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The map label for this gene is yciR [C]

Identifier: 197117046

GI number: 197117046

Start: 770449

End: 772677

Strand: Direct

Name: yciR [C]

Synonym: Gbem_0649

Alternate gene names: 197117046

Gene position: 770449-772677 (Clockwise)

Preceding gene: 197117045

Following gene: 197117053

Centisome position: 16.69

GC content: 64.02

Gene sequence:

>2229_bases
ATGACCCAGGAAAGCCAAAACATCCGGCGCAGGACCACCTTCATTGCGCTGATCGTCTCCACGATGCTGACGGTGGTTCC
CCCCGCTATCTACTTCGTCATGTCCTTTTCTCACATGAGGGGCGTGGTCGAGGCCGAAGGGGAAATCAACGCCCGCCTCG
TAGGGACGCTCGTGGTGGCGAACCCGCAGATGTGGGAGTTCGAAGAACTGCGCCTGAAGGAGTTGCTGGGGCGCCGCTCC
AAAAGCGGCGTAAAGGAAATAAGAAGGATCTACAACCTGAAGCGCGAAGTGATCGCGGAGAGCGGGGAGCCGCTGCCGCG
GCCGGTCTTCGCACTCTCCTTCCCCGTTCACGATGCCGGGCACGAGGTGGCCCTCCTCGAGGTTTCCCGCTCGTTGCAGC
CGGTTCTGATCAAGACGCTCCTGGCCCTTATCGGGGGCGCCCTGGTGGGGGCGTACGCCTTCTTCCGGCTGAGGACCGTG
CCGCTGCGCGCACTCGATGAGGCGTACCGGGTCCTGAAGCAGAGCGAGGAGAAGTACCGCTCCGTGTACGAGTCGCTCAA
CGAAGGGCTGGCGCTGTACCGGGCTTCCCGCCGTGAGGACGGCTCCGCCGACCTGGTCCTGACCGACGTGAACCCTGCCG
CCATCAACGTGTTCGGCTTCAGCAGGGACGACATCGGCGGCTGGATCACGGAGCTTCTGGACGGGCTCTTCGCGGAATGC
GCCGAGCAGGTCTTCGGGGCGCTGCAGGCCCGGGGCGAGGTGAGCCTGGATCTGGAGCAAAACTCCACCGGCCGCATCTT
CTCGCTCACCGCCTTCCCCATGGGGTACGGCATGGTGGCGACGCTCCTTGAGGACGTGACGGAGAAGAAGAGGACCGCGG
AGCAGTTGGAGCGGCTCGCCTACTACGACAGCCTCACCGGGCTTTTGAACCGCCGCATGCTGCTGGACCGGATGGAGCAG
GCCATCGGGACCGCGCAGCGGGAGGGGGTGAAAGTGGCCACCCTGTTCATGGACCTGAACGGCTTCAAGGTGATCAACGA
CACGCTCGGGCACAAGGCGGGGGACCAGATACTTGTCGAGGTGGCAAAGCGCCTGCAGAAGATGGTGCGCAAGAGGGATA
CCCTGGCGAGGCTCGGGGGGGACGAGTTCGTGGTGGCGGCGACCTTCGAGAAGGACGAAAACGCGAGCGCCATCGCCAAG
AACCTGATCAACGCCATCACCCCGGTTTACCAGGTCTGCGACCGGGAGGTCTACGTGGGGGTGAGCGTGGGGATCTCCAT
TTTCCCCGACGACGGGGATGTACCCGAGACCCTCTTGAAGAACGCGGACATCGCCATGTACAACGCCAAGAGCCAGGGGC
AGGGCGGCTTCTGCTTCTACAGCGCGCAGTTGAACGAAAGGCTGCACGAACGGATGCAGCTGGAGTTCAAGCTGAGGGGG
GCCGTGGAGCGCGAGGAATTCTTCCTTGAGTACCAGCCCATCCTGGACAGCAAGACCGGGCGCATCACCGCGGTGGAGGC
GCTGTTGCGCTGGAACGACCCGGAAAAGGGGAGGGTGATGCCCGACTCCTTCATCCCGCTCGCCGAGGATACCGGCGTCA
TCCTCCCGCTTGGGGAATGGGTGCTCCGCACGGCCTGCGCCAAGCTCAGGCAGTGGCAGGACGCAGGGGTCATGCCGGTG
CGGATGGCGGTGAACATCTCGGGGAGACAGTTCACCCAGGGGGACCTGTCGAAGACGGTGGAGGATGCCCTGCTGCAAAG
CGGCGTCCACCCCTCCTGGCTGGAGCTGGAATTGACCGAGACCTGCCTGATCAAGAACGTCGAGGAGACGGTGAGAAAGC
TCTGCCGCCTCAAGGGGTTGTGCGTCTCCATCTCCATCGACGACTTCGGGACCGGCTACTCCTCGCTGCAGTACCTGAAG
AACTTCCCCATCGACCACCTGAAGATCGACAGGGGGTTCATCAACAACGTCTGCGAGCTCCCGGACGACAGGGCCATTGT
GGACGCCATCATCGGCATAGCGAAGGCGATGGATCTCCACGTCATCGCGGAAGGGGTCGAGACGAGGCAGCAGGCGGAGC
ACCTGATGCGGCGCGGCTGCGACGAGTTCCAGGGGTACTACTTCTACCGGCCGCTCCCCGAGGAGAAGCTCCTGGAGGTG
CTGGCGAGCAAGGCCGCAGCGGGCCTTCCCCCCGGCGAAGACGCCGACTGGCTGGAGCTTCAGGCCTAG

Upstream 100 bases:

>100_bases
AAGAGAGCTCCGCCGCGACGGAGAAGTTCGTGAAGTTCCTCTACTCTAAGAAGGGAAAGTCGCTGGCAGTCAGGCACGGG
CTGCTGCCGACCGGGATTAA

Downstream 100 bases:

>100_bases
AGGCAAAGTCAAAGGCGCCGCACGCGGATTTGACGGATACAACGGGAATTCCGGGGAGAAGAGTCCCCCCCTCCCTTGAC
GGGAGGGGGACGGGGGGTGG

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MTQESQNIRRRTTFIALIVSTMLTVVPPAIYFVMSFSHMRGVVEAEGEINARLVGTLVVANPQMWEFEELRLKELLGRRS
KSGVKEIRRIYNLKREVIAESGEPLPRPVFALSFPVHDAGHEVALLEVSRSLQPVLIKTLLALIGGALVGAYAFFRLRTV
PLRALDEAYRVLKQSEEKYRSVYESLNEGLALYRASRREDGSADLVLTDVNPAAINVFGFSRDDIGGWITELLDGLFAEC
AEQVFGALQARGEVSLDLEQNSTGRIFSLTAFPMGYGMVATLLEDVTEKKRTAEQLERLAYYDSLTGLLNRRMLLDRMEQ
AIGTAQREGVKVATLFMDLNGFKVINDTLGHKAGDQILVEVAKRLQKMVRKRDTLARLGGDEFVVAATFEKDENASAIAK
NLINAITPVYQVCDREVYVGVSVGISIFPDDGDVPETLLKNADIAMYNAKSQGQGGFCFYSAQLNERLHERMQLEFKLRG
AVEREEFFLEYQPILDSKTGRITAVEALLRWNDPEKGRVMPDSFIPLAEDTGVILPLGEWVLRTACAKLRQWQDAGVMPV
RMAVNISGRQFTQGDLSKTVEDALLQSGVHPSWLELELTETCLIKNVEETVRKLCRLKGLCVSISIDDFGTGYSSLQYLK
NFPIDHLKIDRGFINNVCELPDDRAIVDAIIGIAKAMDLHVIAEGVETRQQAEHLMRRGCDEFQGYYFYRPLPEEKLLEV
LASKAAAGLPPGEDADWLELQA

Sequences:

>Translated_742_residues
MTQESQNIRRRTTFIALIVSTMLTVVPPAIYFVMSFSHMRGVVEAEGEINARLVGTLVVANPQMWEFEELRLKELLGRRS
KSGVKEIRRIYNLKREVIAESGEPLPRPVFALSFPVHDAGHEVALLEVSRSLQPVLIKTLLALIGGALVGAYAFFRLRTV
PLRALDEAYRVLKQSEEKYRSVYESLNEGLALYRASRREDGSADLVLTDVNPAAINVFGFSRDDIGGWITELLDGLFAEC
AEQVFGALQARGEVSLDLEQNSTGRIFSLTAFPMGYGMVATLLEDVTEKKRTAEQLERLAYYDSLTGLLNRRMLLDRMEQ
AIGTAQREGVKVATLFMDLNGFKVINDTLGHKAGDQILVEVAKRLQKMVRKRDTLARLGGDEFVVAATFEKDENASAIAK
NLINAITPVYQVCDREVYVGVSVGISIFPDDGDVPETLLKNADIAMYNAKSQGQGGFCFYSAQLNERLHERMQLEFKLRG
AVEREEFFLEYQPILDSKTGRITAVEALLRWNDPEKGRVMPDSFIPLAEDTGVILPLGEWVLRTACAKLRQWQDAGVMPV
RMAVNISGRQFTQGDLSKTVEDALLQSGVHPSWLELELTETCLIKNVEETVRKLCRLKGLCVSISIDDFGTGYSSLQYLK
NFPIDHLKIDRGFINNVCELPDDRAIVDAIIGIAKAMDLHVIAEGVETRQQAEHLMRRGCDEFQGYYFYRPLPEEKLLEV
LASKAAAGLPPGEDADWLELQA
>Mature_741_residues
TQESQNIRRRTTFIALIVSTMLTVVPPAIYFVMSFSHMRGVVEAEGEINARLVGTLVVANPQMWEFEELRLKELLGRRSK
SGVKEIRRIYNLKREVIAESGEPLPRPVFALSFPVHDAGHEVALLEVSRSLQPVLIKTLLALIGGALVGAYAFFRLRTVP
LRALDEAYRVLKQSEEKYRSVYESLNEGLALYRASRREDGSADLVLTDVNPAAINVFGFSRDDIGGWITELLDGLFAECA
EQVFGALQARGEVSLDLEQNSTGRIFSLTAFPMGYGMVATLLEDVTEKKRTAEQLERLAYYDSLTGLLNRRMLLDRMEQA
IGTAQREGVKVATLFMDLNGFKVINDTLGHKAGDQILVEVAKRLQKMVRKRDTLARLGGDEFVVAATFEKDENASAIAKN
LINAITPVYQVCDREVYVGVSVGISIFPDDGDVPETLLKNADIAMYNAKSQGQGGFCFYSAQLNERLHERMQLEFKLRGA
VEREEFFLEYQPILDSKTGRITAVEALLRWNDPEKGRVMPDSFIPLAEDTGVILPLGEWVLRTACAKLRQWQDAGVMPVR
MAVNISGRQFTQGDLSKTVEDALLQSGVHPSWLELELTETCLIKNVEETVRKLCRLKGLCVSISIDDFGTGYSSLQYLKN
FPIDHLKIDRGFINNVCELPDDRAIVDAIIGIAKAMDLHVIAEGVETRQQAEHLMRRGCDEFQGYYFYRPLPEEKLLEVL
ASKAAAGLPPGEDADWLELQA

Specific function: Unknown

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MHYT domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=429, Percent_Identity=37.2960372960373, Blast_Score=316, Evalue=4e-87,
Organism=Escherichia coli, GI87081921, Length=430, Percent_Identity=32.7906976744186, Blast_Score=259, Evalue=5e-70,
Organism=Escherichia coli, GI226510982, Length=441, Percent_Identity=28.7981859410431, Blast_Score=188, Evalue=1e-48,
Organism=Escherichia coli, GI1788502, Length=267, Percent_Identity=33.7078651685393, Blast_Score=168, Evalue=9e-43,
Organism=Escherichia coli, GI87081845, Length=270, Percent_Identity=31.1111111111111, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1790496, Length=258, Percent_Identity=32.5581395348837, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI87081980, Length=257, Percent_Identity=32.6848249027237, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786507, Length=255, Percent_Identity=32.156862745098, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1787055, Length=259, Percent_Identity=33.5907335907336, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI87081743, Length=253, Percent_Identity=32.0158102766798, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788849, Length=435, Percent_Identity=25.7471264367816, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788381, Length=345, Percent_Identity=28.695652173913, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI87081977, Length=186, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87081881, Length=267, Percent_Identity=28.4644194756554, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87082096, Length=244, Percent_Identity=29.5081967213115, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI145693134, Length=165, Percent_Identity=35.1515151515151, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1786584, Length=183, Percent_Identity=27.8688524590164, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787262, Length=165, Percent_Identity=30.9090909090909, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1789650, Length=452, Percent_Identity=19.6902654867257, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788956, Length=163, Percent_Identity=33.1288343558282, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081974, Length=169, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1787816, Length=165, Percent_Identity=30.9090909090909, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082007, Length=163, Percent_Identity=28.8343558282209, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788085, Length=164, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787410, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787802, Length=170, Percent_Identity=25.8823529411765, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 82971; Mature: 82840

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQESQNIRRRTTFIALIVSTMLTVVPPAIYFVMSFSHMRGVVEAEGEINARLVGTLVVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEEEE
NPQMWEFEELRLKELLGRRSKSGVKEIRRIYNLKREVIAESGEPLPRPVFALSFPVHDAG
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
HEVALLEVSRSLQPVLIKTLLALIGGALVGAYAFFRLRTVPLRALDEAYRVLKQSEEKYR
CCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVYESLNEGLALYRASRREDGSADLVLTDVNPAAINVFGFSRDDIGGWITELLDGLFAEC
HHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
AEQVFGALQARGEVSLDLEQNSTGRIFSLTAFPMGYGMVATLLEDVTEKKRTAEQLERLA
HHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YYDSLTGLLNRRMLLDRMEQAIGTAQREGVKVATLFMDLNGFKVINDTLGHKAGDQILVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEHHHHHCCCCCHHHHHH
VAKRLQKMVRKRDTLARLGGDEFVVAATFEKDENASAIAKNLINAITPVYQVCDREVYVG
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
VSVGISIFPDDGDVPETLLKNADIAMYNAKSQGQGGFCFYSAQLNERLHERMQLEFKLRG
EEECEEEECCCCCCHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCC
AVEREEFFLEYQPILDSKTGRITAVEALLRWNDPEKGRVMPDSFIPLAEDTGVILPLGEW
CCCHHHHHEEEHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHH
VLRTACAKLRQWQDAGVMPVRMAVNISGRQFTQGDLSKTVEDALLQSGVHPSWLELELTE
HHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHH
TCLIKNVEETVRKLCRLKGLCVSISIDDFGTGYSSLQYLKNFPIDHLKIDRGFINNVCEL
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEECHHHHHHHHCC
PDDRAIVDAIIGIAKAMDLHVIAEGVETRQQAEHLMRRGCDEFQGYYFYRPLPEEKLLEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECCCCHHHHHHH
LASKAAAGLPPGEDADWLELQA
HHHHHHCCCCCCCCCCCEEECC
>Mature Secondary Structure 
TQESQNIRRRTTFIALIVSTMLTVVPPAIYFVMSFSHMRGVVEAEGEINARLVGTLVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEEEE
NPQMWEFEELRLKELLGRRSKSGVKEIRRIYNLKREVIAESGEPLPRPVFALSFPVHDAG
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
HEVALLEVSRSLQPVLIKTLLALIGGALVGAYAFFRLRTVPLRALDEAYRVLKQSEEKYR
CCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVYESLNEGLALYRASRREDGSADLVLTDVNPAAINVFGFSRDDIGGWITELLDGLFAEC
HHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
AEQVFGALQARGEVSLDLEQNSTGRIFSLTAFPMGYGMVATLLEDVTEKKRTAEQLERLA
HHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YYDSLTGLLNRRMLLDRMEQAIGTAQREGVKVATLFMDLNGFKVINDTLGHKAGDQILVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEHHHHHCCCCCHHHHHH
VAKRLQKMVRKRDTLARLGGDEFVVAATFEKDENASAIAKNLINAITPVYQVCDREVYVG
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
VSVGISIFPDDGDVPETLLKNADIAMYNAKSQGQGGFCFYSAQLNERLHERMQLEFKLRG
EEECEEEECCCCCCHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCC
AVEREEFFLEYQPILDSKTGRITAVEALLRWNDPEKGRVMPDSFIPLAEDTGVILPLGEW
CCCHHHHHEEEHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHH
VLRTACAKLRQWQDAGVMPVRMAVNISGRQFTQGDLSKTVEDALLQSGVHPSWLELELTE
HHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHH
TCLIKNVEETVRKLCRLKGLCVSISIDDFGTGYSSLQYLKNFPIDHLKIDRGFINNVCEL
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEECHHHHHHHHCC
PDDRAIVDAIIGIAKAMDLHVIAEGVETRQQAEHLMRRGCDEFQGYYFYRPLPEEKLLEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECCCCHHHHHHH
LASKAAAGLPPGEDADWLELQA
HHHHHHCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]