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The map label for this gene is guaB [H]

Identifier: 197117159

GI number: 197117159

Start: 899434

End: 900903

Strand: Direct

Name: guaB [H]

Synonym: Gbem_0764

Alternate gene names: 197117159

Gene position: 899434-900903 (Clockwise)

Preceding gene: 197117158

Following gene: 197117160

Centisome position: 19.49

GC content: 62.79

Gene sequence:

>1470_bases
ATGTTAGAAAGCAGCCTCCCGGAAGGTCTTACCTTTGACGACGTTCTGCTCCTCCCTGCCCACTCGCTCATCCTCCCCCG
CGATACCGATTTAAGCTCCAGACTCACCAACAACATCCAGTTGAACATCCCGCTGGTGAGTGCCGCCATGGACACTGTCA
CAGAATCGAGGGCGGCTATCTGCATGGCGCGCGAAGGGGGTATCGGCTTCATCCACAAGAACCTCACCGTCGCCGAGCAG
GCGATGGAAGTGGATAAGGTCAAGAAGAGCGAATCCGGGATGATCGTGGACCCGATCACCATGCGCCCCAACCAGCGCAT
CCGGGAGGCTCTGGAGATGATGGCGAAGTACAGGATCTCCGGGGTGCCGATCACCAAGGCCAACGGCAAACTGGTAGGCA
TACTGACCAACAGGGACCTTCGTTTCGAGACCAACCTGGACCTGCTCATCTCCGACCGCATGACCAAGAGGAACCTGGTC
ACCGTGCCGGTCGGGACCACGCTGGAGCAGGCGAAAGAGCACCTGAAGCACACCAGGGTAGAGAAGCTTCTGGTGGTCGA
CGGGGAGAAGAACCTCAAGGGGCTCATCACCATCAAGGACATCGAGAAGATCAAGAAGTACCCCAACGCCTGCAAGGACT
CCCTCGGGCGCCTGCGGGTCGGTGCGGCAGTCGGCCCGACCCCGGACGTGGACGCGCGCATCGACGCTCTCCTGAAGGCG
GGCGTGGACGTCGTGGTCATCGACACCGCCCACGGCCATTCCCAGGGGGTAATCGACACCATCGCCCGCATCAAATCCGA
CTTCCCGGGGCTTGAGCTCGTGGCCGGCAACATCGCCACCGCCGACGCCGCCGAGGCGCTGATCAAGGCCGGCGTCGACG
CCATCAAGGTCGGCATCGGACCGGGCTCCATCTGCACCACCCGCGTGGTCGCCGGCATCGGCGTTCCCCAGATCACCGCC
ATCGCCGAGTGCTCCAGGGTAGCCAAGAAGCACGGCATACCGCTCATCGCCGACGGCGGCATCAAGTACTCCGGCGATCT
CACCAAGGCCGTTGCCGCCGGCGCCGACGTCGTCATGATCGGTTCCCTCTTCGCAGGGACCGAAGAATCCCCGGGCGACA
CCATCCTGTACCAGGGGCGCGCCTACAAGAGCTACCGCGGCATGGGCTCCATCGGCGCCATGAAGGAAGGGAGCAAGGAC
CGCTACTTCCAAAGCGACGTCGACAGCGACGTCAAACTCGTACCCGAAGGGATCGAGGGGATGGTTCCGCTCAGGGGACC
GCTTTCCGCCAACGTGCACCAGCTGATGGGCGGCCTGCGCGCCGGCATGGGCTACACCGGGAGCCGGACCATCGTCGAGC
TGCAGCAAAACGGGCGTTTCGTCAGGATCACCGGCGCAGGCCTCAAAGAGTCCCACGTGCACGACGTCATGATCACCAAA
GAAGCCCCGAACTACCGGGTGGAAAAATAA

Upstream 100 bases:

>100_bases
GGGCCCTTGATTAGGCAAATTTCAGTTGACTTGGACTGCCCCTTGTAATAGGTTTTCCGGTTAATATCCCGCGCCCCAAA
CAACAAAAGGAGTCTCCCTA

Downstream 100 bases:

>100_bases
GGCGCAAGGAACCGGCTCACGCAAAGCCGCAAAGACGCAGAGAAAAGCTGGTTCGGCAGTACTTTGCGCCTTGGCGTCTT
TGCGTGACAGCTTTTGACTT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLESSLPEGLTFDDVLLLPAHSLILPRDTDLSSRLTNNIQLNIPLVSAAMDTVTESRAAICMAREGGIGFIHKNLTVAEQ
AMEVDKVKKSESGMIVDPITMRPNQRIREALEMMAKYRISGVPITKANGKLVGILTNRDLRFETNLDLLISDRMTKRNLV
TVPVGTTLEQAKEHLKHTRVEKLLVVDGEKNLKGLITIKDIEKIKKYPNACKDSLGRLRVGAAVGPTPDVDARIDALLKA
GVDVVVIDTAHGHSQGVIDTIARIKSDFPGLELVAGNIATADAAEALIKAGVDAIKVGIGPGSICTTRVVAGIGVPQITA
IAECSRVAKKHGIPLIADGGIKYSGDLTKAVAAGADVVMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKD
RYFQSDVDSDVKLVPEGIEGMVPLRGPLSANVHQLMGGLRAGMGYTGSRTIVELQQNGRFVRITGAGLKESHVHDVMITK
EAPNYRVEK

Sequences:

>Translated_489_residues
MLESSLPEGLTFDDVLLLPAHSLILPRDTDLSSRLTNNIQLNIPLVSAAMDTVTESRAAICMAREGGIGFIHKNLTVAEQ
AMEVDKVKKSESGMIVDPITMRPNQRIREALEMMAKYRISGVPITKANGKLVGILTNRDLRFETNLDLLISDRMTKRNLV
TVPVGTTLEQAKEHLKHTRVEKLLVVDGEKNLKGLITIKDIEKIKKYPNACKDSLGRLRVGAAVGPTPDVDARIDALLKA
GVDVVVIDTAHGHSQGVIDTIARIKSDFPGLELVAGNIATADAAEALIKAGVDAIKVGIGPGSICTTRVVAGIGVPQITA
IAECSRVAKKHGIPLIADGGIKYSGDLTKAVAAGADVVMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKD
RYFQSDVDSDVKLVPEGIEGMVPLRGPLSANVHQLMGGLRAGMGYTGSRTIVELQQNGRFVRITGAGLKESHVHDVMITK
EAPNYRVEK
>Mature_489_residues
MLESSLPEGLTFDDVLLLPAHSLILPRDTDLSSRLTNNIQLNIPLVSAAMDTVTESRAAICMAREGGIGFIHKNLTVAEQ
AMEVDKVKKSESGMIVDPITMRPNQRIREALEMMAKYRISGVPITKANGKLVGILTNRDLRFETNLDLLISDRMTKRNLV
TVPVGTTLEQAKEHLKHTRVEKLLVVDGEKNLKGLITIKDIEKIKKYPNACKDSLGRLRVGAAVGPTPDVDARIDALLKA
GVDVVVIDTAHGHSQGVIDTIARIKSDFPGLELVAGNIATADAAEALIKAGVDAIKVGIGPGSICTTRVVAGIGVPQITA
IAECSRVAKKHGIPLIADGGIKYSGDLTKAVAAGADVVMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKD
RYFQSDVDSDVKLVPEGIEGMVPLRGPLSANVHQLMGGLRAGMGYTGSRTIVELQQNGRFVRITGAGLKESHVHDVMITK
EAPNYRVEK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=42.5438596491228, Blast_Score=348, Evalue=8e-96,
Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=42.3245614035088, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=42.3245614035088, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=42.3245614035088, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=42.3245614035088, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=42.2222222222222, Blast_Score=328, Evalue=8e-90,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=41.4473684210526, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=38.8157894736842, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI50541956, Length=375, Percent_Identity=31.7333333333333, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI50541954, Length=268, Percent_Identity=35.0746268656716, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI50541952, Length=268, Percent_Identity=35.0746268656716, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI50541948, Length=268, Percent_Identity=35.0746268656716, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI156104880, Length=227, Percent_Identity=37.0044052863436, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1788855, Length=481, Percent_Identity=58.2120582120582, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1786293, Length=228, Percent_Identity=37.280701754386, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=501, Percent_Identity=35.3293413173653, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=37.2365339578454, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=243, Percent_Identity=38.6831275720165, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322012, Length=492, Percent_Identity=41.0569105691057, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=491, Percent_Identity=40.7331975560082, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=492, Percent_Identity=41.260162601626, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=347, Percent_Identity=43.2276657060519, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=38.4615384615385, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=40.702479338843, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=40.702479338843, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=40.2714932126697, Blast_Score=296, Evalue=3e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52309; Mature: 52309

