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The map label for this gene is sifB [H]

Identifier: 194734475

GI number: 194734475

Start: 1662902

End: 1663852

Strand: Direct

Name: sifB [H]

Synonym: SeSA_A1719

Alternate gene names: 194734475

Gene position: 1662902-1663852 (Clockwise)

Preceding gene: 194737788

Following gene: 194733968

Centisome position: 35.31

GC content: 37.33

Gene sequence:

>951_bases
ATGCCAATTACTATCGGGAGAGGGTTTTTAAAGAGTGAGATGTTTTCTCAAAGTGCCATCTCTCAACGCTCCTTCTTTAC
GTTACTATGGGAAAAGATTAAAGATTTTTTCTGTAGCACGCGAAGATCCGCTGCCGATCAATATATAAAGGAATTATGTG
ATGTTGCCTCTCCGCCTGACGCACAACGTTTATTTGATTTATTTTGCAAGTTATATGAATTATCATCACCGTCATGCAAA
GAAAAATTCCATTTTCAGCACTATAAAGATGGTGAGTATCAATATACAAATCTCTGCATTAAAGATGGCGAAGATATTCC
GTTATGCATTGTGATACGTCAGGATCACTACTATTATGATATAATGAATAGAACAGTACTCTGTGTTGATACTCAGTCTG
CCCACCTGAAAAGATATTCTGATATTAATATAAAAACTAGCACTTATGTTTGTGAAGAGCTATGTTGCTTGTTCCCTGAG
CGGTTACTACTCTCGCTATCCGGTGGTATAACATTTTCCGTTGACCTAAAAAATATAAAAGAGACGCTTATCGCCATGGC
AGAAAAGGGTAATTTATGTGACTGGAAGGAACAGGAAAGAAAAGCCGCCATTTCCTCCAGGATTAGTCTGGGCATCACCC
AGGCAGATCTACCACCTATTGACGACGCTATCAAAAACAAAATAGCCGCAAAGGTTATTGAGGATACTAACTTAAAGAAT
GCAACATTTGAACCAAATTATGCACAAAGCTCAGTTACTCAACTAGTTTATTCATGTTTGTTTAAGAATGAGATATTAAT
GAATATGCTTGAGGAAAGTTCCTCTCATGGCCTGCTATGTTTAAACGACCTTGTTGAATATGTAGCGTTACAAGTTCATA
ACAGCCTTTTTTCTGAAGATTTATCTTCACTCGTTGAAACAACAAAAAATGAGGCTCATCACCAGAGTTGA

Upstream 100 bases:

>100_bases
TGTTTCACCGATAGGCAAACCGATGGGCAACATGGGATAATATTTTGAATACCACCTATTCCAGTAATGAAGTATTATAT
ACTCACTTGTGGTCTAAATT

Downstream 100 bases:

>100_bases
CCACACCATAAATAGTATGGCTTACAATCCCCTGGCAATACCAAAACCATCTAATACAATACCTTTAAAATATACTTCCA
GGAAATAATGAATTTCGCAT

Product: secreted effector protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCSTRRSAADQYIKELCDVASPPDAQRLFDLFCKLYELSSPSCK
EKFHFQHYKDGEYQYTNLCIKDGEDIPLCIVIRQDHYYYDIMNRTVLCVDTQSAHLKRYSDINIKTSTYVCEELCCLFPE
RLLLSLSGGITFSVDLKNIKETLIAMAEKGNLCDWKEQERKAAISSRISLGITQADLPPIDDAIKNKIAAKVIEDTNLKN
ATFEPNYAQSSVTQLVYSCLFKNEILMNMLEESSSHGLLCLNDLVEYVALQVHNSLFSEDLSSLVETTKNEAHHQS

Sequences:

>Translated_316_residues
MPITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCSTRRSAADQYIKELCDVASPPDAQRLFDLFCKLYELSSPSCK
EKFHFQHYKDGEYQYTNLCIKDGEDIPLCIVIRQDHYYYDIMNRTVLCVDTQSAHLKRYSDINIKTSTYVCEELCCLFPE
RLLLSLSGGITFSVDLKNIKETLIAMAEKGNLCDWKEQERKAAISSRISLGITQADLPPIDDAIKNKIAAKVIEDTNLKN
ATFEPNYAQSSVTQLVYSCLFKNEILMNMLEESSSHGLLCLNDLVEYVALQVHNSLFSEDLSSLVETTKNEAHHQS
>Mature_315_residues
PITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCSTRRSAADQYIKELCDVASPPDAQRLFDLFCKLYELSSPSCKE
KFHFQHYKDGEYQYTNLCIKDGEDIPLCIVIRQDHYYYDIMNRTVLCVDTQSAHLKRYSDINIKTSTYVCEELCCLFPER
LLLSLSGGITFSVDLKNIKETLIAMAEKGNLCDWKEQERKAAISSRISLGITQADLPPIDDAIKNKIAAKVIEDTNLKNA
TFEPNYAQSSVTQLVYSCLFKNEILMNMLEESSSHGLLCLNDLVEYVALQVHNSLFSEDLSSLVETTKNEAHHQS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. Localizes to the Salmonella-containing vacuole (SCV) at early time points following invasion and subsequently traffics away from t

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Sif family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010637 [H]

Pfam domain/function: PF06767 Sif [H]

EC number: NA

Molecular weight: Translated: 36095; Mature: 35963

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCSTRRSAADQYIKELCDVASPPD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AQRLFDLFCKLYELSSPSCKEKFHFQHYKDGEYQYTNLCIKDGEDIPLCIVIRQDHYYYD
HHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCEEEE
IMNRTVLCVDTQSAHLKRYSDINIKTSTYVCEELCCLFPERLLLSLSGGITFSVDLKNIK
ECCCEEEEEECCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHH
ETLIAMAEKGNLCDWKEQERKAAISSRISLGITQADLPPIDDAIKNKIAAKVIEDTNLKN
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
ATFEPNYAQSSVTQLVYSCLFKNEILMNMLEESSSHGLLCLNDLVEYVALQVHNSLFSED
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LSSLVETTKNEAHHQS
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCSTRRSAADQYIKELCDVASPPD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AQRLFDLFCKLYELSSPSCKEKFHFQHYKDGEYQYTNLCIKDGEDIPLCIVIRQDHYYYD
HHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCEEEE
IMNRTVLCVDTQSAHLKRYSDINIKTSTYVCEELCCLFPERLLLSLSGGITFSVDLKNIK
ECCCEEEEEECCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHH
ETLIAMAEKGNLCDWKEQERKAAISSRISLGITQADLPPIDDAIKNKIAAKVIEDTNLKN
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
ATFEPNYAQSSVTQLVYSCLFKNEILMNMLEESSSHGLLCLNDLVEYVALQVHNSLFSED
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LSSLVETTKNEAHHQS
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10861017; 11677609 [H]