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The map label for this gene is mmcD [H]

Identifier: 197117080

GI number: 197117080

Start: 811127

End: 811906

Strand: Direct

Name: mmcD [H]

Synonym: Gbem_0684

Alternate gene names: 197117080

Gene position: 811127-811906 (Clockwise)

Preceding gene: 197117079

Following gene: 197117090

Centisome position: 17.58

GC content: 62.18

Gene sequence:

>780_bases
ATGGCGGTCATCAGTACCCAGTTGCAGGACAATATCGGGACCATCACATTCAACGATCCGGACCACAGGAACGCCTTGAG
CGGCGTGCTGATAGACGAGATGCTGCAGTCGATCGGCGCACTGCAAAAGGGTAAGATGCGGGTGCTGGTGATCCGGGCGC
CCAAGGGGTCGAAGGTCTGGTCGGCGGGGCACGACGTGCACGAGTTGCCCATGCCCGGCCGCGACCCGCTGGCCTACAAC
GACCCGCTGGTCACCGTCTTGAGGTCGATCCAGTCGCTCCCCATACCGGTGATCGCCATGATAGAGGGAAGCGTTTGGGG
CGGCGCCTGCGACCTGGCGCTTTCCTGCGACATCCTGATCGGCTGCCACAGTTCCACCTTCTGCATGACCCCCGCGAAGA
TCGGCGTCCCCTACAACGTCTCAGGCATCCTGCATTTCATGAACATCATGGGGGTGAACTTCGCCAAGGAGATGTTCTTC
ACCGCGGAGCCGCTCTCTGCTGAGGAAGCGGTCAGGGCGGGGCTTTTGAACCACCTGGTGGAGAGCGAACAGCTTGAGGA
TTTCACCTACGCCATGGCCGGCAAGATCACCAAGAACAGCCCGCTCAGCATCGGGGTGATCAAAGAGCAGATCCGGCTCC
TGGCGAGCGCCCACCCGCTTTCCCCGCTCACCTTCGAGAGGGTGCAGGGGCTGCGCCGCACCGTGTACGACAGCAAGGAC
TACGCGGAGGGGATCAAGGCGTTCCTGGAGAAGCGGACTCCGGTGTTCAGCGGCGAGTAG

Upstream 100 bases:

>100_bases
TTCCTGATTTTTCGTTTTAACCTGATAAAATCAGAGGCTGGCGCTTGACCATCGCGGGGCGTCCTATCTATCGGCGGTAG
TAACGTGGAGGGAGAAACCA

Downstream 100 bases:

>100_bases
CAATGTCGGACCCCTCGCCGGGTGAGAGAGGGGCTGGGGTGAGGGCGGCGCCAAGGCGAGCCGCACGCAGCAGATGAAAC
GCAGAAGGGCCAGGCAAAAC

Product: methylmalonyl-CoA decarboxylase

Products: NA

Alternate protein names: MMCD; Transcarboxylase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAVISTQLQDNIGTITFNDPDHRNALSGVLIDEMLQSIGALQKGKMRVLVIRAPKGSKVWSAGHDVHELPMPGRDPLAYN
DPLVTVLRSIQSLPIPVIAMIEGSVWGGACDLALSCDILIGCHSSTFCMTPAKIGVPYNVSGILHFMNIMGVNFAKEMFF
TAEPLSAEEAVRAGLLNHLVESEQLEDFTYAMAGKITKNSPLSIGVIKEQIRLLASAHPLSPLTFERVQGLRRTVYDSKD
YAEGIKAFLEKRTPVFSGE

Sequences:

>Translated_259_residues
MAVISTQLQDNIGTITFNDPDHRNALSGVLIDEMLQSIGALQKGKMRVLVIRAPKGSKVWSAGHDVHELPMPGRDPLAYN
DPLVTVLRSIQSLPIPVIAMIEGSVWGGACDLALSCDILIGCHSSTFCMTPAKIGVPYNVSGILHFMNIMGVNFAKEMFF
TAEPLSAEEAVRAGLLNHLVESEQLEDFTYAMAGKITKNSPLSIGVIKEQIRLLASAHPLSPLTFERVQGLRRTVYDSKD
YAEGIKAFLEKRTPVFSGE
>Mature_258_residues
AVISTQLQDNIGTITFNDPDHRNALSGVLIDEMLQSIGALQKGKMRVLVIRAPKGSKVWSAGHDVHELPMPGRDPLAYND
PLVTVLRSIQSLPIPVIAMIEGSVWGGACDLALSCDILIGCHSSTFCMTPAKIGVPYNVSGILHFMNIMGVNFAKEMFFT
AEPLSAEEAVRAGLLNHLVESEQLEDFTYAMAGKITKNSPLSIGVIKEQIRLLASAHPLSPLTFERVQGLRRTVYDSKDY
AEGIKAFLEKRTPVFSGE

Specific function: Unknown

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=263, Percent_Identity=32.319391634981, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502327, Length=259, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI70995211, Length=262, Percent_Identity=24.4274809160305, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI87082183, Length=249, Percent_Identity=51.4056224899598, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1787659, Length=252, Percent_Identity=28.1746031746032, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI221142681, Length=217, Percent_Identity=31.7972350230415, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=27.8884462151394, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787660, Length=270, Percent_Identity=28.5185185185185, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790281, Length=183, Percent_Identity=23.4972677595628, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540714, Length=219, Percent_Identity=28.310502283105, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=28.8, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=26.4227642276423, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=247, Percent_Identity=28.3400809716599, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24653139, Length=262, Percent_Identity=27.4809160305344, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20129971, Length=252, Percent_Identity=27.3809523809524, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653477, Length=252, Percent_Identity=27.3809523809524, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922422, Length=251, Percent_Identity=29.4820717131474, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24583165, Length=243, Percent_Identity=24.2798353909465, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.1.41 [H]

Molecular weight: Translated: 28236; Mature: 28105

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVISTQLQDNIGTITFNDPDHRNALSGVLIDEMLQSIGALQKGKMRVLVIRAPKGSKVW
CCEECCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
SAGHDVHELPMPGRDPLAYNDPLVTVLRSIQSLPIPVIAMIEGSVWGGACDLALSCDILI
CCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHEEEEEEEE
GCHSSTFCMTPAKIGVPYNVSGILHFMNIMGVNFAKEMFFTAEPLSAEEAVRAGLLNHLV
ECCCCCEEECCHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ESEQLEDFTYAMAGKITKNSPLSIGVIKEQIRLLASAHPLSPLTFERVQGLRRTVYDSKD
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHH
YAEGIKAFLEKRTPVFSGE
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AVISTQLQDNIGTITFNDPDHRNALSGVLIDEMLQSIGALQKGKMRVLVIRAPKGSKVW
CEECCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
SAGHDVHELPMPGRDPLAYNDPLVTVLRSIQSLPIPVIAMIEGSVWGGACDLALSCDILI
CCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHEEEEEEEE
GCHSSTFCMTPAKIGVPYNVSGILHFMNIMGVNFAKEMFFTAEPLSAEEAVRAGLLNHLV
ECCCCCEEECCHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ESEQLEDFTYAMAGKITKNSPLSIGVIKEQIRLLASAHPLSPLTFERVQGLRRTVYDSKD
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHH
YAEGIKAFLEKRTPVFSGE
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]