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The map label for this gene is mutM-2 [H]

Identifier: 197117207

GI number: 197117207

Start: 965421

End: 966206

Strand: Direct

Name: mutM-2 [H]

Synonym: Gbem_0815

Alternate gene names: 197117207

Gene position: 965421-966206 (Clockwise)

Preceding gene: 197117206

Following gene: 197117208

Centisome position: 20.92

GC content: 63.74

Gene sequence:

>786_bases
ATGCCCGAACTGCCGGATCTCACCATATACGCGGAGAACCTGGCCAGGAAGCTGACCGGGAAGAAGATAGCGACAGTTTC
CTTCCATGACAGGGGACGTCTGAACGTAGCTCCCGATGAACTATCCGCCGCGCTCATAGGTGCAAAGGTCACCGCCGTGC
GCAGGACCGGAAAGCAGGTTTCTTTCCAGGCCGACAACGGCGCCATGTTGCGGGTTCACCTCATGCTGACCGGCGGCTTC
GTGCTGACCAGCACCGAGCATCTGGACCGTCTGGAGGCGCCGGTGGTGACTGTCACCTTCAACGACGGTTCCGCGCTCGC
GGTTTCGGATCCCAAGGGGTGGGCGACGCTCACCTTGAACCCGCAGCCGGAGCGGGAGGCGCCGGACGCCTTGGAGCTAA
GCGCCGATCAGTTGCAGCAGCTGTGCGCGAAGCAGCCGAAGGCGCTGATCAAGGCGCTGCTCCTGGACCAGGCGCTCATC
GGCGGCATCGGCAACGCCTACGCCGACGAAATCCTGTGGGAGGCGCGCATCTCCCCCAAATCGGTGGCGGGAAAGCTTCC
CCCCGAGGCGGTCTCGGCGCTGGCGCGGGCCATTCCCGCCGTTCTCAAGGACGCCATATCGGAACTCCGCAAACGCCACC
CGGACATGGTCGCCGGCGAGTACCGCGAGTTTCTCAAGGTGCACCGCCCCGGCCTGAAGCAATCCCCCACCGGCGCGCCC
GTCATCAAGGAGAACATCTCCTCCAAGCAGACCTACTACACCGACGAACAGCAGCTCTACAAATAA

Upstream 100 bases:

>100_bases
CTGAGTAGGCAGTATGCGCCGCAGGTCGCTTTGATTGACTTCACTACATTCTCGGATACGCTCGCGCAGGTATTTCATCG
CGACTTTATAAGGAGGGGGC

Downstream 100 bases:

>100_bases
GAACCCAAGGGGGCGCGGGGGGATCCCCGCCGCCCCCGAACGCAGCATAGCCGCCCCTTTATCCTCTTTTGCCCGCCGCC
TAGCTCAGCTAATCCCTTCC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MPELPDLTIYAENLARKLTGKKIATVSFHDRGRLNVAPDELSAALIGAKVTAVRRTGKQVSFQADNGAMLRVHLMLTGGF
VLTSTEHLDRLEAPVVTVTFNDGSALAVSDPKGWATLTLNPQPEREAPDALELSADQLQQLCAKQPKALIKALLLDQALI
GGIGNAYADEILWEARISPKSVAGKLPPEAVSALARAIPAVLKDAISELRKRHPDMVAGEYREFLKVHRPGLKQSPTGAP
VIKENISSKQTYYTDEQQLYK

Sequences:

>Translated_261_residues
MPELPDLTIYAENLARKLTGKKIATVSFHDRGRLNVAPDELSAALIGAKVTAVRRTGKQVSFQADNGAMLRVHLMLTGGF
VLTSTEHLDRLEAPVVTVTFNDGSALAVSDPKGWATLTLNPQPEREAPDALELSADQLQQLCAKQPKALIKALLLDQALI
GGIGNAYADEILWEARISPKSVAGKLPPEAVSALARAIPAVLKDAISELRKRHPDMVAGEYREFLKVHRPGLKQSPTGAP
VIKENISSKQTYYTDEQQLYK
>Mature_260_residues
PELPDLTIYAENLARKLTGKKIATVSFHDRGRLNVAPDELSAALIGAKVTAVRRTGKQVSFQADNGAMLRVHLMLTGGFV
LTSTEHLDRLEAPVVTVTFNDGSALAVSDPKGWATLTLNPQPEREAPDALELSADQLQQLCAKQPKALIKALLLDQALIG
GIGNAYADEILWEARISPKSVAGKLPPEAVSALARAIPAVLKDAISELRKRHPDMVAGEYREFLKVHRPGLKQSPTGAPV
IKENISSKQTYYTDEQQLYK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=276, Percent_Identity=27.1739130434783, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786932, Length=266, Percent_Identity=25.5639097744361, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 28349; Mature: 28218

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPDLTIYAENLARKLTGKKIATVSFHDRGRLNVAPDELSAALIGAKVTAVRRTGKQV
CCCCCCCEEEHHHHHHHHCCCEEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHCCCEE
SFQADNGAMLRVHLMLTGGFVLTSTEHLDRLEAPVVTVTFNDGSALAVSDPKGWATLTLN
EEECCCCCEEEEEEEEECCEEEECHHHHHHHCCCEEEEEECCCCEEEEECCCCCEEEEEC
PQPEREAPDALELSADQLQQLCAKQPKALIKALLLDQALIGGIGNAYADEILWEARISPK
CCCCCCCCCHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
SVAGKLPPEAVSALARAIPAVLKDAISELRKRHPDMVAGEYREFLKVHRPGLKQSPTGAP
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC
VIKENISSKQTYYTDEQQLYK
HHHHCCCCCCEEECCHHHHCC
>Mature Secondary Structure 
PELPDLTIYAENLARKLTGKKIATVSFHDRGRLNVAPDELSAALIGAKVTAVRRTGKQV
CCCCCCEEEHHHHHHHHCCCEEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHCCCEE
SFQADNGAMLRVHLMLTGGFVLTSTEHLDRLEAPVVTVTFNDGSALAVSDPKGWATLTLN
EEECCCCCEEEEEEEEECCEEEECHHHHHHHCCCEEEEEECCCCEEEEECCCCCEEEEEC
PQPEREAPDALELSADQLQQLCAKQPKALIKALLLDQALIGGIGNAYADEILWEARISPK
CCCCCCCCCHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
SVAGKLPPEAVSALARAIPAVLKDAISELRKRHPDMVAGEYREFLKVHRPGLKQSPTGAP
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC
VIKENISSKQTYYTDEQQLYK
HHHHCCCCCCEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993; 8638118 [H]