Click here to switch to the map view.

The map label for this gene is lpxD

Identifier: 197117233

GI number: 197117233

Start: 995333

End: 996370

Strand: Direct

Name: lpxD

Synonym: Gbem_0841

Alternate gene names: 197117233

Gene position: 995333-996370 (Clockwise)

Preceding gene: 197117232

Following gene: 197117234

Centisome position: 21.57

GC content: 65.8

Gene sequence:

>1038_bases
ATGAAGAAATCGCTTAATGAAATAGCGCAGTACCTGGGAGGGACCGTTTCCGGCGACGGCGAAGTCCTGATCGGCGGGCT
CGCGACCCTGGACGACGCGGGGGAGGGGACGCTTACTTTTCTGGCCAACCCGAAGTACGCCGCCAAGGTCGCCACCACCA
AGGCTTCGGCCGTGCTGATGGGGACCGGGGGGAACACCCATGGCAAGAACGCCATCTTCCACCCCAACCCTTATCTTGCC
TTCGCGAAGCTGCTCACCCTGTTTTACACCGCACCGGCAAAGCCGGTCGGCGTGTTGCCGGGCGCCTTCGTAGCCGATGG
GGTGAAGCTCGGGGCGGACGTTTCGGTGTACCCGGGCGCCTACATAGGCGCCGGCGCCGTGATCGGCGACCGGGTGGTCC
TGCACCCGGGAGTCGTGCTCTACCCGGGTGTCGTGGTCGGCAACGACGTGACGCTGCACGCCAACGTGAGCGTCCGCGAG
CGGTGCCGCATCGGCAACCGCGTCACCATCCACGACGGGACCGTGATCGGCTCCGACGGCTTCGGCTACGCGCCCGACGG
CGCCTCCTACTACAAGATCCCGCAGATCGGCATCGTCATCGTCGAGGATGACGTCGAGATCGGCTCCAACTGCGTCATCG
ACCGCGCGGCGCTTGAGGCCACCCGGATCCGCCGCGGCACGAAGATCGACAACCTGGTGCAGATCGCGCACAACGTCGTC
ATCGGCGAGGACTGCATCATCGTCTCCCAGGTCGGCATCTCCGGCAGCACCCAGCTGGGGAACCACGTAACCCTCGGGGG
GCAGGTCGGCGTCGCCGGCCACATCAAGATCGGCGACAACGTCATGATCGGCGCGAAGTCCGGCGTGGCGGGGAACGTGG
AGCCGAACCAGGTGCTTTCCGGCATCCCGGTGATGCCGCACCGCGACTGGCTCAGGTCGGCCGGCATAGCGCCCAAGCTT
CCCGAGATGAAGAAGACGCTCTCGGCGCTGGAGAAGCGGGTGGCGGAGTTGGAAGCGAAACTGGCCAAAGGGGAGTAA

Upstream 100 bases:

>100_bases
TGTTCCCCCCTTGGCCAAGCCTCTCATCAGGCCAAGGGGGACTTGTCGTTTCTGACCTGGAACCTCGAACGGCGAACGTC
GAACCCTGCCGAGGTTTTTG

Downstream 100 bases:

>100_bases
TTACCTCGGCTCCCTCGGACGGAGCCGGTTCAAGGAGAGATTTTAATGCTTGATATAGTGCAGATTATGGAACTTCTTCC
GCATCGCTACCCTTTCCTCC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKKSLNEIAQYLGGTVSGDGEVLIGGLATLDDAGEGTLTFLANPKYAAKVATTKASAVLMGTGGNTHGKNAIFHPNPYLA
FAKLLTLFYTAPAKPVGVLPGAFVADGVKLGADVSVYPGAYIGAGAVIGDRVVLHPGVVLYPGVVVGNDVTLHANVSVRE
RCRIGNRVTIHDGTVIGSDGFGYAPDGASYYKIPQIGIVIVEDDVEIGSNCVIDRAALEATRIRRGTKIDNLVQIAHNVV
IGEDCIIVSQVGISGSTQLGNHVTLGGQVGVAGHIKIGDNVMIGAKSGVAGNVEPNQVLSGIPVMPHRDWLRSAGIAPKL
PEMKKTLSALEKRVAELEAKLAKGE

Sequences:

>Translated_345_residues
MKKSLNEIAQYLGGTVSGDGEVLIGGLATLDDAGEGTLTFLANPKYAAKVATTKASAVLMGTGGNTHGKNAIFHPNPYLA
FAKLLTLFYTAPAKPVGVLPGAFVADGVKLGADVSVYPGAYIGAGAVIGDRVVLHPGVVLYPGVVVGNDVTLHANVSVRE
RCRIGNRVTIHDGTVIGSDGFGYAPDGASYYKIPQIGIVIVEDDVEIGSNCVIDRAALEATRIRRGTKIDNLVQIAHNVV
IGEDCIIVSQVGISGSTQLGNHVTLGGQVGVAGHIKIGDNVMIGAKSGVAGNVEPNQVLSGIPVMPHRDWLRSAGIAPKL
PEMKKTLSALEKRVAELEAKLAKGE
>Mature_345_residues
MKKSLNEIAQYLGGTVSGDGEVLIGGLATLDDAGEGTLTFLANPKYAAKVATTKASAVLMGTGGNTHGKNAIFHPNPYLA
FAKLLTLFYTAPAKPVGVLPGAFVADGVKLGADVSVYPGAYIGAGAVIGDRVVLHPGVVLYPGVVVGNDVTLHANVSVRE
RCRIGNRVTIHDGTVIGSDGFGYAPDGASYYKIPQIGIVIVEDDVEIGSNCVIDRAALEATRIRRGTKIDNLVQIAHNVV
IGEDCIIVSQVGISGSTQLGNHVTLGGQVGVAGHIKIGDNVMIGAKSGVAGNVEPNQVLSGIPVMPHRDWLRSAGIAPKL
PEMKKTLSALEKRVAELEAKLAKGE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=37.202380952381, Blast_Score=219, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_GEOBB (B5EEW8)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137660.1
- ProteinModelPortal:   B5EEW8
- SMR:   B5EEW8
- GeneID:   6783679
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0841
- HOGENOM:   HBG469615
- OMA:   GVAGHIK
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35697; Mature: 35697

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLNEIAQYLGGTVSGDGEVLIGGLATLDDAGEGTLTFLANPKYAAKVATTKASAVLM
CCCCHHHHHHHHCCEECCCCCEEEEEEEECCCCCCCEEEEEECCCEEEEEEECCCCEEEE
GTGGNTHGKNAIFHPNPYLAFAKLLTLFYTAPAKPVGVLPGAFVADGVKLGADVSVYPGA
ECCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEECCCCEEECCCC
YIGAGAVIGDRVVLHPGVVLYPGVVVGNDVTLHANVSVRERCRIGNRVTIHDGTVIGSDG
EECCCCEECCEEEECCCEEEECCEEECCCEEEEECCCHHHHHCCCCEEEEECCEEECCCC
FGYAPDGASYYKIPQIGIVIVEDDVEIGSNCVIDRAALEATRIRRGTKIDNLVQIAHNVV
CCCCCCCCCEEECCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHEE
IGEDCIIVSQVGISGSTQLGNHVTLGGQVGVAGHIKIGDNVMIGAKSGVAGNVEPNQVLS
ECCCEEEEEECCCCCCCCCCCEEEECCCCCEEEEEEECCEEEEECCCCCCCCCCHHHHHC
GIPVMPHRDWLRSAGIAPKLPEMKKTLSALEKRVAELEAKLAKGE
CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKSLNEIAQYLGGTVSGDGEVLIGGLATLDDAGEGTLTFLANPKYAAKVATTKASAVLM
CCCCHHHHHHHHCCEECCCCCEEEEEEEECCCCCCCEEEEEECCCEEEEEEECCCCEEEE
GTGGNTHGKNAIFHPNPYLAFAKLLTLFYTAPAKPVGVLPGAFVADGVKLGADVSVYPGA
ECCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEECCCCEEECCCC
YIGAGAVIGDRVVLHPGVVLYPGVVVGNDVTLHANVSVRERCRIGNRVTIHDGTVIGSDG
EECCCCEECCEEEECCCEEEECCEEECCCEEEEECCCHHHHHCCCCEEEEECCEEECCCC
FGYAPDGASYYKIPQIGIVIVEDDVEIGSNCVIDRAALEATRIRRGTKIDNLVQIAHNVV
CCCCCCCCCEEECCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHEE
IGEDCIIVSQVGISGSTQLGNHVTLGGQVGVAGHIKIGDNVMIGAKSGVAGNVEPNQVLS
ECCCEEEEEECCCCCCCCCCCEEEECCCCCEEEEEEECCEEEEECCCCCCCCCCHHHHHC
GIPVMPHRDWLRSAGIAPKLPEMKKTLSALEKRVAELEAKLAKGE
CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA