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The map label for this gene is purE [H]

Identifier: 194333440

GI number: 194333440

Start: 635352

End: 635876

Strand: Reverse

Name: purE [H]

Synonym: Paes_0597

Alternate gene names: 194333440

Gene position: 635876-635352 (Counterclockwise)

Preceding gene: 194333444

Following gene: 194333439

Centisome position: 25.3

GC content: 50.67

Gene sequence:

>525_bases
ATGACAAAACAGACCAATGACGCAACGCCTGTTGTAGGCATCATCATGGGTTCGGATTCCGACTTTGAAATAATGAAAGA
GGCCGCCCTGGTCCTTGACGAATTCAATATCGCCTACCAGGTATCGGTCATATCGGCACACCGCACTCCCAAAGAACTGG
AGCAGTATGCTGGAAGTGCAAAAGAGCGGGGAATGAAAATCATCATTGCCGGCGCAGGCGGTGCAGCTCACCTTCCCGGC
GTCACTGCAGCTCTTACTGTCATTCCGGTTATCGGTGTACCGATCTTCAGTAAAAAACTCAATGGGCAGGATTCGCTCTA
TTCTATCGTGCAGATGCCGGCAGGCATTCCTGTGGCGACTGTCGGGATCGATAACGCCCGCAACGCAGCGCTGCTTGCCG
TACAGATCCTTGCGCTGAGCGATACCGGGATCATGAAGGATATTGAATCGTTCCGGGAAAAACTTGCTGACGCATCGAAA
CTGAAAAACAAAAAAATACAGGAAAAGCTTCATGCTGACAGCTGA

Upstream 100 bases:

>100_bases
CAAGTTTATGTTCTCGTGAAAATACACAAAACTCGACAATTTCATAAATCAATAAGCAAAACGCCACTGCAGCAATGCTG
CAGTTAACCATTTTATTACC

Downstream 100 bases:

>100_bases
AGAATGGATCGACAAACTTGAGCTGACCAAACACCCGGAAGGCGGTTACTTCCGGGAAACCTACCGTAGCAAGGTTTCCT
ATCAGTTCCGTAAAAACCCG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTKQTNDATPVVGIIMGSDSDFEIMKEAALVLDEFNIAYQVSVISAHRTPKELEQYAGSAKERGMKIIIAGAGGAAHLPG
VTAALTVIPVIGVPIFSKKLNGQDSLYSIVQMPAGIPVATVGIDNARNAALLAVQILALSDTGIMKDIESFREKLADASK
LKNKKIQEKLHADS

Sequences:

>Translated_174_residues
MTKQTNDATPVVGIIMGSDSDFEIMKEAALVLDEFNIAYQVSVISAHRTPKELEQYAGSAKERGMKIIIAGAGGAAHLPG
VTAALTVIPVIGVPIFSKKLNGQDSLYSIVQMPAGIPVATVGIDNARNAALLAVQILALSDTGIMKDIESFREKLADASK
LKNKKIQEKLHADS
>Mature_173_residues
TKQTNDATPVVGIIMGSDSDFEIMKEAALVLDEFNIAYQVSVISAHRTPKELEQYAGSAKERGMKIIIAGAGGAAHLPGV
TAALTVIPVIGVPIFSKKLNGQDSLYSIVQMPAGIPVATVGIDNARNAALLAVQILALSDTGIMKDIESFREKLADASKL
KNKKIQEKLHADS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=121, Percent_Identity=55.3719008264463, Blast_Score=135, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=53.7974683544304, Blast_Score=174, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18429; Mature: 18297

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQTNDATPVVGIIMGSDSDFEIMKEAALVLDEFNIAYQVSVISAHRTPKELEQYAGSA
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHCCCH
KERGMKIIIAGAGGAAHLPGVTAALTVIPVIGVPIFSKKLNGQDSLYSIVQMPAGIPVAT
HHCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCCEEE
VGIDNARNAALLAVQILALSDTGIMKDIESFREKLADASKLKNKKIQEKLHADS
ECCCCCCCHHHHHHEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKQTNDATPVVGIIMGSDSDFEIMKEAALVLDEFNIAYQVSVISAHRTPKELEQYAGSA
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHCCCH
KERGMKIIIAGAGGAAHLPGVTAALTVIPVIGVPIFSKKLNGQDSLYSIVQMPAGIPVAT
HHCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCCEEE
VGIDNARNAALLAVQILALSDTGIMKDIESFREKLADASKLKNKKIQEKLHADS
ECCCCCCCHHHHHHEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]