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The map label for this gene is frdB [H]

Identifier: 195952683

GI number: 195952683

Start: 264295

End: 264945

Strand: Direct

Name: frdB [H]

Synonym: HY04AAS1_0305

Alternate gene names: 195952683

Gene position: 264295-264945 (Clockwise)

Preceding gene: 195952682

Following gene: 195952684

Centisome position: 16.95

GC content: 37.48

Gene sequence:

>651_bases
ATGAAGATAAAGCTTAAGATAAAAAGACAGGATAGGTTTGAAACTTACGAAGTGCCCTACAAAGAGGGTATGACGCTTTT
AGACGCTTTAAAGTATATAAAAGAGTATTTGGACCCTTCTTTGGCTTTTAGGCAGTTTTGCGGGGCTGGTATATGTGGTA
CTTGCGCTGTAAACGTTAACGGTTTTCCTAAGCTAATATGCAAAGAACAGGCGTTGTCCTATGCTTTAGATGAAAATCCA
ACGGTTTTGGAACCTTTAAACAACGCTGAAGTTGTAAAAGATTTGGTGGTAGATATCTCAAATATGTCTTATAGAATAAA
AGCTTATAAAGCTTGGATAACCCCCATTGAAACCAATTTAAAGATAGATCAAGAGCTTAGTAAGAAAATAGAAGAGTCAT
CCGATTGCATACTTTGTTATGCTTGTCAGAGCTTTTGTCCAGAAGTAGCCGATAAAGATTATGCAGGACCGCTGTTTTTT
GCTAAACTCTACAGACTCTTTATAGACCCAAGAGACCGTGAACATGGTATTAGGCTTTTAGAAGCAAAAGATACTTTAAT
ATTGCACTGCCTTTCTTGCAACAAGTGTAACAACGCATGTCCTAAAGAGGTAAAACCTGCCACTTTGATAAGGGAGCTTT
TGGATAGTTGA

Upstream 100 bases:

>100_bases
CTATAAACAACTACTGGTTTAAAAGGCTTGATGTATTGTGGGAACTTATCCAAACAAACGTTATGAGAAGAGAGTATATA
GTAAATACATATTTAGAGCG

Downstream 100 bases:

>100_bases
GTCAAGTTATATATCCAGGGACTTTCGATCCACCTCATTTAGGGCACCTTGATATAGTAAAAAGAGCCTCTTATATATTC
GATGAGGTATTTATAGCGAT

Product: succinate dehydrogenase and fumarate reductase iron-sulfur protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKIKLKIKRQDRFETYEVPYKEGMTLLDALKYIKEYLDPSLAFRQFCGAGICGTCAVNVNGFPKLICKEQALSYALDENP
TVLEPLNNAEVVKDLVVDISNMSYRIKAYKAWITPIETNLKIDQELSKKIEESSDCILCYACQSFCPEVADKDYAGPLFF
AKLYRLFIDPRDREHGIRLLEAKDTLILHCLSCNKCNNACPKEVKPATLIRELLDS

Sequences:

>Translated_216_residues
MKIKLKIKRQDRFETYEVPYKEGMTLLDALKYIKEYLDPSLAFRQFCGAGICGTCAVNVNGFPKLICKEQALSYALDENP
TVLEPLNNAEVVKDLVVDISNMSYRIKAYKAWITPIETNLKIDQELSKKIEESSDCILCYACQSFCPEVADKDYAGPLFF
AKLYRLFIDPRDREHGIRLLEAKDTLILHCLSCNKCNNACPKEVKPATLIRELLDS
>Mature_216_residues
MKIKLKIKRQDRFETYEVPYKEGMTLLDALKYIKEYLDPSLAFRQFCGAGICGTCAVNVNGFPKLICKEQALSYALDENP
TVLEPLNNAEVVKDLVVDISNMSYRIKAYKAWITPIETNLKIDQELSKKIEESSDCILCYACQSFCPEVADKDYAGPLFF
AKLYRLFIDPRDREHGIRLLEAKDTLILHCLSCNKCNNACPKEVKPATLIRELLDS

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=216, Percent_Identity=34.2592592592593, Blast_Score=107, Evalue=6e-24,
Organism=Escherichia coli, GI1790596, Length=205, Percent_Identity=32.6829268292683, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=31.0344827586207, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533915, Length=203, Percent_Identity=35.4679802955665, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322987, Length=219, Percent_Identity=31.5068493150685, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643156, Length=226, Percent_Identity=34.5132743362832, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137106, Length=217, Percent_Identity=33.6405529953917, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 24633; Mature: 24633

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
5.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKLKIKRQDRFETYEVPYKEGMTLLDALKYIKEYLDPSLAFRQFCGAGICGTCAVNVN
CEEEEEECCCCCCCEECCCHHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCC
GFPKLICKEQALSYALDENPTVLEPLNNAEVVKDLVVDISNMSYRIKAYKAWITPIETNL
CCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCC
KIDQELSKKIEESSDCILCYACQSFCPEVADKDYAGPLFFAKLYRLFIDPRDREHGIRLL
EECHHHHHHHHCCCCEEEEEEHHHHCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEE
EAKDTLILHCLSCNKCNNACPKEVKPATLIRELLDS
ECCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKIKLKIKRQDRFETYEVPYKEGMTLLDALKYIKEYLDPSLAFRQFCGAGICGTCAVNVN
CEEEEEECCCCCCCEECCCHHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCC
GFPKLICKEQALSYALDENPTVLEPLNNAEVVKDLVVDISNMSYRIKAYKAWITPIETNL
CCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCC
KIDQELSKKIEESSDCILCYACQSFCPEVADKDYAGPLFFAKLYRLFIDPRDREHGIRLL
EECHHHHHHHHCCCCEEEEEEHHHHCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEE
EAKDTLILHCLSCNKCNNACPKEVKPATLIRELLDS
ECCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]