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The map label for this gene is adhP [H]

Identifier: 194734410

GI number: 194734410

Start: 1618540

End: 1619550

Strand: Direct

Name: adhP [H]

Synonym: SeSA_A1683

Alternate gene names: 194734410

Gene position: 1618540-1619550 (Clockwise)

Preceding gene: 194734905

Following gene: 194737424

Centisome position: 34.37

GC content: 53.21

Gene sequence:

>1011_bases
ATGAAAGCTGCTGTTGTCACACAAGATCATCAGGTTGATGTTACTGAGAAAACGCTGCGTCCCCTTCGCCACGGTGAGGC
TTTGCTAAAAATGGAGTGCTGCGGCGTATGCCATACCGATCTACACGTGAAAAACGGAGATTTCGGTGACAAAACCGGCG
TCATTCTGGGACACGAAGGCATTGGCGTCGTGGCGGAAGTCGGTCCTGGTGTCACCTCGCTGAAACCCGGCGATCGCGCG
AGTGTCGCGTGGTTTTATGAAGGATGCGGACACTGTGAGTATTGCAATACGGGCAATGAAACCTTATGCCGCAACGTGAA
AAATGCCGGTTACACGGTAGATGGCGGCATGGCCGAAGAGTGTATTGTCGTCGCGGATTATGCGGTGAAAGTACCGGAAG
GTCTGGACTCTGCGGCGGCAAGTAGTATTACCTGTGCGGGCGTTACCACCTATAAAGCGGTGAAGATTTCTCATATTAAA
CCTGGCCAGTGGATTGCCATCTACGGTCTGGGCGGTCTGGGTAATCTGGCCTTGCAGTACGCGAAAAACGTCTTCAATGC
GAAAGTGATCGCCATTGATGTCAATGATGGACAACTGAAACTGGCCGAGGAAATGGGCGCAGATCTGACCATTAATTCAC
GCACGGAAGATGCGGCTAAAATTGTGCAGGAAAAAACCGGTGGCGCGCACGCAGCGGTGGTTACCGCGGTCGCTAAGGCG
GCGTTTAATTCCGCAGTAGATGCCGTTCGCGCCGGAGGCCGCGTGGTGGCAGTCGGACTGCCGCCAGAAGCCATGAACCT
TGATATCCCTCGCCTGGTGCTGGATGGCATTCAGGTTGTCGGTTCGTTGGTGGGGACACGCCAGGATCTGACCGAAGCTT
TCCAGTTCGCGGCGGAAGGAAAAGTCGTACCAAAAGTCGCTCTACGTCCGCTTGAAGATATCAACGTTATTTTTAAAGAG
ATGGAACAGGGACAAATTCGTGGCCGTATGGTCATCGATTTCCGTCGTTAA

Upstream 100 bases:

>100_bases
GCCTTGCATAACTCATCAGAAATATTAATCCTAAAGAGGTAATAGCACCTTACCTGCTATTACCTGCTATGCAGTTCACT
ATTAATAAAAGGAGAAGGTT

Downstream 100 bases:

>100_bases
ACGATTTGCTGTGGTCGTCTGAGTATACAGACAGCAGATGAAAACAAGGCGCTACCAGGATAGCGCCTTGTTTATCAGAT
CGCGAAAGAATTACTGAATA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAAVVTQDHQVDVTEKTLRPLRHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNTGNETLCRNVKNAGYTVDGGMAEECIVVADYAVKVPEGLDSAAASSITCAGVTTYKAVKISHIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDGQLKLAEEMGADLTINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPEAMNLDIPRLVLDGIQVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLEDINVIFKE
MEQGQIRGRMVIDFRR

Sequences:

>Translated_336_residues
MKAAVVTQDHQVDVTEKTLRPLRHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNTGNETLCRNVKNAGYTVDGGMAEECIVVADYAVKVPEGLDSAAASSITCAGVTTYKAVKISHIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDGQLKLAEEMGADLTINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPEAMNLDIPRLVLDGIQVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLEDINVIFKE
MEQGQIRGRMVIDFRR
>Mature_336_residues
MKAAVVTQDHQVDVTEKTLRPLRHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNTGNETLCRNVKNAGYTVDGGMAEECIVVADYAVKVPEGLDSAAASSITCAGVTTYKAVKISHIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDGQLKLAEEMGADLTINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPEAMNLDIPRLVLDGIQVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLEDINVIFKE
MEQGQIRGRMVIDFRR

Specific function: Preferred specificity is towards 1-propanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=28.6486486486486, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=28.494623655914, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4501929, Length=314, Percent_Identity=29.9363057324841, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=27.1739130434783, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=27.1739130434783, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI71565154, Length=249, Percent_Identity=30.9236947791165, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71565152, Length=353, Percent_Identity=25.4957507082153, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4501939, Length=342, Percent_Identity=26.9005847953216, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI156523966, Length=342, Percent_Identity=26.9005847953216, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI156627571, Length=246, Percent_Identity=29.2682926829268, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI22538446, Length=334, Percent_Identity=24.5508982035928, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI22538444, Length=334, Percent_Identity=24.5508982035928, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=92.5595238095238, Blast_Score=589, Evalue=1e-170,
Organism=Escherichia coli, GI1790045, Length=335, Percent_Identity=28.3582089552239, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI87082401, Length=329, Percent_Identity=27.9635258358663, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786518, Length=341, Percent_Identity=27.5659824046921, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787863, Length=267, Percent_Identity=30.3370786516854, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788073, Length=249, Percent_Identity=30.9236947791165, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1790718, Length=331, Percent_Identity=26.8882175226586, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=26.2857142857143, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI226510992, Length=311, Percent_Identity=26.3665594855305, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=231, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788075, Length=319, Percent_Identity=25.705329153605, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=279, Percent_Identity=27.9569892473118, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788407, Length=227, Percent_Identity=30.3964757709251, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=313, Percent_Identity=37.3801916932907, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=36.1702127659575, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=37.4603174603175, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17562876, Length=254, Percent_Identity=31.1023622047244, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=195, Percent_Identity=33.8461538461538, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=220, Percent_Identity=30.4545454545455, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=205, Percent_Identity=31.219512195122, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=205, Percent_Identity=30.7317073170732, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=334, Percent_Identity=37.4251497005988, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323961, Length=317, Percent_Identity=39.7476340694006, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=36.2573099415205, Blast_Score=205, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6323729, Length=333, Percent_Identity=36.3363363363363, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319949, Length=332, Percent_Identity=27.710843373494, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=329, Percent_Identity=26.7477203647416, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=287, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=287, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=354, Percent_Identity=26.8361581920904, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=244, Percent_Identity=26.2295081967213, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=308, Percent_Identity=24.025974025974, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17137530, Length=212, Percent_Identity=30.188679245283, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737897, Length=208, Percent_Identity=28.8461538461538, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17737895, Length=239, Percent_Identity=29.2887029288703, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35541; Mature: 35541

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVTQDHQVDVTEKTLRPLRHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEECCCCCCCCHHHHHHHHHCCCCEEEHHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNTGNETLCRNVKNAGYTVDGGMAEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCCC
CIVVADYAVKVPEGLDSAAASSITCAGVTTYKAVKISHIKPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCHHHCCEEEECEEEEEEEEEEEECCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDGQLKLAEEMGADLTINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPEAMNLDIPRLVLDGIQVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLEDINVIFKEMEQGQIRGRMVIDFRR
CCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAAVVTQDHQVDVTEKTLRPLRHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEECCCCCCCCHHHHHHHHHCCCCEEEHHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNTGNETLCRNVKNAGYTVDGGMAEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCCC
CIVVADYAVKVPEGLDSAAASSITCAGVTTYKAVKISHIKPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCHHHCCEEEECEEEEEEEEEEEECCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDGQLKLAEEMGADLTINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPEAMNLDIPRLVLDGIQVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLEDINVIFKEMEQGQIRGRMVIDFRR
CCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 2158980 [H]