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The map label for this gene is ilvD [H]

Identifier: 194333578

GI number: 194333578

Start: 794905

End: 796605

Strand: Reverse

Name: ilvD [H]

Synonym: Paes_0744

Alternate gene names: 194333578

Gene position: 796605-794905 (Counterclockwise)

Preceding gene: 194333588

Following gene: 194333577

Centisome position: 31.7

GC content: 52.26

Gene sequence:

>1701_bases
ATGAAACTCATGAGATCCGATACCATAAAAAAAGGCTTTGAAAAAGCCCCGCACAGAAGCCTGCTGAATGCAACCGGCGC
AATCAGAAGCCAGAGCGACTTCAAAAAGCCGTTCATAGGCATCTGCAACTCCTATAATGAACTGATTCCCGGCCACACCC
ATCTTCAGGAGCTGGGGCGCATCGCAAAAGAAGCGATCAGAGAAGCTGGCGGTGTTCCGTTTGAGTTCAATACCATAGGG
GTCTGCGACGGCATTGCCATGGGACATATGGGCATGCGTTATTCGCTTGCCAGCCGGGAACTGATTGCCGACAGCGTCGA
AACAGTCGCACAGGCGCACCGTCTCGACGGTCTTGTCTGTATACCTAATTGCGACAAGATAACCCCGGGAATGATGATGG
GGGTCCTGCGCATCAACATTCCTGCTGTTTTCGTTTCCGGTGGCCCTATGAAAGCCGGCCACACGCCATCAGGAAAAACT
GTCGATCTCATATCGGTCTTCGAGGCTGTCGGACAGTGCAGTACCGGTGAAATCAGCGATGAAGAGCTCAGGTCTATAGA
GAGTAACGCATGCCCCACATGCGGCTCCTGCTCAGGCATGTTCACAGCAAACTCAATGAACTGTCTTGCCGAAGCGCTTG
GCTTTGCGCTTCCTGGCAACGGCACCATTCTTGCGGTCGATCAAGGTCGGAAAGAACTGGTAAAACAGGCATCTGCAGTC
ATTCTCGATCTGGTACAGAACGATATTAAACCAAGGGATATCCTCTCGAGGAAATCAATGCTCAACGCCTTTGCACTCGA
TCTTGCAATGGGAGGAAGCACCAATACCATTCTTCATACACTGGCGATTGCCAATGAAGCGGAACTGGAGTTTGACTTTT
CTGAACTCAACGATCTTTCTGCCAGGACACCCTATATCTGCAAGGTCAGCCCCGCAACTCCCGATGTCCATATCGAGGAT
GTCGACCGAGCAGGCGGCATCAGCGCAATTCTGCATGAACTGTCAAAAATCGACGGCTTGCTGGACCTCTCGACACCAAC
CGTTACGGGAAAAACCCTTGGAGAAAATATCAGCGGAGCCGAAGTCAGAGACAGAAAAGTCATCCGTTCGGTCGAAGAAC
CTTACTCTCCTACCGGTGGCCTGGCAGTCCTGTATGGAAATCTTGCCCCAGACGGCGCTGTTGTCAAAACAGGGGCCGTC
AGCCCGTCGATGATGAAACATACCGGCCCGGCAAGGATCTTCGAATGCCAGGATGATGCCATCAAAGGCATTATGGACGG
CGATGTCGTCAAGGGAGATGTGGTTATCATCCGCTATGAAGGCCCCAAGGGGGGACCTGGTATGCCGGAAATGCTCTCGC
CAACAAGCGCAATCATGGGCAGAGGGCTTGGCGACAGCGTCGCACTGATTACTGACGGCAGGTTCTCGGGAGGCTCCCGC
GGAGCCTGTGTAGGTCATGTTTCTCCCGAAGCAGCAGAAAAAGGCCCAATAGCCGCTGTAGAAAACGGCGATCTGGTTAC
CATAGATATTCCAAACCGGACTATCTCGGTCGATCTCTCAGACGAGGTCATCGAACAGCGTCAGGCCAGTCTGCCAGTCT
TTGAACCTAAAGTTAAAAAAGGATATCTGGCCCGCTACGCGCACATGGTGACGTCAGCAAATACAGGGGCGATACTCAAA
AATCCAGCTATTAATCTTTAA

