BacMap

Definition	Phenylobacterium zucineum HLK1, complete genome.
Accession	NC_011144
Length	3,996,255

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The map label for this gene is fabG [C]

Identifier: 197104142

GI number: 197104142

Start: 734579

End: 735472

Strand: Direct

Name: fabG [C]

Synonym: PHZ_c0676

Alternate gene names: 197104142

Gene position: 734579-735472 (Clockwise)

Preceding gene: 197104141

Following gene: 197104143

Centisome position: 18.38

GC content: 72.6

Gene sequence:

>894_bases
ATGTCGCTTGAAGGTCGTGTCGCCGTCGTCACCGGTTCGGGAGGAGGCCTGGGCCGCGCCCACGCGCTCTACCTGGCCTC
GAAGGGCGCGAAGGTGGTGGTCAACGACCTGAGCCAGGAGGCCGCCGACCGGGTCTGCGCCGAGATCGCGGCCGCCGGCG
GGAGCGCCATCGCCGCCGCCGCTTCGGTGACCGACGAGGCCGGCGTCGCGGCCATGGTGCGGCGGACGCTGGACGCCTGG
GGCCGCGTGGACATCCTGGTGAACAACGCCGGCATCCTGCGCGACAAGAGCTTCGCCAAGATGACCATCGAGGACTTCCG
CCTCGTCGTGGACGTCCACCTGATCGGGGCCGCGATCTGCAGCAAGGCGGTTTGGGACGTGATGCGCGAGCAGGCCTACG
GCCGCATCGTGATGACCACCTCCTCGTCGGGGCTCTACGGCAACTTCGGCCAAGCCAACTACGGCGCGGCCAAGATGGCG
CTGGTCGGGCTGATGCAGACCCTGGCCATCGAGGGGGCCAAGTACGACATCCGGGTCAACTGCCTGGCGCCGACCGCGGC
GACCCAGATGACCCACGGCGTGCTCTCGGACGAGAGCCTGCAGCTGCTGGACCCGGCACTGGTCAGCCCCGGCCTCCTCG
CCCTGGTGTCGGACGAGGCGCCGAGCCGCGCGGTGCTCTGCGCCGGCGCCGGCCACTTCGCCGCCGCCCATGTGACCCTG
ACCGAGGGCGCACAGGTCGGCGCGCGCCCCGACGCAGGCGAGCAGGTGATCGCCCGCTGGGCGGAGGTCGCGGACCGGCG
GGGCGAGATCGTCCCCGCCTACGGCTTCACCCAGGCCGAACGCGAGCTGGCCGCCGCCGGGCTGGCCCCCCAGACCGCGG
TGGTCGCCCGCTGA

Upstream 100 bases:

>100_bases
CCCGCCGCCGGCTAGGAGACCGCGCCTTCACGGCCCCGCTTCACCCCTCCGAGGATATTCGCTAACGTGTGAGTGAAGAA
TCTTTCGGGGGAGGTTTCCG

Downstream 100 bases:

>100_bases
GGACGCGCCGTCCCGCCGGAGCCGACAGGCGTCAACCGCCCACTTGACGGGCGGCAAGGCGCTCCGGCCGAAGCAGGCGC
AGGCTGCAGGGGTCCGAAAC

Product: short-chain alcohol dehydrogenase-like protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSLEGRVAVVTGSGGGLGRAHALYLASKGAKVVVNDLSQEAADRVCAEIAAAGGSAIAAAASVTDEAGVAAMVRRTLDAW
GRVDILVNNAGILRDKSFAKMTIEDFRLVVDVHLIGAAICSKAVWDVMREQAYGRIVMTTSSSGLYGNFGQANYGAAKMA
LVGLMQTLAIEGAKYDIRVNCLAPTAATQMTHGVLSDESLQLLDPALVSPGLLALVSDEAPSRAVLCAGAGHFAAAHVTL
TEGAQVGARPDAGEQVIARWAEVADRRGEIVPAYGFTQAERELAAAGLAPQTAVVAR

Sequences:

>Translated_297_residues
MSLEGRVAVVTGSGGGLGRAHALYLASKGAKVVVNDLSQEAADRVCAEIAAAGGSAIAAAASVTDEAGVAAMVRRTLDAW
GRVDILVNNAGILRDKSFAKMTIEDFRLVVDVHLIGAAICSKAVWDVMREQAYGRIVMTTSSSGLYGNFGQANYGAAKMA
LVGLMQTLAIEGAKYDIRVNCLAPTAATQMTHGVLSDESLQLLDPALVSPGLLALVSDEAPSRAVLCAGAGHFAAAHVTL
TEGAQVGARPDAGEQVIARWAEVADRRGEIVPAYGFTQAERELAAAGLAPQTAVVAR
>Mature_296_residues
SLEGRVAVVTGSGGGLGRAHALYLASKGAKVVVNDLSQEAADRVCAEIAAAGGSAIAAAASVTDEAGVAAMVRRTLDAWG
RVDILVNNAGILRDKSFAKMTIEDFRLVVDVHLIGAAICSKAVWDVMREQAYGRIVMTTSSSGLYGNFGQANYGAAKMAL
VGLMQTLAIEGAKYDIRVNCLAPTAATQMTHGVLSDESLQLLDPALVSPGLLALVSDEAPSRAVLCAGAGHFAAAHVTLT
EGAQVGARPDAGEQVIARWAEVADRRGEIVPAYGFTQAERELAAAGLAPQTAVVAR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=277, Percent_Identity=44.4043321299639, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI40254992, Length=201, Percent_Identity=35.8208955223881, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI32483357, Length=185, Percent_Identity=34.5945945945946, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4758504, Length=195, Percent_Identity=34.3589743589744, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI31542939, Length=251, Percent_Identity=27.4900398406374, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI15277342, Length=202, Percent_Identity=31.6831683168317, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4503817, Length=243, Percent_Identity=25.5144032921811, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI40807363, Length=168, Percent_Identity=31.547619047619, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI5031737, Length=203, Percent_Identity=33.0049261083744, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI33667109, Length=183, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI83715985, Length=180, Percent_Identity=33.8888888888889, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI19923817, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI157739938, Length=189, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI20149619, Length=188, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=31.0344827586207, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=161, Percent_Identity=27.3291925465839, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI210032110, Length=186, Percent_Identity=26.3440860215054, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI109715829, Length=237, Percent_Identity=26.1603375527426, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI10190704, Length=183, Percent_Identity=28.9617486338798, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI126723750, Length=186, Percent_Identity=31.7204301075269, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI142976729, Length=210, Percent_Identity=24.2857142857143, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=204, Percent_Identity=38.2352941176471, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI87082100, Length=184, Percent_Identity=37.5, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=30.0395256916996, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790717, Length=201, Percent_Identity=30.8457711442786, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789057, Length=180, Percent_Identity=36.6666666666667, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=29.1497975708502, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082160, Length=184, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788459, Length=189, Percent_Identity=31.2169312169312, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=184, Percent_Identity=34.7826086956522, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787526, Length=225, Percent_Identity=27.1111111111111, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786812, Length=186, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=278, Percent_Identity=43.8848920863309, Blast_Score=220, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=30.4568527918782, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=186, Percent_Identity=38.1720430107527, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=186, Percent_Identity=32.7956989247312, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567345, Length=170, Percent_Identity=31.7647058823529, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=195, Percent_Identity=36.4102564102564, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=193, Percent_Identity=32.1243523316062, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=188, Percent_Identity=34.0425531914894, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=29.0836653386454, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=231, Percent_Identity=29.4372294372294, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=226, Percent_Identity=28.7610619469027, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=185, Percent_Identity=27.5675675675676, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=212, Percent_Identity=29.7169811320755, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=222, Percent_Identity=29.2792792792793, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=194, Percent_Identity=28.8659793814433, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=201, Percent_Identity=31.3432835820896, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=214, Percent_Identity=27.1028037383178, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=195, Percent_Identity=30.2564102564103, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=217, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=192, Percent_Identity=27.6041666666667, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=30.5, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=198, Percent_Identity=29.2929292929293, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=194, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=211, Percent_Identity=28.436018957346, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=198, Percent_Identity=28.2828282828283, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=210, Percent_Identity=29.0476190476191, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=279, Percent_Identity=45.8781362007168, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6324126, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI18859837, Length=280, Percent_Identity=46.0714285714286, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24639444, Length=185, Percent_Identity=35.6756756756757, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=30.1960784313725, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17737361, Length=194, Percent_Identity=31.4432989690722, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640492, Length=215, Percent_Identity=25.5813953488372, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24649181, Length=203, Percent_Identity=30.5418719211823, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28571526, Length=185, Percent_Identity=31.3513513513514, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644339, Length=199, Percent_Identity=27.1356783919598, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357041, Length=184, Percent_Identity=29.8913043478261, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355319, Length=208, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281364892, Length=219, Percent_Identity=30.1369863013699, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356301, Length=230, Percent_Identity=26.5217391304348, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581726, Length=212, Percent_Identity=28.7735849056604, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=27.2277227722772, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24580925, Length=193, Percent_Identity=29.5336787564767, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643142, Length=183, Percent_Identity=32.2404371584699, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30586; Mature: 30455

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEGRVAVVTGSGGGLGRAHALYLASKGAKVVVNDLSQEAADRVCAEIAAAGGSAIAAA
CCCCCEEEEEECCCCCCCHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHH
ASVTDEAGVAAMVRRTLDAWGRVDILVNNAGILRDKSFAKMTIEDFRLVVDVHLIGAAIC
HHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHEEEHHHHHHHHHHH
SKAVWDVMREQAYGRIVMTTSSSGLYGNFGQANYGAAKMALVGLMQTLAIEGAKYDIRVN
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
CLAPTAATQMTHGVLSDESLQLLDPALVSPGLLALVSDEAPSRAVLCAGAGHFAAAHVTL
EECCHHHHHHHHCCCCCCCHHHHCHHHCCCCEEEEEECCCCCCEEEEECCCCEEEEEEEE
TEGAQVGARPDAGEQVIARWAEVADRRGEIVPAYGFTQAERELAAAGLAPQTAVVAR
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCHHEECC
>Mature Secondary Structure 
SLEGRVAVVTGSGGGLGRAHALYLASKGAKVVVNDLSQEAADRVCAEIAAAGGSAIAAA
CCCCEEEEEECCCCCCCHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHH
ASVTDEAGVAAMVRRTLDAWGRVDILVNNAGILRDKSFAKMTIEDFRLVVDVHLIGAAIC
HHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHEEEHHHHHHHHHHH
SKAVWDVMREQAYGRIVMTTSSSGLYGNFGQANYGAAKMALVGLMQTLAIEGAKYDIRVN
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
CLAPTAATQMTHGVLSDESLQLLDPALVSPGLLALVSDEAPSRAVLCAGAGHFAAAHVTL
EECCHHHHHHHHCCCCCCCHHHHCHHHCCCCEEEEEECCCCCCEEEEECCCCEEEEEEEE
TEGAQVGARPDAGEQVIARWAEVADRRGEIVPAYGFTQAERELAAAGLAPQTAVVAR
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]