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The map label for this gene is btuC [H]

Identifier: 194737002

GI number: 194737002

Start: 1383539

End: 1384519

Strand: Direct

Name: btuC [H]

Synonym: SeSA_A1435

Alternate gene names: 194737002

Gene position: 1383539-1384519 (Clockwise)

Preceding gene: 194736601

Following gene: 194736242

Centisome position: 29.38

GC content: 59.73

Gene sequence:

>981_bases
ATGCTGACTTTTGCCCGCCAACAACAGCGACGAAACGTTCGCTGGCTTCTGAGCCTGTCACTGCTGGTGCTACTGGCTAC
ACTTCTGAGCTTATGCGCAGGCGAACAGTGGATTGCCCCCGGTGACTGGTTAAGCGCCCGGGGGGAACTGTTTGTCTGGC
AAATTCGCCTTCCCCGCACGCTTGCGGTATTGCTGGTTGGCGCTGCGCTGGCGCTATCTGGCGCCGTGATGCAGGCGCTG
TTTGAAAATCCACTTGCTGAACCGGGCCTGCTCGGCGTTTCGAATGGGGCCGGTGTTGGGCTTATTGCCGCCGTCTTACT
GGGGCAGGGGCAACTGCCTGGATGGGCGCTGGGACTGTGCGCTATAGCCGGCGCGCTCATTATTACGTTAATCCTGCTGC
GTTTTGCGCGCCGCCATCTCTCTACCAGCCGCTTGTTGTTGGCGGGCGTCGCGCTGGGCATTATCTGTAGCGCGCTGATG
ACGTGGGCTATCTATTTTTCCACCTCTTTCGATCTGCGGCAATTAATGTACTGGATGATGGGAGGATTCGGCGGCGTTGA
CTGGCAGCAGAGCTGGCTAATGATTGCGCTCATCCCAGTACTCATCTGGATATGTTGCCAGTCGCAACCGCTGAATATGC
TGGCGCTAGGGGAAACCTCGGCGCGGCAGCTTGGCCTGCCGCTGTGGTTCTGGCGCAATTTGTTGGTCGTCGCCACCGGC
TGGATGGTGGGCGTCAGCGTGGCGATGGCGGGGGCGATTGGTTTTATCGGTCTGGTTATTCCGCACATCCTGCGCTTATG
TGGTTTAACCGATCACCGGGTTTTACTTCCCGGCTGCGCGCTGGCCGGGGCTATCGCCCTGCTATTGGCTGATGTGGTCG
CCCGACTGGCGCTGGCGTCGGCTGAACTGCCTATCGGGGTGGTCACCGCCACATTGGGGGCGCCAGTGTTTATCTGGCTG
CTGCTCAAATCCGCGCGTTAG

Upstream 100 bases:

>100_bases
GACTCGTATAACTAAAAAGGCCGCATTGCGGCCTTTTTTCTTTCAAGTAAAGGATACCCACCGTAAAATCACGCTACCTC
TTTTCAGCTGAATGGATAAC

Downstream 100 bases:

>100_bases
CGCATCGGTAAACAACTGCTTTCATCATTCGCAGTCTATGATTAAAGGCTAACGATGAAACCCGCTATTCTACCGACATC
AGGGAGACACCATGCAAAAC

Product: vtamin B12-transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLTFARQQQRRNVRWLLSLSLLVLLATLLSLCAGEQWIAPGDWLSARGELFVWQIRLPRTLAVLLVGAALALSGAVMQAL
FENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPGWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALM
TWAIYFSTSFDLRQLMYWMMGGFGGVDWQQSWLMIALIPVLIWICCQSQPLNMLALGETSARQLGLPLWFWRNLLVVATG
WMVGVSVAMAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGAIALLLADVVARLALASAELPIGVVTATLGAPVFIWL
LLKSAR

Sequences:

>Translated_326_residues
MLTFARQQQRRNVRWLLSLSLLVLLATLLSLCAGEQWIAPGDWLSARGELFVWQIRLPRTLAVLLVGAALALSGAVMQAL
FENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPGWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALM
TWAIYFSTSFDLRQLMYWMMGGFGGVDWQQSWLMIALIPVLIWICCQSQPLNMLALGETSARQLGLPLWFWRNLLVVATG
WMVGVSVAMAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGAIALLLADVVARLALASAELPIGVVTATLGAPVFIWL
LLKSAR
>Mature_326_residues
MLTFARQQQRRNVRWLLSLSLLVLLATLLSLCAGEQWIAPGDWLSARGELFVWQIRLPRTLAVLLVGAALALSGAVMQAL
FENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPGWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALM
TWAIYFSTSFDLRQLMYWMMGGFGGVDWQQSWLMIALIPVLIWICCQSQPLNMLALGETSARQLGLPLWFWRNLLVVATG
WMVGVSVAMAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGAIALLLADVVARLALASAELPIGVVTATLGAPVFIWL
LLKSAR

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane [H]

COG id: COG4139

COG function: function code H; ABC-type cobalamin transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=326, Percent_Identity=91.4110429447853, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1790740, Length=290, Percent_Identity=39.6551724137931, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790741, Length=280, Percent_Identity=33.5714285714286, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1786347, Length=327, Percent_Identity=31.1926605504587, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1786805, Length=288, Percent_Identity=39.5833333333333, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786804, Length=281, Percent_Identity=31.3167259786477, Blast_Score=92, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34885; Mature: 34885

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTFARQQQRRNVRWLLSLSLLVLLATLLSLCAGEQWIAPGDWLSARGELFVWQIRLPRT
CCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECHHH
LAVLLVGAALALSGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPGWALGLC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
AIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALMTWAIYFSTSFDLRQLMYWMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GGFGGVDWQQSWLMIALIPVLIWICCQSQPLNMLALGETSARQLGLPLWFWRNLLVVATG
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHH
WMVGVSVAMAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGAIALLLADVVARLALAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHH
AELPIGVVTATLGAPVFIWLLLKSAR
CCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTFARQQQRRNVRWLLSLSLLVLLATLLSLCAGEQWIAPGDWLSARGELFVWQIRLPRT
CCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECHHH
LAVLLVGAALALSGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPGWALGLC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
AIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALMTWAIYFSTSFDLRQLMYWMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GGFGGVDWQQSWLMIALIPVLIWICCQSQPLNMLALGETSARQLGLPLWFWRNLLVVATG
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHH
WMVGVSVAMAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGAIALLLADVVARLALAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHH
AELPIGVVTATLGAPVFIWLLLKSAR
CCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA