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The map label for this gene is pyrD [H]

Identifier: 194333396

GI number: 194333396

Start: 596438

End: 597367

Strand: Reverse

Name: pyrD [H]

Synonym: Paes_0553

Alternate gene names: 194333396

Gene position: 597367-596438 (Counterclockwise)

Preceding gene: 194333397

Following gene: 194333395

Centisome position: 23.77

GC content: 55.91

Gene sequence:

>930_bases
ATGACACAGGAATCACGACACACCGCAGTCGCTCTGGGAAGAGGGCTCGAACTGCGTTCACCGGTCCTTCTCGCCTCGGG
AACAGTCTCCTACGGCGAAGAACTCTCGAAACTCACCGACCTCAGCCGCATCGGAGGCCTTGTCACCAAAGCAATCTCTC
CCGAACCGCGTATCGGCAACAGGCCCCAGCGAATCGCTGAAACCCCCTGCGGCATGGTCAACGCCATCGGACTGGCCAAT
GTTGGCCTCGAACGCTTTGTAGCAGAAAAACTCCCTTTCCTGCAAAACCTCGATACAGCAGTCATCGTCAACGTGGCCGG
AAAATCCATCGACGATTACGTTCAGGTTGTGCAGCGTATTGATGAATACGACGGCATCGATGGCTACGAAATCAACCTCT
CCTGCCCGAACGTCAAGGGAGAATGCATGATCATGGGCGTCAGCAGCACAGCAACCTTCGAAATCATCTCGAAGCTGCGT
TCGATCACCAATCGCCACCTCATGGTCAAACTCACCCCGAACGTCACCTCTATCAGCGCCATCGCGCTGGCCGCCGAAGA
AGCAGGCGCAGACTCCGTCTCCCTGATCAACACACTGGTCGGAATGGCTGTGGACCACAAAACAAGAAAACCACTCCTCA
CCAACATCACGGGAGGCCTGTCCGGCCCCGCCATCAAGCCCGTTGCTCTTGCCAAAGTCTGGGAAGTCTATAACGCCGTC
AACATCCCTATCGTCGGCATGGGAGGCATTTCCAACGTCGAAGACGCCATGGAATTCCTCGTCACCGGCGCCAGAGCGAT
CCAGATCGGCACCATGAACTTCGTCTACCCCGACATTGGCCAAACCATCGCCGACAAGCTCGAAGAGTACTTCTCAAGCC
CGGAACAGATGACACTGGAAGAGTATAGCGGAAGCTTGATTGTGGCGTAA

Upstream 100 bases:

>100_bases
ATCAACCGGAGAGGCTCAGTTAGCCTCTCCGGAATGATATCGGGAAACACGATCAGTGCTTCACCGAAACACAACACTCC
GGAATTTTACCGCTCCACGT

Downstream 100 bases:

>100_bases
GCAAAAGAGCAGACGGTTGCGTGTTCTCTTTTTCTGGAAAATAGTGCTATCTTTTGCCCACATGAATCACTCACCATAAC
CCATGCAATTCTACTCTCAT

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTQESRHTAVALGRGLELRSPVLLASGTVSYGEELSKLTDLSRIGGLVTKAISPEPRIGNRPQRIAETPCGMVNAIGLAN
VGLERFVAEKLPFLQNLDTAVIVNVAGKSIDDYVQVVQRIDEYDGIDGYEINLSCPNVKGECMIMGVSSTATFEIISKLR
SITNRHLMVKLTPNVTSISAIALAAEEAGADSVSLINTLVGMAVDHKTRKPLLTNITGGLSGPAIKPVALAKVWEVYNAV
NIPIVGMGGISNVEDAMEFLVTGARAIQIGTMNFVYPDIGQTIADKLEEYFSSPEQMTLEEYSGSLIVA

Sequences:

>Translated_309_residues
MTQESRHTAVALGRGLELRSPVLLASGTVSYGEELSKLTDLSRIGGLVTKAISPEPRIGNRPQRIAETPCGMVNAIGLAN
VGLERFVAEKLPFLQNLDTAVIVNVAGKSIDDYVQVVQRIDEYDGIDGYEINLSCPNVKGECMIMGVSSTATFEIISKLR
SITNRHLMVKLTPNVTSISAIALAAEEAGADSVSLINTLVGMAVDHKTRKPLLTNITGGLSGPAIKPVALAKVWEVYNAV
NIPIVGMGGISNVEDAMEFLVTGARAIQIGTMNFVYPDIGQTIADKLEEYFSSPEQMTLEEYSGSLIVA
>Mature_308_residues
TQESRHTAVALGRGLELRSPVLLASGTVSYGEELSKLTDLSRIGGLVTKAISPEPRIGNRPQRIAETPCGMVNAIGLANV
GLERFVAEKLPFLQNLDTAVIVNVAGKSIDDYVQVVQRIDEYDGIDGYEINLSCPNVKGECMIMGVSSTATFEIISKLRS
ITNRHLMVKLTPNVTSISAIALAAEEAGADSVSLINTLVGMAVDHKTRKPLLTNITGGLSGPAIKPVALAKVWEVYNAVN
IPIVGMGGISNVEDAMEFLVTGARAIQIGTMNFVYPDIGQTIADKLEEYFSSPEQMTLEEYSGSLIVA

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=192, Percent_Identity=34.8958333333333, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI45006951, Length=300, Percent_Identity=25.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082059, Length=311, Percent_Identity=26.6881028938907, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71984108, Length=169, Percent_Identity=32.5443786982249, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322633, Length=267, Percent_Identity=32.5842696629214, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24640763, Length=171, Percent_Identity=36.2573099415205, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18858217, Length=171, Percent_Identity=36.2573099415205, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33008; Mature: 32877

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQESRHTAVALGRGLELRSPVLLASGTVSYGEELSKLTDLSRIGGLVTKAISPEPRIGN
CCCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RPQRIAETPCGMVNAIGLANVGLERFVAEKLPFLQNLDTAVIVNVAGKSIDDYVQVVQRI
CCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEECCCCHHHHHHHHHHH
DEYDGIDGYEINLSCPNVKGECMIMGVSSTATFEIISKLRSITNRHLMVKLTPNVTSISA
HHHCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
IALAAEEAGADSVSLINTLVGMAVDHKTRKPLLTNITGGLSGPAIKPVALAKVWEVYNAV
HHEEHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
NIPIVGMGGISNVEDAMEFLVTGARAIQIGTMNFVYPDIGQTIADKLEEYFSSPEQMTLE
CCCEEECCCCCCHHHHHHHHHHCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCHHEEHH
EYSGSLIVA
HCCCCEEEC
>Mature Secondary Structure 
TQESRHTAVALGRGLELRSPVLLASGTVSYGEELSKLTDLSRIGGLVTKAISPEPRIGN
CCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RPQRIAETPCGMVNAIGLANVGLERFVAEKLPFLQNLDTAVIVNVAGKSIDDYVQVVQRI
CCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEECCCCHHHHHHHHHHH
DEYDGIDGYEINLSCPNVKGECMIMGVSSTATFEIISKLRSITNRHLMVKLTPNVTSISA
HHHCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
IALAAEEAGADSVSLINTLVGMAVDHKTRKPLLTNITGGLSGPAIKPVALAKVWEVYNAV
HHEEHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
NIPIVGMGGISNVEDAMEFLVTGARAIQIGTMNFVYPDIGQTIADKLEEYFSSPEQMTLE
CCCEEECCCCCCHHHHHHHHHHCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCHHEEHH
EYSGSLIVA
HCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA