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The map label for this gene is treA [H]

Identifier: 194737640

GI number: 194737640

Start: 1873077

End: 1874789

Strand: Direct

Name: treA [H]

Synonym: SeSA_A1938

Alternate gene names: 194737640

Gene position: 1873077-1874789 (Clockwise)

Preceding gene: 194734885

Following gene: 194738062

Centisome position: 39.78

GC content: 55.58

Gene sequence:

>1713_bases
ATGATACCCCCAGAGATTCGCCGTTCTGTTCTACTGCAGAAAGCCATAAAACTGGCGCTGGCAGGGACGCTGCTGACGTT
TGCATCGTTTTCGGCGACTGCCGCAGACCCGTCTTCCGACACTGAAACTCCGCAGCCGCCGGATATTTTGCTTGGCCCGC
TCTTTAATGATGTCCAGAATGCAAAACTCTTCCCCGATCAGAAAACCTTTGCTGACGCCATACCTAATAGCGATCCGCTC
ATGATTCTTGCGGATTATCGTATGCAGCGGAACCAGTCCGGCTTCGATTTGCGTCATTTTGTTGATGTTAACTTCACCCT
GCCGAAAGCGGGTGAAAAATATGTCCCGCCTGCCGGGCAGTCATTGCGTGAACATATTGATGGCCTGTGGCCGGTGCTGA
CCCGTTCAACTAAAAACGTCGAAAAGTGGGACTCGCTCTTGCCGTTGCCTGAATCCTATGTCGTGCCGGGTGGGCGATTC
AGAGAGATTTACTACTGGGACAGCTACTTTACGATGCTGGGGCTGGCGGAAAGCGGGCACTGGGATAAGGTGGCGGATAT
GGTGGCGAACTTTGGTTACGAAATTGACGCCTGGGGGCATATTCCTAACGGCAACCGTACCTACTACCTGAGTCGTTCGC
AGCCGCCTTTCTTTGCGTTTATGATTGAGTTACTGGCGCAACATGAAGGTGACGATGCGCTGAAAGAATACCTGCCGCAA
CTGCAAAAAGAGTACGCCTACTGGATGGAGGGCGTTGAGACATTGCAGCCAGGGCAACAAAACCAACGCGTCGTCAAACT
GGAAGACGGTAGCGTTCTCAACCGCTACTGGGACGATCGGGATACGCCCCGCCCTGAATCCTGGGTTGAAGATATCGCTA
CCGCCAAAAGCAACCCCAACCGCCCGGCAACGGAGATCTATCGAGACCTCCGCTCTGCCGCCGCCTCCGGCTGGGATTTC
AGCTCCCGCTGGATGGATAATCCGCAGCAGCTCAGTACCATCCGTACCACCACGATTGTCCCTGTCGATCTTAACGCTCT
GCTGTATCAGCTGGAGAAAACCCTCGCCCGCGCCAGCGCTGCGGCGGGCGATCGGGCCGAAGCCTCGCAATATGACGCGC
TGGCCAACGCGCGGCAAAAAGCCATTGAAATGCATCTGTGGAATAACAAAGAGGGTTGGTATGCCGACTACGATCTGCAG
AACAATAAAATCCGTGACCAACTCACCGCTGCCGCGCTGTTCCCGCTCTATGTAAACGCCGCCGCGAAAGATCGCGCCGT
GAAAGTGGCGGCGGCGGCCCAGGCGCATCTGCTACAGCCTGGCGGGCTGGCTACCACCTCGGTTAAAAGCGGACAGCAGT
GGGATGCGCCAAACGGCTGGGCGCCGTTACAATGGGTCGCTGCCGAAGGATTACAAAATTATGGGCAGGATGACGTGGCA
ATGGAAGTCACCTGGCGTTTTTTAACCAATGTGCAGCACACCTACGATCGCGAGAAAAAACTGGTCGAAAAATATGACGT
CAGCAGTACCGGAACCGGCGGTGGCGGCGGCGAATATCCCCTTCAGGACGGCTTTGGCTGGACCAACGGCGTGACGCTGA
AAATGCTCGATCTGATTTGTCCGCAGGAAAAACCGTGTGATAGCGTACCGTCTACTCGTCCGGCATCGTTAAGCGCAACG
CCGACAAAAACGCCGTCTGCAGCGACGCAGTAA

Upstream 100 bases:

>100_bases
GCAAAATAGCGGTTCAATCACGCGTATCTGGTCATCGTAGACTAAGGTTTTGTCATGGTAAATGCCGTTGGCTTTGGCTC
ACCGCTAAGGAGATAACTTG

Downstream 100 bases:

>100_bases
CGCGTGTTTATAGTAGGTTGACCCGGCGCTGACCGGGTCAACGCTTACACGTTCTGCAGCGGTTAGCCGCGTCGCAGAAG
GCGGAAAATCACCAGCACCA

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLFPDQKTFADAIPNSDPL
MILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRF
REIYYWDSYFTMLGLAESGHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMIELLAQHEGDDALKEYLPQ
LQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDF
SSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAEASQYDALANARQKAIEMHLWNNKEGWYADYDLQ
NNKIRDQLTAAALFPLYVNAAAKDRAVKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVA
MEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSAT
PTKTPSAATQ

Sequences:

>Translated_570_residues
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLFPDQKTFADAIPNSDPL
MILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRF
REIYYWDSYFTMLGLAESGHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMIELLAQHEGDDALKEYLPQ
LQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDF
SSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAEASQYDALANARQKAIEMHLWNNKEGWYADYDLQ
NNKIRDQLTAAALFPLYVNAAAKDRAVKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVA
MEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSAT
PTKTPSAATQ
>Mature_570_residues
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLFPDQKTFADAIPNSDPL
MILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRF
REIYYWDSYFTMLGLAESGHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMIELLAQHEGDDALKEYLPQ
LQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDF
SSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAEASQYDALANARQKAIEMHLWNNKEGWYADYDLQ
NNKIRDQLTAAALFPLYVNAAAKDRAVKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVA
MEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSAT
PTKTPSAATQ

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=548, Percent_Identity=34.1240875912409, Blast_Score=262, Evalue=6e-70,
Organism=Escherichia coli, GI1787447, Length=546, Percent_Identity=82.7838827838828, Blast_Score=941, Evalue=0.0,
Organism=Escherichia coli, GI1789936, Length=504, Percent_Identity=51.3888888888889, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17542196, Length=524, Percent_Identity=33.206106870229, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25141398, Length=529, Percent_Identity=32.1361058601134, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI25148109, Length=561, Percent_Identity=30.6595365418895, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17565078, Length=547, Percent_Identity=31.4442413162706, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI71987755, Length=403, Percent_Identity=29.2803970223325, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320204, Length=435, Percent_Identity=29.4252873563218, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319473, Length=445, Percent_Identity=29.438202247191, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24656661, Length=549, Percent_Identity=35.5191256830601, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI17933716, Length=549, Percent_Identity=35.5191256830601, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24656670, Length=549, Percent_Identity=35.5191256830601, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24656680, Length=528, Percent_Identity=35.7954545454545, Blast_Score=277, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24656675, Length=528, Percent_Identity=35.7954545454545, Blast_Score=277, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24656685, Length=502, Percent_Identity=35.2589641434263, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI22024178, Length=527, Percent_Identity=30.9297912713473, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI45551104, Length=367, Percent_Identity=31.8801089918256, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28573474, Length=314, Percent_Identity=27.7070063694268, Blast_Score=116, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 63621; Mature: 63621

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECHHHHHHHC
AKLFPDQKTFADAIPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQ
CCCCCCHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCH
SLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRFREIYYWDSYFTMLGLAESGH
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHCCCCCC
WDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMIELLAQHEGDDALKEYLPQ
HHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
LQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPN
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
RPATEIYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASA
CCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHH
AAGDRAEASQYDALANARQKAIEMHLWNNKEGWYADYDLQNNKIRDQLTAAALFPLYVNA
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
AAKDRAVKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVA
CCCCHHEEHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
MEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLIC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHC
PQEKPCDSVPSTRPASLSATPTKTPSAATQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECHHHHHHHC
AKLFPDQKTFADAIPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQ
CCCCCCHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCH
SLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRFREIYYWDSYFTMLGLAESGH
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHCCCCCC
WDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMIELLAQHEGDDALKEYLPQ
HHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
LQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPN
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
RPATEIYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASA
CCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHH
AAGDRAEASQYDALANARQKAIEMHLWNNKEGWYADYDLQNNKIRDQLTAAALFPLYVNA
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
AAKDRAVKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVA
CCCCHHEEHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
MEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLIC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHC
PQEKPCDSVPSTRPASLSATPTKTPSAATQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA