Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 193213466

GI number: 193213466

Start: 2007166

End: 2008380

Strand: Direct

Name: coaBC [H]

Synonym: Cpar_1827

Alternate gene names: 193213466

Gene position: 2007166-2008380 (Clockwise)

Preceding gene: 193213465

Following gene: 193213467

Centisome position: 87.68

GC content: 63.46

Gene sequence:

>1215_bases
GTGCTGACCGGCAAGAACATTCTCCTCGGCATTTCGGGTGGCATTGCCGCCTATAAAACGCCGCATCTGGTCAGGCTTCT
GAAGAAGTCGGGAGCCGATGTGCAGGTCATGGCCACCGATTCGGCACTGAAGTTCGTCAGCGAGCTGTCGCTTGCGACCG
TCTCGAACCGGTCGGTGCTCACCGATATTTTCACGGCGGATACGGAGGGTGAACGCACCCGCCACATCTCGCTCGGCGAG
TGGGCCGACGCGCTGGTCATAGCGCCCGCAACGGCCAACACGCTCGCAAAGCTGGCTGGCGGCCTGTGTGACGACATGCT
GTCGATCTCGCTCATCACCCTGCGTCCTGGCAAACCGGTGCTGCTCGTGCCCGCGATGGACGGCTACATGTACGACTCCC
CGTCGGTGCAGCGCAACCTTTCGGTGCTCAAGCAGCAGGGCTGCCGAGTCCTCGAACCGGAGAGCGGGCCGCTCGCCTCG
GGTCAGTGCGGTCTGGGACGCATGCCCGAACCGGAGACGATTTTTGAGGCGCTCGCCGAGATGCTCGCCGCGCCTGAGCC
CTCGGCGCTTAGCGGCAAGACGGTGGTGGTCACCGCCGGGCCGACGCGCGAAAAGATCGACGGCGTGCGCTACCTGTCGA
ACTACTCTTCCGGCAAGATGGGTTTCGCCATCGCTGCCGAAGCCGCGCGGCGCGGCGCAACCGTACACCTCGTAAGCGGC
CCGGTCACGCTACCAACTCCGCCGGGCGTGCAGCGCCACGACGCAGAAAGTGCTGTCGAAATGCTGGAGGCGGCGCGCCC
GCTCTTCGCCGATTGTGACCTCTTTATCGGAGCCGCTGCCGTGGCCGATTACCGACCCGAAACTCCGGTCGAGGGCAAGA
TCAAGAAGCATGACGCGGAGATGGAACTCCGTCTCGTCAGGAATCCCGACATTCTCGCCGAGTTCTCGACAAACCGGAAA
CCCGGCCAGCTCGCCGTGGGTTTTGCGCTTGAAACAGCTGGGGGAATCGACTACGCCCGCCGAAAGCTCACGGACAAGAA
GCTCGATCTGGTCGCCTTCAACATCTATGACGGAACCACCTCGGGATTCGAGGTCGATACCAACGTGCTGACCTTGCTGG
ATCGCGACGGCGCAATCACCGAGCTGCCCCTGCTCAGCAAGGAGGAGGCTGCCGAGCGGCTGCTCGATGCCATCGAACTG
CTTCTGCCCCGATAA

Upstream 100 bases:

>100_bases
ATTTCCGCGCCACGATCAGCTCCCCACCGCAGAAGGGGACATCTCATTCGTGGCCCAAGACCGGCGCCATGACCAATAAC
CGCTTATCTGTTTGCATACC

Downstream 100 bases:

>100_bases
TCGAAATTTCCGAAAAACCATCATGACGCAGGAATCGCTTTTCGATCCCGTTCCGGAACAACCGAAACAGCAAGCAGTCC
CGGCCCTCGATCTCGGCTCG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MLTGKNILLGISGGIAAYKTPHLVRLLKKSGADVQVMATDSALKFVSELSLATVSNRSVLTDIFTADTEGERTRHISLGE
WADALVIAPATANTLAKLAGGLCDDMLSISLITLRPGKPVLLVPAMDGYMYDSPSVQRNLSVLKQQGCRVLEPESGPLAS
GQCGLGRMPEPETIFEALAEMLAAPEPSALSGKTVVVTAGPTREKIDGVRYLSNYSSGKMGFAIAAEAARRGATVHLVSG
PVTLPTPPGVQRHDAESAVEMLEAARPLFADCDLFIGAAAVADYRPETPVEGKIKKHDAEMELRLVRNPDILAEFSTNRK
PGQLAVGFALETAGGIDYARRKLTDKKLDLVAFNIYDGTTSGFEVDTNVLTLLDRDGAITELPLLSKEEAAERLLDAIEL
LLPR

Sequences:

>Translated_404_residues
MLTGKNILLGISGGIAAYKTPHLVRLLKKSGADVQVMATDSALKFVSELSLATVSNRSVLTDIFTADTEGERTRHISLGE
WADALVIAPATANTLAKLAGGLCDDMLSISLITLRPGKPVLLVPAMDGYMYDSPSVQRNLSVLKQQGCRVLEPESGPLAS
GQCGLGRMPEPETIFEALAEMLAAPEPSALSGKTVVVTAGPTREKIDGVRYLSNYSSGKMGFAIAAEAARRGATVHLVSG
PVTLPTPPGVQRHDAESAVEMLEAARPLFADCDLFIGAAAVADYRPETPVEGKIKKHDAEMELRLVRNPDILAEFSTNRK
PGQLAVGFALETAGGIDYARRKLTDKKLDLVAFNIYDGTTSGFEVDTNVLTLLDRDGAITELPLLSKEEAAERLLDAIEL
LLPR
>Mature_404_residues
MLTGKNILLGISGGIAAYKTPHLVRLLKKSGADVQVMATDSALKFVSELSLATVSNRSVLTDIFTADTEGERTRHISLGE
WADALVIAPATANTLAKLAGGLCDDMLSISLITLRPGKPVLLVPAMDGYMYDSPSVQRNLSVLKQQGCRVLEPESGPLAS
GQCGLGRMPEPETIFEALAEMLAAPEPSALSGKTVVVTAGPTREKIDGVRYLSNYSSGKMGFAIAAEAARRGATVHLVSG
PVTLPTPPGVQRHDAESAVEMLEAARPLFADCDLFIGAAAVADYRPETPVEGKIKKHDAEMELRLVRNPDILAEFSTNRK
PGQLAVGFALETAGGIDYARRKLTDKKLDLVAFNIYDGTTSGFEVDTNVLTLLDRDGAITELPLLSKEEAAERLLDAIEL
LLPR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=34.0782122905028, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=46.3840399002494, Blast_Score=290, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI17560194, Length=189, Percent_Identity=32.8042328042328, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=185, Percent_Identity=32.972972972973, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322925, Length=210, Percent_Identity=27.1428571428571, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324629, Length=137, Percent_Identity=32.8467153284672, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24657262, Length=192, Percent_Identity=32.8125, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43063; Mature: 43063

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTGKNILLGISGGIAAYKTPHLVRLLKKSGADVQVMATDSALKFVSELSLATVSNRSVL
CCCCCEEEEEECCCCCHHCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHEECCCCCE
TDIFTADTEGERTRHISLGEWADALVIAPATANTLAKLAGGLCDDMLSISLITLRPGKPV
EHEEECCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCE
LLVPAMDGYMYDSPSVQRNLSVLKQQGCRVLEPESGPLASGQCGLGRMPEPETIFEALAE
EEEECCCCEECCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MLAAPEPSALSGKTVVVTAGPTREKIDGVRYLSNYSSGKMGFAIAAEAARRGATVHLVSG
HHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCEEEEEEC
PVTLPTPPGVQRHDAESAVEMLEAARPLFADCDLFIGAAAVADYRPETPVEGKIKKHDAE
CEECCCCCCCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCCCCCCCCCCEECCCCC
MELRLVRNPDILAEFSTNRKPGQLAVGFALETAGGIDYARRKLTDKKLDLVAFNIYDGTT
EEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHCCCCEEEEEEEEECCCC
SGFEVDTNVLTLLDRDGAITELPLLSKEEAAERLLDAIELLLPR
CCEEECCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTGKNILLGISGGIAAYKTPHLVRLLKKSGADVQVMATDSALKFVSELSLATVSNRSVL
CCCCCEEEEEECCCCCHHCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHEECCCCCE
TDIFTADTEGERTRHISLGEWADALVIAPATANTLAKLAGGLCDDMLSISLITLRPGKPV
EHEEECCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCE
LLVPAMDGYMYDSPSVQRNLSVLKQQGCRVLEPESGPLASGQCGLGRMPEPETIFEALAE
EEEECCCCEECCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MLAAPEPSALSGKTVVVTAGPTREKIDGVRYLSNYSSGKMGFAIAAEAARRGATVHLVSG
HHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCEEEEEEC
PVTLPTPPGVQRHDAESAVEMLEAARPLFADCDLFIGAAAVADYRPETPVEGKIKKHDAE
CEECCCCCCCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCCCCCCCCCCEECCCCC
MELRLVRNPDILAEFSTNRKPGQLAVGFALETAGGIDYARRKLTDKKLDLVAFNIYDGTT
EEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHCCCCEEEEEEEEECCCC
SGFEVDTNVLTLLDRDGAITELPLLSKEEAAERLLDAIELLLPR
CCEEECCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]