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The map label for this gene is yqeF [H]

Identifier: 194738001

GI number: 194738001

Start: 3083932

End: 3085110

Strand: Reverse

Name: yqeF [H]

Synonym: SeSA_A3188

Alternate gene names: 194738001

Gene position: 3085110-3083932 (Counterclockwise)

Preceding gene: 194734263

Following gene: 194737538

Centisome position: 65.51

GC content: 58.52

Gene sequence:

>1179_bases
ATGAAAGAGGTTGTGATAGTGGGGGCTTTACGGACACCCATCGGCTGTTTTCAGGGAACGCTGGCCCGTCATTCCGCCGT
CGAGCTGGGGAGCATGGTCGTAAAAGCGTTAATTGAGCGCACCGGCGTGGACGCTAACGCTATCGATGAGGTCATCCTCG
GTCAGGTACTGACGGCTGGCGCCGGGCAGAATCCGGCGCGCCAGTCAGCCATCAAAGGAGGGCTGCCGACAACCGTTTCC
GCCATTACCATTAATGACGTTTGTGGTTCCGGTTTAAAAGCGTTGCACCTGGCGACGCAGGCTATTCAGTGCGGCGAAGC
GGACATTGTTATCGCGGGCGGGCAGGAGAATATGAGCCGTGCGCCGCATGTCCTCAATGATAGCCGTACCGGCGCGTTGC
CTGATGCCGACAATCTGGTGGATAGTCTGGTACATGATGGCTTATGGGATGCCTTCAACGATTATCACATTGGCGTGACG
GCAGAAAACCTGGCGCGGGAATATGGCATCAGCCGCGAGTTACAGGATGCTTATGCGCTCAGTTCGCAGCAAAAAGCCAG
GGCCGCGATTGATACCGGGCGTTTTAAAGATGAGATTGTCCCCATCGTCACGCAACGTAATGGGCAGACCGCAATTGTCG
ATACGGATGAACAACCGCGGGCCGACGCCAGTGCGGAGGGGTTAGCTCTGCTGCACCCGGCGTTTGATAGTTTAGGTTCG
GTGACGGCGGGTAATGCCTCCTCAATCAACGATGGCGCCGCCGCGGTGATGATGATGAGCGAGGCGAAAGCCCAGGCGCT
GGGGCTGCCGGTGCTGGCGCGCATCCGCGCGTTTGCCAGCGTCGGCGTCGATCCTGCGCTAATGGGGATTGCGCCGGTAT
ATGCTACCCGGCGCTGTCTGGAGCGTGCCGGCTGGCAACTGGCGGAGGTCGACCTTATCGAAGCCAACGAAGCGTTTGCC
GCCCAGGCGTTGTCAGTAGGAAAAATGCTGGAATGGGATGAGCGACGGGTAAACGTTAATGGCGGCGCGATTGCGCTGGG
GCATCCTATTGGCGCTTCCGGCTGTCGAATTCTGGTTTCACTGGTGCACGAAATGGTTAAACGCGACGCGCGAAAAGGCC
TGGCGACGCTGTGTATTGGTGGCGGCCAGGGCGTTGCTTTAACCATTGAACGCGATTGA

Upstream 100 bases:

>100_bases
GTCATTTCCTTTGTGATAAAACTCACTTTTTTTAAACAATCAAGATAACTAATTTTAACAATGCTCTACTATGGCGGTGT
CATTTTGCGCTGAGGTGGTA

Downstream 100 bases:

>100_bases
TCCTGCGCCAGCCATCCTTTTTCTGCTTCATTATTCCGTCATAAAAAGCCCTCTATCACGAGGGCAAAGCCAGTGACAGC
CCCCCCTTTTTCGTTATAGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKEVVIVGALRTPIGCFQGTLARHSAVELGSMVVKALIERTGVDANAIDEVILGQVLTAGAGQNPARQSAIKGGLPTTVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLNDSRTGALPDADNLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRELQDAYALSSQQKARAAIDTGRFKDEIVPIVTQRNGQTAIVDTDEQPRADASAEGLALLHPAFDSLGS
VTAGNASSINDGAAAVMMMSEAKAQALGLPVLARIRAFASVGVDPALMGIAPVYATRRCLERAGWQLAEVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRDARKGLATLCIGGGQGVALTIERD

Sequences:

>Translated_392_residues
MKEVVIVGALRTPIGCFQGTLARHSAVELGSMVVKALIERTGVDANAIDEVILGQVLTAGAGQNPARQSAIKGGLPTTVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLNDSRTGALPDADNLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRELQDAYALSSQQKARAAIDTGRFKDEIVPIVTQRNGQTAIVDTDEQPRADASAEGLALLHPAFDSLGS
VTAGNASSINDGAAAVMMMSEAKAQALGLPVLARIRAFASVGVDPALMGIAPVYATRRCLERAGWQLAEVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRDARKGLATLCIGGGQGVALTIERD
>Mature_392_residues
MKEVVIVGALRTPIGCFQGTLARHSAVELGSMVVKALIERTGVDANAIDEVILGQVLTAGAGQNPARQSAIKGGLPTTVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLNDSRTGALPDADNLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRELQDAYALSSQQKARAAIDTGRFKDEIVPIVTQRNGQTAIVDTDEQPRADASAEGLALLHPAFDSLGS
VTAGNASSINDGAAAVMMMSEAKAQALGLPVLARIRAFASVGVDPALMGIAPVYATRRCLERAGWQLAEVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRDARKGLATLCIGGGQGVALTIERD

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=47.8260869565217, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=42.5316455696203, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=41.0126582278481, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=38.8888888888889, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.3953488372093, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=29.040404040404, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=91.8367346938776, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=58.4183673469388, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=44.8877805486284, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=41.3965087281795, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=32.2195704057279, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=42.8571428571429, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=40.4092071611253, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=39.9491094147583, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.3155216284987, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=30.0469483568075, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=42.1717171717172, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=37.5959079283887, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=51.6624040920716, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=43.4782608695652, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=40.920716112532, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=32.2352941176471, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40894; Mature: 40894

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVVIVGALRTPIGCFQGTLARHSAVELGSMVVKALIERTGVDANAIDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPTTVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHC
APHVLNDSRTGALPDADNLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRELQDAYAL
CCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHH
SSQQKARAAIDTGRFKDEIVPIVTQRNGQTAIVDTDEQPRADASAEGLALLHPAFDSLGS
HHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHCC
VTAGNASSINDGAAAVMMMSEAKAQALGLPVLARIRAFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERAGWQLAEVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRDARKGLATLCIGGGQGVALTIERD
HHHHHHHHHHHCCCEEEEEECCCEEEEEEECC
>Mature Secondary Structure
MKEVVIVGALRTPIGCFQGTLARHSAVELGSMVVKALIERTGVDANAIDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPTTVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHC
APHVLNDSRTGALPDADNLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRELQDAYAL
CCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHH
SSQQKARAAIDTGRFKDEIVPIVTQRNGQTAIVDTDEQPRADASAEGLALLHPAFDSLGS
HHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHCC
VTAGNASSINDGAAAVMMMSEAKAQALGLPVLARIRAFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERAGWQLAEVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRDARKGLATLCIGGGQGVALTIERD
HHHHHHHHHHHCCCEEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]