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The map label for this gene is lpxC/fabZ [H]

Identifier: 194333342

GI number: 194333342

Start: 538230

End: 539633

Strand: Reverse

Name: lpxC/fabZ [H]

Synonym: Paes_0499

Alternate gene names: 194333342

Gene position: 539633-538230 (Counterclockwise)

Preceding gene: 194333343

Following gene: 194333338

Centisome position: 21.47

GC content: 50.07

Gene sequence:

>1404_bases
ATGCTCATTCACCAACGAACACTGAAAAATGAAGTCTCTCTCTGGGGCAGAGGATTGCATACCGGAAAGGAATGCATGAT
TACGTTCAAACCGGCCCCTGATAATTACGGCTACCGTTTTATCCGAACCGATGTTGAAGATTGTCCTGAAATCCCGGCAC
TGATTGATAACGTCGTCGATGTCTGCAGAGGCACAACCATTGAATGCAATGGCGTCAAGGTACATACAACGGAACATGTT
CTTGCCGCTCTCTACGGCTTGCAGATCGACAACTGCCGTATTGAAATGAACGGACCTGAACCTCCGGTTATGGACGGAAG
CTCACAGCAATTTGCCGAAGCCCTGCTTGAAGCCGGGTTCCATGAACAGGAAGAACCGAAAAACTATCTTGTGATCGATG
AAAGCATCGAATATCATGATCAGGATAACGGTGTTGACATCGTAGGCCTGCCCCTCGACGGGTTCAGGACAACGGTCATG
GTTGACTATAAAAACCCAGCTCTCGGCTCGCAGCACTCCGGCCTTTTTGATCTTGACAATGAGTTTCTCAAAGACTTTGC
GCCTTGCCGTACCTTCTGCTTTCTGAGCGAAGTCGAAGCGCTGGCAAACCTTGGCATCATTAAAGGCGGCGATATTGATA
ACGCTGTCGTCATTGTCGACAAGACTCTTTCATCCGAAGAACTTGATGCTCTTGCCGAAAAAATCGGAATCGATCCTTCA
GGGCTTATTCTTGGAGACAACGGCATACTCAACAATCGCGAATTGCGTTTCACGAACGAACCTGCCCGTCACAAGCTCCT
CGATCTCCTGGGTGATCTGGCCCTGCTCGGCATGCCGATCAAAGCCCAGATCCTTGCAGCCCGTCCGGGCCATGCATCGA
ACGTCGAGTTTGTCAAACTGCTGAAAAAATATGCTGACCGCAATGCCCTTGCCAGACAGTATCAGCACGAGAAAAAAGCC
GGGGTCATTTTCGACATCAATGCTATCCAGAACATCCTTCCCCACCGCTATCCGTTCCTCCTGATCGACAAGATCGTCGA
ATTCAAACTCGACGAAAAGATCGTCTCGATCAAAAATGTGACGATGAACGAAGAGTTCTTCCAGGGTCACTTTCCCGGAA
ACCCGATCATGCCCGGAGTACTGATTATCGAAGCGATGGCTCAGACAGGCGGGATCATGATGCTCAACGGCAACGACAAC
ATCAACGATATGCAGGTCTACTTCATGGGGATCGACAAAGCACGATTCCGCAAGCCGGTTGTCCCGGGAGACACGCTGGT
TATCGAAGCTGTCATGAAAAGCAGGCGCCGCAGCGTCTGCCAGTTTGATGGAAAAGCCTATGTTCGTGGTGAACTGGTCT
GTGAAGCGTCGCTGATGGCAACCGTCGTCAAGAAAGAAAAATAG

Upstream 100 bases:

>100_bases
CGAGGAATTTGAAAGGGTTGCGCCCTTTATTATCTTAAAAGTTTCTATTGGCCGATTTACTCATTGTCCTGCCGCAGGCG
GGAATAACAACCGATACACC

Downstream 100 bases:

>100_bases
CCATCAGGCTACATTGACAACCTTGCAAGCCGGTCTCTCAGTGAAAGAGAGACCGGCTTTTTTTCAGACCTTGTATTCCA
TGCCCCGCTGAATTCTGTAA

Product: bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Products: NA

Alternate protein names: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MLIHQRTLKNEVSLWGRGLHTGKECMITFKPAPDNYGYRFIRTDVEDCPEIPALIDNVVDVCRGTTIECNGVKVHTTEHV
LAALYGLQIDNCRIEMNGPEPPVMDGSSQQFAEALLEAGFHEQEEPKNYLVIDESIEYHDQDNGVDIVGLPLDGFRTTVM
VDYKNPALGSQHSGLFDLDNEFLKDFAPCRTFCFLSEVEALANLGIIKGGDIDNAVVIVDKTLSSEELDALAEKIGIDPS
GLILGDNGILNNRELRFTNEPARHKLLDLLGDLALLGMPIKAQILAARPGHASNVEFVKLLKKYADRNALARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEEFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGNDN
INDMQVYFMGIDKARFRKPVVPGDTLVIEAVMKSRRRSVCQFDGKAYVRGELVCEASLMATVVKKEK

Sequences:

>Translated_467_residues
MLIHQRTLKNEVSLWGRGLHTGKECMITFKPAPDNYGYRFIRTDVEDCPEIPALIDNVVDVCRGTTIECNGVKVHTTEHV
LAALYGLQIDNCRIEMNGPEPPVMDGSSQQFAEALLEAGFHEQEEPKNYLVIDESIEYHDQDNGVDIVGLPLDGFRTTVM
VDYKNPALGSQHSGLFDLDNEFLKDFAPCRTFCFLSEVEALANLGIIKGGDIDNAVVIVDKTLSSEELDALAEKIGIDPS
GLILGDNGILNNRELRFTNEPARHKLLDLLGDLALLGMPIKAQILAARPGHASNVEFVKLLKKYADRNALARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEEFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGNDN
INDMQVYFMGIDKARFRKPVVPGDTLVIEAVMKSRRRSVCQFDGKAYVRGELVCEASLMATVVKKEK
>Mature_467_residues
MLIHQRTLKNEVSLWGRGLHTGKECMITFKPAPDNYGYRFIRTDVEDCPEIPALIDNVVDVCRGTTIECNGVKVHTTEHV
LAALYGLQIDNCRIEMNGPEPPVMDGSSQQFAEALLEAGFHEQEEPKNYLVIDESIEYHDQDNGVDIVGLPLDGFRTTVM
VDYKNPALGSQHSGLFDLDNEFLKDFAPCRTFCFLSEVEALANLGIIKGGDIDNAVVIVDKTLSSEELDALAEKIGIDPS
GLILGDNGILNNRELRFTNEPARHKLLDLLGDLALLGMPIKAQILAARPGHASNVEFVKLLKKYADRNALARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEEFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGNDN
INDMQVYFMGIDKARFRKPVVPGDTLVIEAVMKSRRRSVCQFDGKAYVRGELVCEASLMATVVKKEK

Specific function: Involved in saturated fatty acids biosynthesis [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thioester dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=301, Percent_Identity=34.5514950166113, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1786377, Length=136, Percent_Identity=48.5294117647059, Blast_Score=149, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013114
- InterPro:   IPR010084
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF07977 FabA; PF03331 LpxC [H]

EC number: 3.5.1.-; 4.2.1.-

Molecular weight: Translated: 52044; Mature: 52044

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIHQRTLKNEVSLWGRGLHTGKECMITFKPAPDNYGYRFIRTDVEDCPEIPALIDNVVD
CCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCHHHCCCHHHHHHHHHH
VCRGTTIECNGVKVHTTEHVLAALYGLQIDNCRIEMNGPEPPVMDGSSQQFAEALLEAGF
HHCCCEEEECCEEEEHHHHHHHHHHCCEEECEEEECCCCCCCCCCCCHHHHHHHHHHCCC
HEQEEPKNYLVIDESIEYHDQDNGVDIVGLPLDGFRTTVMVDYKNPALGSQHSGLFDLDN
CCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCH
EFLKDFAPCRTFCFLSEVEALANLGIIKGGDIDNAVVIVDKTLSSEELDALAEKIGIDPS
HHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCC
GLILGDNGILNNRELRFTNEPARHKLLDLLGDLALLGMPIKAQILAARPGHASNVEFVKL
CEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
LKKYADRNALARQYQHEKKAGVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNV
HHHHHCHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC
TMNEEFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGNDNINDMQVYFMGIDKARFRKPV
EECHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCHHHHCCCC
VPGDTLVIEAVMKSRRRSVCQFDGKAYVRGELVCEASLMATVVKKEK
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MLIHQRTLKNEVSLWGRGLHTGKECMITFKPAPDNYGYRFIRTDVEDCPEIPALIDNVVD
CCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCHHHCCCHHHHHHHHHH
VCRGTTIECNGVKVHTTEHVLAALYGLQIDNCRIEMNGPEPPVMDGSSQQFAEALLEAGF
HHCCCEEEECCEEEEHHHHHHHHHHCCEEECEEEECCCCCCCCCCCCHHHHHHHHHHCCC
HEQEEPKNYLVIDESIEYHDQDNGVDIVGLPLDGFRTTVMVDYKNPALGSQHSGLFDLDN
CCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCH
EFLKDFAPCRTFCFLSEVEALANLGIIKGGDIDNAVVIVDKTLSSEELDALAEKIGIDPS
HHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCC
GLILGDNGILNNRELRFTNEPARHKLLDLLGDLALLGMPIKAQILAARPGHASNVEFVKL
CEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
LKKYADRNALARQYQHEKKAGVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNV
HHHHHCHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC
TMNEEFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGNDNINDMQVYFMGIDKARFRKPV
EECHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCHHHHCCCC
VPGDTLVIEAVMKSRRRSVCQFDGKAYVRGELVCEASLMATVVKKEK
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]