| Definition | Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633 chromosome, complete genome. |
|---|---|
| Accession | NC_011094 |
| Length | 4,709,075 |
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The map label for this gene is topA [H]
Identifier: 194733931
GI number: 194733931
Start: 1787171
End: 1789768
Strand: Reverse
Name: topA [H]
Synonym: SeSA_A1846
Alternate gene names: 194733931
Gene position: 1789768-1787171 (Counterclockwise)
Preceding gene: 194735219
Following gene: 194737763
Centisome position: 38.01
GC content: 54.16
Gene sequence:
>2598_bases ATGGGTAAAGCTCTTGTCATCGTTGAGTCCCCGGCAAAAGCCAAAACGATCAACAAGTATCTGGGTAATGACTACGTGGT GAAATCCAGCGTGGGTCATATCCGTGATTTGCCGACCAGTGGCTCAGCAGCTAAAAAGAGCGCCGACTCTACCTCCACCA AAACGGCTAAAAAGCCCAAAAAGGATGAACGTGGCGCTCTCGTCAACCGTATGGGGGTTGATCCGTGGCACAACTGGGAT GCGCACTATGAAGTGCTGCCCGGTAAAGAGAAGGTCGTCTCTGAACTGAAACAGTTGGCGGAAAAAGCCGACCACATCTA TCTCGCAACCGACCTTGACCGCGAAGGGGAAGCCATTGCATGGCACCTGCGGGAAGTGATCGGCGGCGATGACGCGCGCT ACAGTCGCGTAGTCTTTAACGAAATAACCAAAAATGCCATTCGCCAGGCGTTTGAACAGCCGGGCGAGCTGAACATTAAC AGGGTCAACGCCCAGCAAGCGCGCCGCTTTATGGACCGCGTGGTAGGCTATATGGTCTCGCCGTTGCTGTGGAAAAAGAT CGCCCGTGGTTTGTCGGCAGGTCGCGTTCAGTCTGTCGCGGTCCGTCTGGTCGTTGAGCGCGAGCGCGAGATTAAAGCGT TTGTTCCGGAAGAGTTCTGGGAAATTGACGCTAATACGACGACGCCGTCTGGCGAGGCGCTACCGCTACAGGTCACGCAT CAGAACGACAAGCCATTCCGGCCGGTAAATCGCGAGCAGACGCTTGCCGCCGTCAGCTTGCTGGAAAAAGCCAGCTATAG CGTGCTGGAGCGAGAAGACAAGCCGACCAGCAGCAAGCCAGGCGCGCCGTTTATCACCTCCACGCTACAGCAGGCGGCCA GCACCCGGCTGGGCTTTGGCGTGAAGAAAACCATGATGATGGCGCAGCGTCTGTATGAGGCGGGCTACATCACCTATATG CGTACAGACTCCACCAACCTGAGTCAGGATGCGGTCAACATGGTGCGCGGTTATATTGGCGATAATTTCGGCAAGAAATA CCTGCCGGATAACCCGAACCAGTACGCCAGCAAAGAAAACTCTCAGGAAGCGCACGAAGCGATCCGTCCTTCCGACGTTG CTGTCATGGCGGAGTCGCTGAAAGACATGGAGGCTGACGCGCAGAAGTTGTATCAACTAATTTGGCGTCAGTTTGTCGCC TGTCAGATGACGCCAGCACAATATGACTCTACTACGCTTACCGTTGGCGCAGGCGAGTTCCGCCTGAAAGCGCGTGGGCG TATTTTGCGCTTTGACGGCTGGACAAAAGTGATGCCGGCGCTGCGTAAAGGCGATGAAGATCGCACATTGCCTGCCGTGA ATAAGGGCGATGCGCTGACGCTACTTGAATTGACGCCTGCTCAGCACTTTACTAAACCGCCAGCCCGGTTTAGCGAGGCT TCTCTGGTTAAAGAGCTTGAGAAGCGCGGTATTGGTCGTCCGTCTACCTATGCGTCGATTATCTCGACCATTCAGGATCG CGGCTATGTTCGCGTTGAAAACCGTCGTTTCTATGCGGAAAAAATGGGTGAAATCGTCACCGATCGGCTGGAAGAAAACT TCCGCGAATTGATGAACTACGATTTTACCGCGCAGATGGAAGATAGTCTGGATCAGGTTGCAAATCACCAGGCCGAGTGG AAAGCGGTACTGGATAACTTCTTCAGCGATTTTACTCAGCAGCTCGATAAAGCCGAGAAAGATCCGGAAGAAGGGGGGAT GCGCCCTAACCAGATGGTGCTGACCAGCATCGACTGTCCAACCTGTGGCCGTAAAATGGGAATTCGTACTGCCAGTACGG GGGTTTTCCTTGGATGTTCAGGTTATGCGCTTTCGCCGAAAGAGCGTTGTAAAACGACCATTAACCTGGTGCCGGAAAAT GAAGTTCTGAACGTGCTGGAAGGCGACGACGCCGAAACCAACGCCCTGCGCGCCAAGCGTCGCTGTCAGAAGTGTGGTAC GGCGATGGACAGCTATCTGATCGATCCGAAGCGTAAATTGCATGTGTGTGGTAATAACCCGACCTGTGACGGCTACGAGA TTGAAGAAGGCGAGTTCCGCATCAAAGGGTATGACGGTCCGATCGTTGAGTGTGAGAAATGTGGTTCCGAAATGCACCTG AAAATGGGGCGTTTTGGTAAGTACATGGCCTGTACTAACGACGAATGTAAAAACACCCGTAAGATCTTGCGTAACGGCGA AGTTGCGCCGCCGAAGGAAGATCCTGTTCCATTGCCGGAACTGCCGTGTGAAAAATCGGACGCGTACTTTGTGCTGCGCG ATGGCGCCGCAGGGATATTCCTGGCGGCCAACACGTTCCCGAAATCACGCGAAACGCGCGCGCCATTAGTCGAGGAGCTT TACCGGTTCCGCGATCGCCTGCCGGAAAAACTGCGTTATCTGGCGGATGCGCCGCAGCAGGATCCAGAAGGTAATAAAAC CGTTGTTCGCTTTAGCCGCAAAACAAAACAGCAGTACGTTGCGGCGGAAAAAGACGGGAAGGCGACGGGATGGTCAGCGT TCTTCGTCGACGGCAAGTGGGTTGAAGGCAAGAAATAA
Upstream 100 bases:
>100_bases TCCGCAGACGCAGAGACCATATATCGTTGTCTCGTCGCCAGTGGAAGGTGAATCAACGTGCGACGCATTCCTGGAAGAAT CAACTTAGGTAAAGGTGAAT
Downstream 100 bases:
>100_bases CCCCTGCCTGTCGTCACTATAGTCAAGCGGGCCGCGTAAGCGGCCCTTTTTTATATACCCTTCATATTTAAAGTGGCTTA TGTGTTGGCTACGGATTACT
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 865; Mature: 864
Protein sequence:
>865_residues MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWD AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNIN RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTH QNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYM RTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVA CQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEA SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEW KAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPEN EVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL KMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEEL YRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
Sequences:
>Translated_865_residues MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWD AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNIN RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTH QNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYM RTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVA CQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEA SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEW KAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPEN EVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL KMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEEL YRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK >Mature_864_residues GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDA HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINR VNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQ NDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMR TDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVAC QMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEAS LVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWK AVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENE VLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLK MGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELY RFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=564, Percent_Identity=26.241134751773, Blast_Score=151, Evalue=2e-36, Organism=Homo sapiens, GI4507635, Length=514, Percent_Identity=26.4591439688716, Blast_Score=148, Evalue=2e-35, Organism=Escherichia coli, GI1787529, Length=865, Percent_Identity=96.3005780346821, Blast_Score=1749, Evalue=0.0, Organism=Escherichia coli, GI1788061, Length=649, Percent_Identity=23.1124807395994, Blast_Score=125, Evalue=1e-29, Organism=Caenorhabditis elegans, GI32563869, Length=658, Percent_Identity=24.9240121580547, Blast_Score=135, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17555378, Length=508, Percent_Identity=25.7874015748031, Blast_Score=134, Evalue=1e-31, Organism=Saccharomyces cerevisiae, GI6323263, Length=478, Percent_Identity=25.3138075313808, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI24585251, Length=709, Percent_Identity=24.8236953455571, Blast_Score=139, Evalue=6e-33, Organism=Drosophila melanogaster, GI24640096, Length=500, Percent_Identity=26.2, Blast_Score=123, Evalue=5e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR013263 - InterPro: IPR006171 [H]
Pfam domain/function: PF08272 Topo_Zn_Ribbon; PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 97234; Mature: 97103
Theoretical pI: Translated: 8.38; Mature: 8.38
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK CCCEEEEEECCCHHHHHHHHHCCCEEEECCCCHHHCCCCCCCHHHCCCCCCCCHHCCCCC KDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA CCHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH WHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVS HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHH PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTH HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEC QNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFG CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKEN HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCC SQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEF HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCE RLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEA EEEECCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHH SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY HHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC DFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCC TCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKR CCCHHHCCEEECCCEEEECCCCCCCCHHHCCCEEEECCCHHHHHHHCCCCCHHHHHHHHH RCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHCCCHHHH KMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIF HHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEE LAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYV EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHH AAEKDGKATGWSAFFVDGKWVEGKK HHCCCCCCCCEEEEEECCEECCCCC >Mature Secondary Structure GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK CCEEEEEECCCHHHHHHHHHCCCEEEECCCCHHHCCCCCCCHHHCCCCCCCCHHCCCCC KDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA CCHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH WHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVS HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHH PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTH HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEC QNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFG CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKEN HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCC SQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEF HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCE RLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEA EEEECCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHH SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY HHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC DFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCC TCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKR CCCHHHCCEEECCCEEEECCCCCCCCHHHCCCEEEECCCHHHHHHHCCCCCHHHHHHHHH RCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHCCCHHHH KMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIF HHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEE LAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYV EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHH AAEKDGKATGWSAFFVDGKWVEGKK HHCCCCCCCCEEEEEECCEECCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 3029379; 9097039; 9278503; 3032952; 8114910; 7779808 [H]