Click here to switch to the map view.

The map label for this gene is dtd

Identifier: 194334666

GI number: 194334666

Start: 2040971

End: 2041414

Strand: Reverse

Name: dtd

Synonym: Paes_1867

Alternate gene names: 194334666

Gene position: 2041414-2040971 (Counterclockwise)

Preceding gene: 194334667

Following gene: 194334665

Centisome position: 81.24

GC content: 53.6

Gene sequence:

>444_bases
GTGAGGGCCGTCGTTCAAAGAGTATCGTGCGCCTCTCTGACTGTAGAAGGTCATTCGGGTGCACAGATCGGGCCGGGTTT
GACGGTGCTGCTCGCCATCGCTCCGGGCGATGGGTCGAGAGACATTGACTGGATGGTTCGCAAGCTTCTTGGTCTCAGAA
TTTTTGAGGATGATTCGGGTAAAATGAACGCGTCAGTGGTCGATATCAGGGGTGCGCTGCTCATTGTTTCTCAGTTTACC
CTTTATGGCGACACCTCCAGAGGCAACAGACCGGGATTTTCTGCTTCAGCGCCTTATGAGACGGCTCACGAGATCTATAA
CCAATTTGTCGACAGGCTGCGCTCGTCGTCGCCTCTTGTGGTTCAGACCGGGGTTTTCGGACGCGATATGCAGGTAAGTC
TGACCAATGACGGACCGGTTACCATGATTCTTGATACCCCATGA

Upstream 100 bases:

>100_bases
GGCACTCATCCAGAATCAAGCGTCTGACTATAGATGGTATGGGTGCAGCGGAGGCTGCGACGCTTTTTGGTGAGCATCTT
GAGTCTGTAGAATTTGATCT

Downstream 100 bases:

>100_bases
TTTGAGCACATGACAAGCAGGCTCAGTTGTGCAGATAACCTGCTTCATATACCGGTCTAACACGTAACAGGTTCCGCTAT
GCCTCCAATCAATATCGTCA

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MRAVVQRVSCASLTVEGHSGAQIGPGLTVLLAIAPGDGSRDIDWMVRKLLGLRIFEDDSGKMNASVVDIRGALLIVSQFT
LYGDTSRGNRPGFSASAPYETAHEIYNQFVDRLRSSSPLVVQTGVFGRDMQVSLTNDGPVTMILDTP

Sequences:

>Translated_147_residues
MRAVVQRVSCASLTVEGHSGAQIGPGLTVLLAIAPGDGSRDIDWMVRKLLGLRIFEDDSGKMNASVVDIRGALLIVSQFT
LYGDTSRGNRPGFSASAPYETAHEIYNQFVDRLRSSSPLVVQTGVFGRDMQVSLTNDGPVTMILDTP
>Mature_147_residues
MRAVVQRVSCASLTVEGHSGAQIGPGLTVLLAIAPGDGSRDIDWMVRKLLGLRIFEDDSGKMNASVVDIRGALLIVSQFT
LYGDTSRGNRPGFSASAPYETAHEIYNQFVDRLRSSSPLVVQTGVFGRDMQVSLTNDGPVTMILDTP

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=149, Percent_Identity=46.9798657718121, Blast_Score=130, Evalue=4e-31,
Organism=Escherichia coli, GI1790320, Length=144, Percent_Identity=48.6111111111111, Blast_Score=131, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI115533292, Length=149, Percent_Identity=38.255033557047, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=39.8648648648649, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281361569, Length=148, Percent_Identity=47.2972972972973, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_PROA2 (B4S4I3)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016526.1
- ProteinModelPortal:   B4S4I3
- SMR:   B4S4I3
- GeneID:   6460146
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1867
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15797; Mature: 15797

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVQRVSCASLTVEGHSGAQIGPGLTVLLAIAPGDGSRDIDWMVRKLLGLRIFEDDSG
CCHHHHHCCEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCEEEECCCC
KMNASVVDIRGALLIVSQFTLYGDTSRGNRPGFSASAPYETAHEIYNQFVDRLRSSSPLV
CCCEEEEECCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
VQTGVFGRDMQVSLTNDGPVTMILDTP
EEECCCCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MRAVVQRVSCASLTVEGHSGAQIGPGLTVLLAIAPGDGSRDIDWMVRKLLGLRIFEDDSG
CCHHHHHCCEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCEEEECCCC
KMNASVVDIRGALLIVSQFTLYGDTSRGNRPGFSASAPYETAHEIYNQFVDRLRSSSPLV
CCCEEEEECCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
VQTGVFGRDMQVSLTNDGPVTMILDTP
EEECCCCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA