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The map label for this gene is guaA [H]

Identifier: 197117160

GI number: 197117160

Start: 901022

End: 902572

Strand: Direct

Name: guaA [H]

Synonym: Gbem_0765

Alternate gene names: 197117160

Gene position: 901022-902572 (Clockwise)

Preceding gene: 197117159

Following gene: 197117161

Centisome position: 19.52

GC content: 62.8

Gene sequence:

>1551_bases
ATGACCATCGACATACACTCCGAGAAGGTGCTGATCCTCGACTTCGGCTCCCAGGTAACCCAGCTGATCGCCAGGCGCGT
GAGGGAGCAGAGCGTTTACTGCGAGATCCACCCCTACAACATGGCGCTCGAGAAGATCAAGGCGTTCGCCCCGAAGGGGA
TCATCCTTTCCGGCGGCCCCTCCAGCGTCTACGACAAGGACGCCCCGCACTCCGACCTCGGCATCTACGACCTCGGCATC
CCGGTCCTCGGCATCTGCTACGGCATGCAGCTGATGACCCAGCAACTGGGCGGGCGCGTGGAGCGCTGCGACAAGCGTGA
GTTCGGCCGGGCAACACTTGCCCTCGACGGCAAAAGCGAGATCTTCGCCGGCTTCGACGGCGGCGCCGAGGTCTGGATGT
CCCACGGCGACCGCATCGAGGCGATGCCGGCCGGCTTCCAGCTCATGGCCCACACGACAGGCTGCCCCGTGGCCGCCATG
AAGGACGAGAAGCGCAACTTCTTCGGCGTCCAGTTTCACCCCGAGGTGGTGCACACCCCGCGCGGCGACGAGATGATCGG
CAACTTCCTCTTCAACGTCTGCGGCTCGAAGCCCACCTGGACCATGGCCAACTTCATCGAGACCGAACTGGCCAGCATCC
GCGAGAAGGTCGGCACCGGCAAGGTCCTCTGCGCCCTCTCCGGCGGGGTCGACTCCGCCGTCGTCGCCGTCCTGATCCAC
AAGGCGATCGGCGATCAGCTGCACTGCGTCTTCGTCAACAACGGCCTTTTGAGGAAGGGCGAAGCCGACAAGGTGGTGAA
CCTCTTCACCAAGCACTTCAAGATCAACCTCGCCCATGTCGACGCCGCCGACCGCTTCCTCGGCATGCTGGAAGGGGTCT
CCGACCCCGAGCAAAAGCGCAAGATCATCGGCAACGAGTTCATCTACCTCTTCGAGGAGGAGGCCAAGAAGCTGGGTCAG
GTCGATTACTTGGCGCAGGGGACCCTCTACCCCGACGTGATCGAGTCCGTCTCCACCAAGGGCCCCTCTGCCGTCATCAA
GAGCCACCACAACGTGGGCGGTCTCCCCGAGAAGATGAACCTGAAGCTCCTGGAGCCGGTGCGCGAGCTGTTCAAGGACG
AGGTGCGGCTTCTGGGCAAGGAACTAGGCATGCCCGACGAGGTGGTGTACCGCCAGCCGTTTCCGGGTCCCGGCCTCGCT
ATCCGCTGCATCGGCGAACTCTCCGCGGAGAAGCTCGACATCCTGCGCGATGCCGACGCCATCGTCATCGAAGAGATCAG
GAAAGCCGGGTTATATCGCGAGATCTGGCAGTCGTTTGCCGTACTGCTGCCGGTCAAAACCGTCGGAGTCATGGGCGACG
CCAGGACCTACGAGTGGACCGTGGCCCTTCGCGCCGTCAACTCTCTGGACGGCATGACCGCGGACTGGGTCAAGCTCCCC
TACGAGCTACTCGGCAGTATTTCTTCAAGAATCATCAACGAGGTGAAGGGCGTGAACCGCGTGGTTTACGACATCAGCCA
GAAGCCCCCCGCAACCATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
ACGCAAAGCCGCAAAGACGCAGAGAAAAGCTGGTTCGGCAGTACTTTGCGCCTTGGCGTCTTTGCGTGACAGCTTTTGAC
TTTAGATAAGGAACTCATCA

Downstream 100 bases:

>100_bases
ATCGCTCCTCCCTATGGAGGTTCGTTTTTTGCAGTTAAAACGCCGCGGTAGCCGGGTAGAAGCCGGTTGCCGCGGCTCTT
TCGTATCTTGAAGACTGGTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTIDIHSEKVLILDFGSQVTQLIARRVREQSVYCEIHPYNMALEKIKAFAPKGIILSGGPSSVYDKDAPHSDLGIYDLGI
PVLGICYGMQLMTQQLGGRVERCDKREFGRATLALDGKSEIFAGFDGGAEVWMSHGDRIEAMPAGFQLMAHTTGCPVAAM
KDEKRNFFGVQFHPEVVHTPRGDEMIGNFLFNVCGSKPTWTMANFIETELASIREKVGTGKVLCALSGGVDSAVVAVLIH
KAIGDQLHCVFVNNGLLRKGEADKVVNLFTKHFKINLAHVDAADRFLGMLEGVSDPEQKRKIIGNEFIYLFEEEAKKLGQ
VDYLAQGTLYPDVIESVSTKGPSAVIKSHHNVGGLPEKMNLKLLEPVRELFKDEVRLLGKELGMPDEVVYRQPFPGPGLA
IRCIGELSAEKLDILRDADAIVIEEIRKAGLYREIWQSFAVLLPVKTVGVMGDARTYEWTVALRAVNSLDGMTADWVKLP
YELLGSISSRIINEVKGVNRVVYDISQKPPATIEWE

Sequences:

>Translated_516_residues
MTIDIHSEKVLILDFGSQVTQLIARRVREQSVYCEIHPYNMALEKIKAFAPKGIILSGGPSSVYDKDAPHSDLGIYDLGI
PVLGICYGMQLMTQQLGGRVERCDKREFGRATLALDGKSEIFAGFDGGAEVWMSHGDRIEAMPAGFQLMAHTTGCPVAAM
KDEKRNFFGVQFHPEVVHTPRGDEMIGNFLFNVCGSKPTWTMANFIETELASIREKVGTGKVLCALSGGVDSAVVAVLIH
KAIGDQLHCVFVNNGLLRKGEADKVVNLFTKHFKINLAHVDAADRFLGMLEGVSDPEQKRKIIGNEFIYLFEEEAKKLGQ
VDYLAQGTLYPDVIESVSTKGPSAVIKSHHNVGGLPEKMNLKLLEPVRELFKDEVRLLGKELGMPDEVVYRQPFPGPGLA
IRCIGELSAEKLDILRDADAIVIEEIRKAGLYREIWQSFAVLLPVKTVGVMGDARTYEWTVALRAVNSLDGMTADWVKLP
YELLGSISSRIINEVKGVNRVVYDISQKPPATIEWE
>Mature_515_residues
TIDIHSEKVLILDFGSQVTQLIARRVREQSVYCEIHPYNMALEKIKAFAPKGIILSGGPSSVYDKDAPHSDLGIYDLGIP
VLGICYGMQLMTQQLGGRVERCDKREFGRATLALDGKSEIFAGFDGGAEVWMSHGDRIEAMPAGFQLMAHTTGCPVAAMK
DEKRNFFGVQFHPEVVHTPRGDEMIGNFLFNVCGSKPTWTMANFIETELASIREKVGTGKVLCALSGGVDSAVVAVLIHK
AIGDQLHCVFVNNGLLRKGEADKVVNLFTKHFKINLAHVDAADRFLGMLEGVSDPEQKRKIIGNEFIYLFEEEAKKLGQV
DYLAQGTLYPDVIESVSTKGPSAVIKSHHNVGGLPEKMNLKLLEPVRELFKDEVRLLGKELGMPDEVVYRQPFPGPGLAI
RCIGELSAEKLDILRDADAIVIEEIRKAGLYREIWQSFAVLLPVKTVGVMGDARTYEWTVALRAVNSLDGMTADWVKLPY
ELLGSISSRIINEVKGVNRVVYDISQKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=36.9287020109689, Blast_Score=310, Evalue=1e-84,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=54.6666666666667, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1789760, Length=152, Percent_Identity=28.2894736842105, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=37.3684210526316, Blast_Score=312, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=37.3684210526316, Blast_Score=312, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=37.3684210526316, Blast_Score=311, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=52.9069767441861, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=36.4963503649635, Blast_Score=301, Evalue=8e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57015; Mature: 56883

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDIHSEKVLILDFGSQVTQLIARRVREQSVYCEIHPYNMALEKIKAFAPKGIILSGGP
CEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHCCCCEEEECCC
SSVYDKDAPHSDLGIYDLGIPVLGICYGMQLMTQQLGGRVERCDKREFGRATLALDGKSE
CCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCHHHHCCHHHCCCEEEEECCCCC
IFAGFDGGAEVWMSHGDRIEAMPAGFQLMAHTTGCPVAAMKDEKRNFFGVQFHPEVVHTP
EEECCCCCHHHHHCCCCEEEECCCCEEEEEECCCCCEEEECCCCCCEEEEEECCCEEECC
RGDEMIGNFLFNVCGSKPTWTMANFIETELASIREKVGTGKVLCALSGGVDSAVVAVLIH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
KAIGDQLHCVFVNNGLLRKGEADKVVNLFTKHFKINLAHVDAADRFLGMLEGVSDPEQKR
HHHCCCEEEEEECCCEECCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCHHHHH
KIIGNEFIYLFEEEAKKLGQVDYLAQGTLYPDVIESVSTKGPSAVIKSHHNVGGLPEKMN
HHHCCCEEEEEEHHHHHCCCHHHHHCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCC
LKLLEPVRELFKDEVRLLGKELGMPDEVVYRQPFPGPGLAIRCIGELSAEKLDILRDADA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCEEEEECHHCHHHHHHHHCCCH
IVIEEIRKAGLYREIWQSFAVLLPVKTVGVMGDARTYEWTVALRAVNSLDGMTADWVKLP
HHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEHHHHHHHCCCCCHHHHHCC
YELLGSISSRIINEVKGVNRVVYDISQKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TIDIHSEKVLILDFGSQVTQLIARRVREQSVYCEIHPYNMALEKIKAFAPKGIILSGGP
EEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHCCCCEEEECCC
SSVYDKDAPHSDLGIYDLGIPVLGICYGMQLMTQQLGGRVERCDKREFGRATLALDGKSE
CCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCHHHHCCHHHCCCEEEEECCCCC
IFAGFDGGAEVWMSHGDRIEAMPAGFQLMAHTTGCPVAAMKDEKRNFFGVQFHPEVVHTP
EEECCCCCHHHHHCCCCEEEECCCCEEEEEECCCCCEEEECCCCCCEEEEEECCCEEECC
RGDEMIGNFLFNVCGSKPTWTMANFIETELASIREKVGTGKVLCALSGGVDSAVVAVLIH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
KAIGDQLHCVFVNNGLLRKGEADKVVNLFTKHFKINLAHVDAADRFLGMLEGVSDPEQKR
HHHCCCEEEEEECCCEECCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCHHHHH
KIIGNEFIYLFEEEAKKLGQVDYLAQGTLYPDVIESVSTKGPSAVIKSHHNVGGLPEKMN
HHHCCCEEEEEEHHHHHCCCHHHHHCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCC
LKLLEPVRELFKDEVRLLGKELGMPDEVVYRQPFPGPGLAIRCIGELSAEKLDILRDADA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCEEEEECHHCHHHHHHHHCCCH
IVIEEIRKAGLYREIWQSFAVLLPVKTVGVMGDARTYEWTVALRAVNSLDGMTADWVKLP
HHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEHHHHHHHCCCCCHHHHHCC
YELLGSISSRIINEVKGVNRVVYDISQKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA