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The map label for this gene is cphA [H]

Identifier: 197119537

GI number: 197119537

Start: 3649540

End: 3650448

Strand: Direct

Name: cphA [H]

Synonym: Gbem_3167

Alternate gene names: 197119537

Gene position: 3649540-3650448 (Clockwise)

Preceding gene: 197119536

Following gene: 308535354

Centisome position: 79.08

GC content: 58.86

Gene sequence:

>909_bases
ATGAAAAAGACAGCCGCACTTGCCGCACTCTCCGCACTGGTCCTCACCCTGCTGTTCGTTAACAGCGCCTGCGCGGAACT
CACCAAGATATCCAACAACGTCTATTCCTACGTCGGCGTAAAGGATGCATCCCCCGGCAACAGCTTCGCCGCCAACGCAG
GGATCGTCATCGGGCGGGACGGTGTCCTCGTCGTCGACACGCTGATCTCCGCCAAAGAAGGAAAGCGTTTCCTGGCCGAC
ATCCGCAAGGTCACCAATAAGCCGATCAAGTACGTCGTCAACACCCACACCCATCTCGACCACGCCCTGGGGAACTGCGT
CTTCGCCAATCTGGGCGCCGCCATCATCTCCCACCAGGCGGAGCGGGCCAGTTTAGAGGCGAACGGGCCGCTGATGCTGC
GCAACATCGGGAGCAAGGGGCTGAAACCTGAGGACGTGGCCGGTACCGAGGTCGTGCTCCCTAACCTCGCCTTCAGCGAT
CAGATGCTGATAGACCTGGGAGGGGAGGAGATCCGGCTGATCCGTTTGTCGCCCTCGCACACCGCCGGAAGCATCGTGGT
CTACCTCCCGACGCAGAAGATCCTTTTCAGCGGCGACATCCTCTTCACCGATTTCCATCCCTTTCTTGCCGACGGCGATT
TCAAAGGGTGGATCGGCAGCATCGACAAACTGCTCGACATGGAGATCGACGGCATCATCCCGGGGCACGGCCCGCTTTCC
ACCAAGAAGGACCTCCGGGACATGAAGAATTACATCGTCCTGTTCGACAAGAGGGCGCGGGAGCTGGCCACGAAATCGCA
GGATTCCCAGGTCATTTCCGCGCAGTTATTGAAAGAACTGCCGAAGCGCTCCATGGCTGAATGGATGGTGAACTACAACG
TGCTCAGCAGGTACATCGGGAAAAACTAG

Upstream 100 bases:

>100_bases
GGTAGCACCTCGAAAGAAAAATAAGCCCGGACGCACCTGCCCGATATCGAGCCGTTATCCCATGTGATGCTTAAATCAAA
ATGCAAAAGGAGAACTTCGG

Downstream 100 bases:

>100_bases
GCGCAGCACTGCGCCGCCAAGCGACGACAGAAAAAGGGGACAGGCTACTTTTCGATTCGAAAAAGTAGCCTGTCCCCTTT
TATCTTCCAGTCACCTGTTT

Product: glyoxylase-like zinc-dependent hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKKTAALAALSALVLTLLFVNSACAELTKISNNVYSYVGVKDASPGNSFAANAGIVIGRDGVLVVDTLISAKEGKRFLAD
IRKVTNKPIKYVVNTHTHLDHALGNCVFANLGAAIISHQAERASLEANGPLMLRNIGSKGLKPEDVAGTEVVLPNLAFSD
QMLIDLGGEEIRLIRLSPSHTAGSIVVYLPTQKILFSGDILFTDFHPFLADGDFKGWIGSIDKLLDMEIDGIIPGHGPLS
TKKDLRDMKNYIVLFDKRARELATKSQDSQVISAQLLKELPKRSMAEWMVNYNVLSRYIGKN

Sequences:

>Translated_302_residues
MKKTAALAALSALVLTLLFVNSACAELTKISNNVYSYVGVKDASPGNSFAANAGIVIGRDGVLVVDTLISAKEGKRFLAD
IRKVTNKPIKYVVNTHTHLDHALGNCVFANLGAAIISHQAERASLEANGPLMLRNIGSKGLKPEDVAGTEVVLPNLAFSD
QMLIDLGGEEIRLIRLSPSHTAGSIVVYLPTQKILFSGDILFTDFHPFLADGDFKGWIGSIDKLLDMEIDGIIPGHGPLS
TKKDLRDMKNYIVLFDKRARELATKSQDSQVISAQLLKELPKRSMAEWMVNYNVLSRYIGKN
>Mature_302_residues
MKKTAALAALSALVLTLLFVNSACAELTKISNNVYSYVGVKDASPGNSFAANAGIVIGRDGVLVVDTLISAKEGKRFLAD
IRKVTNKPIKYVVNTHTHLDHALGNCVFANLGAAIISHQAERASLEANGPLMLRNIGSKGLKPEDVAGTEVVLPNLAFSD
QMLIDLGGEEIRLIRLSPSHTAGSIVVYLPTQKILFSGDILFTDFHPFLADGDFKGWIGSIDKLLDMEIDGIIPGHGPLS
TKKDLRDMKNYIVLFDKRARELATKSQDSQVISAQLLKELPKRSMAEWMVNYNVLSRYIGKN

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 32832; Mature: 32832

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTAALAALSALVLTLLFVNSACAELTKISNNVYSYVGVKDASPGNSFAANAGIVIGRD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCC
GVLVVDTLISAKEGKRFLADIRKVTNKPIKYVVNTHTHLDHALGNCVFANLGAAIISHQA
CEEEEHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCH
ERASLEANGPLMLRNIGSKGLKPEDVAGTEVVLPNLAFSDQMLIDLGGEEIRLIRLSPSH
HHCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCEEEEEEECCCC
TAGSIVVYLPTQKILFSGDILFTDFHPFLADGDFKGWIGSIDKLLDMEIDGIIPGHGPLS
CCCEEEEEECCCEEEEECCEEEEECCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
TKKDLRDMKNYIVLFDKRARELATKSQDSQVISAQLLKELPKRSMAEWMVNYNVLSRYIG
CHHHHHHHHHHEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KN
CC
>Mature Secondary Structure
MKKTAALAALSALVLTLLFVNSACAELTKISNNVYSYVGVKDASPGNSFAANAGIVIGRD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCC
GVLVVDTLISAKEGKRFLADIRKVTNKPIKYVVNTHTHLDHALGNCVFANLGAAIISHQA
CEEEEHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCH
ERASLEANGPLMLRNIGSKGLKPEDVAGTEVVLPNLAFSDQMLIDLGGEEIRLIRLSPSH
HHCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCEEEEEEECCCC
TAGSIVVYLPTQKILFSGDILFTDFHPFLADGDFKGWIGSIDKLLDMEIDGIIPGHGPLS
CCCEEEEEECCCEEEEECCEEEEECCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
TKKDLRDMKNYIVLFDKRARELATKSQDSQVISAQLLKELPKRSMAEWMVNYNVLSRYIG
CHHHHHHHHHHEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1856163 [H]