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The map label for this gene is uraH [H]

Identifier: 194737332

GI number: 194737332

Start: 1143124

End: 1143534

Strand: Direct

Name: uraH [H]

Synonym: SeSA_A1161

Alternate gene names: 194737332

Gene position: 1143124-1143534 (Clockwise)

Preceding gene: 194737041

Following gene: 194738089

Centisome position: 24.27

GC content: 49.39

Gene sequence:

>411_bases
ATGAAACGATATATACTGGCTACCGCGATAGCATCTCTTGTTGCAGCCCCGGCAATGGCGCTGGCCGCTGGCAACAATAT
TCTCAGCGTACATATTCTCGATCAGCAAACAGGCAAACCGGCACCCGGCGTGGAGGTGGTACTGGAGCAGAAAAAGGACA
ACGGATGGACGCAATTAAACACCGGGCATACCGACCAGGATGGACGTATTAAAGCTCTGTGGCCCGAAAAAGCTGCCGCG
CCGGGGGATTATCGCGTTATTTTTAAAACCGGCCAGTATTTTGAAAGTAAAAGACTGGACACGTTTTTCCCGGAGATTCC
CGTCGAGTTTCATATCAGCAAAACGAATGAGCACTATCATGTGCCGCTGTTATTAAGTCAGTATGGTTATTCAACCTATC
GCGGGAGCTAA

Upstream 100 bases:

>100_bases
TAAATCTCCAACAAGATGACATAATTGTCATGTCCGTGTAAGGTTAATCCTGGACGCGCCAGATATATTTTCCTGCATCA
ATACCGTAAAGGAGTGAAGC

Downstream 100 bases:

>100_bases
TTTAGAGCCTATCCCATTAGGGCTATTTTACTTGCCATTTTGGTCCTGGGCAGTGCTCGCCAAAACGCGTTAGCGTTTTG
AACGCCGCTTGCGGCGGCCC

Product: hydroxyisourate hydrolase

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP; Transthyretin-related protein; TRP [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MKRYILATAIASLVAAPAMALAAGNNILSVHILDQQTGKPAPGVEVVLEQKKDNGWTQLNTGHTDQDGRIKALWPEKAAA
PGDYRVIFKTGQYFESKRLDTFFPEIPVEFHISKTNEHYHVPLLLSQYGYSTYRGS

Sequences:

>Translated_136_residues
MKRYILATAIASLVAAPAMALAAGNNILSVHILDQQTGKPAPGVEVVLEQKKDNGWTQLNTGHTDQDGRIKALWPEKAAA
PGDYRVIFKTGQYFESKRLDTFFPEIPVEFHISKTNEHYHVPLLLSQYGYSTYRGS
>Mature_136_residues
MKRYILATAIASLVAAPAMALAAGNNILSVHILDQQTGKPAPGVEVVLEQKKDNGWTQLNTGHTDQDGRIKALWPEKAAA
PGDYRVIFKTGQYFESKRLDTFFPEIPVEFHISKTNEHYHVPLLLSQYGYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=136, Percent_Identity=67.6470588235294, Blast_Score=205, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI115534555, Length=136, Percent_Identity=37.5, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115532920, Length=137, Percent_Identity=35.7664233576642, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI115532922, Length=109, Percent_Identity=39.4495412844037, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24652571, Length=110, Percent_Identity=38.1818181818182, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 15131; Mature: 15131

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00768 TRANSTHYRETIN_1 ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYILATAIASLVAAPAMALAAGNNILSVHILDQQTGKPAPGVEVVLEQKKDNGWTQLN
CCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEEC
TGHTDQDGRIKALWPEKAAAPGDYRVIFKTGQYFESKRLDTFFPEIPVEFHISKTNEHYH
CCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCEEE
VPLLLSQYGYSTYRGS
EEEEEECCCCCCCCCC
>Mature Secondary Structure
MKRYILATAIASLVAAPAMALAAGNNILSVHILDQQTGKPAPGVEVVLEQKKDNGWTQLN
CCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEEC
TGHTDQDGRIKALWPEKAAAPGDYRVIFKTGQYFESKRLDTFFPEIPVEFHISKTNEHYH
CCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCEEE
VPLLLSQYGYSTYRGS
EEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9723926 [H]