Click here to switch to the map view.

The map label for this gene is hppA [H]

Identifier: 197116963

GI number: 197116963

Start: 684661

End: 686703

Strand: Direct

Name: hppA [H]

Synonym: Gbem_0566

Alternate gene names: 197116963

Gene position: 684661-686703 (Clockwise)

Preceding gene: 197116957

Following gene: 197116968

Centisome position: 14.84

GC content: 63.09

Gene sequence:

>2043_bases
ATGGAACAGTATGCAGTAGTCTTCGCCCTGGCTTGTGCCGCGGCGGCAGTGGCCTACGGTCTTATCTCGGCCCAGTGGAT
CTTGGGGCTCCCCCAGGGTAACGAGCGGATGCGTCAGATCGCCGCAGCCATCCAGGAAGGGGCAGGGGCCTACATGAAGC
GTCAGTACACCATCATCGCGGTGGTCGGCGTCGCCATGTTCGTCGCACTCTTCGCAACCCTCGGCTGGAAGACCGCGGTC
GGCTTCCTGGTCGGCGCAGTCTTCTCCGGCCTCACCGGCTTCATCGGGATGTTCGTCTCGGTACGCGCCAACGTGAGGAC
CACCGAGGCTGCCAAGTCCGGCATCCACAAGGCGCTCAACGTCGCTTTCAAGGGTGGTGCGATCACCGGTATGCTGGTTG
TCGGTCTCGGTCTTCTGGGCGTTGCAGGCTACTACATGGTGCTCCAGCAGATCATGCCGGGCGCTCCGGTCAAAGAAATC
GTCAGCCAGTTGGTCGGCCTCGGCTTCGGCGGCTCGCTGATCTCCATCTTCGCCCGTCTGGGCGGCGGTATCTTCACCAA
GGGCGCTGACGTCGGCGCCGACCTCGTAGGCAAGGTCGAAGCCGGTATCCCCGAAGACGACCCCCGCAACCCGGCAGTCA
TCGCCGACAACGTGGGCGACAACGTCGGCGACTGCGCCGGCATGGCCGCCGACCTCTTCGAGACCTACGCGGTAACCCTG
ATCGCCGCCATGCTCCTTGGCGCCATCACCTTCACCAACTCGGCTGCAGTAAACTACCCGCTGATCCTGGGGGGCATCTC
CATCATCGCCTCCATCATCGGCACCTACTTCGTCAAGCTCGGCGGCTCCGGCAAGATCATGGGCGCGCTCTACAAGGGGC
TCATCGCTTCGGCCGTGATCGCCTGCATCGCCTTCTACTTCGTGACCGTGCAGATGTTCCCGCAGGGGCTGACCACCGCC
ACCGGCGCCACCATCAGCGCCCTCAACATCTTCATCTCCGCCATCGTCGGCCTCGTGGTCACCGGTGCCATCTTCTGGAT
CACCGAGTACTACACCGCCACCGAGTACGCTCCGGTCAAGCACATCGCCGAAGCCTCCAAGACCGGCCACGCCACCAACA
TCATCGCCGGTCTCGGCGTTTCCATGAAGTCCACCGCCCTTCCGGTCATCGTCATCGCTGCCGGCATCGTGGTCGCCTCC
AACTGCGCCGGGGTCTACGGCATCGCCATCGCGGCTGTGTCCATGCTCTCCCTGACCGGTATCGTCGTCGCCATGGACGC
CTACGGCCCCATCACCGACAACGCCGGCGGCATCGCCGAGATGGCTGAACTGGACGATTCCGTCCGCGCCGTTACCGACC
CGCTCGACGCGGTCGGCAACACCACCAAGGCCGTCACCAAAGGCTACGCCATCGGCTCCGCAGGCCTTGCCGCAATCATC
CTGTTCACCTCCTATGTGCAGGAGCTGACCATCGCCGACAAGAGCTTCTCCCTCTCCGATCCGTACATCATCGTCGGCCT
CTTCATCGGCGGCATGCTCCCCTACTACTTCGCGGCTATGTGCATGGAAGCTGTCGGTAAGGCAGGCGGCGCGGTCGTAG
ACGAGGTTCGTCGCCAGTTCCGCACCATCAAGGGGATCATGGAAGGCACCGGCAAGCCGGACTATGCTGCCTGCGTCGAC
ATCGTCACCAAGACCGCTCTTAAAGAGATGGTCATCCCGGGTCTCATCCCGATCCTCGCCCCGATCGTCGTAGGCTTCAC
CCTCGGGCCCAAGGCTCTGGGCGGCGTCATCGTCGGTTCCATCGTCACCGGTATCTTCGTCGCTATCTCCATGACCACCG
GCGGCGGCGCATGGGACAACGCCAAGAAGTACATCGAGGACGGCTATCACGGCGGCAAAGGTAGCGAAGCCCACAAGGCT
GCAGTTACCGGCGACACCGTAGGCGACCCGTACAAGGACACCGCAGGCCCTGCGGTCAACCCGATGATCAAAATCATCAA
CATCGTCTCGCTGCTCATCGTTCCGCTGCTGAACAAGATGTAG

Upstream 100 bases:

>100_bases
TCTTTTCGATAACAATCACCCGTTTTTATGAAAGGATTTGTACTGCGCAAAGGGAAGTCACGCCTTTTCGAGGCATATCT
AAATAGGAGGATTTTTTTCA

Downstream 100 bases:

>100_bases
CAACAGGCTTTGGCTGAAACTAAAAAGGCGTCCCGGATTTCCGGGGCGCCTTTTTTCGTGGCTCGTAAGGGAATTGCGGG
GGACTTCGAGTCCCCTCCCC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MEQYAVVFALACAAAAVAYGLISAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIIAVVGVAMFVALFATLGWKTAV
GFLVGAVFSGLTGFIGMFVSVRANVRTTEAAKSGIHKALNVAFKGGAITGMLVVGLGLLGVAGYYMVLQQIMPGAPVKEI
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAITFTNSAAVNYPLILGGISIIASIIGTYFVKLGGSGKIMGALYKGLIASAVIACIAFYFVTVQMFPQGLTTA
TGATISALNIFISAIVGLVVTGAIFWITEYYTATEYAPVKHIAEASKTGHATNIIAGLGVSMKSTALPVIVIAAGIVVAS
NCAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAII
LFTSYVQELTIADKSFSLSDPYIIVGLFIGGMLPYYFAAMCMEAVGKAGGAVVDEVRRQFRTIKGIMEGTGKPDYAACVD
IVTKTALKEMVIPGLIPILAPIVVGFTLGPKALGGVIVGSIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGSEAHKA
AVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLNKM

Sequences:

>Translated_680_residues
MEQYAVVFALACAAAAVAYGLISAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIIAVVGVAMFVALFATLGWKTAV
GFLVGAVFSGLTGFIGMFVSVRANVRTTEAAKSGIHKALNVAFKGGAITGMLVVGLGLLGVAGYYMVLQQIMPGAPVKEI
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAITFTNSAAVNYPLILGGISIIASIIGTYFVKLGGSGKIMGALYKGLIASAVIACIAFYFVTVQMFPQGLTTA
TGATISALNIFISAIVGLVVTGAIFWITEYYTATEYAPVKHIAEASKTGHATNIIAGLGVSMKSTALPVIVIAAGIVVAS
NCAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAII
LFTSYVQELTIADKSFSLSDPYIIVGLFIGGMLPYYFAAMCMEAVGKAGGAVVDEVRRQFRTIKGIMEGTGKPDYAACVD
IVTKTALKEMVIPGLIPILAPIVVGFTLGPKALGGVIVGSIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGSEAHKA
AVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLNKM
>Mature_680_residues
MEQYAVVFALACAAAAVAYGLISAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIIAVVGVAMFVALFATLGWKTAV
GFLVGAVFSGLTGFIGMFVSVRANVRTTEAAKSGIHKALNVAFKGGAITGMLVVGLGLLGVAGYYMVLQQIMPGAPVKEI
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAITFTNSAAVNYPLILGGISIIASIIGTYFVKLGGSGKIMGALYKGLIASAVIACIAFYFVTVQMFPQGLTTA
TGATISALNIFISAIVGLVVTGAIFWITEYYTATEYAPVKHIAEASKTGHATNIIAGLGVSMKSTALPVIVIAAGIVVAS
NCAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAII
LFTSYVQELTIADKSFSLSDPYIIVGLFIGGMLPYYFAAMCMEAVGKAGGAVVDEVRRQFRTIKGIMEGTGKPDYAACVD
IVTKTALKEMVIPGLIPILAPIVVGFTLGPKALGGVIVGSIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGSEAHKA
AVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLNKM

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 69620; Mature: 69620

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQYAVVFALACAAAAVAYGLISAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGVAMFVALFATLGWKTAVGFLVGAVFSGLTGFIGMFVSVRANVRTTEAAKSGIHKALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAFKGGAITGMLVVGLGLLGVAGYYMVLQQIMPGAPVKEIVSQLVGLGFGGSLISIFARL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IAAMLLGAITFTNSAAVNYPLILGGISIIASIIGTYFVKLGGSGKIMGALYKGLIASAVI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ACIAFYFVTVQMFPQGLTTATGATISALNIFISAIVGLVVTGAIFWITEYYTATEYAPVK
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
HIAEASKTGHATNIIAGLGVSMKSTALPVIVIAAGIVVASNCAGVYGIAIAAVSMLSLTG
HHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAII
HHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHCCCCCHHHHHHHH
LFTSYVQELTIADKSFSLSDPYIIVGLFIGGMLPYYFAAMCMEAVGKAGGAVVDEVRRQF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RTIKGIMEGTGKPDYAACVDIVTKTALKEMVIPGLIPILAPIVVGFTLGPKALGGVIVGS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVN
HHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCHH
PMIKIINIVSLLIVPLLNKM
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEQYAVVFALACAAAAVAYGLISAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGVAMFVALFATLGWKTAVGFLVGAVFSGLTGFIGMFVSVRANVRTTEAAKSGIHKALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAFKGGAITGMLVVGLGLLGVAGYYMVLQQIMPGAPVKEIVSQLVGLGFGGSLISIFARL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IAAMLLGAITFTNSAAVNYPLILGGISIIASIIGTYFVKLGGSGKIMGALYKGLIASAVI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ACIAFYFVTVQMFPQGLTTATGATISALNIFISAIVGLVVTGAIFWITEYYTATEYAPVK
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
HIAEASKTGHATNIIAGLGVSMKSTALPVIVIAAGIVVASNCAGVYGIAIAAVSMLSLTG
HHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAII
HHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHCCCCCHHHHHHHH
LFTSYVQELTIADKSFSLSDPYIIVGLFIGGMLPYYFAAMCMEAVGKAGGAVVDEVRRQF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RTIKGIMEGTGKPDYAACVDIVTKTALKEMVIPGLIPILAPIVVGFTLGPKALGGVIVGS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVN
HHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCHH
PMIKIINIVSLLIVPLLNKM
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]