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The map label for this gene is clpP [H]

Identifier: 194334636

GI number: 194334636

Start: 2007521

End: 2008201

Strand: Reverse

Name: clpP [H]

Synonym: Paes_1837

Alternate gene names: 194334636

Gene position: 2008201-2007521 (Counterclockwise)

Preceding gene: 194334638

Following gene: 194334635

Centisome position: 79.91

GC content: 51.4

Gene sequence:

>681_bases
ATGGCAAATATCAATTTCGGCTTTGAGCGGCAGGCACAGAAAATGTATTCCGGCGCTATAGAGCAGGGTATCCAGAACAG
TCTTGTCCCGATGGTTATCGAAACATCCGGCCGCGGTGAAAGGGCTTTCGATATCTTTTCCCGTCTTCTCAGGGAACGTA
TCATTTTTCTGGGCACTCCCATTGACGAGCATGTGGCAAGTCTTCTCATGGCTCAGCTGATTTTTCTGGAATCCGAAGAT
CCTGAGCGCGATATATATATTTACATTAATTCACCGGGGGGCAGTGTTTCGGCCGGACTGGGTATTTACGATACCATGCA
GTATATCCGTCCCGAAGTCTCTACCGTCTGCGTCGGTATGGCAGCCAGCATGGGCGCGTTTCTTCTGGCAAGCGGTGCGA
AAGATAAACGAGCGTCGCTTCCGCACTCCCGCATCATGATCCATCAGCCATCCGGCGGTGCTCAGGGCCAGGAGACAGAT
ATTCTTATTCAGGCTCGCGAGATCGAGAAAATACGCAAGCTCCTTGATGAAATCCTTGCACAGCATACCGGTCAGGACGT
CCAGAAAATCAGGTCTGATTCCGAACGGGACCGCTGGATGAATGCAGAAGAGGCGAAAGCCTATGGCATTATCGACCAGA
TTTTCGACCGCCGTCCAGCCCTGGATAAAAAGGATGCCTGA

Upstream 100 bases:

>100_bases
AAAATTCGTACTGATATGCTGATTCGGACCGGGTTGCCATGCCAGAAGAGGGCCGGGGTCCGGCAGAAGATACAGTAACA
CCATAAACGGGAACTATATA

Downstream 100 bases:

>100_bases
AGAGGCGTTCTGAACGATGACGGTCGTCCGGGTATCTTCCCACGGCCGTTATAGCAGTAAGGAACCTCTTTTAATTTGTT
GCGCGACCCGAATACTTCGT

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MANINFGFERQAQKMYSGAIEQGIQNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTPIDEHVASLLMAQLIFLESED
PERDIYIYINSPGGSVSAGLGIYDTMQYIRPEVSTVCVGMAASMGAFLLASGAKDKRASLPHSRIMIHQPSGGAQGQETD
ILIQAREIEKIRKLLDEILAQHTGQDVQKIRSDSERDRWMNAEEAKAYGIIDQIFDRRPALDKKDA

Sequences:

>Translated_226_residues
MANINFGFERQAQKMYSGAIEQGIQNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTPIDEHVASLLMAQLIFLESED
PERDIYIYINSPGGSVSAGLGIYDTMQYIRPEVSTVCVGMAASMGAFLLASGAKDKRASLPHSRIMIHQPSGGAQGQETD
ILIQAREIEKIRKLLDEILAQHTGQDVQKIRSDSERDRWMNAEEAKAYGIIDQIFDRRPALDKKDA
>Mature_225_residues
ANINFGFERQAQKMYSGAIEQGIQNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTPIDEHVASLLMAQLIFLESEDP
ERDIYIYINSPGGSVSAGLGIYDTMQYIRPEVSTVCVGMAASMGAFLLASGAKDKRASLPHSRIMIHQPSGGAQGQETDI
LIQAREIEKIRKLLDEILAQHTGQDVQKIRSDSERDRWMNAEEAKAYGIIDQIFDRRPALDKKDA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=59.8958333333333, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=60.4166666666667, Blast_Score=263, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.3010752688172, Blast_Score=219, Evalue=6e-58,
Organism=Drosophila melanogaster, GI20129427, Length=210, Percent_Identity=53.3333333333333, Blast_Score=233, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 25217; Mature: 25086

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINFGFERQAQKMYSGAIEQGIQNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTP
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVASLLMAQLIFLESEDPERDIYIYINSPGGSVSAGLGIYDTMQYIRPEVSTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AASMGAFLLASGAKDKRASLPHSRIMIHQPSGGAQGQETDILIQAREIEKIRKLLDEILA
HHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
QHTGQDVQKIRSDSERDRWMNAEEAKAYGIIDQIFDRRPALDKKDA
HHCCHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ANINFGFERQAQKMYSGAIEQGIQNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTP
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVASLLMAQLIFLESEDPERDIYIYINSPGGSVSAGLGIYDTMQYIRPEVSTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AASMGAFLLASGAKDKRASLPHSRIMIHQPSGGAQGQETDILIQAREIEKIRKLLDEILA
HHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
QHTGQDVQKIRSDSERDRWMNAEEAKAYGIIDQIFDRRPALDKKDA
HHCCHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA