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The map label for this gene is btuD [H]

Identifier: 194736020

GI number: 194736020

Start: 1385174

End: 1385911

Strand: Direct

Name: btuD [H]

Synonym: SeSA_A1437

Alternate gene names: 194736020

Gene position: 1385174-1385911 (Clockwise)

Preceding gene: 194736242

Following gene: 194735392

Centisome position: 29.41

GC content: 56.64

Gene sequence:

>738_bases
ATGCAATTAAAGGATGTCGCCGAGAGCACCCGCCTGGGGCCGCTTTCCGGCGAAGTAAGCGCAGGAGAGATCCTTCATCT
TGTCGGGCCGAACGGCGCCGGAAAAAGCACGCTACTGGCGCGTATGGCGGGGTTAACCTCAGGCGAGGGGAGCATCAGGT
TTGGCGGAGCGCCGCTGGAGGCATGGGCGACGGCAACGCTTGCCCAACACCGCGCTTATCTTGCGCAACAGCAAAATCCG
CCGTTCGCCATGCCAGTCTGGCATTACCTGACATTGCATCAACCTGATAAAACGCGAACCGGGCAGCTTAACGAGGTGGC
CGATATGCTTGGATTGGGCGACAAACTGGGGCGAAGCGTGAATCAGCTTTCCGGTGGCGAGTGGCAGCGCGTTCGCCTTG
CTGCCGTTGTACTACAAATTCATCCTGACGCTAATCCGGTCGGTCAATTATTGCTGCTTGATGAGCCGATGAACAGTCTC
GATGTTGCGCAACAAAACGCTCTGGATCGGGTATTACATCATTTGTGTCAGGTAGGAATTGCGATTGTGATGAGTAGCCA
CGATCTGAACCACACGCTGCGCCATGCGCATAAAGCCTGGTTACTAAAGCGCGGTAAACTCATTGCCTGCGGCCGCCGGG
AAGAGGTGCTCACCCCCTCTTATCTGGCGCAAGCCTACGGTCTGCGCTTTCGACGACTCGACGTTGAGGGGCATCCAATG
CTCATTTCGGCCACTTAA

Upstream 100 bases:

>100_bases
ATGGTCAGGTAGTACAGCGTTTTTCGCCGGATATGACGCCTGAAGATCCTATTGTGATGGAAAGCATAAAAATCGCGTTG
GCAAAATAATGTCTCAATTG

Downstream 100 bases:

>100_bases
GTAAAATCGTTTCTTGAAAAGCAGGTAATTTCGACGCTAAATTAATACCAAAATAAAAACAGAGGATTGTTGCGGCATGC
GTTTTTGGCTTCTTGTTATC

Product: vitamin B12-transporter ATPase

Products: NA

Alternate protein names: Vitamin B12-transporting ATPase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLEAWATATLAQHRAYLAQQQNP
PFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSL
DVAQQNALDRVLHHLCQVGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVEGHPM
LISAT

Sequences:

>Translated_245_residues
MQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLEAWATATLAQHRAYLAQQQNP
PFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSL
DVAQQNALDRVLHHLCQVGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVEGHPM
LISAT
>Mature_245_residues
MQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLEAWATATLAQHRAYLAQQQNP
PFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSL
DVAQQNALDRVLHHLCQVGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVEGHPM
LISAT

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system [H]

COG id: COG4138

COG function: function code H; ABC-type cobalamin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI46592915, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI46592956, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI46592898, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI46592978, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI46592971, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI46592964, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1788002, Length=243, Percent_Identity=81.4814814814815, Blast_Score=403, Evalue=1e-114,
Organism=Escherichia coli, GI1786345, Length=232, Percent_Identity=34.9137931034483, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786803, Length=241, Percent_Identity=31.5352697095436, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790739, Length=245, Percent_Identity=29.3877551020408, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789593, Length=229, Percent_Identity=30.1310043668122, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI87081791, Length=238, Percent_Identity=28.9915966386555, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1786253, Length=224, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789891, Length=231, Percent_Identity=31.1688311688312, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081782, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788506, Length=211, Percent_Identity=30.8056872037915, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788450, Length=220, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786398, Length=237, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788165, Length=222, Percent_Identity=30.1801801801802, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790467, Length=206, Percent_Identity=30.5825242718447, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786563, Length=195, Percent_Identity=31.2820512820513, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788225, Length=211, Percent_Identity=25.5924170616114, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786703, Length=183, Percent_Identity=34.4262295081967, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787370, Length=208, Percent_Identity=28.8461538461538, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787105, Length=211, Percent_Identity=28.436018957346, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787712, Length=195, Percent_Identity=27.1794871794872, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71992285, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25146777, Length=221, Percent_Identity=27.6018099547511, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.33 [H]

Molecular weight: Translated: 26678; Mature: 26678

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLE
CCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEECCCCHH
AWATATLAQHRAYLAQQQNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSV
HHHHHHHHHHHHHHHHCCCCCEECCHHHEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHH
NQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSLDVAQQNALDRVLHHLCQVGI
HHCCCCCHHHHEEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVEGHPM
HEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHCCEEEEECCCCCCE
LISAT
EEEEC
>Mature Secondary Structure
MQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLE
CCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEECCCCHH
AWATATLAQHRAYLAQQQNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSV
HHHHHHHHHHHHHHHHCCCCCEECCHHHEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHH
NQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSLDVAQQNALDRVLHHLCQVGI
HHCCCCCHHHHEEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVEGHPM
HEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHCCEEEEECCCCCCE
LISAT
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA