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The map label for this gene is tmk [H]

Identifier: 194733912

GI number: 194733912

Start: 1248271

End: 1248912

Strand: Direct

Name: tmk [H]

Synonym: SeSA_A1276

Alternate gene names: 194733912

Gene position: 1248271-1248912 (Clockwise)

Preceding gene: 194735901

Following gene: 194737080

Centisome position: 26.51

GC content: 57.94

Gene sequence:

>642_bases
ATGGGCAGTAATTATATCGTCATCGAGGGCCTGGAAGGCGCCGGAAAAACCACTGCGCGCGACGTGGTGGTGGAGACCCT
TGAGCAACTGGGTATTCGTAACATGATTTTTACCCGTGAGCCGGGCGGTACGCAGCTTGCCGAAAAACTGAGAAGTCTGG
TGCTGGATATTCGATCGGTAGGCGACGAAGTGATTACCGATAAAGCGGAAGTGCTGATGTTTTATGCCGCTCGCGTACAG
CTCGTCGAAACGGTAATCAAACCCGCGCTGGCGCAAGGCGTATGGGTGATCGGCGATCGACACGATCTCTCGACCCAGGC
GTATCAGGGGGGAGGGCGCGGCATTGATCAAACCATGCTGGCGACACTACGCGATGCCGTGCTGGGCGATTTTCGCCCTG
ACCTGACGCTGTATCTGGATGTCACGCCGGAAGTCGGGCTAAAACGCGCCAGAGCGCGCGGCGATTTGGATCGCATTGAG
CAGGAATCTTTTGATTTCTTTAACCGGACTCGCGCGCGCTATCTGGAACTGGCGGCGCAAGACTCGCGTATCCGCACCAT
TGACGCGACCCAGCCGCTGGATGCCGTCATGCGCGACATTCGCGCCACGGTGACGAAGTGGGTACAGGAGCAAGCGGCAT
GA

Upstream 100 bases:

>100_bases
TATTTTGTGGCCGACGGTAAAGGCGGTCACACATTTAACACCAATCTTGCCAGCCATAATCGGTCAGTGCAGGAGTACCT
GAAAGTGCTTAAGGAAAAAA

Downstream 100 bases:

>100_bases
AATGGTATCCATGGTTACGGCCCGCCTATGAAAAACTGGTAGAAAGTTACCAGGCGGGACGTGGGCACCATGCGCTACTG
ATTCAGGCCTTACCTGGCAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MGSNYIVIEGLEGAGKTTARDVVVETLEQLGIRNMIFTREPGGTQLAEKLRSLVLDIRSVGDEVITDKAEVLMFYAARVQ
LVETVIKPALAQGVWVIGDRHDLSTQAYQGGGRGIDQTMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGDLDRIE
QESFDFFNRTRARYLELAAQDSRIRTIDATQPLDAVMRDIRATVTKWVQEQAA

Sequences:

>Translated_213_residues
MGSNYIVIEGLEGAGKTTARDVVVETLEQLGIRNMIFTREPGGTQLAEKLRSLVLDIRSVGDEVITDKAEVLMFYAARVQ
LVETVIKPALAQGVWVIGDRHDLSTQAYQGGGRGIDQTMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGDLDRIE
QESFDFFNRTRARYLELAAQDSRIRTIDATQPLDAVMRDIRATVTKWVQEQAA
>Mature_212_residues
GSNYIVIEGLEGAGKTTARDVVVETLEQLGIRNMIFTREPGGTQLAEKLRSLVLDIRSVGDEVITDKAEVLMFYAARVQL
VETVIKPALAQGVWVIGDRHDLSTQAYQGGGRGIDQTMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGDLDRIEQ
ESFDFFNRTRARYLELAAQDSRIRTIDATQPLDAVMRDIRATVTKWVQEQAA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=90.9523809523809, Blast_Score=384, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23724; Mature: 23593

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSNYIVIEGLEGAGKTTARDVVVETLEQLGIRNMIFTREPGGTQLAEKLRSLVLDIRSV
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHH
GDEVITDKAEVLMFYAARVQLVETVIKPALAQGVWVIGDRHDLSTQAYQGGGRGIDQTML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCCCCHHHHHH
ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGDLDRIEQESFDFFNRTRARYLELAAQ
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DSRIRTIDATQPLDAVMRDIRATVTKWVQEQAA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSNYIVIEGLEGAGKTTARDVVVETLEQLGIRNMIFTREPGGTQLAEKLRSLVLDIRSV
CCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHH
GDEVITDKAEVLMFYAARVQLVETVIKPALAQGVWVIGDRHDLSTQAYQGGGRGIDQTML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCCCCHHHHHH
ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGDLDRIEQESFDFFNRTRARYLELAAQ
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DSRIRTIDATQPLDAVMRDIRATVTKWVQEQAA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA