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The map label for this gene is gmr [H]

Identifier: 197116874

GI number: 197116874

Start: 575582

End: 576877

Strand: Reverse

Name: gmr [H]

Synonym: Gbem_0476

Alternate gene names: 197116874

Gene position: 576877-575582 (Counterclockwise)

Preceding gene: 197116897

Following gene: 197116868

Centisome position: 12.5

GC content: 61.65

Gene sequence:

>1296_bases
ATGGGAAGATTGCTCAGAGTTTTGATGGTAGAAGACGCTCCTGACGATGCACAGCTCATCGTGATCCGGTTGGAACAGGG
AGGTTTCGACGTCCAGTTCCAGCGTGTCGACAGCGCCCAGGCCATGTGTGACGCCTTGGAAGGCTCTCCGTGGGACATCA
TCATCTGCGACTACGTCATGCCGGGCTTCAGCGGCCTGCAGGCTCTGAAAATCCTTAAGGAGAAAGGGACCGACACTCCC
TTCCTGATGATCTCCGGCAAGGTCGGGGAAGAGGCCGCGGCTGAGGCTATACGTTGCGGCGCCGACGGATTCCTGCTCAA
GGGGAACCTCACCGGCTTGGTCCCCGCCGTGCAGAGGGGGCTCGCCGACGCGGCACTGCGCGAACAGAACCGCCGCCACG
AGCAGGAGCTCAAGGACAAGCTCTCCTTCATCCAGATACTGATCGACACCCTCCCCACACCCATCTTCTACAACGACCCC
AACGGACTCTATTTGGGTTGCAACAAGGCCTTCGAGGAGCAGATCGGGATGAAGCGGGGCGAGAGCATCAACAAGAGCAT
CTACGACATCCTCCCGCCGGACCTGGCGGCATTGTACACCCGGGGGGAAGAGGTGGCAGAAAGCGGTAGCGGACCGCGCA
GCTTCGAAGGGACCATCACCTGCGCCGACGGCGAAGAGCGCGACGTCATCTTCTACAGCGCGTCCTTCAGCAACTCGGGG
TCTACGGACGGCGGCGTCGTCGGCGCGCTCCTCGACATCTCCGAGAGAAAACGCGCCGAGACCAAGCTCCGCTACTTAAG
CACCCACGACATGCTTACCGGCATCTACAACCGCGCCTATTTCGATGAGGAACTGGAGCGCCTTAAGAAGGGGCGCAAGT
TCCCGGTCAGCATCGTCATGGCAGACGTGGACTGCCTCAAGGAGGCCAACGACCGGTACGGCCACGCCGCTGGGGACGAA
CTGCTGAAACAAGCTGCCGAGGTGTTGAAGAGCGCTTTCAGGAGGGAGGACGTGGCGGCGCGCATAGGCGGCGACGAATT
TGCGGCGCTGCTCCCCAACACCGACGAGGCGGCCCTGGTCGAGGCGATGGAGCGGCTGCAGCAGCAACTGCTGCTAAGCA
ACAAGGAACACCACGGCTTCCCCCTAACCTTAAGCCTCTCGACAGGGGCGGCTACCGCTTTAAACGGCGAGGAGCTCTCC
GCCGCCTGGCGCGTTGCGGATCAAAGGATGTACCGTGAGAAAAAAGGGCGCAGCGCCGGCACTCCCCACTTCAGGCAGCG
CCACATAAGCGTCTGA

Upstream 100 bases:

>100_bases
AATGAGCACAAATATTAAAGCTTGCCTTTACACATTAGTAAAGTACAATCCTGTGTCTCCGATGTTTCGGGTCTATATCG
CGTTTTAGGAGAAGCATTCC

Downstream 100 bases:

>100_bases
GGCGAATCGCCGCTCCCCGCTTCACTGCGACCGAACCTGCCCGGCTACACCCCGTGAGAGGAGTAGTCGGCGAAGCCTTT
CTGCAGCAGTGCGGCAGCTT

Product: response receiver sensor diguanylate cyclase, PAS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MGRLLRVLMVEDAPDDAQLIVIRLEQGGFDVQFQRVDSAQAMCDALEGSPWDIIICDYVMPGFSGLQALKILKEKGTDTP
FLMISGKVGEEAAAEAIRCGADGFLLKGNLTGLVPAVQRGLADAALREQNRRHEQELKDKLSFIQILIDTLPTPIFYNDP
NGLYLGCNKAFEEQIGMKRGESINKSIYDILPPDLAALYTRGEEVAESGSGPRSFEGTITCADGEERDVIFYSASFSNSG
STDGGVVGALLDISERKRAETKLRYLSTHDMLTGIYNRAYFDEELERLKKGRKFPVSIVMADVDCLKEANDRYGHAAGDE
LLKQAAEVLKSAFRREDVAARIGGDEFAALLPNTDEAALVEAMERLQQQLLLSNKEHHGFPLTLSLSTGAATALNGEELS
AAWRVADQRMYREKKGRSAGTPHFRQRHISV

Sequences:

>Translated_431_residues
MGRLLRVLMVEDAPDDAQLIVIRLEQGGFDVQFQRVDSAQAMCDALEGSPWDIIICDYVMPGFSGLQALKILKEKGTDTP
FLMISGKVGEEAAAEAIRCGADGFLLKGNLTGLVPAVQRGLADAALREQNRRHEQELKDKLSFIQILIDTLPTPIFYNDP
NGLYLGCNKAFEEQIGMKRGESINKSIYDILPPDLAALYTRGEEVAESGSGPRSFEGTITCADGEERDVIFYSASFSNSG
STDGGVVGALLDISERKRAETKLRYLSTHDMLTGIYNRAYFDEELERLKKGRKFPVSIVMADVDCLKEANDRYGHAAGDE
LLKQAAEVLKSAFRREDVAARIGGDEFAALLPNTDEAALVEAMERLQQQLLLSNKEHHGFPLTLSLSTGAATALNGEELS
AAWRVADQRMYREKKGRSAGTPHFRQRHISV
>Mature_430_residues
GRLLRVLMVEDAPDDAQLIVIRLEQGGFDVQFQRVDSAQAMCDALEGSPWDIIICDYVMPGFSGLQALKILKEKGTDTPF
LMISGKVGEEAAAEAIRCGADGFLLKGNLTGLVPAVQRGLADAALREQNRRHEQELKDKLSFIQILIDTLPTPIFYNDPN
GLYLGCNKAFEEQIGMKRGESINKSIYDILPPDLAALYTRGEEVAESGSGPRSFEGTITCADGEERDVIFYSASFSNSGS
TDGGVVGALLDISERKRAETKLRYLSTHDMLTGIYNRAYFDEELERLKKGRKFPVSIVMADVDCLKEANDRYGHAAGDEL
LKQAAEVLKSAFRREDVAARIGGDEFAALLPNTDEAALVEAMERLQQQLLLSNKEHHGFPLTLSLSTGAATALNGEELSA
AWRVADQRMYREKKGRSAGTPHFRQRHISV

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=301, Percent_Identity=27.5747508305648, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082007, Length=166, Percent_Identity=31.9277108433735, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788381, Length=164, Percent_Identity=32.3170731707317, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081881, Length=225, Percent_Identity=30.6666666666667, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787262, Length=157, Percent_Identity=32.484076433121, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081974, Length=153, Percent_Identity=30.718954248366, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786584, Length=175, Percent_Identity=30.8571428571429, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI145693134, Length=155, Percent_Identity=30.9677419354839, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081977, Length=221, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788085, Length=132, Percent_Identity=28.7878787878788, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788956, Length=154, Percent_Identity=33.1168831168831, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787816, Length=154, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786599, Length=131, Percent_Identity=32.0610687022901, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787802, Length=156, Percent_Identity=27.5641025641026, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 47439; Mature: 47308

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLLRVLMVEDAPDDAQLIVIRLEQGGFDVQFQRVDSAQAMCDALEGSPWDIIICDYVM
CCCCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCEEEEECCCC
PGFSGLQALKILKEKGTDTPFLMISGKVGEEAAAEAIRCGADGFLLKGNLTGLVPAVQRG
CCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
LADAALREQNRRHEQELKDKLSFIQILIDTLPTPIFYNDPNGLYLGCNKAFEEQIGMKRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHCCCCC
ESINKSIYDILPPDLAALYTRGEEVAESGSGPRSFEGTITCADGEERDVIFYSASFSNSG
CCHHHHHHHHCCHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCC
STDGGVVGALLDISERKRAETKLRYLSTHDMLTGIYNRAYFDEELERLKKGRKFPVSIVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ADVDCLKEANDRYGHAAGDELLKQAAEVLKSAFRREDVAARIGGDEFAALLPNTDEAALV
ECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHH
EAMERLQQQLLLSNKEHHGFPLTLSLSTGAATALNGEELSAAWRVADQRMYREKKGRSAG
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCC
TPHFRQRHISV
CCHHHHHCCCC
>Mature Secondary Structure 
GRLLRVLMVEDAPDDAQLIVIRLEQGGFDVQFQRVDSAQAMCDALEGSPWDIIICDYVM
CCCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCEEEEECCCC
PGFSGLQALKILKEKGTDTPFLMISGKVGEEAAAEAIRCGADGFLLKGNLTGLVPAVQRG
CCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
LADAALREQNRRHEQELKDKLSFIQILIDTLPTPIFYNDPNGLYLGCNKAFEEQIGMKRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHCCCCC
ESINKSIYDILPPDLAALYTRGEEVAESGSGPRSFEGTITCADGEERDVIFYSASFSNSG
CCHHHHHHHHCCHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCC
STDGGVVGALLDISERKRAETKLRYLSTHDMLTGIYNRAYFDEELERLKKGRKFPVSIVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ADVDCLKEANDRYGHAAGDELLKQAAEVLKSAFRREDVAARIGGDEFAALLPNTDEAALV
ECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHH
EAMERLQQQLLLSNKEHHGFPLTLSLSTGAATALNGEELSAAWRVADQRMYREKKGRSAG
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCC
TPHFRQRHISV
CCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]