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The map label for this gene is malI [H]

Identifier: 194737753

GI number: 194737753

Start: 1505566

End: 1506594

Strand: Direct

Name: malI [H]

Synonym: SeSA_A1564

Alternate gene names: 194737753

Gene position: 1505566-1506594 (Clockwise)

Preceding gene: 194735214

Following gene: 194735303

Centisome position: 31.97

GC content: 58.41

Gene sequence:

>1029_bases
ATGGCTATCGCCAAAAAAATCACTATCCACGATGTTGCGCTGGCGGCTGGCGTGTCGGTGAGCACCGTTTCCTTAGTGCT
GAGCGGCAAGGGGCGAATATCGGCCGCGACCGGCGAGCGCGTGAACGCGGCAATTGAACAACTGGGTTTTGTGCGTAACC
GCCAGGCGTCCGCGCTGCGTGGCGGGCAAAGCGGCGTTATCGGTTTGATCGTGCGTGATTTATCGGCACCCTTTTATGCC
GAATTGACCGCCGGGTTAACGGAAGCGCTGGAAGCGCAAGGCCGTATGGTTTTTCTCCTGCACGGGGGGAAAGATGGCGA
ACAGCTAAATCAGCGTTTTACCATGCTGCTTAATCAGGGCGTGGATGGCATGGTGATCGCCGGTGCGGCGGGTAGTAGCG
AAGCGCTGAGAGCGCAGGCCGACGCACAAGGAATTCCGGTGGTGTTTGCGTCACGCGCCAGCTATCTTGATGATGCGGAT
ACCGTTCGGCCTGACAACATGCAGGCGGCGCAGCTCCTGACGGAGTACCTTATTCGTCAGGGCCATCAGCGCATCGCCTG
GCTGGGAGGACAAAGCGCATCTTTAACCCGCGCGGAGCGCGTGGGCGGCTATTGCGCGACGTTGTTAAAATACGGTCTAC
CGTTTCACAGCGAGTGGGTCGTGGAATGCGCTTCCAGTCAGAAGCAGGCAGCAGAAAGCATTACCGCGCTGTTGCGATAC
AATCCGACCATTAGCGCTGTCGTTTGTTACAACGAAACCATTGCGATGGGGGCGTGGTTTGGCCTGCTGAGAGCCGGACG
ACAGAGTGGCGAGAGCGGTGTCGATCGTTATTTCGAGCAGCAGGTGTCGCTGGCGGCGTTTGCTGATGTGGCGGAGAACG
CCCTCGACGACCTGCCGATTATCTGGGCCAGTACGCCGGCGCGAGAAATAGGCTATACCCTGGCCGAACGAATATTGCAG
CGTATTGCTCACGACGAGCACCATGTGCGGAGTCAAACGATAGCCGCTCGCCTGGTAACGCAAAAGTAG

Upstream 100 bases:

>100_bases
TAGTGCGGCATTAATCACATTACTGACCGATAATAACGCGTATAAAGATAACGGATAGGTAAAACGTTTTATCTGTCAGA
TTCTGGAGCGATTTGTTGAC

Downstream 100 bases:

>100_bases
AGGCTGCGCGTCGTTCGGCGCAGACCGGGTGCAGCGTCGCGACACCCGGCAAGGCGATTATTGTTGAGGCAGCGCCGGAA
CGTCCGGTACGGAAAGCGCT

Product: DNA-binding transcriptional repressor MalI

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MAIAKKITIHDVALAAGVSVSTVSLVLSGKGRISAATGERVNAAIEQLGFVRNRQASALRGGQSGVIGLIVRDLSAPFYA
ELTAGLTEALEAQGRMVFLLHGGKDGEQLNQRFTMLLNQGVDGMVIAGAAGSSEALRAQADAQGIPVVFASRASYLDDAD
TVRPDNMQAAQLLTEYLIRQGHQRIAWLGGQSASLTRAERVGGYCATLLKYGLPFHSEWVVECASSQKQAAESITALLRY
NPTISAVVCYNETIAMGAWFGLLRAGRQSGESGVDRYFEQQVSLAAFADVAENALDDLPIIWASTPAREIGYTLAERILQ
RIAHDEHHVRSQTIAARLVTQK

Sequences:

>Translated_342_residues
MAIAKKITIHDVALAAGVSVSTVSLVLSGKGRISAATGERVNAAIEQLGFVRNRQASALRGGQSGVIGLIVRDLSAPFYA
ELTAGLTEALEAQGRMVFLLHGGKDGEQLNQRFTMLLNQGVDGMVIAGAAGSSEALRAQADAQGIPVVFASRASYLDDAD
TVRPDNMQAAQLLTEYLIRQGHQRIAWLGGQSASLTRAERVGGYCATLLKYGLPFHSEWVVECASSQKQAAESITALLRY
NPTISAVVCYNETIAMGAWFGLLRAGRQSGESGVDRYFEQQVSLAAFADVAENALDDLPIIWASTPAREIGYTLAERILQ
RIAHDEHHVRSQTIAARLVTQK
>Mature_341_residues
AIAKKITIHDVALAAGVSVSTVSLVLSGKGRISAATGERVNAAIEQLGFVRNRQASALRGGQSGVIGLIVRDLSAPFYAE
LTAGLTEALEAQGRMVFLLHGGKDGEQLNQRFTMLLNQGVDGMVIAGAAGSSEALRAQADAQGIPVVFASRASYLDDADT
VRPDNMQAAQLLTEYLIRQGHQRIAWLGGQSASLTRAERVGGYCATLLKYGLPFHSEWVVECASSQKQAAESITALLRYN
PTISAVVCYNETIAMGAWFGLLRAGRQSGESGVDRYFEQQVSLAAFADVAENALDDLPIIWASTPAREIGYTLAERILQR
IAHDEHHVRSQTIAARLVTQK

Specific function: Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787906, Length=342, Percent_Identity=84.5029239766082, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI48994940, Length=322, Percent_Identity=29.8136645962733, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790194, Length=317, Percent_Identity=25.2365930599369, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789068, Length=286, Percent_Identity=30.4195804195804, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790369, Length=305, Percent_Identity=25.5737704918033, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787580, Length=261, Percent_Identity=29.1187739463602, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789202, Length=283, Percent_Identity=28.2685512367491, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788474, Length=261, Percent_Identity=29.1187739463602, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790715, Length=330, Percent_Identity=25.1515151515152, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786540, Length=322, Percent_Identity=25.776397515528, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790689, Length=286, Percent_Identity=26.5734265734266, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787948, Length=336, Percent_Identity=23.2142857142857, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36639; Mature: 36508

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAKKITIHDVALAAGVSVSTVSLVLSGKGRISAATGERVNAAIEQLGFVRNRQASALR
CCCCCEEEHHHHHHHCCCCHHEEEEEEECCCCEEECCCHHHHHHHHHHHHHHCCCHHHHC
GGQSGVIGLIVRDLSAPFYAELTAGLTEALEAQGRMVFLLHGGKDGEQLNQRFTMLLNQG
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCC
VDGMVIAGAAGSSEALRAQADAQGIPVVFASRASYLDDADTVRPDNMQAAQLLTEYLIRQ
CCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GHQRIAWLGGQSASLTRAERVGGYCATLLKYGLPFHSEWVVECASSQKQAAESITALLRY
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NPTISAVVCYNETIAMGAWFGLLRAGRQSGESGVDRYFEQQVSLAAFADVAENALDDLPI
CCCEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IWASTPAREIGYTLAERILQRIAHDEHHVRSQTIAARLVTQK
EEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIAKKITIHDVALAAGVSVSTVSLVLSGKGRISAATGERVNAAIEQLGFVRNRQASALR
CCCCEEEHHHHHHHCCCCHHEEEEEEECCCCEEECCCHHHHHHHHHHHHHHCCCHHHHC
GGQSGVIGLIVRDLSAPFYAELTAGLTEALEAQGRMVFLLHGGKDGEQLNQRFTMLLNQG
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCC
VDGMVIAGAAGSSEALRAQADAQGIPVVFASRASYLDDADTVRPDNMQAAQLLTEYLIRQ
CCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GHQRIAWLGGQSASLTRAERVGGYCATLLKYGLPFHSEWVVECASSQKQAAESITALLRY
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NPTISAVVCYNETIAMGAWFGLLRAGRQSGESGVDRYFEQQVSLAAFADVAENALDDLPI
CCCEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IWASTPAREIGYTLAERILQRIAHDEHHVRSQTIAARLVTQK
EEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2670898; 1856179; 9097039; 9278503 [H]