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The map label for this gene is mtd [H]

Identifier: 197116799

GI number: 197116799

Start: 477192

End: 478250

Strand: Reverse

Name: mtd [H]

Synonym: Gbem_0401

Alternate gene names: 197116799

Gene position: 478250-477192 (Counterclockwise)

Preceding gene: 197116800

Following gene: 197116792

Centisome position: 10.36

GC content: 61.47

Gene sequence:

>1059_bases
ATGCCCAACGCCAAAGCCTACTCCGCTGCCAGCGCCACTTCGCCGCTGGCTTCCACCACCATATCCCGCCGCGAACCAAC
CGAGCGCGACGTGCAGATCGAGATCCTTTTTTGCGGCATCTGCCACTCCGACCTGCACTCCGTGCGTAACGAGTGGAGCA
GCGTCATGCCCACGGTGTACCCCATCGTCCCCGGCCACGAAATAGTGGGACGCGTCACCAAGGTCGGGTCCGCGGTCACC
AATTTCAAGCCGGGCGACCTGGCCGGGGTCGGCTGCCTGGTCGATTCGGACCAAAGCTGCCCCCATTGCCACGAGAATCT
GGAACAGTTATGCCCGAACCAGGTATTGACCTACAACTCGCCCGACAGACACCTTGGGGGTGTTACCTACGGCGGCTACT
CCGAGAGCATCGTGGTGGACGAGCACTTCGTACTGCACGTCCCCGGCAATTTGGAGCTCGCCGGTGTCGCGCCCTTGCTC
TGCGCTGGGATCACGACATACTCCCCGATACACCGCTGGGGGGACATCAAAGGCAAAAAGGTCGGCATCGTCGGCCTGGG
CGGCCTGGGTCACATGGGGGTGAAGTTCGCCCACGCCTTCGGAGCCCATGTAGTCGTCTTCACCACCTCCCCCGGGAAGA
AAGAAGATGCGTTGCGCCTGGGGGCAGACGAGGTGATCATCTCCACGAGCGCCGAAGAAATGAAAAAACATGCAGGGAGC
TTCCATTTCATCCTCGACACCATAGCCGCCGACCATGACATCAACGCCTACCTGGGCATGCTCACCCACGACGGCAACCT
AACCCTCGTGGGTGCGCCGGAGACGCCTCTCGCCGTCTCCGCCTTCGCTCTTTTGTTCGGTCGCCGCAGCCTCTCCGGCT
CCATCATCGGCGGCATCAAAGAGACCCAGGAGATGCTCGACTTCTGCGGCGCGCACAACATCACCAGCGACGTGGAGGTG
ATCCCCATCCAGAGGGTAAACGAGGCCTACGAGCGGCTGCTCAAGTCCGATGTGAAGTACCGCTTCTCCATCGACATGGC
GTCGCTCAAGGCAGAATAA

Upstream 100 bases:

>100_bases
GCCTCCAAGATCCAGGTGGAGGGTGCCCGTTACCCGGAAAGGCTGGAAGAATTGACCGGCCGTTAACACGCAGGAAACAA
CACTAAAGGAGGAATATCAA

Downstream 100 bases:

>100_bases
CAAAGTTGGCAAAAGATGCGAAAAAGCCGCTGGATTTTGAGTCCAGCGGCTTTTTCTGTATGGCGATCAGGGAAGAGAAG
GCAAATCCCCCCAGTCTCCT

Product: mannitol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPNAKAYSAASATSPLASTTISRREPTERDVQIEILFCGICHSDLHSVRNEWSSVMPTVYPIVPGHEIVGRVTKVGSAVT
NFKPGDLAGVGCLVDSDQSCPHCHENLEQLCPNQVLTYNSPDRHLGGVTYGGYSESIVVDEHFVLHVPGNLELAGVAPLL
CAGITTYSPIHRWGDIKGKKVGIVGLGGLGHMGVKFAHAFGAHVVVFTTSPGKKEDALRLGADEVIISTSAEEMKKHAGS
FHFILDTIAADHDINAYLGMLTHDGNLTLVGAPETPLAVSAFALLFGRRSLSGSIIGGIKETQEMLDFCGAHNITSDVEV
IPIQRVNEAYERLLKSDVKYRFSIDMASLKAE

Sequences:

>Translated_352_residues
MPNAKAYSAASATSPLASTTISRREPTERDVQIEILFCGICHSDLHSVRNEWSSVMPTVYPIVPGHEIVGRVTKVGSAVT
NFKPGDLAGVGCLVDSDQSCPHCHENLEQLCPNQVLTYNSPDRHLGGVTYGGYSESIVVDEHFVLHVPGNLELAGVAPLL
CAGITTYSPIHRWGDIKGKKVGIVGLGGLGHMGVKFAHAFGAHVVVFTTSPGKKEDALRLGADEVIISTSAEEMKKHAGS
FHFILDTIAADHDINAYLGMLTHDGNLTLVGAPETPLAVSAFALLFGRRSLSGSIIGGIKETQEMLDFCGAHNITSDVEV
IPIQRVNEAYERLLKSDVKYRFSIDMASLKAE
>Mature_351_residues
PNAKAYSAASATSPLASTTISRREPTERDVQIEILFCGICHSDLHSVRNEWSSVMPTVYPIVPGHEIVGRVTKVGSAVTN
FKPGDLAGVGCLVDSDQSCPHCHENLEQLCPNQVLTYNSPDRHLGGVTYGGYSESIVVDEHFVLHVPGNLELAGVAPLLC
AGITTYSPIHRWGDIKGKKVGIVGLGGLGHMGVKFAHAFGAHVVVFTTSPGKKEDALRLGADEVIISTSAEEMKKHAGSF
HFILDTIAADHDINAYLGMLTHDGNLTLVGAPETPLAVSAFALLFGRRSLSGSIIGGIKETQEMLDFCGAHNITSDVEVI
PIQRVNEAYERLLKSDVKYRFSIDMASLKAE

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=24.7311827956989, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=24.7311827956989, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=27.3972602739726, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4501929, Length=368, Percent_Identity=27.1739130434783, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=26.9021739130435, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565152, Length=369, Percent_Identity=23.8482384823848, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=57.0605187319885, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI87082401, Length=347, Percent_Identity=33.4293948126801, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=26.1980830670927, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=249, Percent_Identity=28.5140562248996, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790045, Length=355, Percent_Identity=25.6338028169014, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI226510992, Length=322, Percent_Identity=26.3975155279503, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788407, Length=263, Percent_Identity=28.1368821292776, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=335, Percent_Identity=25.3731343283582, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=26.9794721407625, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=24.7863247863248, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=334, Percent_Identity=26.9461077844311, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=336, Percent_Identity=26.7857142857143, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=208, Percent_Identity=30.2884615384615, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=217, Percent_Identity=30.8755760368664, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=323, Percent_Identity=37.1517027863777, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319949, Length=324, Percent_Identity=36.1111111111111, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323961, Length=331, Percent_Identity=31.1178247734139, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=29.9093655589124, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=29.0697674418605, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323729, Length=332, Percent_Identity=29.2168674698795, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=362, Percent_Identity=25.9668508287293, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37756; Mature: 37625

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNAKAYSAASATSPLASTTISRREPTERDVQIEILFCGICHSDLHSVRNEWSSVMPTVY
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCEEE
PIVPGHEIVGRVTKVGSAVTNFKPGDLAGVGCLVDSDQSCPHCHENLEQLCPNQVLTYNS
ECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCC
PDRHLGGVTYGGYSESIVVDEHFVLHVPGNLELAGVAPLLCAGITTYSPIHRWGDIKGKK
CCCCCCCEEECCCCCEEEEECEEEEECCCCEEEHHHHHHHHHCCCCCCHHHHHCCCCCCE
VGIVGLGGLGHMGVKFAHAFGAHVVVFTTSPGKKEDALRLGADEVIISTSAEEMKKHAGS
EEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHCCC
FHFILDTIAADHDINAYLGMLTHDGNLTLVGAPETPLAVSAFALLFGRRSLSGSIIGGIK
EEEEHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHCCHH
ETQEMLDFCGAHNITSDVEVIPIQRVNEAYERLLKSDVKYRFSIDMASLKAE
HHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEEHHHHCCC
>Mature Secondary Structure 
PNAKAYSAASATSPLASTTISRREPTERDVQIEILFCGICHSDLHSVRNEWSSVMPTVY
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCEEE
PIVPGHEIVGRVTKVGSAVTNFKPGDLAGVGCLVDSDQSCPHCHENLEQLCPNQVLTYNS
ECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCC
PDRHLGGVTYGGYSESIVVDEHFVLHVPGNLELAGVAPLLCAGITTYSPIHRWGDIKGKK
CCCCCCCEEECCCCCEEEEECEEEEECCCCEEEHHHHHHHHHCCCCCCHHHHHCCCCCCE
VGIVGLGGLGHMGVKFAHAFGAHVVVFTTSPGKKEDALRLGADEVIISTSAEEMKKHAGS
EEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHCCC
FHFILDTIAADHDINAYLGMLTHDGNLTLVGAPETPLAVSAFALLFGRRSLSGSIIGGIK
EEEEHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHCCHH
ETQEMLDFCGAHNITSDVEVIPIQRVNEAYERLLKSDVKYRFSIDMASLKAE
HHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]