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The map label for this gene is guaA [H]

Identifier: 194333159

GI number: 194333159

Start: 339406

End: 340962

Strand: Reverse

Name: guaA [H]

Synonym: Paes_0315

Alternate gene names: 194333159

Gene position: 340962-339406 (Counterclockwise)

Preceding gene: 194333160

Following gene: 194333158

Centisome position: 13.57

GC content: 52.67

Gene sequence:

>1557_bases
ATGTTCACGTTTATGCAGTCTGTTCTTGTACTCGATTTCGGCTCTCAATATACCCAGCTCATTGCCAGGAGAATCCGCGA
AATCGGGATCTATTCTGAAATTATCCCATACAGCACACCGCTGGACACCATCAAAGAGCACAAGCCAGGAGCAATCATTC
TTTCCGGAGGGCCAAACAGCGTCTACGGCGAAGATGCGCTGCTCCCCGATAAAGGAATATTCTCTCTCGGAGTGCCGATT
CTGGGGATCTGTTATGGTCTGCAGGTTATCGCGACGCACTTTGGAGGAGAGGTCGCCGTATCGTCAAAACAGGAATTCGG
TCGCGCCAAAATACTGGTTGACCGGGAAAACGACGTAGCCGCAAGCAGGCTTTTCAGCGATATTCCCGATTCGGATGTCT
GGATGAGCCATGGCGACAAGGTCGTCAGAATGCCTGAAGGATTTTCCATTACCGCAAGCAGCGGCAACTCTGAAATGTGC
GCTATTGAAGCAACGGGCAGCAAAGCCGCTCTGAAGGTCTATGGACTGCAGTTCCATCCCGAAGTCCAGCACTCACTCTA
CGGAAAACAGCTGCTCTCAAACTTTCTTATCGATATCGCCGGGCTCAAGCCCGACTGGTCACCTAAAAGCTTTATCGAGC
ATCAGATCGAAGAGATTCGAAAAACAGCAGGCAACGCTACCGTCATTTGCGGTATCAGCGGCGGCGTCGATTCCACGGTA
GCCGCAGTGCTCGTCAGCAAAGCCATCGGGAAAAAACTCCACTGCGTCTTTGTCAACAACGGTCTGTTGCGTAAAAACGA
GGGTGAAAAAGTGATGAGTATCCTCAAGCCGCTCGGCCTCAACATCACGATGGTCGATGCCGAAGAGATCTTCCTCAAAC
GCCTCAAAAGCGTTGCCTCACCCGAGAAAAAGCGCAAAATCATCGGCCGGACCTTTATCCATATTTTTGAGGAACAGATT
CACGAAGAAAAATTTCTCGTTCAGGGGACCCTCTATCCTGACGTCATCGAAAGCGTCAGCGTCAAAGGACCGTCAGAAAC
CATCAAGTCGCACCACAATGTCGGCGGCCTGCCGAAACGCATGAAACTCAAACTGATCGAACCCCTGCGGGAGCTTTTCA
AAGATGAAGTCCGCGCCGTCGGGCGAGAACTCGGTATCGACGAGGATATCCTCATGCGCCACCCCTTCCCGGGCCCTGGT
CTGGCTGTACGCGTCCTTGGATCACTCACCAAAGAACGGCTCGATATCCTGCGGGATGCAGATGAAATCTTCCTCGAAGA
GCTCAAAAAGCAGAACCTCTATCAGCAGGTCTGGCAGGCGTTCTCCGTCCTGCTGCCGGTCCAGTCCGTCGGCGTCATGG
GTGATAAACGAACCTACGAAAACGTCCTTGCGCTGCGGGCTGTTGAATCTTCCGACGGCATGACAGCTGACTGGGCGCAT
CTGCCGCACGAATTCCTCTCTCATGTTTCAAACCGCATCATCAACGAAGTTCGCGGTATCAACAGGGTTGCCTACGACAT
CTCCTCCAAACCACCGGCAACCATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
GCTACTCCTTCAGAAGAGCAATTGATGCCGGCAAGCGACAACACCTATGAATCACCGGGATGGCAGGAAGACCGGTACTG
ATTTTCTATTCAACCACTTA

Downstream 100 bases:

>100_bases
CCTCAACGCATCGGCAACGACACTAACCGACAACAAAATACCATGAGAGAAATTCTTCTCATCACCCTTTCAGGCCCGGA
TCAACCGGGCCTGACGTCGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MFTFMQSVLVLDFGSQYTQLIARRIREIGIYSEIIPYSTPLDTIKEHKPGAIILSGGPNSVYGEDALLPDKGIFSLGVPI
LGICYGLQVIATHFGGEVAVSSKQEFGRAKILVDRENDVAASRLFSDIPDSDVWMSHGDKVVRMPEGFSITASSGNSEMC
AIEATGSKAALKVYGLQFHPEVQHSLYGKQLLSNFLIDIAGLKPDWSPKSFIEHQIEEIRKTAGNATVICGISGGVDSTV
AAVLVSKAIGKKLHCVFVNNGLLRKNEGEKVMSILKPLGLNITMVDAEEIFLKRLKSVASPEKKRKIIGRTFIHIFEEQI
HEEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIDEDILMRHPFPGPG
LAVRVLGSLTKERLDILRDADEIFLEELKKQNLYQQVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAH
LPHEFLSHVSNRIINEVRGINRVAYDISSKPPATIEWE

Sequences:

>Translated_518_residues
MFTFMQSVLVLDFGSQYTQLIARRIREIGIYSEIIPYSTPLDTIKEHKPGAIILSGGPNSVYGEDALLPDKGIFSLGVPI
LGICYGLQVIATHFGGEVAVSSKQEFGRAKILVDRENDVAASRLFSDIPDSDVWMSHGDKVVRMPEGFSITASSGNSEMC
AIEATGSKAALKVYGLQFHPEVQHSLYGKQLLSNFLIDIAGLKPDWSPKSFIEHQIEEIRKTAGNATVICGISGGVDSTV
AAVLVSKAIGKKLHCVFVNNGLLRKNEGEKVMSILKPLGLNITMVDAEEIFLKRLKSVASPEKKRKIIGRTFIHIFEEQI
HEEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIDEDILMRHPFPGPG
LAVRVLGSLTKERLDILRDADEIFLEELKKQNLYQQVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAH
LPHEFLSHVSNRIINEVRGINRVAYDISSKPPATIEWE
>Mature_518_residues
MFTFMQSVLVLDFGSQYTQLIARRIREIGIYSEIIPYSTPLDTIKEHKPGAIILSGGPNSVYGEDALLPDKGIFSLGVPI
LGICYGLQVIATHFGGEVAVSSKQEFGRAKILVDRENDVAASRLFSDIPDSDVWMSHGDKVVRMPEGFSITASSGNSEMC
AIEATGSKAALKVYGLQFHPEVQHSLYGKQLLSNFLIDIAGLKPDWSPKSFIEHQIEEIRKTAGNATVICGISGGVDSTV
AAVLVSKAIGKKLHCVFVNNGLLRKNEGEKVMSILKPLGLNITMVDAEEIFLKRLKSVASPEKKRKIIGRTFIHIFEEQI
HEEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIDEDILMRHPFPGPG
LAVRVLGSLTKERLDILRDADEIFLEELKKQNLYQQVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAH
LPHEFLSHVSNRIINEVRGINRVAYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=559, Percent_Identity=38.4615384615385, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=54.0229885057471, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=32.8719723183391, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=32.8719723183391, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=32.8719723183391, Blast_Score=278, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=527, Percent_Identity=54.26944971537, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI281365319, Length=555, Percent_Identity=36.9369369369369, Blast_Score=309, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57389; Mature: 57389

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTFMQSVLVLDFGSQYTQLIARRIREIGIYSEIIPYSTPLDTIKEHKPGAIILSGGPNS
CHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHCCCCCEEEEECCCCC
VYGEDALLPDKGIFSLGVPILGICYGLQVIATHFGGEVAVSSKQEFGRAKILVDRENDVA
CCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCEEEEEECCCCHH
ASRLFSDIPDSDVWMSHGDKVVRMPEGFSITASSGNSEMCAIEATGSKAALKVYGLQFHP
HHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCEEEEEECCCCEEEEEEEEEECC
EVQHSLYGKQLLSNFLIDIAGLKPDWSPKSFIEHQIEEIRKTAGNATVICGISGGVDSTV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
AAVLVSKAIGKKLHCVFVNNGLLRKNEGEKVMSILKPLGLNITMVDAEEIFLKRLKSVAS
HHHHHHHHHCCCEEEEEECCCCEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCC
PEKKRKIIGRTFIHIFEEQIHEEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKR
CHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHH
MKLKLIEPLRELFKDEVRAVGRELGIDEDILMRHPFPGPGLAVRVLGSLTKERLDILRDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCH
DEIFLEELKKQNLYQQVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCHHHH
LPHEFLSHVSNRIINEVRGINRVAYDISSKPPATIEWE
CHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
>Mature Secondary Structure
MFTFMQSVLVLDFGSQYTQLIARRIREIGIYSEIIPYSTPLDTIKEHKPGAIILSGGPNS
CHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHCCCCCEEEEECCCCC
VYGEDALLPDKGIFSLGVPILGICYGLQVIATHFGGEVAVSSKQEFGRAKILVDRENDVA
CCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCEEEEEECCCCHH
ASRLFSDIPDSDVWMSHGDKVVRMPEGFSITASSGNSEMCAIEATGSKAALKVYGLQFHP
HHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCEEEEEECCCCEEEEEEEEEECC
EVQHSLYGKQLLSNFLIDIAGLKPDWSPKSFIEHQIEEIRKTAGNATVICGISGGVDSTV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
AAVLVSKAIGKKLHCVFVNNGLLRKNEGEKVMSILKPLGLNITMVDAEEIFLKRLKSVAS
HHHHHHHHHCCCEEEEEECCCCEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCC
PEKKRKIIGRTFIHIFEEQIHEEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKR
CHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHH
MKLKLIEPLRELFKDEVRAVGRELGIDEDILMRHPFPGPGLAVRVLGSLTKERLDILRDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCH
DEIFLEELKKQNLYQQVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCHHHH
LPHEFLSHVSNRIINEVRGINRVAYDISSKPPATIEWE
CHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA