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The map label for this gene is maeA [H]

Identifier: 194734905

GI number: 194734905

Start: 1616561

End: 1618258

Strand: Direct

Name: maeA [H]

Synonym: SeSA_A1682

Alternate gene names: 194734905

Gene position: 1616561-1618258 (Clockwise)

Preceding gene: 194735945

Following gene: 194734410

Centisome position: 34.33

GC content: 53.42

Gene sequence:

>1698_bases
ATGGAAACTACAACCAAGAAAGCACGTTCCCTTTATATCCCTTACGCTGGCCCTGTATTGCTGGAATTCCCCCTGTTAAA
CAAAGGCAGCGCTTTTAGCGTAGAAGAGCGCCGCAACTTCAATTTGTCAGGGCTGCTGCCGGAGGTCGTCGAGTCGATTG
AAGAACAGGCCGAACGCGCCTGGCTCCAGTATCAGGGGTTTAAAACAGAAATCGATAAGCATATTTACCTGCGTAACATC
CAGGATACCAACGAAACGCTCTTTTATCGACTGGTGCAAAACCATCTTGAAGAGATGATGCCGGTTATCTATACCCCGAC
CGTGGGCGCGGCCTGTGAGCGCTTCTCTGAGATTTATCGCCGGGCGCGCGGCGTATTTATCTCTTATCCGAACCGTCACA
ATATGGACGACATTTTGCAGAATGTGCCTAACCACAACATTAAAGTTATTGTGGTGACGGATGGCGAGCGGATTCTGGGG
CTCGGCGATCAGGGCATCGGCGGGATGGGGATCCCTATCGGTAAGCTGTCATTATACACCGCCTGCGGCGGCATTAGTCC
GGCCTATACCCTTCCCGTTGTGCTGGATGTCGGCACCAACAATCAACAGTTACTCAACGATCCGCTTTACATGGGCTGGC
GTCATCCGCGCATTACCGACGATGAGTATTATGCGTTTGTCGACGAGTTTATTCAGGCCGTTAAGCAGCGCTGGCCAGAT
ATCCTGCTACAGTTCGAAGATTTCGCGCAGAAAAACGCAATGCCGCTGTTGACGCGCTATCGTGATGAGATTTGCTCCTT
TAACGATGATATTCAGGGCACCGCAGCCGTGACCGTCGGTACGTTGATCGCCGCCAGCCGCGCTGCCGGCAGTCAGCTTA
GCGAGCAGAAAATCGTTTTCCTCGGCGCGGGTTCCGCCGGATGTGGAATTGCTGAACAGATCATCGCGCAGACTCAGCGT
GAAGGTTTAAGCGAAGATGCCGCTCGACAGAACGTTTTTATGGTCGATCGCTTCGGCCTGTTGACGGACCGGATGCCTAA
TTTATTGCCGTTCCAGGCAAAACTGGTGCAGAAATGCGACAATCTCCAGCACTGGGATACCGAAAATGACGTGCTGTCGC
TGCTGGATGTGGTGCGTAACGTGAAGCCGGATATTCTGATCGGGGTTTCCGGCCAGACCGGGCTCTTTACTGAAGAGATC
ATCCGCGAGATGCATAAGCATTGCCCTCGCCCGATCGTCATGCCGCTCTCTAATCCCACCTCTCGCGTGGAGGCCACGCC
ACAGGACATTATCGCCTGGACGGAAGGCAACGCGCTGGTGGCGACCGGTAGTCCATTCTCGCCGGTCATCTGGAAAGATA
AGGTTTATCCGATCGCACAATGTAATAACGCCTATATTTTCCCCGGCATCGGTCTGGGGGTTATCGCTTCCGGCGCATCG
CGCATTACTGATGAAATGCTGATGTCAGCCAGTGAGACGCTGGCGAAACATTCTCCGCTGGTGAATAACGGCGAAGGATT
AGTGTTGCCAGCGCTTAAAGACATCCAGGTCGTGTCGCGCGCTATCGCTTTTGCCGTAGGCAAAATGGCGCAGCAACAAG
GCGTAGCGGTGAAAACCTCTGCGGAAGCGCTACAACAGGCGATTGACGATAACTTCTGGAAACCGGAATACCGCGACTAC
CGTCGGACTTCCATTTAA

Upstream 100 bases:

>100_bases
CTCACAATGCTTTATACTCAGGGTCGGTTCCCTGGTGGAAGGCAATATATGATGATAAACGACGGTGCCAGGGACAGTTA
TTCGAAAAAGAGTGAGTAAC

Downstream 100 bases:

>100_bases
TACGTACCCGGCGGTGAATGCCGCCGGATATCACTTTCTTCTTTAGTTTTGGTGAGTCTGTCGACACACCTGAATTCCTT
TCCCTGCTTATTTGTCAAGC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
METTTKKARSLYIPYAGPVLLEFPLLNKGSAFSVEERRNFNLSGLLPEVVESIEEQAERAWLQYQGFKTEIDKHIYLRNI
QDTNETLFYRLVQNHLEEMMPVIYTPTVGAACERFSEIYRRARGVFISYPNRHNMDDILQNVPNHNIKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRHPRITDDEYYAFVDEFIQAVKQRWPD
ILLQFEDFAQKNAMPLLTRYRDEICSFNDDIQGTAAVTVGTLIAASRAAGSQLSEQKIVFLGAGSAGCGIAEQIIAQTQR
EGLSEDAARQNVFMVDRFGLLTDRMPNLLPFQAKLVQKCDNLQHWDTENDVLSLLDVVRNVKPDILIGVSGQTGLFTEEI
IREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFSPVIWKDKVYPIAQCNNAYIFPGIGLGVIASGAS
RITDEMLMSASETLAKHSPLVNNGEGLVLPALKDIQVVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWKPEYRDY
RRTSI

Sequences:

>Translated_565_residues
METTTKKARSLYIPYAGPVLLEFPLLNKGSAFSVEERRNFNLSGLLPEVVESIEEQAERAWLQYQGFKTEIDKHIYLRNI
QDTNETLFYRLVQNHLEEMMPVIYTPTVGAACERFSEIYRRARGVFISYPNRHNMDDILQNVPNHNIKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRHPRITDDEYYAFVDEFIQAVKQRWPD
ILLQFEDFAQKNAMPLLTRYRDEICSFNDDIQGTAAVTVGTLIAASRAAGSQLSEQKIVFLGAGSAGCGIAEQIIAQTQR
EGLSEDAARQNVFMVDRFGLLTDRMPNLLPFQAKLVQKCDNLQHWDTENDVLSLLDVVRNVKPDILIGVSGQTGLFTEEI
IREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFSPVIWKDKVYPIAQCNNAYIFPGIGLGVIASGAS
RITDEMLMSASETLAKHSPLVNNGEGLVLPALKDIQVVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWKPEYRDY
RRTSI
>Mature_565_residues
METTTKKARSLYIPYAGPVLLEFPLLNKGSAFSVEERRNFNLSGLLPEVVESIEEQAERAWLQYQGFKTEIDKHIYLRNI
QDTNETLFYRLVQNHLEEMMPVIYTPTVGAACERFSEIYRRARGVFISYPNRHNMDDILQNVPNHNIKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRHPRITDDEYYAFVDEFIQAVKQRWPD
ILLQFEDFAQKNAMPLLTRYRDEICSFNDDIQGTAAVTVGTLIAASRAAGSQLSEQKIVFLGAGSAGCGIAEQIIAQTQR
EGLSEDAARQNVFMVDRFGLLTDRMPNLLPFQAKLVQKCDNLQHWDTENDVLSLLDVVRNVKPDILIGVSGQTGLFTEEI
IREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFSPVIWKDKVYPIAQCNNAYIFPGIGLGVIASGAS
RITDEMLMSASETLAKHSPLVNNGEGLVLPALKDIQVVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWKPEYRDY
RRTSI

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=523, Percent_Identity=43.7858508604207, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI62420882, Length=515, Percent_Identity=44.0776699029126, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI62420880, Length=515, Percent_Identity=44.0776699029126, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI239049447, Length=515, Percent_Identity=44.0776699029126, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI4505145, Length=558, Percent_Identity=41.3978494623656, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI270265879, Length=469, Percent_Identity=44.5628997867804, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI87081919, Length=565, Percent_Identity=92.5663716814159, Blast_Score=1068, Evalue=0.0,
Organism=Escherichia coli, GI1788806, Length=458, Percent_Identity=24.0174672489083, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17537199, Length=544, Percent_Identity=44.3014705882353, Blast_Score=420, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322823, Length=559, Percent_Identity=43.8282647584973, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI21356279, Length=516, Percent_Identity=43.9922480620155, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281362674, Length=516, Percent_Identity=43.9922480620155, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281362672, Length=516, Percent_Identity=43.9922480620155, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24646386, Length=512, Percent_Identity=42.3828125, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24646388, Length=512, Percent_Identity=42.3828125, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI78707242, Length=537, Percent_Identity=38.7337057728119, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707238, Length=537, Percent_Identity=38.7337057728119, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707240, Length=513, Percent_Identity=39.3762183235867, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363505, Length=535, Percent_Identity=35.7009345794393, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707236, Length=535, Percent_Identity=35.7009345794393, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707232, Length=507, Percent_Identity=37.4753451676529, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363503, Length=538, Percent_Identity=35.3159851301115, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19922384, Length=537, Percent_Identity=30.7262569832402, Blast_Score=274, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62897; Mature: 62897

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTTKKARSLYIPYAGPVLLEFPLLNKGSAFSVEERRNFNLSGLLPEVVESIEEQAERA
CCCCCCCHHEEECCCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHH
WLQYQGFKTEIDKHIYLRNIQDTNETLFYRLVQNHLEEMMPVIYTPTVGAACERFSEIYR
HHHHCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
RARGVFISYPNRHNMDDILQNVPNHNIKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRHPRITDDEYYAFVDEFIQAVKQRWPD
HHCCCCCCEEEEEEEEECCCCHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCHH
ILLQFEDFAQKNAMPLLTRYRDEICSFNDDIQGTAAVTVGTLIAASRAAGSQLSEQKIVF
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEE
LGAGSAGCGIAEQIIAQTQREGLSEDAARQNVFMVDRFGLLTDRMPNLLPFQAKLVQKCD
EECCCCCCHHHHHHHHHHHHCCCCHHHHHCCEEEEEHHHHHHHCCCCCCCHHHHHHHHHC
NLQHWDTENDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPT
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEATPQDIIAWTEGNALVATGSPFSPVIWKDKVYPIAQCNNAYIFPGIGLGVIASGAS
HHCCCCHHHEEEEECCCEEEECCCCCCCCEECCCCCCCEECCCEEEECCCCHHHHHCCHH
RITDEMLMSASETLAKHSPLVNNGEGLVLPALKDIQVVSRAIAFAVGKMAQQQGVAVKTS
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
AEALQQAIDDNFWKPEYRDYRRTSI
HHHHHHHHCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
METTTKKARSLYIPYAGPVLLEFPLLNKGSAFSVEERRNFNLSGLLPEVVESIEEQAERA
CCCCCCCHHEEECCCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHH
WLQYQGFKTEIDKHIYLRNIQDTNETLFYRLVQNHLEEMMPVIYTPTVGAACERFSEIYR
HHHHCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
RARGVFISYPNRHNMDDILQNVPNHNIKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRHPRITDDEYYAFVDEFIQAVKQRWPD
HHCCCCCCEEEEEEEEECCCCHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCHH
ILLQFEDFAQKNAMPLLTRYRDEICSFNDDIQGTAAVTVGTLIAASRAAGSQLSEQKIVF
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEE
LGAGSAGCGIAEQIIAQTQREGLSEDAARQNVFMVDRFGLLTDRMPNLLPFQAKLVQKCD
EECCCCCCHHHHHHHHHHHHCCCCHHHHHCCEEEEEHHHHHHHCCCCCCCHHHHHHHHHC
NLQHWDTENDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPT
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEATPQDIIAWTEGNALVATGSPFSPVIWKDKVYPIAQCNNAYIFPGIGLGVIASGAS
HHCCCCHHHEEEEECCCEEEECCCCCCCCEECCCCCCCEECCCEEEECCCCHHHHHCCHH
RITDEMLMSASETLAKHSPLVNNGEGLVLPALKDIQVVSRAIAFAVGKMAQQQGVAVKTS
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
AEALQQAIDDNFWKPEYRDYRRTSI
HHHHHHHHCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA