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The map label for this gene is sglT [H]

Identifier: 194333076

GI number: 194333076

Start: 242575

End: 243978

Strand: Reverse

Name: sglT [H]

Synonym: Paes_0232

Alternate gene names: 194333076

Gene position: 243978-242575 (Counterclockwise)

Preceding gene: 194333077

Following gene: 194333075

Centisome position: 9.71

GC content: 51.78

Gene sequence:

>1404_bases
ATGCAGCCACTTGACCTGTCCATTATCATCGTTTTTCTCCTGGCAATGACCGTGTACGGTATATGGCAGGGGCACACCAA
CCGTTCGACCGGAGACTATTTTCTCGGAGGAAGAAATCTGCCGTGGATAGTCGCCATGCTCTCAATCGTTGCAACAGAAA
CGTCTGTTCTGACCTTTGTCAGTATTCCCGGCATCGCCTACAGGGGAGACTGGACCTTTCTTCAGCTCGCCATGGGCTAC
ATTCTCGGGAGAATTCTCGTCAGCGCAATCCTGCTGCCCGTCTATTTCAAGCAGGGAGTCTCTTCCATCTACGAGGTCAT
CGGAAAGCGTTTCGGAAAACCGATGCAGAAACTCTCTTCCATCGTCTTCCTTATCACCAGAATTCTTGCTGACGGGGTCC
GGTTTCTGGCGACGGCTGTCGTCGTCGAAGCAGTCACCGGCTGGCCGATGCCTGTCGCTGTTCTCATTATCGGAGTGGTA
ACCCTTATCTATACCCTCTCTGGCGGTATTAAAACGGTTGTCTGGCTCGACAGCATCCAGTTCATGCTCTACCTTGCCGG
AGGAGTACTCACCATCGGTTTCATTCTTTCATCTCTTGACGCAGATCCGGCAAGCGCCCTGCTCTCTCTTGCCAGGGAAG
GAAAGCTCAGGATCATCAATACCGATACCCACCTCCTGAGTAACCCCTGGGCATTTTTCAGCGCTTTTGCCGGTGGAACG
CTGCTCTCCTTCGCATCTCACGGCGTTGACTATATGATGGTCCAGCGAGCACTCGGCTGTAAAAACCTTGAGTCGGCTCA
AAAAGCAATGATCGGCAGCGGTGTCTTTGTGTTCATACAATTCTCCGTCTTCCTGCTGGCAGGCTCACTTATCTACCTCT
ATCTTGAAGGAGATCTGAATGTCGCAAAAGACAGAGAATTTGCAACATTCATCGTCAGCTACCTACCGCCCGGCCTCAAA
GGACTCCTTCTGGCTGGTGTTCTCTCGGCGGCTATGTCGACGCTCAGCTCTTCGATCAATGCTCTTGCCTCGTCGACCGT
CACCGACCTTCTGGGGGGGAAAGCGTCGTTAAACCAGTCCCGCCTGATCAGTTTCGTATGGGCTGCAATACTTATTGCCA
TAGCGCTGGGATTTGATGAAAGTGACAATGCCATTGTCATTCTCGGACTGCAGATCGCATCGTTCACCTATGGCGGACTG
CTCAGCCTCTTTCTTCTCTCGCAGAGCAAAAAAACATTTCACCCCGCAAGCCTTGCTGCAGGGCTCATGACAGGAATGGG
CAGCGTTTTTCTTCTTCAGTACGCAGGTATTGCCTGGACGTGGTATATTTCGTTCTCTCTCGTGATCAATATTTCAACCG
CTTTTATCGTGAACCTTCTGCTGCCGGCCAGGAATCAGACGTAA

Upstream 100 bases:

>100_bases
AAACCGCCCGTTTGAGGAACTGAGAGCCTCATGGAAAAAGGATGAGGCAGCATTTCTTTCTGCCAAGGAAATCTTTCACC
TCTACTGACCCTGATGCACC

Downstream 100 bases:

>100_bases
AAGAATAGGCTTTGGAGTACATGACCAGTTTGCATGACATAATTATTTCTCTAAATTAGATATATAGCGTTCCTCACTAA
CGGCCAACAGCAAAAGAATC

Product: Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Na(+)/glucose symporter [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MQPLDLSIIIVFLLAMTVYGIWQGHTNRSTGDYFLGGRNLPWIVAMLSIVATETSVLTFVSIPGIAYRGDWTFLQLAMGY
ILGRILVSAILLPVYFKQGVSSIYEVIGKRFGKPMQKLSSIVFLITRILADGVRFLATAVVVEAVTGWPMPVAVLIIGVV
TLIYTLSGGIKTVVWLDSIQFMLYLAGGVLTIGFILSSLDADPASALLSLAREGKLRIINTDTHLLSNPWAFFSAFAGGT
LLSFASHGVDYMMVQRALGCKNLESAQKAMIGSGVFVFIQFSVFLLAGSLIYLYLEGDLNVAKDREFATFIVSYLPPGLK
GLLLAGVLSAAMSTLSSSINALASSTVTDLLGGKASLNQSRLISFVWAAILIAIALGFDESDNAIVILGLQIASFTYGGL
LSLFLLSQSKKTFHPASLAAGLMTGMGSVFLLQYAGIAWTWYISFSLVINISTAFIVNLLLPARNQT

Sequences:

>Translated_467_residues
MQPLDLSIIIVFLLAMTVYGIWQGHTNRSTGDYFLGGRNLPWIVAMLSIVATETSVLTFVSIPGIAYRGDWTFLQLAMGY
ILGRILVSAILLPVYFKQGVSSIYEVIGKRFGKPMQKLSSIVFLITRILADGVRFLATAVVVEAVTGWPMPVAVLIIGVV
TLIYTLSGGIKTVVWLDSIQFMLYLAGGVLTIGFILSSLDADPASALLSLAREGKLRIINTDTHLLSNPWAFFSAFAGGT
LLSFASHGVDYMMVQRALGCKNLESAQKAMIGSGVFVFIQFSVFLLAGSLIYLYLEGDLNVAKDREFATFIVSYLPPGLK
GLLLAGVLSAAMSTLSSSINALASSTVTDLLGGKASLNQSRLISFVWAAILIAIALGFDESDNAIVILGLQIASFTYGGL
LSLFLLSQSKKTFHPASLAAGLMTGMGSVFLLQYAGIAWTWYISFSLVINISTAFIVNLLLPARNQT
>Mature_467_residues
MQPLDLSIIIVFLLAMTVYGIWQGHTNRSTGDYFLGGRNLPWIVAMLSIVATETSVLTFVSIPGIAYRGDWTFLQLAMGY
ILGRILVSAILLPVYFKQGVSSIYEVIGKRFGKPMQKLSSIVFLITRILADGVRFLATAVVVEAVTGWPMPVAVLIIGVV
TLIYTLSGGIKTVVWLDSIQFMLYLAGGVLTIGFILSSLDADPASALLSLAREGKLRIINTDTHLLSNPWAFFSAFAGGT
LLSFASHGVDYMMVQRALGCKNLESAQKAMIGSGVFVFIQFSVFLLAGSLIYLYLEGDLNVAKDREFATFIVSYLPPGLK
GLLLAGVLSAAMSTLSSSINALASSTVTDLLGGKASLNQSRLISFVWAAILIAIALGFDESDNAIVILGLQIASFTYGGL
LSLFLLSQSKKTFHPASLAAGLMTGMGSVFLLQYAGIAWTWYISFSLVINISTAFIVNLLLPARNQT

Specific function: Actively transports glucose into cells by Na(+) cotransport [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI4507035, Length=378, Percent_Identity=28.042328042328, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI157671931, Length=335, Percent_Identity=29.8507462686567, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI167466278, Length=385, Percent_Identity=30.1298701298701, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI256985183, Length=435, Percent_Identity=25.9770114942529, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4507031, Length=391, Percent_Identity=23.7851662404092, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4507033, Length=416, Percent_Identity=23.0769230769231, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI110835708, Length=432, Percent_Identity=22.9166666666667, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI14140236, Length=393, Percent_Identity=24.6819338422392, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI206597483, Length=383, Percent_Identity=24.0208877284595, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI17941285, Length=389, Percent_Identity=21.8508997429306, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI206597487, Length=309, Percent_Identity=24.5954692556634, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI109659836, Length=383, Percent_Identity=22.7154046997389, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082237, Length=380, Percent_Identity=26.3157894736842, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790113, Length=334, Percent_Identity=25.4491017964072, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI115533094, Length=338, Percent_Identity=27.810650887574, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32566512, Length=279, Percent_Identity=27.9569892473118, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115533096, Length=214, Percent_Identity=29.4392523364486, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573698, Length=362, Percent_Identity=27.0718232044199, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24645928, Length=365, Percent_Identity=29.041095890411, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221459584, Length=400, Percent_Identity=29.5, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641117, Length=453, Percent_Identity=24.9448123620309, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24651741, Length=395, Percent_Identity=25.5696202531646, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24640370, Length=390, Percent_Identity=26.1538461538462, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651739, Length=424, Percent_Identity=24.5283018867925, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24650192, Length=400, Percent_Identity=26.75, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221459588, Length=405, Percent_Identity=27.1604938271605, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161076631, Length=389, Percent_Identity=27.7634961439589, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281362054, Length=454, Percent_Identity=24.4493392070485, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281362052, Length=454, Percent_Identity=24.4493392070485, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281362050, Length=454, Percent_Identity=24.4493392070485, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24648056, Length=454, Percent_Identity=24.4493392070485, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356827, Length=454, Percent_Identity=24.4493392070485, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281362918, Length=276, Percent_Identity=25, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574994, Length=345, Percent_Identity=24.6376811594203, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19920916, Length=369, Percent_Identity=27.9132791327913, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281364280, Length=370, Percent_Identity=26.2162162162162, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221459586, Length=413, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 50198; Mature: 50198

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLDLSIIIVFLLAMTVYGIWQGHTNRSTGDYFLGGRNLPWIVAMLSIVATETSVLTFV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHEEEE
SIPGIAYRGDWTFLQLAMGYILGRILVSAILLPVYFKQGVSSIYEVIGKRFGKPMQKLSS
ECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IVFLITRILADGVRFLATAVVVEAVTGWPMPVAVLIIGVVTLIYTLSGGIKTVVWLDSIQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHH
FMLYLAGGVLTIGFILSSLDADPASALLSLAREGKLRIINTDTHLLSNPWAFFSAFAGGT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHCCHH
LLSFASHGVDYMMVQRALGCKNLESAQKAMIGSGVFVFIQFSVFLLAGSLIYLYLEGDLN
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCC
VAKDREFATFIVSYLPPGLKGLLLAGVLSAAMSTLSSSINALASSTVTDLLGGKASLNQS
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
RLISFVWAAILIAIALGFDESDNAIVILGLQIASFTYGGLLSLFLLSQSKKTFHPASLAA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GLMTGMGSVFLLQYAGIAWTWYISFSLVINISTAFIVNLLLPARNQT
HHHHHHHHHHHHHHHCHHEEEEEEEHHEEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQPLDLSIIIVFLLAMTVYGIWQGHTNRSTGDYFLGGRNLPWIVAMLSIVATETSVLTFV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHEEEE
SIPGIAYRGDWTFLQLAMGYILGRILVSAILLPVYFKQGVSSIYEVIGKRFGKPMQKLSS
ECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IVFLITRILADGVRFLATAVVVEAVTGWPMPVAVLIIGVVTLIYTLSGGIKTVVWLDSIQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHH
FMLYLAGGVLTIGFILSSLDADPASALLSLAREGKLRIINTDTHLLSNPWAFFSAFAGGT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHCCHH
LLSFASHGVDYMMVQRALGCKNLESAQKAMIGSGVFVFIQFSVFLLAGSLIYLYLEGDLN
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCC
VAKDREFATFIVSYLPPGLKGLLLAGVLSAAMSTLSSSINALASSTVTDLLGGKASLNQS
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
RLISFVWAAILIAIALGFDESDNAIVILGLQIASFTYGGLLSLFLLSQSKKTFHPASLAA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GLMTGMGSVFLLQYAGIAWTWYISFSLVINISTAFIVNLLLPARNQT
HHHHHHHHHHHHHHHCHHEEEEEEEHHEEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8652595; 10835424; 10757971 [H]