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The map label for this gene is adhI [H]

Identifier: 197104311

GI number: 197104311

Start: 935785

End: 936870

Strand: Direct

Name: adhI [H]

Synonym: PHZ_c0845

Alternate gene names: 197104311

Gene position: 935785-936870 (Clockwise)

Preceding gene: 197104309

Following gene: 197104318

Centisome position: 23.42

GC content: 68.32

Gene sequence:

>1086_bases
ATGAAGGCCGCCGTGCTGCGTGAAGTCCGCAAGCCGCTTCAGATCGAGGACGTGCAGATTTCCAAGCCTGGCCCGCACGA
GGTGCTGATCCGCACCGCCGCGGCCGGCGTCTGCCACTCGGACCTTCACTTCGTGGAAGGCTCGTATCCCCACCCGCTGC
CGGCCGTGCTGGGCCACGAGAGCGCCGGCGTCGTCGAGGCCGTGGGCTCGGAAGTGCGCACGGTGAAGCCGGGCGACCAC
GTCATCACCTGCCTGTCGGCGTTCTGCGGCCACTGCGAGCACTGCCTGACCGGCCACATGAGCCTGTGCGTCTCCCCCGA
CACCAAGCGCGGCGACGAGGACGAGCCGCGCCTGACGTCGCCCAAGGGGCCGATGATGCAGTACCTGAACCTGTCCTCCT
TCGCCGAGCAGATGCTGGTGCACGAGCACGCCTGCGTGGCGATCCGCAAGGACATGCCGCTGGACCGCGCCGCCCTGATC
GGCTGTTCGGTGATGACCGGCGTCGGCGCGGTGATGCACACCTCCAATGTCCGCCCGGGCGACACCGTGGCGGTCATCGG
CTGCGGCGGCGTGGGACTGTCGGCGATCAACGGCGCGGCCATCGCGGGCGCGGGCCGGATCATCGCCATCGACGTGGTGC
CGGGTAAGGAGAACTTCGCCCGCGCCTTCGGCGCCACCGACTTCGTCAACGCCGCCGAGACCGATCCGGTGAAGGCGGTG
ATCGAGCTGACCAAGGGCGGCGTGCAGCACTCGTTCGAGGCGCTGGGCATGACCAAGACCGCCGAGCAGGCGTTCAACAT
GCTCCGCCGCGGCGGCACCGCGAACATCATCGGCATGATCCCCGTCGGCCAGAGCATCAGCCTGATGGGCGCGGCGTTCC
TGGGCGAGAAGCGCATCCAGGGCTCGATGATGGGCTCGAACCGCTTCCCGGTGGACATGCCGCGGCTGGTCGACATGTAC
ATGGCCGGCAAGCTGAAGCTCGACGGCATGATCTCCCAGCGGCTGAAGCTGGAGCAGGTGAACGAGGCGTTCGCCGAGAT
GAAGACCGGCTCGATCGCCCGGTCCGTGATCGTCTTCGACGCCTAG

Upstream 100 bases:

>100_bases
TAACGGCGCGCTGTCGACCCGTTTCGCCGAAAGACGCTTCCCACGCCCGGCTGAACGGCGATAAGGCTTGTTCAAACGCC
AGTATGAAAGGGGAAACGAC

Downstream 100 bases:

>100_bases
CGGGCGCCGGCGGCGGCGGGGCCCGGCTCCACCGCCGACCGCTGCCGGGTCTGGATGGCGTCGAGGTAGTCGATGATCGC
CTCGACGTCCTCCTGGCCGA

Product: alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKAAVLREVRKPLQIEDVQISKPGPHEVLIRTAAAGVCHSDLHFVEGSYPHPLPAVLGHESAGVVEAVGSEVRTVKPGDH
VITCLSAFCGHCEHCLTGHMSLCVSPDTKRGDEDEPRLTSPKGPMMQYLNLSSFAEQMLVHEHACVAIRKDMPLDRAALI
GCSVMTGVGAVMHTSNVRPGDTVAVIGCGGVGLSAINGAAIAGAGRIIAIDVVPGKENFARAFGATDFVNAAETDPVKAV
IELTKGGVQHSFEALGMTKTAEQAFNMLRRGGTANIIGMIPVGQSISLMGAAFLGEKRIQGSMMGSNRFPVDMPRLVDMY
MAGKLKLDGMISQRLKLEQVNEAFAEMKTGSIARSVIVFDA

Sequences:

>Translated_361_residues
MKAAVLREVRKPLQIEDVQISKPGPHEVLIRTAAAGVCHSDLHFVEGSYPHPLPAVLGHESAGVVEAVGSEVRTVKPGDH
VITCLSAFCGHCEHCLTGHMSLCVSPDTKRGDEDEPRLTSPKGPMMQYLNLSSFAEQMLVHEHACVAIRKDMPLDRAALI
GCSVMTGVGAVMHTSNVRPGDTVAVIGCGGVGLSAINGAAIAGAGRIIAIDVVPGKENFARAFGATDFVNAAETDPVKAV
IELTKGGVQHSFEALGMTKTAEQAFNMLRRGGTANIIGMIPVGQSISLMGAAFLGEKRIQGSMMGSNRFPVDMPRLVDMY
MAGKLKLDGMISQRLKLEQVNEAFAEMKTGSIARSVIVFDA
>Mature_361_residues
MKAAVLREVRKPLQIEDVQISKPGPHEVLIRTAAAGVCHSDLHFVEGSYPHPLPAVLGHESAGVVEAVGSEVRTVKPGDH
VITCLSAFCGHCEHCLTGHMSLCVSPDTKRGDEDEPRLTSPKGPMMQYLNLSSFAEQMLVHEHACVAIRKDMPLDRAALI
GCSVMTGVGAVMHTSNVRPGDTVAVIGCGGVGLSAINGAAIAGAGRIIAIDVVPGKENFARAFGATDFVNAAETDPVKAV
IELTKGGVQHSFEALGMTKTAEQAFNMLRRGGTANIIGMIPVGQSISLMGAAFLGEKRIQGSMMGSNRFPVDMPRLVDMY
MAGKLKLDGMISQRLKLEQVNEAFAEMKTGSIARSVIVFDA

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=39.5095367847411, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=38.9645776566758, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI4501929, Length=367, Percent_Identity=38.4196185286104, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=36.0655737704918, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI71565152, Length=370, Percent_Identity=34.5945945945946, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=35.149863760218, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=34.6153846153846, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=35.7541899441341, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=34.6153846153846, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI156627571, Length=353, Percent_Identity=26.3456090651558, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=38.5245901639344, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788073, Length=343, Percent_Identity=30.0291545189504, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786518, Length=367, Percent_Identity=28.3378746594005, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082125, Length=361, Percent_Identity=25.7617728531856, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87081918, Length=338, Percent_Identity=28.9940828402367, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788407, Length=340, Percent_Identity=27.3529411764706, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788075, Length=345, Percent_Identity=27.536231884058, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790045, Length=369, Percent_Identity=24.9322493224932, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786825, Length=366, Percent_Identity=25.4098360655738, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787863, Length=356, Percent_Identity=22.4719101123595, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082401, Length=370, Percent_Identity=21.6216216216216, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=34.5013477088949, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71997431, Length=373, Percent_Identity=34.3163538873995, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17565904, Length=335, Percent_Identity=34.0298507462687, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17562584, Length=361, Percent_Identity=29.0858725761773, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17562876, Length=364, Percent_Identity=27.1978021978022, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=28.2485875706215, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71988145, Length=361, Percent_Identity=26.8698060941828, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=364, Percent_Identity=29.6703296703297, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=39.7297297297297, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6323961, Length=363, Percent_Identity=30.3030303030303, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=369, Percent_Identity=30.8943089430894, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324486, Length=363, Percent_Identity=29.4765840220386, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=331, Percent_Identity=29.607250755287, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=277, Percent_Identity=28.158844765343, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=336, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=336, Percent_Identity=27.3809523809524, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=350, Percent_Identity=25.1428571428571, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=356, Percent_Identity=25.8426966292135, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=38.5869565217391, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17737897, Length=352, Percent_Identity=25, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137530, Length=352, Percent_Identity=26.4204545454545, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 38211; Mature: 38211

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVLREVRKPLQIEDVQISKPGPHEVLIRTAAAGVCHSDLHFVEGSYPHPLPAVLGHE
CCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHCCC
SAGVVEAVGSEVRTVKPGDHVITCLSAFCGHCEHCLTGHMSLCVSPDTKRGDEDEPRLTS
CCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
PKGPMMQYLNLSSFAEQMLVHEHACVAIRKDMPLDRAALIGCSVMTGVGAVMHTSNVRPG
CCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DTVAVIGCGGVGLSAINGAAIAGAGRIIAIDVVPGKENFARAFGATDFVNAAETDPVKAV
CEEEEEEECCCCHHHCCCCEEECCCCEEEEEEECCCHHHHHHHCCCHHCCCCCCCHHHHH
IELTKGGVQHSFEALGMTKTAEQAFNMLRRGGTANIIGMIPVGQSISLMGAAFLGEKRIQ
HHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
GSMMGSNRFPVDMPRLVDMYMAGKLKLDGMISQRLKLEQVNEAFAEMKTGSIARSVIVFD
CEECCCCCCCCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
A
C
>Mature Secondary Structure
MKAAVLREVRKPLQIEDVQISKPGPHEVLIRTAAAGVCHSDLHFVEGSYPHPLPAVLGHE
CCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHCCC
SAGVVEAVGSEVRTVKPGDHVITCLSAFCGHCEHCLTGHMSLCVSPDTKRGDEDEPRLTS
CCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
PKGPMMQYLNLSSFAEQMLVHEHACVAIRKDMPLDRAALIGCSVMTGVGAVMHTSNVRPG
CCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DTVAVIGCGGVGLSAINGAAIAGAGRIIAIDVVPGKENFARAFGATDFVNAAETDPVKAV
CEEEEEEECCCCHHHCCCCEEECCCCEEEEEEECCCHHHHHHHCCCHHCCCCCCCHHHHH
IELTKGGVQHSFEALGMTKTAEQAFNMLRRGGTANIIGMIPVGQSISLMGAAFLGEKRIQ
HHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
GSMMGSNRFPVDMPRLVDMYMAGKLKLDGMISQRLKLEQVNEAFAEMKTGSIARSVIVFD
CEECCCCCCCCCHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]