Upstream 100 bases:

>100_bases
CAGCCGGTCCCAAGTCCAGATTTCTTTCTTGAAAATACTCATGATTTCATCGGCTTCGGGGACGGCGCTCCCTGGCATGG
CTTTTTGTTAATTGTTAACC

Downstream 100 bases:

>100_bases
ATATCCGATCCATGGTTACATCAGGCCAAACAATGAACGGCTCTGAAATATTGTTCGAATGTCTCCGACGCGAACATGTT
GAGTATATTTTCGGCTACCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MKLMRSDTIKKGFEKAPHRSLLNATGAIRSQSDFKKPFIGICNSYNELIPGHTHLQELGRIAKEAIREAGGVPFEFNTIG
VCDGIAMGHMGMRYSLASRELIADSVETVAQAHRLDGLVCIPNCDKITPGMMMGVLRINIPAVFVSGGPMKAGHTPSGKT
VDLISVFEAVGQCSTGEISDEELRSIESNACPTCGSCSGMFTANSMNCLAEALGFALPGNGTILAVDQGRKELVKQASAV
ILDLVQNDIKPRDILSRKSMLNAFALDLAMGGSTNTILHTLAIANEAELEFDFSELNDLSARTPYICKVSPATPDVHIED
VDRAGGISAILHELSKIDGLLDLSTPTVTGKTLGENISGAEVRDRKVIRSVEEPYSPTGGLAVLYGNLAPDGAVVKTGAV
SPSMMKHTGPARIFECQDDAIKGIMDGDVVKGDVVIIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSR
GACVGHVSPEAAEKGPIAAVENGDLVTIDIPNRTISVDLSDEVIEQRQASLPVFEPKVKKGYLARYAHMVTSANTGAILK
NPAINL

Sequences:

>Translated_566_residues
MKLMRSDTIKKGFEKAPHRSLLNATGAIRSQSDFKKPFIGICNSYNELIPGHTHLQELGRIAKEAIREAGGVPFEFNTIG
VCDGIAMGHMGMRYSLASRELIADSVETVAQAHRLDGLVCIPNCDKITPGMMMGVLRINIPAVFVSGGPMKAGHTPSGKT
VDLISVFEAVGQCSTGEISDEELRSIESNACPTCGSCSGMFTANSMNCLAEALGFALPGNGTILAVDQGRKELVKQASAV
ILDLVQNDIKPRDILSRKSMLNAFALDLAMGGSTNTILHTLAIANEAELEFDFSELNDLSARTPYICKVSPATPDVHIED
VDRAGGISAILHELSKIDGLLDLSTPTVTGKTLGENISGAEVRDRKVIRSVEEPYSPTGGLAVLYGNLAPDGAVVKTGAV
SPSMMKHTGPARIFECQDDAIKGIMDGDVVKGDVVIIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSR
GACVGHVSPEAAEKGPIAAVENGDLVTIDIPNRTISVDLSDEVIEQRQASLPVFEPKVKKGYLARYAHMVTSANTGAILK
NPAINL
>Mature_566_residues
MKLMRSDTIKKGFEKAPHRSLLNATGAIRSQSDFKKPFIGICNSYNELIPGHTHLQELGRIAKEAIREAGGVPFEFNTIG
VCDGIAMGHMGMRYSLASRELIADSVETVAQAHRLDGLVCIPNCDKITPGMMMGVLRINIPAVFVSGGPMKAGHTPSGKT
VDLISVFEAVGQCSTGEISDEELRSIESNACPTCGSCSGMFTANSMNCLAEALGFALPGNGTILAVDQGRKELVKQASAV
ILDLVQNDIKPRDILSRKSMLNAFALDLAMGGSTNTILHTLAIANEAELEFDFSELNDLSARTPYICKVSPATPDVHIED
VDRAGGISAILHELSKIDGLLDLSTPTVTGKTLGENISGAEVRDRKVIRSVEEPYSPTGGLAVLYGNLAPDGAVVKTGAV
SPSMMKHTGPARIFECQDDAIKGIMDGDVVKGDVVIIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSR
GACVGHVSPEAAEKGPIAAVENGDLVTIDIPNRTISVDLSDEVIEQRQASLPVFEPKVKKGYLARYAHMVTSANTGAILK
NPAINL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=48.772504091653, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1788157, Length=523, Percent_Identity=30.9751434034417, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1786464, Length=501, Percent_Identity=32.1357285429142, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI2367371, Length=535, Percent_Identity=31.0280373831776, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=550, Percent_Identity=40.1818181818182, Blast_Score=393, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59781; Mature: 59781

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLMRSDTIKKGFEKAPHRSLLNATGAIRSQSDFKKPFIGICNSYNELIPGHTHLQELGR
CCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCHHHHHHCCHHHHCCCHHHHHHHHH
IAKEAIREAGGVPFEFNTIGVCDGIAMGHMGMRYSLASRELIADSVETVAQAHRLDGLVC
HHHHHHHHHCCCCEEECEEECCCCHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEE
IPNCDKITPGMMMGVLRINIPAVFVSGGPMKAGHTPSGKTVDLISVFEAVGQCSTGEISD
CCCCCCCCHHHHHHEEEEECCEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCH
EELRSIESNACPTCGSCSGMFTANSMNCLAEALGFALPGNGTILAVDQGRKELVKQASAV
HHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
ILDLVQNDIKPRDILSRKSMLNAFALDLAMGGSTNTILHTLAIANEAELEFDFSELNDLS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECHHHHCCCC
ARTPYICKVSPATPDVHIEDVDRAGGISAILHELSKIDGLLDLSTPTVTGKTLGENISGA
CCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCHHHCCCCCCC
EVRDRKVIRSVEEPYSPTGGLAVLYGNLAPDGAVVKTGAVSPSMMKHTGPARIFECQDDA
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHCCCCCEEEECCHHH
IKGIMDGDVVKGDVVIIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSR
HCCCCCCCEEECCEEEEEECCCCCCCCCCHHCCCHHHHHCCCCCCCEEEEECCCCCCCCC
GACVGHVSPEAAEKGPIAAVENGDLVTIDIPNRTISVDLSDEVIEQRQASLPVFEPKVKK
CEEEECCCCCHHCCCCEEEECCCCEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCHHHH
GYLARYAHMVTSANTGAILKNPAINL
HHHHHHHHHHHCCCCCCEECCCCCCC
>Mature Secondary Structure
MKLMRSDTIKKGFEKAPHRSLLNATGAIRSQSDFKKPFIGICNSYNELIPGHTHLQELGR
CCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCHHHHHHCCHHHHCCCHHHHHHHHH
IAKEAIREAGGVPFEFNTIGVCDGIAMGHMGMRYSLASRELIADSVETVAQAHRLDGLVC
HHHHHHHHHCCCCEEECEEECCCCHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEE
IPNCDKITPGMMMGVLRINIPAVFVSGGPMKAGHTPSGKTVDLISVFEAVGQCSTGEISD
CCCCCCCCHHHHHHEEEEECCEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCH
EELRSIESNACPTCGSCSGMFTANSMNCLAEALGFALPGNGTILAVDQGRKELVKQASAV
HHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
ILDLVQNDIKPRDILSRKSMLNAFALDLAMGGSTNTILHTLAIANEAELEFDFSELNDLS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECHHHHCCCC
ARTPYICKVSPATPDVHIEDVDRAGGISAILHELSKIDGLLDLSTPTVTGKTLGENISGA
CCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCHHHCCCCCCC
EVRDRKVIRSVEEPYSPTGGLAVLYGNLAPDGAVVKTGAVSPSMMKHTGPARIFECQDDA
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHCCCCCEEEECCHHH
IKGIMDGDVVKGDVVIIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSR
HCCCCCCCEEECCEEEEEECCCCCCCCCCHHCCCHHHHHCCCCCCCEEEEECCCCCCCCC
GACVGHVSPEAAEKGPIAAVENGDLVTIDIPNRTISVDLSDEVIEQRQASLPVFEPKVKK
CEEEECCCCCHHCCCCEEEECCCCEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCHHHH
GYLARYAHMVTSANTGAILKNPAINL
HHHHHHHHHHHCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA