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The map label for this gene is coaBC [H]

Identifier: 194333184

GI number: 194333184

Start: 370540

End: 371778

Strand: Reverse

Name: coaBC [H]

Synonym: Paes_0340

Alternate gene names: 194333184

Gene position: 371778-370540 (Counterclockwise)

Preceding gene: 194333185

Following gene: 194333183

Centisome position: 14.79

GC content: 52.62

Gene sequence:

>1239_bases
ATGATACTGAACGGAAAAAACATTCTTCTCGGGATCTGCGGAGGTATTGCCGCATATAAAATGCCAATGCTCATCCGATT
ACTGAAAAAAGAGGGCGCTCATGTCCGGGTAGTCATGACCGGCTCAGCCACCCGTTTTGTCACTGAGCTGACCCTGGCGA
CGGTCTCACAGGAGCCAGTCAACCGGGATATCTTCCCGGAATCATACGACACTGCACATGACTGGACCCGTCATATCTCT
CTTGGAGAGTGGGCAGATATGATGATCATCTCGCCAGCGACCGCCAATACGATTGCAAAAATCACGGCCGGGCTCTGCGA
TGATCTTCTCTCGACCTGCTTTATCACGCTGCGCCCCGACAGACCGAAACTTATCTTCCCTGCCATGGATGGGGAGATGT
ACCGCTCCGACTCGGTACAGCGGAATCTGGCATGGCTCAAAAGTAACGGATGCAGGGTAGTCGAGCCTGAAAGCGGCTCG
CTGGCTTCAGGCCAATGCGGTACAGGAAGAATGCCGGAACCTGAAACCATCCTGGAATCTATCATCGAATCCTTAGGCGA
AAAACGGCAGTCCAGCCGCCTTCAAGACAAAAACATCATCGTCACAGCCGGGCCGACAAGAGAAAAAATCGACGGAGTAC
GCTTTCTTTCCAACTACTCCTCCGGTAAAATGGGCTTTGCTATAGCATGCGCAGCAGCTCGAAGAGGAGCCGACGTAACG
CTCATCACTGGCCCTGTCAGCCTTCCTACTCCCGAAGGGGTCCGCAGAATCGATATAGAAACCGCCTGCGACATGCAGCG
GGAGGTTCAGCGCATCGCTTCCGGATGTGATATCTTTATTGGTGCCGCTGCCGTTGCCGATTACCGGCCCGCTGAAACCG
TCACCGGAAAAATCAAGAAAACCAGTGAAACCATAGCATTGTCACTGATACGAAACCCTGATATTCTCGCCGGTTTTTCA
GCGGAGAAAAAAACACATCAGCTCGCCGTCGGCTTCTCGCTTGAAACAGAGAACGGACTCGGATACGCAGCAGAAAAGCT
CCGTGCAAAGAACCTCGATCTGATCGCCTATAATACCTATGACGGAGAAACATCAGGTTTTGAAGTCGACACCAATGCGC
TGACACTCATCGATAGACAGGGCACGACAACCGAACTGCCGCTACTGACAAAAAGAGACGCAGCAATCCGGCTACTCGAT
GCCATTGAATCACTGCTGAGCAGACCGGACAACGGCTGA

Upstream 100 bases:

>100_bases
TTCTTGACACATTCGTGTAAATTGCCCCATTGCCACCCAGGCATGCGCCCATGCAACGGGCATACTGAAATGCACCTCAT
AGAGAACACTTGATGGTTTT

Downstream 100 bases:

>100_bases
CAAGCTCCATTCACTCTCGACCATCCATATCGTCAACCATGCAGGCCAAGCTTTTTAACGACATACCGCAGCAAACACCG
CAACGCGACAGGAACGACTA

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MILNGKNILLGICGGIAAYKMPMLIRLLKKEGAHVRVVMTGSATRFVTELTLATVSQEPVNRDIFPESYDTAHDWTRHIS
LGEWADMMIISPATANTIAKITAGLCDDLLSTCFITLRPDRPKLIFPAMDGEMYRSDSVQRNLAWLKSNGCRVVEPESGS
LASGQCGTGRMPEPETILESIIESLGEKRQSSRLQDKNIIVTAGPTREKIDGVRFLSNYSSGKMGFAIACAAARRGADVT
LITGPVSLPTPEGVRRIDIETACDMQREVQRIASGCDIFIGAAAVADYRPAETVTGKIKKTSETIALSLIRNPDILAGFS
AEKKTHQLAVGFSLETENGLGYAAEKLRAKNLDLIAYNTYDGETSGFEVDTNALTLIDRQGTTTELPLLTKRDAAIRLLD
AIESLLSRPDNG

Sequences:

>Translated_412_residues
MILNGKNILLGICGGIAAYKMPMLIRLLKKEGAHVRVVMTGSATRFVTELTLATVSQEPVNRDIFPESYDTAHDWTRHIS
LGEWADMMIISPATANTIAKITAGLCDDLLSTCFITLRPDRPKLIFPAMDGEMYRSDSVQRNLAWLKSNGCRVVEPESGS
LASGQCGTGRMPEPETILESIIESLGEKRQSSRLQDKNIIVTAGPTREKIDGVRFLSNYSSGKMGFAIACAAARRGADVT
LITGPVSLPTPEGVRRIDIETACDMQREVQRIASGCDIFIGAAAVADYRPAETVTGKIKKTSETIALSLIRNPDILAGFS
AEKKTHQLAVGFSLETENGLGYAAEKLRAKNLDLIAYNTYDGETSGFEVDTNALTLIDRQGTTTELPLLTKRDAAIRLLD
AIESLLSRPDNG
>Mature_412_residues
MILNGKNILLGICGGIAAYKMPMLIRLLKKEGAHVRVVMTGSATRFVTELTLATVSQEPVNRDIFPESYDTAHDWTRHIS
LGEWADMMIISPATANTIAKITAGLCDDLLSTCFITLRPDRPKLIFPAMDGEMYRSDSVQRNLAWLKSNGCRVVEPESGS
LASGQCGTGRMPEPETILESIIESLGEKRQSSRLQDKNIIVTAGPTREKIDGVRFLSNYSSGKMGFAIACAAARRGADVT
LITGPVSLPTPEGVRRIDIETACDMQREVQRIASGCDIFIGAAAVADYRPAETVTGKIKKTSETIALSLIRNPDILAGFS
AEKKTHQLAVGFSLETENGLGYAAEKLRAKNLDLIAYNTYDGETSGFEVDTNALTLIDRQGTTTELPLLTKRDAAIRLLD
AIESLLSRPDNG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=191, Percent_Identity=29.8429319371728, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=46.9135802469136, Blast_Score=312, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17560194, Length=196, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=203, Percent_Identity=29.064039408867, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322925, Length=225, Percent_Identity=24.4444444444444, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44699; Mature: 44699

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILNGKNILLGICGGIAAYKMPMLIRLLKKEGAHVRVVMTGSATRFVTELTLATVSQEPV
CEECCCEEEEEHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCC
NRDIFPESYDTAHDWTRHISLGEWADMMIISPATANTIAKITAGLCDDLLSTCFITLRPD
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEEECCC
RPKLIFPAMDGEMYRSDSVQRNLAWLKSNGCRVVEPESGSLASGQCGTGRMPEPETILES
CCCEEEEECCCCHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
IIESLGEKRQSSRLQDKNIIVTAGPTREKIDGVRFLSNYSSGKMGFAIACAAARRGADVT
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHCCCCCEE
LITGPVSLPTPEGVRRIDIETACDMQREVQRIASGCDIFIGAAAVADYRPAETVTGKIKK
EEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCHHHHCCCCC
TSETIALSLIRNPDILAGFSAEKKTHQLAVGFSLETENGLGYAAEKLRAKNLDLIAYNTY
CCCEEEEEEECCCCEEECCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECC
DGETSGFEVDTNALTLIDRQGTTTELPLLTKRDAAIRLLDAIESLLSRPDNG
CCCCCCEEECCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MILNGKNILLGICGGIAAYKMPMLIRLLKKEGAHVRVVMTGSATRFVTELTLATVSQEPV
CEECCCEEEEEHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCC
NRDIFPESYDTAHDWTRHISLGEWADMMIISPATANTIAKITAGLCDDLLSTCFITLRPD
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEEECCC
RPKLIFPAMDGEMYRSDSVQRNLAWLKSNGCRVVEPESGSLASGQCGTGRMPEPETILES
CCCEEEEECCCCHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
IIESLGEKRQSSRLQDKNIIVTAGPTREKIDGVRFLSNYSSGKMGFAIACAAARRGADVT
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHCCCCCEE
LITGPVSLPTPEGVRRIDIETACDMQREVQRIASGCDIFIGAAAVADYRPAETVTGKIKK
EEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCHHHHCCCCC
TSETIALSLIRNPDILAGFSAEKKTHQLAVGFSLETENGLGYAAEKLRAKNLDLIAYNTY
CCCEEEEEEECCCCEEECCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECC
DGETSGFEVDTNALTLIDRQGTTTELPLLTKRDAAIRLLDAIESLLSRPDNG
CCCCCCEEECCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]