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The map label for this gene is trpB2 [H]

Identifier: 193213485

GI number: 193213485

Start: 2027643

End: 2029019

Strand: Direct

Name: trpB2 [H]

Synonym: Cpar_1846

Alternate gene names: 193213485

Gene position: 2027643-2029019 (Clockwise)

Preceding gene: 193213476

Following gene: 193213488

Centisome position: 88.57

GC content: 63.62

Gene sequence:

>1377_bases
ATGAGTACAGAGCCTACCAAAATCCTCCTCGGCGAGGATGAACTTCCCCGTCAGTGGTACAATATTCAGGCTGACCTGCC
TTCACCCATGCCACCGCCGGTGGGACTGGATGGCAATCCGATCGGGCCGGATGCGCTGGCCAAGGTTTTTCCGATGAACC
TGATCGAGCAGGAGGTGAGCACCGAGCGCTGGATCGATATTCCGGAAGAGATTCTCGGCATCCTCAAGCTGTGGCGGCCG
TCGCCGCTCTACCGCGCGCGGCGGCTCGAAGCAGCGCTCGGCACTCCGGCCAAAATCTACTACAAGAACGAAGGGGTCTC
GCCCGCCGGGAGCCACAAGCCCAACACGGCGGTGGCGCAGGCGTGGTACAACCGGGAGTTCGGCATCAAGTACCTCACCA
CCGAAACCGGCGCGGGGCAGTGGGGCAGCGCGCTGGCGATGAGCTGCAAGCTGATCGGCATCGAGTGCAAGGTGTTCATG
GTGCGCATCAGCTTCGACCAGAAGCCGTTCCGCAAAATCATGATGAAAACCTGGGGCGCGGAGTGCATCCCGAGCCCGAG
TCCGCAGACGGCCATCGGGCGCAAGATTCTCGAAGAGATGCCCGACACCCCCGGCAGCCTCGGCATCGCCATCAGCGAAG
CGATCGAGCAGGCCGTCGAACGCGACGACACCCGCTACGCCCTCGGCAGCGTGCTGAACCACGTGATGCTGCACCAGACC
ATCATCGGCCTCGAAGCCAAGAAGCAGTTCGACAAGATCGGGCGCTACCCGGATATCGTCATCGGCTGCGCGGGCGGCGG
CTCGAACTTCGCGGGCATCAGCTTCCCATTCCTCTACGACAAGATTCACGGCAGGGATGTGCGGGTAATCGGCACGGAAC
CGGAGGCGTGCCCGACGCTGACCCGCGCCCCCTACGCCTACGATTCAGGCGACGTGGCGATGATGACGCCGCTCCTGCCG
ATGCACAGCCTGGGCCACACCTTCATTCCCCCGGCCATCCACGCAGGCGGCCTGCGCTACCACGGCATGGCGCCGCTGGT
GAGCCACACCAAGCAGCTCGGGCTGATCGAAGCCACCGCGCTGCCGCAGACCGAATGCTACGAAGCGGCGCTGCTCTTCG
CCCACACCGAAGGCTTCATTCCCGCGCCGGAGACCTCGCACGCCATCGCACAGACCATCCGCGAGGCGAAGCAGGCAAAA
GAGGAGGGCAAGGAGAAGGTGATTCTGATGAACTGGTCGGGCCACGGGCTGATGGACTTGCAGGGCTACGACGCCTACCT
CTCAGGCAAAATCAGCGACTACCCGCTGCCAGAGGAGCTGCTGCAACGCTCGTTGACCGCCTCACTGGCGGGACTTCCGA
AAGTGCCGGGAGTTTAA

Upstream 100 bases:

>100_bases
AATCCGACCGCACTCTCCCTACCTTGAAAAATGGCCACCAGACACCCGGCCATGAGAGCCGTCACCGGCCTCTTTTCTCT
TACTTCAAAGCACTACACGC

Downstream 100 bases:

>100_bases
AAAGAGGGGCTGTCTTATCTATTCAATGATGGAACAAACCCTCTTTTTAATGACCCCATGAAAACGCAAAGGGCTACCAA
GATAAGAAGGTAGCCCTTGT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSTEPTKILLGEDELPRQWYNIQADLPSPMPPPVGLDGNPIGPDALAKVFPMNLIEQEVSTERWIDIPEEILGILKLWRP
SPLYRARRLEAALGTPAKIYYKNEGVSPAGSHKPNTAVAQAWYNREFGIKYLTTETGAGQWGSALAMSCKLIGIECKVFM
VRISFDQKPFRKIMMKTWGAECIPSPSPQTAIGRKILEEMPDTPGSLGIAISEAIEQAVERDDTRYALGSVLNHVMLHQT
IIGLEAKKQFDKIGRYPDIVIGCAGGGSNFAGISFPFLYDKIHGRDVRVIGTEPEACPTLTRAPYAYDSGDVAMMTPLLP
MHSLGHTFIPPAIHAGGLRYHGMAPLVSHTKQLGLIEATALPQTECYEAALLFAHTEGFIPAPETSHAIAQTIREAKQAK
EEGKEKVILMNWSGHGLMDLQGYDAYLSGKISDYPLPEELLQRSLTASLAGLPKVPGV

Sequences:

>Translated_458_residues
MSTEPTKILLGEDELPRQWYNIQADLPSPMPPPVGLDGNPIGPDALAKVFPMNLIEQEVSTERWIDIPEEILGILKLWRP
SPLYRARRLEAALGTPAKIYYKNEGVSPAGSHKPNTAVAQAWYNREFGIKYLTTETGAGQWGSALAMSCKLIGIECKVFM
VRISFDQKPFRKIMMKTWGAECIPSPSPQTAIGRKILEEMPDTPGSLGIAISEAIEQAVERDDTRYALGSVLNHVMLHQT
IIGLEAKKQFDKIGRYPDIVIGCAGGGSNFAGISFPFLYDKIHGRDVRVIGTEPEACPTLTRAPYAYDSGDVAMMTPLLP
MHSLGHTFIPPAIHAGGLRYHGMAPLVSHTKQLGLIEATALPQTECYEAALLFAHTEGFIPAPETSHAIAQTIREAKQAK
EEGKEKVILMNWSGHGLMDLQGYDAYLSGKISDYPLPEELLQRSLTASLAGLPKVPGV
>Mature_457_residues
STEPTKILLGEDELPRQWYNIQADLPSPMPPPVGLDGNPIGPDALAKVFPMNLIEQEVSTERWIDIPEEILGILKLWRPS
PLYRARRLEAALGTPAKIYYKNEGVSPAGSHKPNTAVAQAWYNREFGIKYLTTETGAGQWGSALAMSCKLIGIECKVFMV
RISFDQKPFRKIMMKTWGAECIPSPSPQTAIGRKILEEMPDTPGSLGIAISEAIEQAVERDDTRYALGSVLNHVMLHQTI
IGLEAKKQFDKIGRYPDIVIGCAGGGSNFAGISFPFLYDKIHGRDVRVIGTEPEACPTLTRAPYAYDSGDVAMMTPLLPM
HSLGHTFIPPAIHAGGLRYHGMAPLVSHTKQLGLIEATALPQTECYEAALLFAHTEGFIPAPETSHAIAQTIREAKQAKE
EGKEKVILMNWSGHGLMDLQGYDAYLSGKISDYPLPEELLQRSLTASLAGLPKVPGV

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG1350

COG function: function code R; Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=381, Percent_Identity=28.8713910761155, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321412, Length=359, Percent_Identity=31.1977715877437, Blast_Score=130, Evalue=5e-31,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006316
- InterPro:   IPR006653
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 50109; Mature: 49978

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEPTKILLGEDELPRQWYNIQADLPSPMPPPVGLDGNPIGPDALAKVFPMNLIEQEVS
CCCCCCEEEECCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TERWIDIPEEILGILKLWRPSPLYRARRLEAALGTPAKIYYKNEGVSPAGSHKPNTAVAQ
HHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHH
AWYNREFGIKYLTTETGAGQWGSALAMSCKLIGIECKVFMVRISFDQKPFRKIMMKTWGA
HHHCCCCCEEEEEECCCCCCCCHHHHEEEEEEEEEEEEEEEEEECCCCHHHHHHHHHCCC
ECIPSPSPQTAIGRKILEEMPDTPGSLGIAISEAIEQAVERDDTRYALGSVLNHVMLHQT
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IIGLEAKKQFDKIGRYPDIVIGCAGGGSNFAGISFPFLYDKIHGRDVRVIGTEPEACPTL
HHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCC
TRAPYAYDSGDVAMMTPLLPMHSLGHTFIPPAIHAGGLRYHGMAPLVSHTKQLGLIEATA
CCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCHHCCCEEECCCCHHHHHHHHCCCEEECC
LPQTECYEAALLFAHTEGFIPAPETSHAIAQTIREAKQAKEEGKEKVILMNWSGHGLMDL
CCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEE
QGYDAYLSGKISDYPLPEELLQRSLTASLAGLPKVPGV
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STEPTKILLGEDELPRQWYNIQADLPSPMPPPVGLDGNPIGPDALAKVFPMNLIEQEVS
CCCCCEEEECCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TERWIDIPEEILGILKLWRPSPLYRARRLEAALGTPAKIYYKNEGVSPAGSHKPNTAVAQ
HHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHH
AWYNREFGIKYLTTETGAGQWGSALAMSCKLIGIECKVFMVRISFDQKPFRKIMMKTWGA
HHHCCCCCEEEEEECCCCCCCCHHHHEEEEEEEEEEEEEEEEEECCCCHHHHHHHHHCCC
ECIPSPSPQTAIGRKILEEMPDTPGSLGIAISEAIEQAVERDDTRYALGSVLNHVMLHQT
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IIGLEAKKQFDKIGRYPDIVIGCAGGGSNFAGISFPFLYDKIHGRDVRVIGTEPEACPTL
HHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCC
TRAPYAYDSGDVAMMTPLLPMHSLGHTFIPPAIHAGGLRYHGMAPLVSHTKQLGLIEATA
CCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCHHCCCEEECCCCHHHHHHHHCCCEEECC
LPQTECYEAALLFAHTEGFIPAPETSHAIAQTIREAKQAKEEGKEKVILMNWSGHGLMDL
CCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEE
QGYDAYLSGKISDYPLPEELLQRSLTASLAGLPKVPGV
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]