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESSLPEGLTFDDVLLLPAHSLILPRDTDLSSRLTNNIQLNIPLVSAAMDTVTESRAAI
CCCCCCCCCCCCCCEEEECCCEEECCCCCCHHHHHCCCEEEEEEEHHHHHHHHHHCCEEE
CMAREGGIGFIHKNLTVAEQAMEVDKVKKSESGMIVDPITMRPNQRIREALEMMAKYRIS
EEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPITKANGKLVGILTNRDLRFETNLDLLISDRMTKRNLVTVPVGTTLEQAKEHLKHTRV
CCEEEECCCEEEEEEECCCEEEECCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHH
EKLLVVDGEKNLKGLITIKDIEKIKKYPNACKDSLGRLRVGAAVGPTPDVDARIDALLKA
EEEEEECCCCCCEEEEEHHHHHHHHHCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHHC
GVDVVVIDTAHGHSQGVIDTIARIKSDFPGLELVAGNIATADAAEALIKAGVDAIKVGIG
CCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGIGVPQITAIAECSRVAKKHGIPLIADGGIKYSGDLTKAVAAGADVVMI
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEE
GSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKDRYFQSDVDSDVKLVPEGIEG
EHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
MVPLRGPLSANVHQLMGGLRAGMGYTGSRTIVELQQNGRFVRITGAGLKESHVHDVMITK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEEE
EAPNYRVEK
CCCCCCCCC
>Mature Secondary Structure
MLESSLPEGLTFDDVLLLPAHSLILPRDTDLSSRLTNNIQLNIPLVSAAMDTVTESRAAI
CCCCCCCCCCCCCCEEEECCCEEECCCCCCHHHHHCCCEEEEEEEHHHHHHHHHHCCEEE
CMAREGGIGFIHKNLTVAEQAMEVDKVKKSESGMIVDPITMRPNQRIREALEMMAKYRIS
EEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPITKANGKLVGILTNRDLRFETNLDLLISDRMTKRNLVTVPVGTTLEQAKEHLKHTRV
CCEEEECCCEEEEEEECCCEEEECCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHH
EKLLVVDGEKNLKGLITIKDIEKIKKYPNACKDSLGRLRVGAAVGPTPDVDARIDALLKA
EEEEEECCCCCCEEEEEHHHHHHHHHCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHHC
GVDVVVIDTAHGHSQGVIDTIARIKSDFPGLELVAGNIATADAAEALIKAGVDAIKVGIG
CCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGIGVPQITAIAECSRVAKKHGIPLIADGGIKYSGDLTKAVAAGADVVMI
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEE
GSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKDRYFQSDVDSDVKLVPEGIEG
EHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
MVPLRGPLSANVHQLMGGLRAGMGYTGSRTIVELQQNGRFVRITGAGLKESHVHDVMITK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEEE
EAPNYRVEK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]