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The map label for this gene is xanP [H]

Identifier: 194734456

GI number: 194734456

Start: 3825593

End: 3826984

Strand: Direct

Name: xanP [H]

Synonym: SeSA_A3954

Alternate gene names: 194734456

Gene position: 3825593-3826984 (Clockwise)

Preceding gene: 194735749

Following gene: 194737842

Centisome position: 81.24

GC content: 57.47

Gene sequence:

>1392_bases
ATGTCCGTTAACGCCATCGAGCCGGCAGATGCGCAACCGGTTGCGCAGACGCAAAACAGCGAATTAATTTACCGTCTTGA
AGATCGCCCGCCGCTCCCTCAAACCCTTTTTGCCGCTTGTCAGCATCTGCTGGCCATGTTTGTCGCGGTAATCACGCCAG
CGCTGTTAATCTGCCAGGCGTTGGGTTTACCGGCGCAGGATACGCAGCACATTATCAGCATGTCGCTGTTCGCCTCCGGC
GTAGCCTCTATTATTCAAATCAAAGCGTGGGGGCCGGTAGGATCGGGGCTGTTATCCATCCAGGGAACCAGTTTTAACTT
TGTCGCCCCGCTGATTATGGGCGGTACCGCGCTGAAAACCGGCGGCGCGGACGTCCCGACGATGATGGCGGCGCTGTTCG
GCACGCTGATGCTGGCAAGCTGCACCGAGATGGTGCTTTCTCGCATTCTACATCTGGCGCGACGGATTATCACGCCGTTA
GTCTCCGGCGTCGTGGTGATGATTATTGGCCTGTCGCTGATTCAGGTGGGGCTAACCTCCATCGGCGGCGGCTATGCCGC
CATGAGCGACAACACCTTTGGCGCACCGAAAAACCTGCTGCTGGCCGGCGTCGTCCTGGCCATTATTATCCTGCTGAATC
GGCAGCGTAATCCCTACCTGCGCGTGGCTTCTTTGGTTATTGCCATGGCGGCAGGCTATCTTTTGGCCTGGTTTATGGGC
ATGTTGCCTGAGAATAACGCGCCAGTCTCGCAGGACATCCTGATGGTGCCGACCCCGCTGTATTATGGTCTGGGCATTGA
CTGGAACCTGTTACTGCCGTTGATGCTGGTCTTTATGATTACGTCGCTGGAGACCATCGGCGACATCACCGCCACCTCTG
ATGTCTCCGAGCAGCCGGTATCCGGCCCCTTGTATATGAAACGGCTAAAGGGCGGCGTACTGGCTAACGGCCTGAACTCA
TTTGTTTCAGCGGTATTTAATACGTTCCCGAATTCCTGTTTCGGTCAGAACAACGGCGTAATTCAGTTGACCGGCGTCGC
CAGTCGCTATGTGGGATTTGTCGTCGCGCTGATGCTGATTGTGCTCGGCCTGTTCCCGGCGGTAAGCGGTTTTGTGCAGC
ATATCCCGGAACCGGTGCTCGGCGGCGCCACGTTAGTGATGTTCGGCACCATTGCCGCCTCCGGGGTGCGTATTGTCTCG
CGTGAGCCGCTGAACCGCCGCGCGATTCTGATTATCGCCCTGTCGCTGGCCGTGGGTCTTGGCGTCTCGCAACAGCCGCA
GATCCTGCAGTTCGCGCCGGAATGGGTGAAAAATCTGCTCTCATCCGGAATTGCCGCTGGCGGCATCACGGCTATCGTGT
TGAACCTGATTCTCCCGCCGGAAAAACCGTAA

Upstream 100 bases:

>100_bases
ATTTATCTTTTTTAAATATTAAGAATATTCGCTCGCAATCGTTTGCTTTTACCACCTGGTCAGATAAAATCACCGCTTTT
CCACCACGAGAATGTCCCTG

Downstream 100 bases:

>100_bases
AAACCCTGCGGCGGCGACGCGATTCGCCGCTGCTGTAACGCTCTTTCACCATTCCTGTCTTGAGGATTGCACGCAAATCG
TGCATAAATCCCCTATGTGC

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSVNAIEPADAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPL
VSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLAIIILLNRQRNPYLRVASLVIAMAAGYLLAWFMG
MLPENNAPVSQDILMVPTPLYYGLGIDWNLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPQILQFAPEWVKNLLSSGIAAGGITAIVLNLILPPEKP

Sequences:

>Translated_463_residues
MSVNAIEPADAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPL
VSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLAIIILLNRQRNPYLRVASLVIAMAAGYLLAWFMG
MLPENNAPVSQDILMVPTPLYYGLGIDWNLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPQILQFAPEWVKNLLSSGIAAGGITAIVLNLILPPEKP
>Mature_462_residues
SVNAIEPADAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASGV
ASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPLV
SGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLAIIILLNRQRNPYLRVASLVIAMAAGYLLAWFMGM
LPENNAPVSQDILMVPTPLYYGLGIDWNLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNSF
VSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
EPLNRRAILIIALSLAVGLGVSQQPQILQFAPEWVKNLLSSGIAAGGITAIVLNLILPPEKP

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790087, Length=462, Percent_Identity=95.2380952380952, Blast_Score=858, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=441, Percent_Identity=44.671201814059, Blast_Score=354, Evalue=7e-99,
Organism=Escherichia coli, GI87082181, Length=424, Percent_Identity=30.4245283018868, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788843, Length=409, Percent_Identity=25.1833740831296, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081818, Length=408, Percent_Identity=25.4901960784314, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=454, Percent_Identity=24.4493392070485, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48733; Mature: 48602

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNAIEPADAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPLVSGVVVMIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLAIIILLNRQRNPYLRVASLVIAMAAGYLLAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPENNAPVSQDILMVPTPLYYGLGIDWNLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHC
GVSQQPQILQFAPEWVKNLLSSGIAAGGITAIVLNLILPPEKP
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVNAIEPADAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPLVSGVVVMIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLAIIILLNRQRNPYLRVASLVIAMAAGYLLAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPENNAPVSQDILMVPTPLYYGLGIDWNLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHC
GVSQQPQILQFAPEWVKNLLSSGIAAGGITAIVLNLILPPEKP
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]