHFAKKAENSLKGFLTPGTL
FEGLGFEYVGPIAGHDLPTLLGVLENVKRLEGPILLHVMTKKGKGYPPAETMPDKFHGVAPTKPASASPAKLPPPSYTSV
FGNTMVKLGEIDPKILAITAAMPDGTGLTPFAERFPDRFFDVGIAEQHALTFAAGLAVEGFRPVAAIYSTFTQRAYDQIF
HDVCLQKLPVTLALDRAGLVGDDGPTHHGSFDISYLRHLPELTVMAPKDENELQHMLKTALYSGRPISLRYPRGAGFGVP
LDHELQELPIGKGELLIDGGDLTIVAIGSTVHPALEAAAQLRQKGIFAAVVNARFIKPIDSELILAQAKKTGCLVTVEEN
ALLGGFGSAVLELLSDAGLNAVRIKRIGIPDRFIEQGTQAQLRADLGLDAAGIAATCETFLKGESGTSPQLAVVK

Sequences:

>Translated_635_residues
MYKLLSKINGPDDLKKLDAEELTPLAEEVRAFLLETVTRTGGHLASNLGAVELTIALHYCFDSPKDKIIWDVGHQAYTHK
ILTGRRDSFHTQRCYKGISGFPKRAESPHDAFGVGHSSTSISAGLGMAVAQGLKEDAARVISVIGDGSLTGGMAFEALNQ
AGHLKKNLIVVLNDNEMSISKNVGALSSFISRKMTGGYYRSLKKEMEALMANIPAIGGNILHFAKKAENSLKGFLTPGTL
FEGLGFEYVGPIAGHDLPTLLGVLENVKRLEGPILLHVMTKKGKGYPPAETMPDKFHGVAPTKPASASPAKLPPPSYTSV
FGNTMVKLGEIDPKILAITAAMPDGTGLTPFAERFPDRFFDVGIAEQHALTFAAGLAVEGFRPVAAIYSTFTQRAYDQIF
HDVCLQKLPVTLALDRAGLVGDDGPTHHGSFDISYLRHLPELTVMAPKDENELQHMLKTALYSGRPISLRYPRGAGFGVP
LDHELQELPIGKGELLIDGGDLTIVAIGSTVHPALEAAAQLRQKGIFAAVVNARFIKPIDSELILAQAKKTGCLVTVEEN
ALLGGFGSAVLELLSDAGLNAVRIKRIGIPDRFIEQGTQAQLRADLGLDAAGIAATCETFLKGESGTSPQLAVVK
>Mature_635_residues
MYKLLSKINGPDDLKKLDAEELTPLAEEVRAFLLETVTRTGGHLASNLGAVELTIALHYCFDSPKDKIIWDVGHQAYTHK
ILTGRRDSFHTQRCYKGISGFPKRAESPHDAFGVGHSSTSISAGLGMAVAQGLKEDAARVISVIGDGSLTGGMAFEALNQ
AGHLKKNLIVVLNDNEMSISKNVGALSSFISRKMTGGYYRSLKKEMEALMANIPAIGGNILHFAKKAENSLKGFLTPGTL
FEGLGFEYVGPIAGHDLPTLLGVLENVKRLEGPILLHVMTKKGKGYPPAETMPDKFHGVAPTKPASASPAKLPPPSYTSV
FGNTMVKLGEIDPKILAITAAMPDGTGLTPFAERFPDRFFDVGIAEQHALTFAAGLAVEGFRPVAAIYSTFTQRAYDQIF
HDVCLQKLPVTLALDRAGLVGDDGPTHHGSFDISYLRHLPELTVMAPKDENELQHMLKTALYSGRPISLRYPRGAGFGVP
LDHELQELPIGKGELLIDGGDLTIVAIGSTVHPALEAAAQLRQKGIFAAVVNARFIKPIDSELILAQAKKTGCLVTVEEN
ALLGGFGSAVLELLSDAGLNAVRIKRIGIPDRFIEQGTQAQLRADLGLDAAGIAATCETFLKGESGTSPQLAVVK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=634, Percent_Identity=24.9211356466877, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI4507521, Length=634, Percent_Identity=24.9211356466877, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI133778974, Length=508, Percent_Identity=23.4251968503937, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI225637459, Length=522, Percent_Identity=24.3295019157088, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI225637461, Length=522, Percent_Identity=24.3295019157088, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI225637463, Length=522, Percent_Identity=24.3295019157088, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI156564403, Length=255, Percent_Identity=27.4509803921569, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4557353, Length=228, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI34101272, Length=228, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI291084858, Length=208, Percent_Identity=28.8461538461538, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=49.9197431781701, Blast_Score=609, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17539652, Length=673, Percent_Identity=23.9227340267459, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17538422, Length=225, Percent_Identity=28.4444444444444, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319698, Length=240, Percent_Identity=28.75, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45551847, Length=607, Percent_Identity=25.8649093904448, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45550715, Length=607, Percent_Identity=25.8649093904448, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24645119, Length=565, Percent_Identity=26.1946902654867, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24666278, Length=605, Percent_Identity=24.7933884297521, Blast_Score=106, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21358145, Length=227, Percent_Identity=29.5154185022026, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24650940, Length=227, Percent_Identity=29.5154185022026, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI160714832, Length=233, Percent_Identity=26.6094420600858, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI160714828, Length=234, Percent_Identity=26.4957264957265, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67894; Mature: 67894

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLLSKINGPDDLKKLDAEELTPLAEEVRAFLLETVTRTGGHLASNLGAVELTIALHYC
CCCHHHHCCCHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEEEEH
FDSPKDKIIWDVGHQAYTHKILTGRRDSFHTQRCYKGISGFPKRAESPHDAFGVGHSSTS
HCCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCC
ISAGLGMAVAQGLKEDAARVISVIGDGSLTGGMAFEALNQAGHLKKNLIVVLNDNEMSIS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEHH
KNVGALSSFISRKMTGGYYRSLKKEMEALMANIPAIGGNILHFAKKAENSLKGFLTPGTL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHH
FEGLGFEYVGPIAGHDLPTLLGVLENVKRLEGPILLHVMTKKGKGYPPAETMPDKFHGVA
HHCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHCCCC
PTKPASASPAKLPPPSYTSVFGNTMVKLGEIDPKILAITAAMPDGTGLTPFAERFPDRFF
CCCCCCCCCCCCCCCCHHHHHHCHHEEECCCCCEEEEEEEECCCCCCCCHHHHHCCHHHH
DVGIAEQHALTFAAGLAVEGFRPVAAIYSTFTQRAYDQIFHDVCLQKLPVTLALDRAGLV
HCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
GDDGPTHHGSFDISYLRHLPELTVMAPKDENELQHMLKTALYSGRPISLRYPRGAGFGVP
CCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
LDHELQELPIGKGELLIDGGDLTIVAIGSTVHPALEAAAQLRQKGIFAAVVNARFIKPID
CCCHHHHCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHCCHHEEEHHHHHCCCCC
SELILAQAKKTGCLVTVEENALLGGFGSAVLELLSDAGLNAVRIKRIGIPDRFIEQGTQA
CHHHHHECCCCCEEEEEECCCEECHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHH
QLRADLGLDAAGIAATCETFLKGESGTSPQLAVVK
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEC
>Mature Secondary Structure
MYKLLSKINGPDDLKKLDAEELTPLAEEVRAFLLETVTRTGGHLASNLGAVELTIALHYC
CCCHHHHCCCHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEEEEH
FDSPKDKIIWDVGHQAYTHKILTGRRDSFHTQRCYKGISGFPKRAESPHDAFGVGHSSTS
HCCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCC
ISAGLGMAVAQGLKEDAARVISVIGDGSLTGGMAFEALNQAGHLKKNLIVVLNDNEMSIS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEHH
KNVGALSSFISRKMTGGYYRSLKKEMEALMANIPAIGGNILHFAKKAENSLKGFLTPGTL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHH
FEGLGFEYVGPIAGHDLPTLLGVLENVKRLEGPILLHVMTKKGKGYPPAETMPDKFHGVA
HHCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHCCCC
PTKPASASPAKLPPPSYTSVFGNTMVKLGEIDPKILAITAAMPDGTGLTPFAERFPDRFF
CCCCCCCCCCCCCCCCHHHHHHCHHEEECCCCCEEEEEEEECCCCCCCCHHHHHCCHHHH
DVGIAEQHALTFAAGLAVEGFRPVAAIYSTFTQRAYDQIFHDVCLQKLPVTLALDRAGLV
HCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
GDDGPTHHGSFDISYLRHLPELTVMAPKDENELQHMLKTALYSGRPISLRYPRGAGFGVP
CCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
LDHELQELPIGKGELLIDGGDLTIVAIGSTVHPALEAAAQLRQKGIFAAVVNARFIKPID
CCCHHHHCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHCCHHEEEHHHHHCCCCC
SELILAQAKKTGCLVTVEENALLGGFGSAVLELLSDAGLNAVRIKRIGIPDRFIEQGTQA
CHHHHHECCCCCEEEEEECCCEECHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHH
QLRADLGLDAAGIAATCETFLKGESGTSPQLAVVK
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA