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The map label for this gene is capL-1 [H]

Identifier: 197118139

GI number: 197118139

Start: 2021930

End: 2023216

Strand: Direct

Name: capL-1 [H]

Synonym: Gbem_1754

Alternate gene names: 197118139

Gene position: 2021930-2023216 (Clockwise)

Preceding gene: 197118136

Following gene: 197118140

Centisome position: 43.81

GC content: 60.45

Gene sequence:

>1287_bases
ATGACGCACAATCGTAAGATTTCGGTGGTAGGGCTTGGGTACGTTGGGCTCCCGGTGGCGGTCGCCTTCGGCAGGGTGCA
GCGAACCATAGGGTTTGACATCAGCGCGAAGAGGATCGAGGAGTTGCGTTCAGGATGGGACCGTACGGGGGAAGTTTCCT
CAGAGGACTTGGTCGGCGCCGACATCTGCTTCACCGATAATATCGATGAGCTGGCGCGGGCGGATTTTCACGTGGTGGCG
GTGCCGACACCTGTCGATCCCGCCAACCAGCCGGACCTCTCCCTGCTCCGCAGCGCATCGGAAACGGTGGGGAGGGCGCT
CAAAAAGGGTGACATCGTGGTCTACGAGTCTACGGTCTATCCGGGCGTCACCGAGGAGGTCTGCCTCCCCATCCTGGAGT
CGGTATCGGGGCTGAAGAGTCCTGTAGACTTCACCGTCGGTTACAGCCCGGAGCGGATCAATCCTGGCGACAAGGAGCAT
ACCTTCACCAGCATCCTCAAGGTCGTCTCCGGTCAGGATCAGCACACCTTGGAACAGGTGGCCGCGGTATATTCCTCGGT
GGTCAAGCCGGGGGTGCACCGTGCACCATCCATCAAGGTAGCCGAGGCCGCCAAGGTCATCGAGAACACGCAGCGCGACC
TGAACATCGCCCTCATGAACGAGCTGGCGCTGATTTTCGACCGTTTGGGGATCGACACCAGCGAGGTGCTGGCTGCGGCG
GGAAGCAAATGGAACTTCCTGAACTTCAAGCCGGGGCTGGTAGGCGGCCACTGCATCGGCGTCGACCCATACTATCTCAC
CTACCAGGCTGAGAAGATCGGGTACATCCCCCAGGTTATCCTGGCCGGGCGGCGCATAAACGACGGCATGGGCAAATTCA
TCGCGCAACGGGCGGTAAAGGAGATCATCAGGGCGGGGCACCACGTGCTTGGCTCGTATGTGACGGTGCTGGGACTGACC
TTCAAGGAGAATTGCCCCGACCTGCGCAACTCGAAGGTCGTGGATATTTTGACCGAGCTCAGTGACTATGGGTTGAAGGT
GCAGGTATGCGACCCGATAGCAGACCCGGTTGAGGCGCAGCAGGCCTACGGGGTAACACTCAAGGAGCCCGGAAAACTCC
ATCCTGCGGTTGCTGTTATCGCCGCGGTCGCCCACGACTCCTACCGCGCCTGGGGGGCCGCCAAGTTCGCGAGCCTTATG
GTAGAGAACCCGGTGCTCATAGACGTAAAGGGTATTTACAACAGTCGGGCCATGTCTGCCGCGGGGATTCGGGTCTGGTG
CCTGTAG

Upstream 100 bases:

>100_bases
AGCGGCAAATCGGGATATCGGACATGGCGGGTGTATCGAGCACGAGGCCGCCTGGCCGCAGTGGGCACATCGAAGCATGT
GCCGGATAGGGAGGTGCAGC

Downstream 100 bases:

>100_bases
TCGTCGGCCGAGGCAGGGGAGAGGAGCATGTCAAAGATCAAGGAATCACTTACGCGTACCCCGTCGCAGTTCGGACACAG
TTACCCGAGGGACCTGGTCT

Product: UDP-N-acetyl-D-galactosamine 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTHNRKISVVGLGYVGLPVAVAFGRVQRTIGFDISAKRIEELRSGWDRTGEVSSEDLVGADICFTDNIDELARADFHVVA
VPTPVDPANQPDLSLLRSASETVGRALKKGDIVVYESTVYPGVTEEVCLPILESVSGLKSPVDFTVGYSPERINPGDKEH
TFTSILKVVSGQDQHTLEQVAAVYSSVVKPGVHRAPSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLAAA
GSKWNFLNFKPGLVGGHCIGVDPYYLTYQAEKIGYIPQVILAGRRINDGMGKFIAQRAVKEIIRAGHHVLGSYVTVLGLT
FKENCPDLRNSKVVDILTELSDYGLKVQVCDPIADPVEAQQAYGVTLKEPGKLHPAVAVIAAVAHDSYRAWGAAKFASLM
VENPVLIDVKGIYNSRAMSAAGIRVWCL

Sequences:

>Translated_428_residues
MTHNRKISVVGLGYVGLPVAVAFGRVQRTIGFDISAKRIEELRSGWDRTGEVSSEDLVGADICFTDNIDELARADFHVVA
VPTPVDPANQPDLSLLRSASETVGRALKKGDIVVYESTVYPGVTEEVCLPILESVSGLKSPVDFTVGYSPERINPGDKEH
TFTSILKVVSGQDQHTLEQVAAVYSSVVKPGVHRAPSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLAAA
GSKWNFLNFKPGLVGGHCIGVDPYYLTYQAEKIGYIPQVILAGRRINDGMGKFIAQRAVKEIIRAGHHVLGSYVTVLGLT
FKENCPDLRNSKVVDILTELSDYGLKVQVCDPIADPVEAQQAYGVTLKEPGKLHPAVAVIAAVAHDSYRAWGAAKFASLM
VENPVLIDVKGIYNSRAMSAAGIRVWCL
>Mature_427_residues
THNRKISVVGLGYVGLPVAVAFGRVQRTIGFDISAKRIEELRSGWDRTGEVSSEDLVGADICFTDNIDELARADFHVVAV
PTPVDPANQPDLSLLRSASETVGRALKKGDIVVYESTVYPGVTEEVCLPILESVSGLKSPVDFTVGYSPERINPGDKEHT
FTSILKVVSGQDQHTLEQVAAVYSSVVKPGVHRAPSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLAAAG
SKWNFLNFKPGLVGGHCIGVDPYYLTYQAEKIGYIPQVILAGRRINDGMGKFIAQRAVKEIIRAGHHVLGSYVTVLGLTF
KENCPDLRNSKVVDILTELSDYGLKVQVCDPIADPVEAQQAYGVTLKEPGKLHPAVAVIAAVAHDSYRAWGAAKFASLMV
ENPVLIDVKGIYNSRAMSAAGIRVWCL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=433, Percent_Identity=23.7875288683603, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI48994968, Length=352, Percent_Identity=30.9659090909091, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17560350, Length=372, Percent_Identity=24.1935483870968, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136908, Length=439, Percent_Identity=23.4624145785877, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46305; Mature: 46173

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHNRKISVVGLGYVGLPVAVAFGRVQRTIGFDISAKRIEELRSGWDRTGEVSSEDLVGA
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCE
DICFTDNIDELARADFHVVAVPTPVDPANQPDLSLLRSASETVGRALKKGDIVVYESTVY
EEEECCCHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PGVTEEVCLPILESVSGLKSPVDFTVGYSPERINPGDKEHTFTSILKVVSGQDQHTLEQV
CCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
AAVYSSVVKPGVHRAPSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLAAA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GSKWNFLNFKPGLVGGHCIGVDPYYLTYQAEKIGYIPQVILAGRRINDGMGKFIAQRAVK
CCCCCEEECCCCCCCCEEECCCCEEEEEEHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHH
EIIRAGHHVLGSYVTVLGLTFKENCPDLRNSKVVDILTELSDYGLKVQVCDPIADPVEAQ
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHH
QAYGVTLKEPGKLHPAVAVIAAVAHDSYRAWGAAKFASLMVENPVLIDVKGIYNSRAMSA
HHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
AGIRVWCL
CCEEEEEC
>Mature Secondary Structure 
THNRKISVVGLGYVGLPVAVAFGRVQRTIGFDISAKRIEELRSGWDRTGEVSSEDLVGA
CCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCE
DICFTDNIDELARADFHVVAVPTPVDPANQPDLSLLRSASETVGRALKKGDIVVYESTVY
EEEECCCHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PGVTEEVCLPILESVSGLKSPVDFTVGYSPERINPGDKEHTFTSILKVVSGQDQHTLEQV
CCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
AAVYSSVVKPGVHRAPSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLAAA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GSKWNFLNFKPGLVGGHCIGVDPYYLTYQAEKIGYIPQVILAGRRINDGMGKFIAQRAVK
CCCCCEEECCCCCCCCEEECCCCEEEEEEHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHH
EIIRAGHHVLGSYVTVLGLTFKENCPDLRNSKVVDILTELSDYGLKVQVCDPIADPVEAQ
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHH
QAYGVTLKEPGKLHPAVAVIAAVAHDSYRAWGAAKFASLMVENPVLIDVKGIYNSRAMSA
HHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
AGIRVWCL
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]